Maternal blood pressure and hypertensive disorders during pregnancy and childhood respiratory morbidity: the Generation R Study

Pre-eclampsia is associated with an increased risk of bronchopulmonary dysplasia, wheezing and asthma in later childhood. Currently, there are no studies available investigating maternal blood pressure measurements during multiple time-points in pregnancy and respiratory outcome measures in the child.We examined the associations of maternal blood pressure and hypertensive disorders with the risk of lower lung function, wheezing and asthma in children aged 10 years. This study among 4894 children was embedded in a population-based prospective cohort study. We used multivariate analyses, taking lifestyle and socioeconomic factors into account.We observed consistent associations per 5 mmHg higher maternal blood pressure in early pregnancy with a lower forced expiratory volume in 1 s/forced vital capacity ratio (z-score −0.03 (95% CI −0.05– −0.01)) and per 5 mmHg higher blood pressure in late pregnancy with a higher risk for current wheezing and current asthma (OR 1.07 (95% CI 1.02–1.12) and 1.06 (95% CI 1.00–1.11), respectively). We found no associations of maternal hypertensive disorders during pregnancy with child lung function, current wheezing or current asthma.Our results suggest that higher blood pressure in pregnant women is associated with lower lung function and increased risks of current wheezing and current asthma in children. The associations may be trimester specific.

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29. Maternal blood pressure and hypertensive disorders during pregnancy and childhood respiratory morbidity. The Generation R Study

Pregnancy Hypertension ◽

10.1016/j.preghy.2018.08.171 ◽

2018 ◽

Vol 13 ◽

pp. S58

Author(s):

Freke Wilmink ◽

Herman den Dekker ◽

Johan de Jongste ◽

Irwin Reiss ◽

Vincent Jaddoe ◽

...

Keyword(s):

Blood Pressure ◽

Maternal Blood ◽

Respiratory Morbidity ◽

Hypertensive Disorders ◽

Maternal Blood Pressure

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Traffic-related air pollution exposure over a 5-year period is associated with increased risk of asthma and poor lung function in middle age

European Respiratory Journal ◽

10.1183/13993003.02357-2016 ◽

2017 ◽

Vol 50 (4) ◽

pp. 1602357 ◽

Cited By ~ 33

Author(s):

Gayan Bowatte ◽

Bircan Erbas ◽

Caroline J. Lodge ◽

Luke D. Knibbs ◽

Lyle C. Gurrin ◽

...

Keyword(s):

Air Pollution ◽

Lung Function ◽

Current Evidence ◽

Respiratory Morbidity ◽

Asthma Prevalence ◽

Major Road ◽

Current Asthma ◽

Increased Risk ◽

Lower Lung ◽

The Impact

Current evidence concerning the impact of exposure to traffic-related air pollution (TRAP) on adult respiratory morbidity mainly comes from cross-sectional studies. We sought to establish more robust measures of this association and potential gene–environment interactions using longitudinal data from an established cohort study.Associations between measures of TRAP (nitrogen dioxide (NO2) and distance to major roads) and wheeze, asthma prevalence and lung function were investigated in participants of the Tasmanian Longitudinal Health Study at 45- and 50-year follow-ups. Generalised estimating equations were used to quantify associations and the potential modifying effect of glutathioneS-transferase gene variants.Living <200 m from a major road was associated with increased prevalence of current asthma and wheeze, and lower lung function. The association between living <200 m from a major road and current asthma and wheeze was more marked for carriers of theGSTT1null andGSTP1 val/valorile/valgenotypes. Over the 5-year period, higher NO2exposures were associated with increased current asthma prevalence. Higher NO2exposure was associated with lower forced vital capacity for carriers of theGSTT1null genotype.TRAP exposures were associated with increased risk of asthma, wheeze and lower lung function in middle-aged adults. The interaction with theGSTT1genotype suggests that deficient antioxidant mechanisms may play a role in these adverse health effects.

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Parental psychological distress during pregnancy and the risk of childhood lower lung function and asthma: a population-based prospective cohort study

Thorax ◽

10.1136/thoraxjnl-2019-214099 ◽

2020 ◽

Vol 75 (12) ◽

pp. 1074-1081

Author(s):

Evelien R van Meel ◽

Gautam Saharan ◽

Vincent WV Jaddoe ◽

Johan C de Jongste ◽

Irwin KM Reiss ◽

...

Keyword(s):

Psychological Distress ◽

Lung Function ◽

Prospective Cohort ◽

Later Life ◽

Population Based ◽

Brief Symptom Inventory ◽

Respiratory Morbidity ◽

Maternal Psychological Distress ◽

Increased Risk ◽

Lower Lung

BackgroundAlthough maternal psychological distress during pregnancy is associated with increased risks of respiratory morbidity in preschool children, it is unknown whether this association persists into later childhood.ObjectiveTo examine the association between parental psychological distress during pregnancy and lung function and asthma in children of school age.MethodsThis study of 4231 children was embedded in a population-based prospective cohort. Parental psychological distress was assessed by the Brief Symptom Inventory during and 3 years after pregnancy, and in mothers also at 2 and 6 months after pregnancy. At age 10 years, lung function was obtained by spirometry and asthma by questionnaire.ResultsThe prevalence of asthma was 5.9%. Maternal overall psychological distress during pregnancy was associated with a lower forced vital capacity (FVC) (z-score difference −0.10 (95% CI −0.20 to –0.01) per 1-unit increase), maternal depressive symptoms during pregnancy with a lower forced expiratory volume in the first second (FEV1) and FVC (−0.13 (95% CI −0.24 to –0.01) and −0.13 (95% CI −0.24 to –0.02) when using clinical cut-offs) in their children. All maternal psychological distress measures during pregnancy were associated with an increased risk of asthma (range OR: 1.46 (95% CI 1.12 to 1.90) to 1.91 (95% CI 1.26 to 2.91)). Additional adjustment for paternal psychological distress during pregnancy and parental psychological distress after pregnancy did not materially change the associations. Paternal psychological distress during pregnancy was not associated with childhood respiratory morbidity.ConclusionMaternal, but not paternal, psychological distress during pregnancy is associated with an increased risk of asthma and partly lower lung function in children. This suggests intrauterine programming for the risk of later-life respiratory disease.

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Influence of Maternal Gestational Hypertensive Disorders on Microvasculature in School-Age Children

American Journal of Epidemiology ◽

10.1093/aje/kww059 ◽

2016 ◽

Vol 184 (9) ◽

pp. 605-615 ◽

Cited By ~ 10

Author(s):

Gizem Dilan Yesil ◽

Olta Gishti ◽

Janine F. Felix ◽

Irwin Reiss ◽

Mohammad Kamran Ikram ◽

...

Keyword(s):

Blood Pressure ◽

Standard Deviation ◽

Confidence Interval ◽

Systolic Blood Pressure ◽

Standard Deviation Score ◽

Maternal Blood ◽

Deviation Score ◽

Hypertensive Disorders ◽

Maternal Blood Pressure ◽

Retinal Arteriolar

Abstract Gestational hypertensive disorders may lead to vascular changes in the offspring. We examined the associations of maternal blood pressure development and hypertensive disorders during pregnancy with microvasculature adaptations in the offspring in childhood. This study was performed as part of the Generation R Study in Rotterdam, the Netherlands (2002–2012), among 3,748 pregnant mothers and their children for whom information was available on maternal blood pressure in different periods of pregnancy and gestational hypertensive disorders. Childhood retinal arteriolar and venular calibers were assessed at the age of 6 years. We found that higher maternal systolic and diastolic blood pressures in early pregnancy were associated with childhood retinal arteriolar narrowing (P < 0.05). Higher maternal systolic blood pressure in late pregnancy, but not in middle pregnancy, was associated with childhood narrower retinal venular caliber (standard deviation score per standardized residual increase in systolic blood pressure: −0.05; 95% confidence interval: −0.08, −0.01). Paternal blood pressure was not associated with childhood retinal vessel calibers. Children of mothers with gestational hypertensive disorders tended to have narrower retinal arteriolar caliber (standard deviation score: −0.13, 95% confidence interval: −0.27, 0.01). Our results suggest that higher maternal blood pressure during pregnancy is associated with persistent microvasculature adaptations in their children. Further studies are needed to replicate these observations.

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