scholarly journals A rare case of coexistence of Wegener’s granulomatosis and pulmonary tuberculosis with subsequent development of thrombosis of the cerebral veins

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zohreh Rostami ◽  
Luca Cegolon ◽  
Nematollah Jonaidi Jafari ◽  
Nasrin Gholami ◽  
Seyed Vahid Mousavi ◽  
...  
Keyword(s):  
Wegener’S Granulomatosis ◽  
Histopathological Examination ◽  
Systemic Disease ◽  
Subsequent Development ◽  
Basal Membrane ◽  
Wegener's Granulomatosis ◽  
University Hospital ◽  
Cerebral Veins ◽  
Crescent Formation ◽  
Lung Lobe

Abstract Background Granulomatosis with polyangiitis (GPA), also known as Wegener’s granulomatosis, is an idiopathic systemic disease typically affecting the lungs, although other organs may also be involved. Case presentation A 28-year-old male was admitted to Baqiyatallah university hospital in Teheran (Iran) after a 3-week history of fever and productive cough. The patient gradually developed fatigue, arthralgia, hematuria, nausea, vomiting, dyspnea, hemoptysis, weight loss, oliguria and then anuria. Chest-X-ray (CXR) and computerized tomography scan revealed cavitating nodular opacities in the right lung lobe. Furthermore, plasma creatinine increased from 2.2 to 4 mg/dl in a few days. Histopathological examination of kidney biopsy revealed peri-glomerular and peri-vascular inflammation, degeneration and necrosis of the tubular epithelial lining, red blood cell casts, distorted glomerular structure, fibrin thrombi, segmental breaks of the glomerular basal membrane, disruption of Bowman's capsular membrane and crescent formation of the affected glomeruli. An abnormal CXR, an abnormal urinary sediment and a typical kidney histology were used as criteria to diagnose glomerulonefritis with poliangiitis (GPA). Bronchoalveolar lavage smear and PCR turned out positive for mycobacterium tuberculosis. After 3 months of treatment for (GPA) and tuberculosis the patient developed headache and seizure. Cerebral Magnetic Resonance Venography revealed cerebral venous thrombosis of the sinus transverse and sigmoid. Conclusions Tuberculosis may coexist with GPA, as it occurred in our patient. Since a crescentic glomerulonephritis can progress to renal failure, clinicians should always be aware of potential multiple conditions when considering differential diagnoses.

Wegener’s granulomatosis: diagnostic dilemma

2001 ◽  
Vol 115 (1) ◽  
pp. 46-47 ◽  
Author(s):  
A. Banerjee ◽  
J. M. Armas ◽  
J. H. Dempster
Keyword(s):  
Early Diagnosis ◽  
Wegener’S Granulomatosis ◽  
Systemic Disease ◽  
Wegener's Granulomatosis ◽  
The Body ◽  
Facial Nerve Paralysis ◽  
Diagnostic Dilemma ◽  
Nerve Paralysis ◽  
Atypical Presentations ◽  
High Index Of Suspicion

Wegener’s granulomatosis is a systemic disease characterized by a granulomatous lesion that can affect any organ throughout the body.This case-report illustrates the problem posed by a patient presenting with bilateral serous otitis media with marked sensorineural hearing loss, facial nerve paralysis and an atypical serological picture. The importance of early diagnosis and the protocol for the management of a patient with an uncertain diagnosis is discussed. Due to atypical presentations, only a high index of suspicion will ensure an early diagnosis.

Wegener's granulomatosis presenting as acute systemic vasculitis following 20 years of limited tracheobronchial disease

2009 ◽  
Vol 123 (12) ◽  
pp. 1375-1377 ◽  
Author(s):  
J E Peters ◽  
A D Salama ◽  
P W Ind
Keyword(s):  
World Literature ◽  
Wegener’S Granulomatosis ◽  
Systemic Vasculitis ◽  
Systemic Disease ◽  
Airway Disease ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Wegener's Granulomatosis ◽  
Airway Stenosis ◽  
History Of ◽  
Tracheobronchial Disease

AbstractObjective:We report a patient with a 20-year history of apparently idiopathic airways stenoses, who presented with an antineutrophil cytoplasmic antibody (ANCA) associated, acute, systemic vasculitis with necrotising glomerulonephritis, subsequently diagnosed as Wegener's granulomatosis.Methods:We present a case report and a review of the world literature on airway stenosis in Wegener's granulomatosis.Results:To our knowledge, this is the first report of Wegener's granulomatosis manifesting as local airway disease for such a prolonged period, before transforming into a systemic vasculitis.Conclusions:This case highlights the need for physicians to be alert to the possibility of Wegener's granulomatosis as a cause of apparently idiopathic airway stenosis, and to be aware that systemic disease may occur in very long-standing, limited Wegener's granulomatosis.

‘Prostate Abscess' as the Initial Manifestation of Granulomatosis with Polyangiitis (Wegener's Granulomatosis)

2014 ◽  
Vol 96 (2) ◽  
pp. 244-246 ◽  
Author(s):  
Sotirios Tsiodras ◽  
Garyfalia Poulakou ◽  
Konstantinos Leventakos ◽  
Helen Panopoulou ◽  
Antonia Elezoglou ◽  
...  
Keyword(s):  
Wegener’S Granulomatosis ◽  
Granulomatosis With Polyangiitis ◽  
Systemic Disease ◽  
Wegener's Granulomatosis ◽  
Initial Manifestation ◽  
Postoperative Fever ◽  
Systemic Involvement ◽  
Left Pleural Effusion ◽  
Antibody Levels

Prostatic involvement in granulomatosis with polyangiitis (GWP), formerly known as Wegener's granulomatosis, is rare, mostly arising in the context of systemic involvement. Prostatic involvement as the first manifestation of this systemic disease is exceptionally rare. We hereby present the case of a 41-year-old male patient who underwent transurethral prostate resection for what was initially diagnosed as suppurative, focally necrotizing prostatitis. Prolonged postoperative fever that did not respond to various treatments, as well as the subsequent appearance of a left pleural effusion, a left upper pulmonary lobe lesion and cutaneous nodules, led to a reevaluation of histological slides which, along with the determination of serum c-ANCA/anti-PR3 antibody levels, established the diagnosis of GWP. Physicians, and especially urologists and infectious diseases specialists, should be aware of this rare association and consider GWP in the event of nonresolving prostatitis, especially when characteristic symptoms from other systems appear.

Wegener's granulomatosis: clinical and laboratory results of a university hospital study of 20 patients from Turkey

2005 ◽  
Vol 25 (3) ◽  
pp. 358-363 ◽  
Author(s):  
Zeynep Ozbalkan ◽  
Sedat Kiraz ◽  
M. Akif Ozturk ◽  
A. Ihsan Ertenli ◽  
Sule Apras ◽  
...  
Keyword(s):  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
University Hospital ◽  
Laboratory Results ◽  
Hospital Study

scholarly journals Awareness About Wegeners Granulomatosis Disease Among Dental Students

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 1081-1084
Author(s):  
Nithyanandham Masilamani ◽  
Dhanraj Ganapathy
Keyword(s):  
Clinical Features ◽  
Diagnostic Tests ◽  
Wegener’S Granulomatosis ◽  
Systemic Disease ◽  
Clinical Manifestations ◽  
Granulomatous Inflammation ◽  
Wegener's Granulomatosis ◽  
Dental Students ◽  
Multiple Choice Questions ◽  
Cross Sectional Survey

Wegener’s granulomatosis (WG) is a systemic disease characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis, and vasculitis. The clinical manifestations and laboratory findings suggest an autoimmune disease resulting from a hypersensitivity reaction to some environmental agent. The purpose of the survey is for assessing the awareness about wegeners granulomatosis disease amongst dental students. A cross-sectional survey was done with questionnaire comprising a total of ten multiple-choice questions which were distributed to 100  undergraduate dental students. The questions elicited awareness about the etiology, clinical features, diagnostic tests, treatment methods and complications of wegeners granulomatosis. The responses were collected and analysed. 7% were aware of etiology of Wegeners granulomatosis, 9% were aware of clinical features of Wegeners granulomatosis, 5% were aware of diagnostic tests of Wegeners granulomatosis, 5% were aware of the treatment of Wegeners granulomatosis, and 4% were aware of complications of Wegeners granulomatosis. The awareness of Wegener's granulomatosis among dental students is inadequate. Granulomatosis of Wegener is a relatively uncommon, autoimmune condition of unknown origin. Without medication, thus many patients would then inevitably die of those same illness. Therefore, awareness and education initiatives must be pursued to enlighten students about this illness. 

Wegener's Granulomatosis in the Pediatric Age Group

PEDIATRICS ◽  
1978 ◽  
Vol 61 (1) ◽  
pp. 83-90
Author(s):  
James P. Orlowski ◽  
John D. Clough ◽  
Paul G. Dyment
Keyword(s):  
Wegener’S Granulomatosis ◽  
Systemic Disease ◽  
Renal Involvement ◽  
Wegener's Granulomatosis ◽  
Age Group ◽  
Pediatric Age ◽  
Presenting Symptoms ◽  
Pediatric Age Group ◽  
Pulmonary Infiltration ◽  
Clinical Triad

Six cases of Wegener's granulomatosis (WG) occurring in patients younger than 21 years are described. Only 11 other cases in the pediatric age group have been reported, and all 17 of these patients had the onset of the disease during the second decade of life. Wegener's granulomatosis is a systemic disease characterized by a clinical triad of paranasal sinus and nasal mucosa involvement, pulmonary infiltration and cavitation, and renal disease with hematuria. The most common presenting symptoms are malaise and fever, sinusitis, epistaxis, and hematuria. Most patients have roentgenographic evidence of pulmonary and sinus disease and laboratory evidence of renal involvement on initial evaluation. The prognosis of WG was formerly dismal; more than 90% of patients died in less than two years, but with recent therapeutic regimens, more than 50% of these patients are surviving. The treatment we recommend consists of nitrogen mustard with adrenocorticotropic hormone or prednisone for the induction of remission, followed by cyclophosphamide and prednisone as maintenance drugs. This regimen has proved effective in inducing a remission in four of four patients.

Nontraumatic, Nonneoplastic Subglottic Stenosis

1975 ◽  
Vol 84 (6) ◽  
pp. 757-763 ◽  
Author(s):  
Mohsen Djalilian ◽  
Thomas J. McDonald ◽  
Kenneth D. Devine ◽  
Louis H. Weiland
Keyword(s):  
Physical Examination ◽  
Mayo Clinic ◽  
Wegener’S Granulomatosis ◽  
Systemic Disease ◽  
Relapsing Polychondritis ◽  
Wegener's Granulomatosis ◽  
Subglottic Stenosis ◽  
Initial Presentation ◽  
Systemic Disorder

During a 20-year period, 12 patients with nontraumatic, nonneoplastic subglottic stenosis were seen at the Mayo Clinic. The etiologic factors were relapsing polychondritis, amyloidosis, sarcoidosis, and Wegener's granulomatosis. Because of the diverse initial presentation of the disease, the clinician should consider that the stenosis is a manifestation of a systemic disorder and carry out an otolaryngologic and physical examination with the appropriate roentgenograms and blood and urine tests. Treatment, if a systemic disease is proved, consists of appropriate medication. Surgery may be necessary, depending on the nature of the lesion. Small strictures may not need to be treated.

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