scholarly journals Role of Vitamin D Levels in Venous Thrombosis

Blood ◽  
2021 ◽  
Vol 138 (Supplement 1) ◽  
pp. 4255-4255
Author(s):  
Marwah W Farooqui ◽  
Yhana Chavis ◽  
Nailah Ghouse ◽  
Julia Bank ◽  
Michelle Chan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Venous Thromboembolism ◽  
Vitamin D Deficiency ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
P Value ◽  
International Studies ◽  
Vitamin D Levels ◽  
Cancer Associated Thrombosis

Abstract Venous thromboembolism (VTE) is a complex condition that impacts over 900,000 people in the United States annually. It is estimated that about 100,000 people in the US die from deep vein thrombosis (DVT) or pulmonary embolism (PE) annually. Several biomarkers, including Vitamin D most recently, have been investigated and linked to the risk of developing VTE or recurrent VTE. Vitamin D is known to control the expression of over 200 genes and it has shown to have anti-thrombotic effects through various mechanisms. There is emerging data regarding its role in the coagulation pathway, platelet activation, inflammatory pathways and endothelial activation (1). There have been a few international studies linking Vitamin D deficiency to VTE(2). However; no such study has been replicated in the North American population where the prevalence of Vitamin D deficiency is 40%. The focus of this study will be to determine the prevalence of Vitamin D deficiency in patients with VTE. Based on the role of Vitamin D in the pathway for thrombogenesis and antithrombin effects, there is likely a correlation between VTE and Vitamin D levels. This is a retrospective chart review of all patients admitted to Franciscan Health- Olympia Fields with VTE between July 2018 and June2020. A total of 181 patients with VTE were reviewed. Data such as age, gender, race, D-dimer, and Vitamin D levels were collected. Vitamin D levels <30ng/mL was defined as deficient. In addition, further data collection, included provoked vs unprovoked VTE, presence of malignancy, and the severity of DVT and PE based on location and extent of the VTE (severity was scored on a scale of 1-3 with 1 being mild and 3 as severe). A regression analysis was done to find a correlation between several variables and T-test was used to determine P-value. Of the 181 patients, 110 had a vitamin D level documented at the time of their VTE and data was specifically analyzed for this subgroup. There were 46 males and 64 females, 53.6%AA, 7.3% Hispanic, 38.2% Caucasian, and 0.9% unknown. 25.5% had an unprovoked VTE event and 74.5% had a provoked event. 39 patients had a known active malignancy and a likely cancer associated thrombosis. 85.7% of patients with unprovoked DVT had a low Vitamin D level. In patients with cancer associated thrombosis there was no significant correlation with vitamin D levels. A strong correlation was noted between vitamin D levels and the severity of PE (p value=0.036). This retrospective chart review from a patient population at a community hospital indicates that there is some correlation between venous thromboembolism and Vitamin D levels. Specifically, it appears that patients with an unprovoked VTE have low Vitamin D levels suggesting that vitamin D deficiency may be a risk factor for VTE development as indicated by previous international studies (2). In addition, it appears that there is an inverse relationship between the severity of PE and vitamin D levels. Perhaps Vitamin D may be used as a biomarker for VTE risk assessment and management. Large scale studies are needed in the future to determine the exact relationship between VTE and Vitamin D and further studies are needed to test the role of vitamin D supplementation and risk of recurrent VTE. Disclosures No relevant conflicts of interest to declare.

Role of Vitamin D in the Management of COVID-19 Patients Regarding Morbidity and Mortality

2021 ◽  
Vol 15 (6) ◽  
pp. 1231-1233
Author(s):  
A. W. Khan ◽  
H. T. Hussain ◽  
Z.U. Mustafa ◽  
M. A. Qamar ◽  
M. A. Qamar ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Body Mass ◽  
Morbidity And Mortality ◽  
P Value ◽  
Mortality And Morbidity ◽  
Severe Vitamin ◽  
Vitamin D Levels

Aim: To determine the role of vitamin D in the management of COVID-19 patients regarding morbidity and mortality. Study Design: Prospective/Observational Place and Duration: Departments of Medicine & Pulmonology, Allama Iqbal Memorial Teaching Hospital, Sialkot and Department of Medicine, Sughra Shafi Medical Complex Narowal from 1st November 2020 to 30th April 2020. Methodology: One hundred and sixty patients of both genders diagnosed to have COVID-19, were enrolled. Patient’s ages were ranging from 17 to 70 years. The detailed demographics such as age, sex, and body mass index were recorded. 5 ml blood samples were taken from all the patients to check their vitamin D levels. Severe Vitamin D deficiency was defined as 25(OH)D <25 nmol/L (10 ng/dl). Association between mortality and morbidity was examined. Results: Ninety (56.25%) were males while 70 (43.75%) were females with mean age 40.15±17.37 years. Mean body mass index of patients was 24.16±7.26 kg/m2. Severe vitamin D deficiency was observed in 80 (50%) patients. Mortality found in 30 (18.75%) patients. Frequency of morbidity was among 66 (41.25%) patients. Patients with severe vitamin D deficiency had high rate of mortality 20 (25%) and morbidity 50 (62.5%) as compared to patients with no vitamin D deficiency had 10 (8%) mortality and 16 (20%) morbidity. A significant association was observed between severe vitamin D deficiency regarding morbidity and mortality among patients with covid-19 disease with p-value <0.05. Conclusion: The vitamin-D has strongest relationship among patients with covid-19 disease to reduce mortality and morbidity. Keywords: Morbidity, COVID-19, Vitamin D, Mortality

P–683 Correlation of vitamin D deficiency with anti-Mullerian hormone (AMH) among infertile women in comparison to fertile women in a tertiary health facility in North-Western Nigeria

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
B Lawal ◽  
A Adesiyun ◽  
M Manu ◽  
J El-Bashir ◽  
A Olorukooba ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Reproductive Age ◽  
P Value ◽  
Infertile Women ◽  
Reproductive Age Women ◽  
Vitamin D Levels ◽  
North Western ◽  
Fertile Women

Abstract Study question is there correlation between Vitamin D Deficiency and AMH levels in infertile and fertile women? Summary answer there is no significant correlation between Vitamin D deficiency and AMH levels in both infertile and fertile women What is known already Vitamin D deficiency and insufficiency is a global health problem affecting over a billion people with higher prevalence among reproductive-age women, and blacks. Vitamin D is well known to play significant role in calcium-phosphate homeostasis and bone metabolism, however, recent studies have demonstrated diverse expression of vitamin D receptors in reproductive organs. This suggest the probable role of vitamin D in reproductive physiology and fertility. The pathogenesis of vitamin D in infertility is poorly understood, but thought to involve hypothalamo-pituitary axis, ovarian folliculogenesis and uterine implantation. Most studies are done in Assisted Reproduction Technology and in developed countries Study design, size, duration A case-control study that involved 128 consecutively consenting women within the reproductive age group; 64 infertile women as the cases and 64 age and body mass index (BMI) matched fertile women as the controls. The study was conducted over a period of six (6) months Participants/materials, setting, methods The study was conducted in Obstetrics and Gynaecology and Chemical pathology departments of Ahmadu Bello University Teaching Hospital Zaria, a tertiary hospital in North-Western Nigeria. It involved all cases of female-factor infertility as cases, while the controls were fertile women from 6 weeks postpartum to 1 year. Venous blood samples were assayed for serum 25(-hydroxy) vitamin D and AMH levels using Enzyme-Linked Immunosorbent Assay (ELISA) and data analysed with level of significance set as &lt; 0.05 Main results and the role of chance The mean ± standard deviation (SD) of serum Vitamin D levels in the infertile women and fertile women were 17.01 ± 7.61ng/ml and 11.34 ± 6.12ng/ml respectively, significantly higher in the infertile women (p-value &lt;0.000). The prevalence of Vitamin D deficiency (&lt;20ng/ml) was found to be significantly higher in the fertile women compared to infertile women (89.1% versus 68.8%; p-value 0.007). Vitamin D levels were found to be positively correlated with age (r 0.374; p-value 0.002) and parity (r 0.338; p-value 0.006). There was no association between vitamin D with type of, and causes of infertility. Vitamin D deficient women were found to be 6.5 times less likely to be infertile than non-deficient women (aOR 95% confidence interval 1.96–21.55; p-value 0.002). There was no significant correlation between vitamin D and AMH levels in vitamin D deficient women of both study groups (rs 0.180; p-value 0.242 and rs 0.088; p-value 0.521). Interestingly, there was significant relationship between AMH levels and causes of infertility (p-value 0.001), with higher levels of AMH found in infertile women with polycystic ovarian syndrome Limitations, reasons for caution There is no consensus on the cut-off values for vitamin D levels as it relates to fertility, and no reference values for vitamin D deficiency and AMH levels in study area. The sample size was limited by cost, and the study was conducted in a single study area Wider implications of the findings: The vitamin D levels in women with infertility was low but yet not significantly correlated with AMH. Overall, prevalence of vitamin D deficiency among reproductive-age women was found high. There is need for life-style and dietary modifications. Further researches are needed to ascertain the effect of vitamin D on fertility. Trial registration number Not applicable

Association between vitamin D deficiency and prostate cancer: Prospective case-control study

2021 ◽  
pp. 205141582199360
Author(s):  
Ghanshyam Kumawat ◽  
Vijay Chaudhary ◽  
Anurag Garg ◽  
Nishkarsh Mehta ◽  
Gagan Talwar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Case Control Study ◽  
Serum Vitamin ◽  
P Value ◽  
Serum Vitamin D ◽  
Severe Vitamin ◽  
Vitamin D Levels ◽  
Control Study

Objective: We aimed to find out the association of low serum vitamin D levels with the incidence of prostate cancer through a prospective case-control study. Material and methods: This study was carried out in the tertiary care hospital (India). All newly diagnosed patients of prostate cancer and age-matched controls were included. Serum vitamin D levels were measured in all of them. Vitamin D status (ng/mL) was classified as severe deficiency <10, moderate deficiency 10–<30, normal 30–100, and toxicity >100. Normality of the data was tested by the Kolmogorov–Smirnov test, statistical analysis was done with Statistical Package for the Social Sciences version 26.0, p-value of <0.05 was considered significant. Results: In our study, 320 cases and 320 controls were included. The mean vitamin D levels in cases and controls were 15.71 ± 6.5 (ng/mL) and 17.63 ± 4.54 (ng/mL), respectively, ( p-Value <0.01). Patients with severe vitamin D deficiency (73.58%) had a Gleason score ⩾8 on biopsy and 79.24% of them had a serum prostate specific antigen (PSA) level >20 ng/mL. Conclusion: We had concluded that there was no significant association between vitamin D deficiency and increased risk of prostate cancer, although patients with higher-grade prostate cancer and with higher PSA level had severe vitamin D deficiency. Level of evidence: Not applicable for this multicentre audit.

scholarly journals Correlation of psoriasis and serum vitamin D

2021 ◽  
Vol 7 (4) ◽  
pp. 320-323
Author(s):  
Ritika Gujrati ◽  
Krishnendra Varma ◽  
Ujjwal Kumar
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Psoriasis Vulgaris ◽  
Systemic Disease ◽  
Serum Vitamin ◽  
Psoriatic Skin ◽  
Control Group ◽  
P Value ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Psoriasis is an immuno-mediated chronic systemic disease involving cytokines of helper Th1 pathway. Vitamin D has an effect on keratinocyte proliferation, differentiation and immune modulation of immune system especially Th1 pathway, which is altered in psoriatic skin suggesting that Vitamin D may have a role in pathogenesis of psoriasis. To study correlation between psoriasis vulgaris and serum vitamin D. To evaluate serum vitamin D level in psoriasis cases and in control group and correlating vitamin D level with severity and duration of the psoriasis. 57 cases (&#62;15years of age) with psoriasis and 57 healthy subjects were recruited. Psoriasis was clinically diagnosed and severity evaluated by PASI scale. Vitamin D was analysed by enhanced chemilumine scence on vitrus Eci autoanalyzer of Orth clinical diagnostic. Vitamin D deficiency defined as &#60;20ng/ml, insufficiency 20-30ng/ml and sufficient 30-100ng/ml. Vitamin D deficiency in the study was 22.8% in patients and 14% in control group. Vitamin D insufficiency was found in 42.1% of cases and 19.3% of control. According to chi-square the p-value is 0.003 showing significant association. There was a tendency towards decrease in vitamin D level with increase in disease duration. There was negative correlation between vitamin D and PASI score. The study found a significant relationship between vitamin D and psoriasis. Further metanalysis involving larger study population will be required to establish whether vitamin D levels benefits patient with psoriasis vulgaris.

scholarly journals A clinical study to determine the relationship between serum vitamin D levels and severity of asthma

2017 ◽  
Vol 4 (4) ◽  
pp. 1397
Author(s):  
Pragalatha Kumar ◽  
Aruna Gowdra ◽  
Arathi Arathi ◽  
Ananya Sampath
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Asthma Severity ◽  
Severe Form ◽  
P Value ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Children With Asthma ◽  
Age And Sex

Background: Vitamin D deficiency has been rediscovered as a public health problem worldwide. Few studies have shown that vitamin D deficiency is associated with asthma severity. The objective of present work was to study the serum vitamin D levels and its relationship with asthma severity in children.Methods: A prospective cohort study of 100 children with asthma between the age group of 5 to 15 years and age and sex matched 40 healthy controls who had come to Indira Gandhi Institute of Child Health, Bengaluru was done. These children’s serum vitamin D levels were estimated and correlated with asthma severity.Results: A total of 100 children with asthma and 40 healthy age and sex matched controls were evaluated. The study group had lower vitamin D (34.95 ng/ml) levels as compared to the control group (57.94 ng/ml) which was statistically significant (p<0.05). 68.4% children had significantly low vitamin D levels and severe form of asthma (p value <0.001). There was also a marked rise in absolute eosinophil count in those who had low vitamin D levels (56.6%) (p-value <0.0001).Conclusions: Vitamin D deficiency is an important risk factor for asthma severity. It modifies the immune system and reduces the inflammation. In the present study, low serum vitamin D levels were significantly correlated with severe form of asthma. There was a significant rise in the absolute eosinophil count in those who exhibited deficiency of vitamin D.  

scholarly journals Relation of serum 25(OH) D with variables of thyroid and lipid profile in perimenopausal women

2017 ◽  
Vol 6 (3) ◽  
pp. 1087
Author(s):  
Poonam Rani ◽  
Seema Gupta ◽  
Gaurav Gupta
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin D ◽  
Lipid Profile ◽  
Vitamin D Deficiency ◽  
Serum Levels ◽  
The Body ◽  
P Value ◽  
Thyroid Disorder ◽  
Vitamin D Levels ◽  
Perimenopausal Women

Background: Deficiency of vitamin D is quite prevalent among elderly population or postmenopausal women worldwide and may affect various function of the body. The status of its deficiency with their relation with other variables are not well explored in perimenopausal women.Methods: 100 perimenopausal women from the department of obstetrics and gynaecology were selected without having known risk of thyroid disorder and cardiovascular disease. The age group criteria for these women were 40 to 50 years. Thyroid profile including TSH, T3, and T4 were estimated by using enzyme linked immunesorbent assay. Serum levels of 25(OH) D3 was estimated by using spectrophotometric method. Lipid profile including TC, TG and HDL-C were estimated CHOD-POD method, GPO-PAP method, and CHOD-POD/Phosphotungustate method. LDL-C was calculated by friedewald formula.Results: There 58 women were presented with insufficient amount of vitamin D. They were characterised with increased BMI, elevated thyrotropin alongwith lower concentrations of T3 and T4. Increased levels of TC, TG and LDL-cholesterol alongwith lower concentration of HDL-C were also observed in women with vitamin d deficiency. Women having vitamin D deficiency were presented with overweight (OR-18.0, p-value=<0.001) and dyslipidemia (OR-12.13, p-value≤0.001). Vitamin D was negatively correlated with variable i.e. BMI, TSH, TC, TG and LDL-C. This negative association was significant (<0.001) while HDL-C and T4 were positively correlated with vitamin D levels in this study population.Conclusions: Vitamin D deficiency frequently occurs in middle aged perimenopausal women. Negative correlation of it with BMI, TSH and lipid variables may suggest the development of cardiovascular disease and hypothyroidism in coming years. Vitamin D supplements or vitamin D containing diet and regular exposure to sun is highly recommended to perimenopausal women.

scholarly journals Role of Vitamin D in Reducing the Frequency of Asthma Attacks in Patients with Frequent Exacerbation of Asthma

2021 ◽  
pp. 11-16
Author(s):  
Mubeen Ahmed Memon ◽  
Sheeba Faryal Ansari ◽  
Mumtaz Ali Lakho ◽  
Mukhtiar Hussain Jaffery ◽  
Syed Zulfiquar Ali Shah ◽  
...  
Keyword(s):  
Vitamin D ◽  
Corticosteroid Treatment ◽  
Vitamin D Supplementation ◽  
The Body ◽  
P Value ◽  
Care Hospital ◽  
Asthma Exacerbations ◽  
Vitamin D Levels ◽  
Interventional Group

Introduction: Vitamin D deficiency is common among asthmatics with literature suggesting that its low levels in the body may trigger exacerbations and decrease the response to corticosteroid treatment. It has also shown to inhibit the production of cytokines, which in turn enhances the body’s response to corticosteroid treatment during an exacerbation. Therefore, maintenance of adequate levels of vitamin D in patients with asthma may reduce the risk of exacerbation and improve their general health. This study aims to explore the role of vitamin D supplementation in preventing asthma exacerbations. Methods: This single blind parallel arm interventional study was conducted in the pulmonology ward in a tertiary care hospital from June 2018 to April 2020. Two hundred (n= 200) participants with a history of frequent acute exacerbation of asthma were enrolled in the study via consecutive convenient non-probability technique. Participants were divided into two groups; the placebo and the interventional group that received 200,000 IU of vitamin D capsule. Results: Compared to day 0, mean episodes of exacerbation in the interventional group were significantly lower after 180 days (1.1 ± 0.4 vs. 0.61 ± 0.3; p-value <0.0001). Similarly, number of asthma attacks in past 7 days was significantly lower in intervention group after 180 days (4.4 ± 2.7 vs. 3.1 ± 1.5; p-value 0.0001) Conclusion: Vitamin D supplementation is a safe and cost-friendly approach to reducing asthma exacerbations. It may also help to improve the condition in severe asthmatics with low vitamin D levels.

P–662 Study on D-vitamin, AMH and insulin interrelation in Polycystic Ovary Syndrome (PCOS) patients

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
A Coc. Lizarraga ◽  
S Lindenberg ◽  
G Juu. Almind ◽  
F Lindenberg
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Group A ◽  
D Values ◽  
Group B

Abstract Study question Is vitamin D deficiency more prevalent in PCOS patients? Is there a link between vitamin D levels and metabolic status in PCOS subjects? Summary answer An inverse relationship between vitamin D levels and metabolic status was demonstrated and it is thought to be responsible of its pathogenesis. What is known already PCOS is a multifactorial condition, characterised by failure in oogenesis and anovulation. Obesity is a common condition linked to its clinical features and studies have reported inverse associations between BMI and severity of the condition. Furthermore, 67–85% of PCOS patients have vitamin D deficiency. Low levels of vitamin D have been found to be closely related to insulin resistance, obesity, or hyperandrogenism and there is a significant association between serum vitamin D levels and reproductive function. Other factors such as AMH have also been described as possibly involved in the pathophysiology. Study design, size, duration We performed a retrospective, analytical and observational study in the Copenhagen Fertility Center. Patients referred with cycle abnormalities, hirsutism, and infertility were evaluated. A total of 778 women were enrolled consecutively from January 2019 to October 2020. Subjects who had major medical disorders were excluded. We selected those in which vitamin D was measured in the baseline analysis selecting a total of 396 patients. The further analysis has been carried out from 100 randomly selected patients. Participants/materials, setting, methods Blood samples were drawn after overnight fasting. They were all assayed in the same laboratory. Biochemical parameters were analyzed using descriptive statistics. Same parameters were studied after dividing into vitamin D deficiency group or optimal levels using a multiple t-test. Correlation between variables was determined. Graphpad Prism program version 8 was used to perform the calculations. The level of statistical significance was set at P-value &lt; 0.05. Main results and the role of chance A total of 100 subjects fulfilling the inclusion criteria were selected randomly from 396 PCOS women. Serum vitamin D concentrations were highly variable ranging from 16 nmol/L to 175 nmol/L. The prevalence of vitamin D deficiency was 24% and 41% of the subjects were classified as vitamin D insufficient. Only 35% of our patients had optimal vitamin D values. We compared data between the group with optimal values of vitamin D (Group A) versus the group with insufficient/deficient vitamin D values (Group B). We found statistical difference between groups in PTH values, being notably higher in group B compared with group A. Despite no statistically significant difference was obtained, it is important to highlight that the mean of SHBG was lower in group B and the mean of androstenedione, AMH, FAI and HOMA-IR were much higher in this group as well. Following the HOMA-IR criteria, 55% of patients had insulin resistance. Specifically, 26% had moderate insulin resistance and 29% severe insulin resistance. Levels of vitamin D were negatively correlated with FAI, AMH and HOMA-IR and positively correlated with HDL-Cholesterol and SHBG. Statistically significant differences were evidenced in the correlation between vitamin D and FAI and SHBG. Limitations, reasons for caution This is a retrospective observational study on a consecutive admitted patient group with a lack of a control group. Another limitation is the small sample size. It is difficult to generalize with other degrees of severity. We didn’t assess seasonal variability or if they were taking any vitamin D supplementation. Wider implications of the findings: Properly randomized clinical trials are mandatory to achieve more conclusive results about the role of vitamin D. Available evidence is promising but not sufficient to draw final conclusions. The aim is to better understand the pathophysiology of the condition and the factors involved and to find new target treatments. Trial registration number 1

scholarly journals 0809 A Randomized Double-blind, Placebo Controlled Trial With Cross-over, To Assess The Efficacy Of Correcting Vitamin D Deficiency In Improving The Symptoms Of Restless Legs Syndrome (RLS)

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A307-A308
Author(s):  
J Wong ◽  
D Gupta ◽  
A Nadhim ◽  
S Bhat ◽  
P Polos
Keyword(s):  
Vitamin D ◽  
Iron Deficiency ◽  
Vitamin D Deficiency ◽  
Controlled Trial ◽  
Activity Count ◽  
Double Blind ◽  
Vitamin D Levels ◽  
Effect Of Treatment ◽  
B Vitamin

Abstract Introduction Recent studies have shown an association of low Vitamin D levels and severity of RLS symptoms. However, effect of treatment of Vit D deficiency on RLS symptoms was not reported, nor were other exacerbating factors for RLS such as iron deficiency or OSA addressed in prior studies, but have been addressed in our study. Methods This is an ongoing study at the JFKMC Sleep Clinic. Eligible Patients with RLS include those with vitamin D 25,hydroxy deficiency (&lt;20 ng/ml), or insufficiency (&lt;30 ng/ml). Such patients will be enrolled in the study after comorbid conditions like iron deficiency and OSA have been adequately corrected. Randomization of the patients will be done by the JFK pharmacy so the patient and provider are blinded to the substance. Substance A or B could be either Vitamin D3 Capsule 50,000 IU, or placebo. Each patient takes A for 6 weeks and then crosses over to B for 6 weeks. Weekly iRLS questionnaires will be collected. Actiwatch Device, to assess activity count per minute, will be worn on the ankle at night for one week time periods: at baseline, at end of 6 weeks of taking A and then at the end of 6 weeks of taking B. Vitamin D levels will also be assessed after each course of supplementation and correlated with subjective and objective findings. Results Between July 7, 2019 to current, 50 consecutive patients seen in sleep clinic with RLS were assessed for vitamin D levels. Ages ranged from 23-86 years. 27 patients were female (54%). Two patients met inclusion criteria and have started their 13-week study. Conclusion This study will help to establish the role of Vitamin D deficiency as a risk factor for RLS, independent of ferritin levels, and comorbid OSA, in affected individuals. This may help to discover a potentially treatable form of RLS. Support No financial support.

Role of nutrition in incidence and management of cancer therapy-induced diarrhea (CTID): HEAT (Health Eat and Toxicity) prospective interventional study and preliminary data.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e18251-e18251
Author(s):  
Aurora Mirabile ◽  
Erika Vecchio ◽  
Stefania Falvella ◽  
Lucia Barbarini ◽  
Chiara Butti ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Dihydropyrimidine Dehydrogenase ◽  
P Value ◽  
Interventional Study ◽  
Diet Adherence ◽  
Vitamin D Levels ◽  
Strict Diet ◽  
Grade 3

e18251 Background: Metastatic colorectal cancer (mCRC) patients (pts) are at high risk of CTID influencing treatment outcome. The primary end-point of our study was the decrease of grade 3-4 (G3-4 from Common Terminology Criteria for Adverse Events 4.0) CTID incidence to 50% in respect to literature data. A predefined nutritional regimen was planned and administrated to each pts. In explorative analyses, we investigated the correlation between Vitamin D deficiency and CTID incidence and between dihydropyrimidine dehydrogenase (DpD) mutations and CTID. Methods: All mCRC pts undergoing chemotherapy (CT) with an expected G3-4 CTID incidence of about 17% were enrolled. During CT the nutritionist administered a predefined, slag free diet according to Italian Society of Human Nutrition indications and within World Cancer Research Found recommendations. Results: Fifty consecutive pts were enrolled within 11 months. Pts characteristics are summarized in the table. A significant decrease (p-value 0.00096; IC 95% 0.059) of G3-4 CTID incidence to 95% was obtained in respect to literature data. No CT modification or admissions/supportive care were needed. Due to strict diet adherence (96%) > 50% pts had no diarrhea and no one had G4 diarrhea. BMI improved in 35% over-weights and in 40% obese, no changes in normal-weights. The correlation analysis showed the decrease of CTID incidence with the increase of vitamin D levels, but did not reveal a relation between DpD mutations and diarrhea. Conclusions: The preliminary results suggest a possible role of the diet on CTID prevention and a correlation with vitamin D levels. [Table: see text]

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