scholarly journals The relationship between preoperative creatinine clearance and outcomes for patients undergoing liver transplantation: a retrospective observational study

2013 ◽  
Vol 14 (1) ◽  
Author(s):  
Urs Wenger ◽  
Thomas A Neff ◽  
Christian E Oberkofler ◽  
Manuel Zimmermann ◽  
Paul A Stehberger ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Observational Study ◽  
Creatinine Clearance ◽  
Retrospective Observational Study ◽  
The Relationship ◽  
Preoperative Creatinine

Hemmkörperentwicklung bei Hämophilie-Patienten nach Präparate wechsel

2012 ◽  
Vol 32 (S 01) ◽  
pp. S39-S42 ◽  
Author(s):  
S. Kocher ◽  
G. Asmelash ◽  
V. Makki ◽  
S. Müller ◽  
S. Krekeler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Observational Study ◽  
Retrospective Observational Study ◽  
Frequent Change ◽  
Patient Age ◽  
Treatment Regimens ◽  
Patient Âgé ◽  
The Relationship ◽  
Observation Period

SummaryThe retrospective observational study surveys the relationship between development of inhibitors in the treatment of haemophilia patients and risk factors such as changing FVIII products. A total of 119 patients were included in this study, 198 changes of FVIII products were evaluated. Results: During the observation period of 12 months none of the patients developed an inhibitor, which was temporally associated with a change of FVIII products. A frequent change of FVIII products didn’t lead to an increase in inhibitor risk. The change between plasmatic and recombinant preparations could not be confirmed as a risk factor. Furthermore, no correlation between treatment regimens, severity, patient age and comorbidities of the patients could be found.

scholarly journals Outcomes of pregnancy in Egyptian women with multiple sclerosis in the new treatment era: a multi-center retrospective observational study

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Ali Mahmoud Ahmed ◽  
Mohamed Al-Bahay M. G. Reda ◽  
Ahmed Hassan Elsheshiny
Keyword(s):  
Multiple Sclerosis ◽  
Observational Study ◽  
Exclusive Breastfeeding ◽  
Retrospective Observational Study ◽  
Third Trimester ◽  
Early Postpartum ◽  
Egyptian Women ◽  
History Of ◽  
New Treatment ◽  
The Relationship

Abstract Background Pregnancy is a recent growing issue in multiple sclerosis (MS) and the update in the diagnostic criteria of MS and introduction of many disease-modifying therapies (DMTs) may cause changes in the relationship between MS, pregnancy, and breastfeeding. This study aimed to investigate the effect of pregnancy and breastfeeding on MS and vice versa. A retrospective observational study was conducted to include MS women with a history of at least one pregnancy during the last 7 years. Data were collected from the archived files in addition to a self-administrating questionnaire. The annualized relapsing rate (ARR) was calculated before, during, and after pregnancy. Results We included 116 successful pregnancies from 93 MS women with mean age 32.74 ± 5.12 years. Interferon-beta was the commonly used DMT during and after pregnancy. Despite the ARR during the two years preceding the conception was 0.36 (95% CI 0.32–0.41), this rate was significantly decreased during first, second, and third trimester (0.07; 95% CI 0.04–0.15, 0.10; 95% CI 0.03–0.17, and 0.15; 95% CI 0.08–0.24, respectively; P-value < 0.001 in all). Furthermore, this ARR was significantly decreased during the first and last three months after delivery (0.27; 95% CI 0.16–0.39; P-value = 0.037, and 0.24; 95% CI 0.17–0.38; P-value = 0.023). Exclusive breastfeeding was associated with deceased risk of postpartum relapse, with HR 0.31 (95% CI 0.12–0.67; P = 0.002). Conclusions Pregnancy is protective from MS relapse, with a significant decrease of ARR from the pre-pregnancy period. Postpartum reactivation of the disease occurs from the third month after labor, rather than the early postpartum period. Exclusive breastfeeding for at least 2 months decreased the risk of postpartum relapse.

scholarly journals Myocardial bridging is an independent predictor of positive spasm provocation testing by intracoronary ergonovine injections: a retrospective observational study

2019 ◽  
Vol 35 (4) ◽  
pp. 474-486 ◽  
Author(s):  
Riku Arai ◽  
Hiroto Kano ◽  
Shinya Suzuki ◽  
Hiroaki Semba ◽  
Takuto Arita ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Observational Study ◽  
Multivariate Regression ◽  
Interventricular Septum ◽  
Multivariate Regression Analysis ◽  
Retrospective Observational Study ◽  
Myocardial Bridging ◽  
Provocation Tests ◽  
Provocation Testing ◽  
The Relationship

Abstract The relationship between myocardial bridging (MB) and coronary spasms during spasm provocation testing (SPT) remains unclear. We aimed to investigate whether MB was correlated with the SPT by ergonovine (ER) injections in a retrospective observational study. Of the 3340 patients who underwent a first coronary angiography, 166 underwent SPT using ER injections and were divided into 2 groups: MB(+) (n = 23), and MB(−) (n = 143). MB was defined as an angiographic reduction in the diameter of the coronary artery during systole. The patients who had severe organic stenosis in the left anterior descending coronary artery were excluded. The MB(+) group more frequently had diabetes mellitus and chronic kidney disease, and a thicker interventricular septum thickness. The rate of SPT-positivity was higher in the MB(+) group than MB(−) group (56.5% vs. 22.4%, P = 0.001). A multivariate regression analysis showed that the presence of MB was independently associated with SPT-positivity (odds ratio 5.587, 95% confidence interval 2.061–15.149, P = 0.001). In conclusion, coronary spasms during provocation tests with ER independently correlated with the MB. MB may predict coronary spasms.

scholarly journals Clinical specialty training in UK undergraduate medical schools: a retrospective observational study

BMJ Open ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. e025403 ◽  
Author(s):  
Hrisheekesh J Vaidya ◽  
Alexander W Emery ◽  
Emma C Alexander ◽  
Angus J McDonnell ◽  
Charlotte Burford ◽  
...  
Keyword(s):  
Observational Study ◽  
Medical School ◽  
Clinical Training ◽  
Medical Schools ◽  
Retrospective Observational Study ◽  
Specialty Training ◽  
Clinical Specialty ◽  
Graduate Entry ◽  
School Training ◽  
The Relationship

ObjectivesTo determine if increased exposure to clinical specialties at medical school is associated with increased interest in pursuing that specialty as a career after foundation training.DesignA retrospective observational study.Setting31 UK medical schools were asked how much time students spend in each of the clinical specialties. We excluded two schools that were solely Graduate Entry, and two schools were excluded for insufficient information.Main outcome measuresTime spent on clinical placement from UK undergraduate medical schools, and the training destinations of graduates from each school. A general linear model was used to analyse the relationship between the number of weeks spent in a specialty at medical school and the percentage of graduates from that medical school entering each of the Core Training (CT1)/Specialty Training (ST1) specialties directly after Foundation Year 2 (FY2).ResultsStudents spend a median of 85 weeks in clinical training. This includes a median of 28 weeks on medical firms, 15 weeks in surgical firms, and 8 weeks in general practice (GP). In general, the number of training posts available in a specialty was proportionate to the number of weeks spent in medical school, with some notable exceptions including GP. Importantly, we found that the number of weeks spent in a specialty at medical school did not predict the percentage of graduates of that school training in that specialty at CT1/ST1 level (ß coefficient=0.061, p=0.228).ConclusionsThis study found that there was no correlation between the percentage of FY2 doctors appointed directly to a CT1/ST1 specialty and the length of time that they would have spent in those specialties at medical school. This suggests that curriculum adjustments focusing solely on length of time spent in a specialty in medical school would be unlikely to solve recruitment gaps in individual specialties.

scholarly journals Long-Term Exposure to PM10 Above WHO Guidelines Exacerbates COVID-19 Severity and Mortality

2021 ◽  
Author(s):  
Montse Marquès ◽  
Eudald Correig ◽  
Daiana Ibarretxe ◽  
Eva Anoro ◽  
Juan Antonio Arroyo ◽  
...  
Keyword(s):  
Observational Study ◽  
Health Outcomes ◽  
Predictive Models ◽  
Severe Disease ◽  
Important Variable ◽  
Retrospective Observational Study ◽  
Who Guidelines ◽  
Odds Ratios ◽  
The Relationship

Abstract A retrospective observational study with patients suffering COVID-19 was performed to assess the underlying effect of long-term exposure to NO2 and PM10 on the COVID-19 outcomes. We built multivariate predictive models to assess the relationship between the long-term exposure to NO2 and PM10 and COVID-19 outcomes. The probability of either death or severe COVID-19 outcome and the percentage of dead or severe patients were predicted, while odds ratios and effects estimates were calculated. Whilst the long-term exposure to NO2 is a variable with a rather low importance in the prediction of COVID-19 health outcomes, the long-term exposure to PM10 is a more important variable than some stated comorbidities. PM10 showed the highest effects estimates (1.65, 95% CI 1.32-2.06) on COVID-19 severity. For mortality, the highest effect estimates corresponded to age (3.59, 95% CI 2.94-4.40), followed by PM10 (2.37, 95% CI 1.71-3.32). Finally, an increase of 1 µg/m3 in PM10 concentration causes an increase of 3.06% (95% CI 1.11%-4.25%) and 2.68% (95% CI 0.53%-5.58%) of patients suffering COVID-19 as a severe disease and deaths, respectively. These results demonstrate that long-term PM10 burdens above WHO guidelines exacerbate COVID-19 outcomes, while it must be considered for an accurate medical prognosis of COVID-19.

scholarly journals Association of Lactate Dehydrogenase with In-Hospital Mortality in Patients with Acute Aortic Dissection: A Retrospective Observational Study

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Huaping He ◽  
Xiangping Chai ◽  
Yang Zhou ◽  
Xiaogao Pan ◽  
Guifang Yang
Keyword(s):  
Blood Pressure ◽  
Lactate Dehydrogenase ◽  
Observational Study ◽  
Aortic Dissection ◽  
Hospital Mortality ◽  
Acute Aortic Dissection ◽  
Serum Lactate ◽  
Retrospective Observational Study ◽  
Serum Lactate Dehydrogenase ◽  
The Relationship

Background. Evidence regarding the relationship between serum lactate dehydrogenase (LDH) levels and in-hospital mortality in acute aortic dissection (AAD) patients is extremely limited. We aimed to investigate the relationship between LDH and in-hospital mortality in AAD patients. Methods. The present study was a retrospective observational study. A total of 1526 participants with acute aortic dissection were involved in a hospital in China from January 2014 to December 2018. The target-independent variable was LDH measured at baseline, and the dependent was all-cause mortality during hospitalization. Covariates involved in this study included age, gender, body mass index (BMI), hypertension, diabetes, smoking, stroke, atherosclerosis, systolic blood pressure (SBP), diastolic blood pressure (DBP), white blood cell (WBC), hemoglobin (Hb), alanine transaminase (ALT), aspartate aminotransferase (AST), albumin (ALB), creatinine (Cr), symptom, type of AAD (Stanford), and management. Results. The average age of 1526 selected participants was 52.72 ± 11.94 years old, and about 80.41% of them were male. The result of the fully adjusted model showed LDH was positively associated with in-hospital mortality in AAD patients after adjusting confounders (OR = 1.09, 95% CI 1.05 to 1.13). A nonlinear relationship was detected between LDH and in-hospital mortality in AAD patients after adjusting for potential confounders (age, gender, BMI, hypertension, diabetes, stroke, atherosclerosis, smoking, symptom, SBP, DBP, WBC, Hb, ALT, AST, ALB, Cr, type of AAD (Stanford), and management), whose point was 557. The effect sizes and the confidence intervals of the left and right sides of the inflection point were 0.90 (0.74–1.10) and 1.12 (1.06–1.19), respectively. Subgroup analysis in participants showed that the relationship between LDH and in-hospital mortality was stable, and all of the P value for the interaction in different subgroup were more than 0.05. Conclusions. The relationship between LDH and in-hospital mortality in AAD patients is nonlinear. LDH was positively related with in-hospital mortality when LDH is more than 557.

Eosinophilia and cystic echinococcosis: what is the relationship?

2019 ◽  
Author(s):  
Javier Collado-Aliaga ◽  
Ángela Romero-Alegría ◽  
Montserrat Alonso-Sardón ◽  
Amparo López-Bernus ◽  
Inmaculada Galindo-Pérez ◽  
...  
Keyword(s):  
Observational Study ◽  
Echinococcus Granulosus ◽  
Cystic Echinococcosis ◽  
Combined Treatment ◽  
Clinical Manifestations ◽  
Zoonotic Disease ◽  
Retrospective Observational Study ◽  
The Mean ◽  
Western Spain ◽  
The Relationship

Abstract Background Cystic echinococcosis (CE) is a chronic, complex and neglected zoonotic disease caused by Echinococcus granulosus. Eosinophilia in CE is a classic analytic alteration, although its presentation and importance is very variable and not well established. Methods We performed a retrospective observational study of inpatients diagnosed with CE and eosinophilia from January 1998 to December 2017 in the Complejo Asistencial Universitario de Salamanca in western Spain. Results During the study period, 475 patients with a CE diagnosis underwent a haemogram and 118 (24.8%) patients had eosinophilia. Eighty-two (69.5%) were male and the mean age was 52.1±20.8 y, which was younger in the group with eosinophilia (p<0.001). The patients with eosinophilia had less comorbidity (33.1% vs 52.9%; p<0.001) and they were diagnosed with more complications (60.2% vs 39.8% asymptomatic; p<0.001). Clinical manifestations appeared in 71 cases (60.2%). The eosinophilia was related to the presence of pre-surgical fistulas (p=0.005). We observed significant differences when considering whether eosinophilia is a marker of the type of treatment (p<0.001). Conclusions Eosinophilia can be an indicator for an active search in CE because as much as 40% of cases are asymptomatic at diagnosis. In patients with eosinophilia, management is usually more aggressive and is usually a combined treatment. Our work shows the importance of eosinophilia in our patients with CE and raises unresolved questions.

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