scholarly journals Disseminated Eosinophilic Collagen Disease

Blood ◽  
1967 ◽  
Vol 29 (4) ◽  
pp. 540-549 ◽  
Author(s):  
LAWRENCE E. PIERCE ◽  
ABDOL H. HOSSEINIAN ◽  
ANTHONY B. CONSTANTINE
Keyword(s):  
Skeletal Muscle ◽  
Cause Of Death ◽  
Cardiac Failure ◽  
Muscle Pain ◽  
Clinical Findings ◽  
Collagen Disease ◽  
Blood Examination ◽  
European Literature ◽  
Normochromic Anemia ◽  
Bacterial Products

Abstract A patient with disseminated eosinophilic collagen disease as reported in the Scandanavian and European literature and perhaps described under various titles—such as eosinophilic leukemia, Loeffler’s syndrome, parietal endocarditis,16 and allergic granulomatosis17—is presented. The major clinical findings are dermal edema and erythema with pruritus and scaling; skeletal muscle pain, tenderness, and weakness; severe arthralgias and stiffness of small and weightbearing joints; hepatomegaly; and conspicuous lack of adenopathy. Blood examination shows normochromic anemia with intense neutrophilic leukocytosis and eosinophilia. Granulocytic leukemoid features eventually appear resembling chronic to subacute myelogenous or eosinophilic leukemia. Cardiac failure or infection is the usual cause of death. At autopsy there is generalized eosinophilic and neutrophilic with lesser mononuclear infiltrations of many organs, particularly the skin, myocardium, and skeletal muscle. The etiology is unknown. Environmental toxicities and hyperimmunity perhaps to drugs, bacterial products, or sustained autoantigenic stimuli are suggested possible explanations. Corticosteroids afford some symptomatic stabilization but the disease pursues a persistent downhill course.

scholarly journals Added value of post-mortem computed tomography (PMCT) to clinical findings for cause of death determination in adult “natural deaths”

2019 ◽  
Vol 134 (4) ◽  
pp. 1457-1463
Author(s):  
M. E. M. Vester ◽  
R. R. van Rijn ◽  
W. L. J. M. Duijst ◽  
L. F. M. Beenen ◽  
M. Clerkx ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Cause Of Death ◽  
Medical Records ◽  
Clinical Findings ◽  
Added Value ◽  
Post Mortem ◽  
Additional Information ◽  
Organ Failures ◽  
Total Body ◽  
Underlying Diseases

Abstract Purpose The aim of this study was to investigate whether post-mortem computed tomography (PMCT) provides additional information regarding the cause of death and underlying diseases in a general practitioners’ (GP), out-of-hospital population. Methods and materials Bodies donated to our anatomy department between January 2014 and January 2018, who consecutively underwent a total body PMCT and had given permission for retrieval of their medical records during life, were included. PMCT scans were assessed by a radiologist and compared with the cause of death as stated in the medical records. Discrepancies were analyzed with an adjusted Goldman classification. Results Ninety-three out of the 274 scanned donors during the inclusion period had given consent for the retrieval of their medical records, of which 79 GP’s responded to the request thereof (31 men, 48 women, average age 72.8 years, range 36–99). PMCT identified 49 (62%) cases of cancer, 10 (12.7%) cardiovascular diseases, 8 (10.1%) severe organ failures, 5 (6.3%) cases with signs of pneumonia, 2 (2.5%) other causes, and 7 (8.9%) cases without an (underlying) definitive cause of death. Eleven major discrepancies on the Goldman classification scale, with possible relevance to survival between PMCT and GP records, were identified. Conclusion PMCT can have added value for the detection of additional findings regarding the cause of death in an out-of-hospital, GP’s population, especially to identify or exclude major (previously non-diagnosed) underlying diseases.

Infrared Thermography – A Tool for Computer Assisted Research in Rehabilitation Medicine

2015 ◽  
Vol 772 ◽  
pp. 603-607
Author(s):  
Marius Cristian Cojocaru ◽  
Ioana Maria Cojocaru ◽  
Nida Alexandra Cojan Carlea ◽  
Delia Cinteza ◽  
Mihai Berteanu
Keyword(s):  
Infrared Thermography ◽  
Muscle Pain ◽  
Myofascial Pain ◽  
Pain Syndrome ◽  
Myofascial Pain Syndrome ◽  
Trigger Points ◽  
Rehabilitation Medicine ◽  
Clinical Findings ◽  
Computer Assisted ◽  
The Central Nervous System

Muscle pain can be elicited by any irritation of the nociceptors in the muscle or central sensitization in the central nervous system and represent a challenge for medical as well as for neurological rehabilitation. The most frequently described muscle pain syndromes are myofascial pain syndrome (MPS) and fibromyalgia syndrome (FMS). The use of infrared thermography in rehabilitation medicine for assessment of musculoskeletal disorders is not well documented in the current literature. This study is focused around MPS due to the more localized manifestations of this syndrome and it’s objective is to asses a correlation between the clinical findings, ultrasound examination and the thermal pattern of trigger points.

Morbidity and Mortality in the Koala (Phascolarctos cinereus).

1961 ◽  
Vol 9 (1) ◽  
pp. 24 ◽  
Author(s):  
TC Backhouse ◽  
A Bolliger
Keyword(s):  
Ulcerative Colitis ◽  
Cause Of Death ◽  
Middle Ear ◽  
Cardiac Failure ◽  
Unknown Origin ◽  
Primary Lesion ◽  
Blood Dyscrasia ◽  
Cystic Disease ◽  
Phascolarctos Cinereus ◽  
Suppurative Cholangitis

In all, 28 koalas (Phascolarctos cinereus), 26 of which had died exclusively of natural causes, were autopsied and in 21 of these a probable cause of death could be recognized. Different forms of pneumonia head the list of these causes with six cases, including two where the primary lesion was trauma. Hepatitis with suppurative cholangitis was observed in three instances. Cryptococcosis, an infection by the yeast Cryptococcus neoformans, was responsible for three deaths, and two forms of blood dyscrasia, i.e. lymphoblastic leukaemia, and an anaemia of unknown origin accounted for two more deaths. Cystic disease of the ovary was observed in six koalas, and in four cases was complicated by infection and was the main cause of death. Middle ear sepsis, ulcerative colitis, and cardiac failure associated with senility were seen once each. In the remaining seven cases the cause of death was indeterminate, though senility appeared to be the predisposing cause in two.

Pyomyositis mimicking leptospirosis: two cases in a Brazilian tertiary care hospital in a non-tropical area

2008 ◽  
Vol 38 (4) ◽  
pp. 254-256
Author(s):  
Letícia Perondi Luz ◽  
José Miguel Dora ◽  
Luciano Zubaran Goldani
Keyword(s):  
Skeletal Muscle ◽  
Muscle Pain ◽  
Clinical Presentation ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Southern Brazil ◽  
Temperate Region ◽  
Tropical Area ◽  
Tropical Areas

Pyomyositis is a subacute, deep suppurative bacterial infection of skeletal muscle not arising from contiguous infection. It is presumably haematogenous in origin, and characterized by muscle pain and swelling. We report on two patients who presented with pyomyositis in a tertiary care hospital in temperate region located in southern Brazil with a clinical presentation, which was initially suggestive of leptospirosis. This report discusses the pathogenesis, clinical presentation, diagnosis and management of pyomyositis. Physicians living in non-tropical areas should note that pyomyositis might occur in those areas, and its initial clinical presentation may be similar to leptospirosis

Giant right ventricular fibroma co-existing atrial septal defect in a 15 year old girl

2009 ◽  
Vol 19 (6) ◽  
pp. 630-632 ◽  
Author(s):  
Adel Dimassi ◽  
Wael Dimassi ◽  
M. Samir Arnaout
Keyword(s):  
Magnetic Resonance Imaging ◽  
Chest Pain ◽  
Magnetic Resonance ◽  
Atrial Septal Defect ◽  
Cardiac Failure ◽  
Septal Defect ◽  
Surgical Excision ◽  
Clinical Findings ◽  
Resonance Imaging ◽  
Cardiac Tumours

AbstractThe most common benign cardiac tumours are the myxomas, the rhabdomyomas, and the fibromas, with the latter 2 variants being the most common tumours encountered in children. The size and location of tumours within the heart create a variety of clinical findings, such as murmurs, chest pain, tachyarrythmias, and congestive cardiac failure. Nowadays, the tumours are usually diagnosed by echocardiography, magnetic resonance imaging and cardiac catheterization. Surgical excision is the treatment of choice if the tumour causes either arrhythmia or cavitary obstruction. In this report, we describe a giant ventricular fibroma co-existing with an atrial septal defect in a girl aged 15 years.

scholarly journals Prevalence of cardiac lesions in cases of bovine clostridial myositis

2020 ◽  
Author(s):  
Kim Newkirk ◽  
Caitlin M. Culligan ◽  
Chika C. Okafor ◽  
Francisco A. Uzal
Keyword(s):  
Skeletal Muscle ◽  
Retrospective Study ◽  
Cause Of Death ◽  
Cardiac Involvement ◽  
Common Cause ◽  
Heart Involvement ◽  
Cardiac Lesions ◽  
Muscle Lesions ◽  
Clostridium Chauvoei

Abstract ObjectiveThe aim of this retrospective study was to determine the prevalence of cardiac lesions in cases of clostridial myositis. Clostridial myositis (blackleg) is a common cause of death in cattle and is caused by the bacterium Clostridium chauvoei. The characteristic lesions include hemorrhage, necrosis, edema, and emphysema within skeletal muscle and, less commonly, the heart.ResultsOf the 37 cases of blackleg identified, 26 animals (70.3%) had cardiac lesions, including 4 (10.8%) which had only cardiac involvement without skeletal muscle lesions. Cardiac lesions were characterized as necrotizing myocarditis (n=21), fibrinous to fibrinosuppurative pericarditis, epicarditis, or endocarditis (n=24), or both (n=19). These data demonstrate that, in cases of bovine clostridial myositis, cardiac lesions are common, while heart involvement in the absence of skeletal muscle lesions is uncommon.

Comprehensive analysis of radiographic, clinical, and inflammatory markers demonstrating changes in lean muscle correlate with outcome in patients (pts) with metastatic pancreatic adenocarcinoma (mPDAC) who undergo taxane-based chemotherapy (CT).

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 349-349
Author(s):  
Daniel H. Ahn ◽  
Chul Ahn ◽  
Veena Nagar ◽  
Anne M. Noonan ◽  
Matthew Farren ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Clinical Response ◽  
Cox Regression ◽  
Prognostic Score ◽  
Glasgow Prognostic Score ◽  
Progression Free Survival ◽  
Clinical Findings ◽  
Comprehensive Analysis ◽  
Muscle Area ◽  
Neutrophil Lymphocyte Ratio

349 Background: MPDAC is associated with a poor prognosis. The mechanisms of carcinogenesis are complex; involve multiple signaling pathways and inflammatory cytokines that may promote cachexia, a major cause of morbidity and mortality in mPDAC. The purpose of this study is to understand factors related to skeletal muscle changes, and its effect on outcomes in pts with mPDAC. Methods: Pt and clinical data were obtained from a recent prospective clinical trial in mPDAC where all pts received first-line taxane-based CT. We examined changes in modified Glasgow prognostic score, neutrophil lymphocyte ratio, a 32-cytokine panel, weight, and skeletal muscle area (SMA), determined by validated methodology with computed tomography, at baseline and cycle 3. We defined > 6cm2 in SMA, correlating to 1kg of skeletal muscle gain (SMG), as significant. Univariate and multivariate Cox regression models were used to determine the association between laboratory, radiographic and clinical findings with progression free survival (PFS) and overall survival (OS). Results: 66 evaluable pts were included. Independent of clinical response, an OS advantage was seen in pts who experienced significant SMG (p = 0.023) and in patients with nominal SMG (p = 0.012). A numerical benefit in PFS was observed with SMG. Decreases in IFN-a (p = 0.024), IFN-g (p = 0.001) and IL-6 (p = 0.042) were inversely associated with SMG. A comprehensive analysis incorporating all relevant laboratory, radiographic and clinical assessments demonstrated a 4.62-month OS advantage in pts with favorable characteristics vs. those with poor prognostic factors (11.47 versus 6.84 mos., p = 0.0029). Conclusions: SMG, or the reversal of cachexia confers an OS advantage in pts with mPDAC treated with taxane-based CT regardless of clinical response. A comprehensive assessment of muscle change is a precise measurement that can identify pts at greatest risk for muscle loss, which could predict for trmt response and pt outcomes. This merits further investigation as a tool and in trials directed at reversing the process of cachexia.

scholarly journals Synanthropic rodent reservoirs of Trypanosoma (Schizotrypanum) cruzi in the valley of Caracas, Venezuela

1997 ◽  
Vol 39 (5) ◽  
pp. 279-282 ◽  
Author(s):  
Leidi HERRERA ◽  
Servio URDANETA-MORALES
Keyword(s):  
Skeletal Muscle ◽  
Smooth Muscle ◽  
Mus Musculus ◽  
Rattus Rattus ◽  
Tissue Tropism ◽  
Blood Examination ◽  
Host Mortality ◽  
Rats And Mice ◽  
Synanthropic Rodents

Direct blood examination and xenodiagnosis of 47 synanthropic rodents (Rattus rattus, R. norvegicus, Mus musculus) captured in the valley of Caracas, Venezuela, revealed trypanosomal infections in 12 R. rattus, 10 with T. lewisi and 2 with T. cruzi. Of the latter the course of parasitemia, the pleomorphism of the bloodstream trypomastigotes, tissue tropism in naturally and experimentally infected rats and mice, host mortality, morphology of fecal parasites in Rhodnius prolixus used for xenodiagnosis, and infectivity of the bug feces for NMRI mice, were all characteristic of Trypanosoma (Schizotrypanum) cruzi. One rat, with a patent parasitemia, had numerous nests of amastigotes in cardiac muscle and moderate parasitism of the smooth muscle of the duodenum and of skeletal muscle. Mice inoculated with fecal flagellates from the bugs had moderate tissue tropism in the same organs and also in the colon and pancreas. The possible role of R. rattus in the establishment of foci of Chagas’ disease in Caracas is discussed

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