Distribution of HPV genotypes in cervical intraepithelial lesions and cervical cancer in Tanzanian women

Background. Human Pappilloma Virus (HPV) is the necessary cause of cervical cancer. A number of risk factors are believed to influence the role of HPV in the development of cervical cancer. This is so because majority of HPV infections are cleared and only a few are able to result into cancer. Chlamydia trachomatis (CT) is considered a potential cofactor in the development of cervical intraepithelial neoplasia (CIN), although different studies have produced contradicting information (Silins et al., 2005, Bellaminutti et al., 2014, and Bhatla et al., 2013). The objective of this cross-sectional study was to determine the prevalence and association of HPV-Chlamydial coinfection with cervical intraepithelial lesions and other risk factors for cervical intraepithelial lesions at a hospital in south western Uganda (MRRH). Methods. The study included 93 participants, with an age range of 25 to 80 years, from whom cervical specimens were collected and enrolment forms were completed upon consent. Experienced midwives collected one cervical smear and two endocervical swabs from each participant. The swabs were used for HPV DNA and Chlamydia trachomatis antigen testing. Data was entered in Microsoft excel and analysed using STATA 12 software. With the help of spearman’s correlation at the 0.05 level of significance, bivariate and multivariate analysis were done by logistic regression, to determine associations of risk factors to cervical lesions. Results. The results showed the prevalence of HPV-Chlamydial coinfection to be 8.6% (8/93). Positive Pap smear results were found in 60.22% (56/93) participants, most of whom had low grade squamous intraepitherial lesion (LSIL) (54.84%). HPV-Chlamydial coinfection showed a significant correlation with a positive cytology result and only relatively significantly correlated with LSIL grade of cytological positivity. HPV was found to be the risk factors associated with cervical intraepithelial lesions at MRRH. Conclusion. HPV, Chlamydia, and HPV-Chlamydial coinfection are prevalent infections and there is a likelihood of association between HPV-Chlamydial coinfection and with cervical intraepithelial lesions. This study recommends general sexually transimitted infections (STIS) screening for every woman that turns up for cervical cancer screening and a larger study, probably a multicentre study.

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Analysis of cytosine-adenine repeats in P1 promoter region of IGF-1 gene in peripheral blood cells and cervical tissue samples of females with cervical intraepithelial lesions and squamous cervical cancer

Molecular Medicine Reports ◽

10.3892/mmr.2014.2916 ◽

2014 ◽

Vol 11 (2) ◽

pp. 766-774 ◽

Cited By ~ 3

Author(s):

WOJCIECH KWASNIEWSKI ◽

ANNA GOZDZICKA-JOZEFIAK ◽

MARIA KOTARSKA ◽

GRZEGORZ POLAK ◽

BARTLOMIEJ BARCZYNSKI ◽

...

Keyword(s):

Cervical Cancer ◽

Peripheral Blood ◽

Blood Cells ◽

Promoter Region ◽

Peripheral Blood Cells ◽

Cervical Tissue ◽

Tissue Samples ◽

Cervical Intraepithelial Lesions ◽

Squamous Cervical Cancer ◽

Intraepithelial Lesions

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Association of Cervical Intraepithelial Lesions in Women with Genital Warts; A Cytological and Molecular Study

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2021/v33i2031107 ◽

2021 ◽

pp. 82-92

Author(s):

Nada S. Fathallah ◽

Ahmed M. Hagras ◽

Safinaz H. El-Shorbagy ◽

Manal M. Abd Allah

Keyword(s):

High Risk ◽

Genital Warts ◽

World Health ◽

Health Concern ◽

Cervical Smear ◽

University Hospitals ◽

Cervical Intraepithelial Lesions ◽

Hpv Genotypes ◽

High Risk Hpv ◽

Intraepithelial Lesions

Background: Cervical cancer is a major health concern worldwide, according to the World Health Organization. It is now the fourth most common cancer after breast, colorectal and lung cancers in women worldwide. It is also the world's third most common cause of cancer death in women. objective of the study is to clarify association between genital warts & cervical intraepithelial lesions using cervical smear cytology with real time PCR. Methods: The study was carried out at The Department of gynecology & dermatology in Tanta University Hospitals. 50 patients were included started from June 2019 to June 2020. Results: From June 2019 to June 2020, 50 married women with genital warts are include in the study. Ten women out of 50 were married twice. Number of pregnancies ranged from 0 to 4 with a median (IQR) of 2.56. As regard LSIL group; 6 patients were infected by low risk HPV genotypes while only 2 patients had a mixed infection with high risk HPV genotypes. While all HSIL patients were infected by high risk HPV genotypes. Conclusions: The cytological characteristics of HPV on cervical smear appear to be non-specific. Therefore, PCR for HPV should be made use of as an adjunct to cervical smears in high risk patients to diagnose and follow up early cervical intraepithelial lesions.

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Human Papillomavirus Genotype Distribution among Thai Women with High-Grade Cervical Intraepithelial Lesions and Invasive Cervical Cancer: a Literature Review

Asian Pacific Journal of Cancer Prevention ◽

10.7314/apjcp.2015.16.13.5153 ◽

2015 ◽

Vol 16 (13) ◽

pp. 5153-5158 ◽

Cited By ~ 3

Author(s):

Chumnan Kietpeerakool ◽

Pilaiwan Kleebkaow ◽

Jatupol Srisomboon

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Literature Review ◽

Invasive Cervical Cancer ◽

Genotype Distribution ◽

High Grade ◽

Thai Women ◽

Cervical Intraepithelial Lesions ◽

Intraepithelial Lesions

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HUBUNGAN ANTARA LESI PRAKANKER SERVIKS DENGAN SOSIODEMOGRAFI PEREMPUAN DI KECAMATAN LEGOK KABUPATEN TANGERANG TAHUN 2018

Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan ◽

10.24912/jmstkik.v4i1.6321 ◽

2020 ◽

Vol 4 (1) ◽

pp. 193 ◽

Cited By ~ 1

Author(s):

Destiyana Cika Claritha ◽

Chandra Dewi ◽

Shintia Christina

Keyword(s):

Breast Cancer ◽

Cervical Cancer ◽

Analytical Study ◽

Precancerous Lesions ◽

Total Sample ◽

Cervical Lesions ◽

Cervical Intraepithelial Lesions ◽

Cervical Precancerous Lesions ◽

Precancerous Cervical Lesions ◽

Intraepithelial Lesions

Cervical and breast cancer are the highest prevalence cancer in Indonesia in 2013 which caused death to Indonesian women, cervical cancer by 0.8‰ and breast cancer by 0.5‰. Precancerous lesions of the cervix also known as cervical intraepithelial lesions (Cervical Intraepithelial Neoplastic) are the beginning of changes to cervical carcinoma. In general, precancerous lesions of the cervix originate from the squamous columnar junction in the uterine cervix, which undergoes the process of metaplasia. This study aims to determine whether there is a relationship between precancerous cervical lesions and sociodemography of women in Kecamatan Legok Kabupaten Tangerang in 2018. This study uses an analytical study with cross sectionaI approach. The population is all women in Kecamatan Legok Kabupaten Tangerang who had sexual relations. Total sample are 47 people. Keywords: cervical cancer, cervical precancerous lesions, parity ABSTRAKPenyakit kanker serviks dan payudara merupakan penyakit kanker dengan prevalensi tertinggi di Indonesia pada tahun 2013 yang menyebabkan kematian pada perempuan Indonesia, yaitu kanker serviks sebesar 0,8‰ dan kanker payudara sebesar 0,5‰. Lesi prakanker pada serviks dikenal juga dengan sebutan lesi intraepitelial serviks (Cervical Intraephitelial Neoplasia) merupakan awal dari perubahan menuju karsinoma serviks. Pada umumnya lesi prakanker serviks ini berawal dari daerah squamocolumnar junction pada serviks uteri yang mengalami proses metaplasia. Penelitian ini bertujuan untuk mengetahui adakah hubungan antara lesi prakanker serviks dengn sosiodemografi perempuan di Kecamatan Legok Kabupaten Tangerang tahun 2018. Penelitian ini merupakan studi analitik dengan pendekatan cross sectionaI. Populasi penelitian adalah semua perempuan di Kecamatan Legok Kabupaten Tangerang yang sudah berhubungan seksual. Total sampel 47 orang.

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