scholarly journals Myocardial bridging is an independent predictor of positive spasm provocation testing by intracoronary ergonovine injections: a retrospective observational study

2019 ◽  
Vol 35 (4) ◽  
pp. 474-486 ◽  
Author(s):  
Riku Arai ◽  
Hiroto Kano ◽  
Shinya Suzuki ◽  
Hiroaki Semba ◽  
Takuto Arita ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Observational Study ◽  
Multivariate Regression ◽  
Interventricular Septum ◽  
Multivariate Regression Analysis ◽  
Retrospective Observational Study ◽  
Myocardial Bridging ◽  
Provocation Tests ◽  
Provocation Testing ◽  
The Relationship

Abstract The relationship between myocardial bridging (MB) and coronary spasms during spasm provocation testing (SPT) remains unclear. We aimed to investigate whether MB was correlated with the SPT by ergonovine (ER) injections in a retrospective observational study. Of the 3340 patients who underwent a first coronary angiography, 166 underwent SPT using ER injections and were divided into 2 groups: MB(+) (n = 23), and MB(−) (n = 143). MB was defined as an angiographic reduction in the diameter of the coronary artery during systole. The patients who had severe organic stenosis in the left anterior descending coronary artery were excluded. The MB(+) group more frequently had diabetes mellitus and chronic kidney disease, and a thicker interventricular septum thickness. The rate of SPT-positivity was higher in the MB(+) group than MB(−) group (56.5% vs. 22.4%, P = 0.001). A multivariate regression analysis showed that the presence of MB was independently associated with SPT-positivity (odds ratio 5.587, 95% confidence interval 2.061–15.149, P = 0.001). In conclusion, coronary spasms during provocation tests with ER independently correlated with the MB. MB may predict coronary spasms.

Hemmkörperentwicklung bei Hämophilie-Patienten nach Präparate wechsel

2012 ◽  
Vol 32 (S 01) ◽  
pp. S39-S42 ◽  
Author(s):  
S. Kocher ◽  
G. Asmelash ◽  
V. Makki ◽  
S. Müller ◽  
S. Krekeler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Observational Study ◽  
Retrospective Observational Study ◽  
Frequent Change ◽  
Patient Age ◽  
Treatment Regimens ◽  
Patient Âgé ◽  
The Relationship ◽  
Observation Period

SummaryThe retrospective observational study surveys the relationship between development of inhibitors in the treatment of haemophilia patients and risk factors such as changing FVIII products. A total of 119 patients were included in this study, 198 changes of FVIII products were evaluated. Results: During the observation period of 12 months none of the patients developed an inhibitor, which was temporally associated with a change of FVIII products. A frequent change of FVIII products didn’t lead to an increase in inhibitor risk. The change between plasmatic and recombinant preparations could not be confirmed as a risk factor. Furthermore, no correlation between treatment regimens, severity, patient age and comorbidities of the patients could be found.

scholarly journals Investigating the effect of social capital on delinquency of 15-to-19-year-old juveniles in shiraz

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Zinab Adelmand ◽  
Fatemeh Adelmand ◽  
Tahmineh Adelmand ◽  
Maryam Zarnaghash
Keyword(s):  
Social Capital ◽  
Regression Analysis ◽  
Life Style ◽  
Multivariate Regression ◽  
Religious Life ◽  
Multivariate Regression Analysis ◽  
Modern Life ◽  
Family Control ◽  
New Variables ◽  
The Relationship

<p>The aim of this study was to investigate the effect of social capital on 15-to-19-year-old juveniles’ delinquency. Regarding this objective, Yang internet addiction questionnaire (1996) was used to collect the data. This questionnaire contains 20questions classified in some groups. Results of Multivariate Regression Analysis for explaining delinquency indicate that among the variables selected in the analytical model of this study, 5 factors(religious life style, modern life style (friends network), family control, communications (the relationship between social capital and the groups), the respondents’ fathers’ income) have had a significant effect on delinquency and have remained in the equation. After entering these five variables, the entry of new variables have been stopped. In fact, these five variables totally explain 36/1% changes of the dependent variable (delinquency.</p><p> </p><p>Keywords: delinquency, Social Capital</p>

scholarly journals Impact of Firm Specific Factors on Credit Risk: A Case of Karachi Stock Exchange

2015 ◽  
Vol 54 ◽  
pp. 140-143
Author(s):  
Sajid Iqbal ◽  
Saima Nasir Chaudry ◽  
Nadeem Iqbal
Keyword(s):  
Regression Analysis ◽  
Credit Risk ◽  
Significant Relationship ◽  
Multivariate Regression ◽  
Stock Exchange ◽  
Manufacturing Sector ◽  
Multivariate Regression Analysis ◽  
Specific Factors ◽  
Relationship Of ◽  
The Relationship

The current study aims to explore the relationship of firm’s specific factors i-e profitability, ROA, leverage and bank size on credit risk. The population of the study consists of manufacturing sector of Pakistan. The sample of study is cement sector of Pakistan. The sample units are 22 and listed at Karachi stocks exchange. The multivariate regression analysis is used to test the data of sample. The study revealed negative significant relationship of all firm specific factors with credit risk in Pakistan. Thus, the study supported historic investigations regarding credit risk.

scholarly journals Outcomes of pregnancy in Egyptian women with multiple sclerosis in the new treatment era: a multi-center retrospective observational study

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Ali Mahmoud Ahmed ◽  
Mohamed Al-Bahay M. G. Reda ◽  
Ahmed Hassan Elsheshiny
Keyword(s):  
Multiple Sclerosis ◽  
Observational Study ◽  
Exclusive Breastfeeding ◽  
Retrospective Observational Study ◽  
Third Trimester ◽  
Early Postpartum ◽  
Egyptian Women ◽  
History Of ◽  
New Treatment ◽  
The Relationship

Abstract Background Pregnancy is a recent growing issue in multiple sclerosis (MS) and the update in the diagnostic criteria of MS and introduction of many disease-modifying therapies (DMTs) may cause changes in the relationship between MS, pregnancy, and breastfeeding. This study aimed to investigate the effect of pregnancy and breastfeeding on MS and vice versa. A retrospective observational study was conducted to include MS women with a history of at least one pregnancy during the last 7 years. Data were collected from the archived files in addition to a self-administrating questionnaire. The annualized relapsing rate (ARR) was calculated before, during, and after pregnancy. Results We included 116 successful pregnancies from 93 MS women with mean age 32.74 ± 5.12 years. Interferon-beta was the commonly used DMT during and after pregnancy. Despite the ARR during the two years preceding the conception was 0.36 (95% CI 0.32–0.41), this rate was significantly decreased during first, second, and third trimester (0.07; 95% CI 0.04–0.15, 0.10; 95% CI 0.03–0.17, and 0.15; 95% CI 0.08–0.24, respectively; P-value < 0.001 in all). Furthermore, this ARR was significantly decreased during the first and last three months after delivery (0.27; 95% CI 0.16–0.39; P-value = 0.037, and 0.24; 95% CI 0.17–0.38; P-value = 0.023). Exclusive breastfeeding was associated with deceased risk of postpartum relapse, with HR 0.31 (95% CI 0.12–0.67; P = 0.002). Conclusions Pregnancy is protective from MS relapse, with a significant decrease of ARR from the pre-pregnancy period. Postpartum reactivation of the disease occurs from the third month after labor, rather than the early postpartum period. Exclusive breastfeeding for at least 2 months decreased the risk of postpartum relapse.

scholarly journals Demographic and clinic-angiographic profile of coronary artery disease in young adults: a retrospective observational study

2018 ◽  
Vol 6 (7) ◽  
pp. 2264 ◽  
Author(s):  
Lalatendu Swain ◽  
Prabhat Nalini Routray
Keyword(s):  
Young Adults ◽  
Heart Disease ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
Observational Study ◽  
Young Patients ◽  
Retrospective Observational Study ◽  
Age Group ◽  
Artery Disease ◽  
One Year

Background: Cardiovascular diseases (CVD) and its complications are on an increased trend in the younger age group. In this study we aimed to identify the different risk factor profile and coronary angiographic characteristics of young adults presenting with coronary artery disease.Methods: We conducted this retrospective observational study at SCB MC and H and Ashwini Hospital, Cuttack, Odisha, India over a period of one year from June 2016 to June 2017 on 170 patients who undergone coronary angiogram. Inclusion criteria being patients admitted for STEMI, NSTEMI, or UA, age <40 years and those who underwent coronary angiography. All patients who underwent coronary angiography for surgical fitness e.g., patients of rheumatic heart disease and congenital heart disease were excluded from the study.Results: Among the 150 cases included in the study, 85.3%were males and 14.7% were females. Maximum number of cases i.e. 71.3% were in the age group 36-40 yr, while 23.3% were between 31-35 and 5.4% were between 25-30 age group. Among 150 cases with critical CAD, SVD was most prevalent seen in 68.7% cases, followed by DVD in 22.6% and TVD in 8.7% cases.Conclusions: Incidence of critical CAD in young adults is quite high. Young patients with CAD are mainly males, and SVD is more common. Comparative analysis of young patients with STEMI and NTEMI/ UA revealed that SVD was predominantly involved in STEMI group, whereas TVD was predominant in NSTEMI/UA group.

Abstract TP208: Medullary Infarction is Associated with Severe Sleep Disordered Breathing

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Shuichi Fujii ◽  
Kensaku Shibazaki ◽  
Kenichiro Sakai ◽  
Junya Aoki ◽  
Junichi Uemura ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Multivariate Regression ◽  
Sleep Disordered Breathing ◽  
Multivariate Regression Analysis ◽  
Stroke Patients ◽  
Sleep Study ◽  
Respiratory Disturbance ◽  
The Relationship ◽  
Medullary Infarction ◽  
Disordered Breathing

Background and Purpose: A relationship between presence or severity of sleep disordered breathing (SDB) and site of lesion in ischemic stroke patients has been unclear. Our aim of the present study was to investigate the relationship between presence or severity of SDB and site of ischemic lesions in stroke patients. Subjects and Methods: Between April 2010 and March 2012, consecutive ischemic stroke patients within 24 hours of onset were prospectively enrolled. Ischemic lesions were identified by MRI on admission. Patient underwent sleep study to evaluate the presence and severity of SDB within 7 days after admission. SDB was defined as a respiratory disturbance index (RDI; apnea/hypopnea events per hour) ≥ 5, and severe SDB was defined as a RDI ≥ 40. We investigated the relationship between presence or severity of SDB and clinical characteristics including site of ischemic lesions. Results: A total of 214 patients (mean age 71.3, male 132) were enrolled. Supratentrial lesion was observed in 166 (77.6%) patients and right side lesion in 101 (47.2%) patients. Sites of ischemic lesions were as follows; cortex (n=11), subcortex (n=35), cortex plus subcortex (n=75), basal ganglia (n=57), thalamus (n=13), midbrain (n=3), pons (n=27), medulla (n=11), and cerebellum (n=22). Sleep study was performed at 4 days (median). The median RDI (IQR) was 20 (10-34). SDB patients were found in 187 (87%) patients. There were no significant differences in frequency of each site of lesions between SDB and non-SDB patients. Severe SDB was observed in 42 (19.6%) patients. Age (75 (70-83) vs. 72 (64-78), p=0.047), NIHSS score on admission (3 (1-10) vs. 7 (2-12), p=0.047), the frequency of atrial fibrillation (41% vs. 22%, p=0.012) and medullary lesions (12% vs. 4%, p=0.027) were significantly higher in severe SDB patients than non-severe SDB. Multivariate regression analysis demonstrated that medullary lesions (OR 5.5, 95%CI 1.41-21.8, p=0.014) was independently associated with severe SDB. Conclusions: Medullary lesion in stroke patients should be associated with severe SDB.

Sign in / Sign up

Export Citation Format

Share Document