scholarly journals Agreement of the mMRC and NYHA scales for assessing the impact of self-rated breathlessness in cardiopulmonary disease

2021 ◽  
pp. 00460-2021
Author(s):  
Zainab Ahmadi ◽  
Helena Igelström ◽  
Jacob Sandberg ◽  
Josefin Sundh ◽  
Magnus Sköld ◽  
...  
Keyword(s):  
Heart Failure ◽  
Respiratory Disease ◽  
Concurrent Validity ◽  
Patient Reported Outcomes ◽  
Chronic Respiratory Disease ◽  
Chronic Obstructive ◽  
Kendall’S Tau ◽  
Kendall's Tau ◽  
Patient Reported ◽  
The Impact

BackgroundFunctional impact of breathlessness is assessed using the modified Medical Research Council (mMRC) scale in chronic respiratory disease and with the New York Heart Association Functional Classification (NYHA) scale in heart failure. We evaluated agreement between the scales and their concurrent validity with other clinically relevant patient-reported outcomes in cardiorespiratory disease.MethodsOutpatients with stable chronic respiratory disease or heart failure were recruited. Agreement between mMRC and NYHA was analysed using Cramer's V and Kendall's Tau B. Concurrent validity was evaluated using correlations with clinically relevant measures of breathlessness, anxiety, depression and health-related quality of life. Analyses were conducted in all participants and separately in chronic obstructive pulmonary disease (COPD) and heart failure.ResultsIn a total of 182 participants with cardiorespiratory disease, agreement between mMRC and NYHA was moderate (Cramer's V: 0.46; Kendall's Tau B: 0.57,) with similar results in COPD (Cramer's V: 0.46; Kendall's Tau B: 0.66) and in heart failure (Cramer's V: 0.46; Kendall's Tau B: 0.67). In the total population, the scales correlated in similar ways to the other patient-reported outcomes.ConclusionIn outpatients with cardiorespiratory disease, the mMRC and NYHA scales show moderate to strong correlations and similar associations with other patient-reported outcomes. This supports that the scales are comparable when assessing the impact of breathlessness on function and patient-reported outcomes.

scholarly journals Correction to: Financial difficulties and patient‑reported outcomes among patients with advanced heart failure

2021 ◽  
Author(s):  
Chetna Malhotra ◽  
Filipinas Bundoc ◽  
Felicia Jia Ler Ang ◽  
Semra Ozdemir ◽  
Irene Teo ◽  
...  
Keyword(s):  
Heart Failure ◽  
Patient Reported Outcomes ◽  
Advanced Heart Failure ◽  
Financial Difficulties ◽  
Patient Reported

Overview of the Patient Perspective at OMERACT 10 — Conceptualizing Methods for Developing Patient-Reported Outcomes

2011 ◽  
Vol 38 (8) ◽  
pp. 1699-1701 ◽  
Author(s):  
JOHN R. KIRWAN ◽  
PETER S. TUGWELL
Keyword(s):  
Clinical Trials ◽  
Experimental Work ◽  
Patient Reported Outcomes ◽  
Patient Perspective ◽  
Methodological Issues ◽  
Instrument Selection ◽  
Patient Reported ◽  
The Impact ◽  
Choice Of Instruments ◽  
The Way

This overview draws out the main conclusions from the 4 workshops focused on incorporating the patient perspective into outcome assessment at the 10th Outcome Measures in Rheumatology (OMERACT 10) conference. They raised methodological issues about the choice of outcome domains to include in clinical trials, the development or choice of instruments to measure these domains, and the way these instruments might capture the impact of a disease and its treatment. The need to develop a more rigorous conceptual model of quantifying the way conditions affect health, and the need to ensure patients are directly involved in the decisions about domains and instruments, emerged clearly. The OMERACT participants voted to develop guidelines for domain and instrument selection, and conceptual and experimental work will be brought forward to revise and upgrade the OMERACT Filter.

The impact of a recent relapse on patient-reported outcomes in subjects with multiple sclerosis

2012 ◽  
Vol 21 (10) ◽  
pp. 1677-1684 ◽  
Author(s):  
Brian C. Healy ◽  
Irene R. Degano ◽  
Ana Schreck ◽  
David Rintell ◽  
Howard Weiner ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Patient Reported Outcomes ◽  
Patient Reported ◽  
The Impact

Patient reported outcomes in patients with desmoid type fibromatosis.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 11574-11574
Author(s):  
VIKAS GARG ◽  
Sameer Rastogi ◽  
Adarsh Barwad ◽  
Rambha Panday ◽  
Sandeep Kumar Bhoriwal ◽  
...  
Keyword(s):  
Patient Reported Outcomes ◽  
Symptom Burden ◽  
Benign Neoplasm ◽  
Anxiety And Depression ◽  
Appendicular Skeleton ◽  
Healthy Controls ◽  
Symptom Scale ◽  
Cross Sectional ◽  
Patient Reported ◽  
The Impact

11574 Background: Desmoid type fibromatosis (DTF) is a rare benign neoplasm with infiltrative growth and high local recurrences. Due to long disease course, unpredictable growth pattern, and low mortality, using only survival outcomes may be inappropriate. In this study we assessed the impact of DTF on health related quality of life (HRQoL). Methods: This was a cross-sectional study done in patients with DTF. The study participants were asked to fill the EORTC QLQ-C30, GAD-7 and PHQ- 9 q uestionnaires to assess HRQoL, anxiety and depression . Outcomes were also compared with healthy controls. Results: 204 subjects (102 DTF patients and 102 healthy controls) were recruited. Study parameters have been summarized in Table. Appendicular skeleton (limbs + girdle) was most commonly involved in 59 % patients and abdominal wall or mesentery was involved in 22.5 %. Patients have received median of 2 lines of therapy. 54 % patients were currently on sorafenib and 41 % were under active surveillance. Mean global health status in DTF patient 65.58 ± 22.64, was significantly lower than healthy controls. Similarly, DTF patients scored low on all functional scales except cognitive functioning. Symptom scale showed significantly higher symptom burden of fatigue, pain, insomnia and financial difficulties. Anxiety & depression was observed in 39.22 % and 50 % of DTF patients respectively. DTF patients had higher rates of mild, moderate and severe anxiety and depression compared to healthy controls. No difference was observed based on site of disease. Conclusions: DTF patients have significant symptom burden, poor functioning, and heightened anxiety and depression. Patient reported outcomes should be routinely used to assess treatment efficacy in DTF patients.[Table: see text]

Implementation of Real-Time Assessment of Patient-Reported Outcomes in a Heart Failure Clinic: A Feasibility Study

2017 ◽  
Vol 23 (11) ◽  
pp. 813-816 ◽  
Author(s):  
Josef Stehlik ◽  
Carlos Rodriguez-Correa ◽  
John A. Spertus ◽  
Joshua Biber ◽  
Jose Nativi-Nicolau ◽  
...  
Keyword(s):  
Heart Failure ◽  
Real Time ◽  
Feasibility Study ◽  
Patient Reported Outcomes ◽  
Heart Failure Clinic ◽  
Patient Reported ◽  
Time Assessment

scholarly journals High association of COVID-19 severity with poor gut health score in Lebanese patients

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258913
Author(s):  
Imad Al Kassaa ◽  
Sarah El Omari ◽  
Nada Abbas ◽  
Nicolas Papon ◽  
Djamel Drider ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Models ◽  
Equal Proportion ◽  
Gut Health ◽  
Kendall’S Tau ◽  
High Association ◽  
Kendall's Tau ◽  
Health Score ◽  
Logistic Regression Models ◽  
The Impact

Background Coronavirus disease 2019 (COVID-19) has affected millions of lives globally. However, the disease has presented more extreme challenges for developing countries that are experiencing economic crises. Studies on COVID-19 symptoms and gut health are scarce and have not fully analyzed possible associations between gut health and disease pathophysiology. Therefore, this study aimed to demonstrate a potential association between gut health and COVID-19 severity in the Lebanese community, which has been experiencing a severe economic crisis. Methods This cross-sectional study investigated SARS-CoV-2 PCR-positive Lebanese patients. Participants were interviewed and gut health, COVID-19 symptoms, and different metrics were analyzed using simple and multiple logistic regression models. Results Analysis of the data showed that 25% of participants were asymptomatic, while an equal proportion experienced severe symptoms, including dyspnea (22.7%), oxygen need (7.5%), and hospitalization (3.1%). The mean age of the participants was 38.3 ±0.8 years, and the majority were males (63.9%), married (68.2%), and currently employed (66.7%). A negative correlation was found between gut health score and COVID-19 symptoms (Kendall’s tau-b = -0.153, P = 0.004); indicating that low gut health was associated with more severe COVID-19 cases. Additionally, participants who reported unhealthy food intake were more likely to experience severe symptoms (Kendall’s tau-b = 0.118, P = 0.049). When all items were taken into consideration, multiple ordinal logistic regression models showed a significant association between COVID-19 symptoms and each of the following variables: working status, flu-like illness episodes, and gut health score. COVID-19 severe symptoms were more common among patients having poor gut health scores (OR:1.31, 95%CI:1.07–1.61; P = 0.008), experiencing more than one episode of flu-like illness per year (OR:2.85, 95%CI:1.58–5.15; P = 0.001), and owning a job (OR:2.00, 95%CI:1.1–3.65; P = 0.023). Conclusions To our knowledge, this is the first study that showed the impact of gut health and exposure to respiratory viruses on COVID-19 severity in Lebanon. These findings can facilitate combating the pandemic in Lebanon.

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