scholarly journals COVID-19 in patients undergoing chronic kidney replacement therapy and kidney transplant recipients in Scotland: findings and experience from the Scottish renal registry

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Samira Bell ◽  
◽  
Jacqueline Campbell ◽  
Jackie McDonald ◽  
Martin O’Neill ◽  
...  
Keyword(s):  
Public Health ◽  
Replacement Therapy ◽  
Study Data ◽  
Data Sets ◽  
Kidney Transplant Recipients ◽  
The Public ◽  
Transplant Patients ◽  
Kidney Replacement Therapy ◽  
Observational Cohort ◽  
Respiratory Coronavirus

Abstract Background Infection with the severe acute respiratory coronavirus 2 (SARS-CoV-2) has led to a worldwide pandemic with coronavirus disease 2019 (COVID-19), the disease caused by SARS-CoV-2, overwhelming healthcare systems globally. Preliminary reports suggest a high incidence of infection and mortality with SARS-CoV-2 in patients receiving kidney replacement therapy (KRT). The aims of this study are to report characteristics, rates and outcomes of all patients affected by infection with SARS-CoV-2 undergoing KRT in Scotland. Methods Study design was an observational cohort study. Data were linked between the Scottish Renal Registry, Health Protection Scotland and the Scottish Intensive Care Society Audit Group national data sets using a unique patient identifier (Community Health Index (CHI)) for each individual by the Public Health and Intelligence unit of Public Health, Scotland. Descriptive statistics and survival analyses were performed. Results During the period 1st March 2020 to 31st May 2020, 110 patients receiving KRT tested positive for SARS-CoV-2 amounting to 2% of the prevalent KRT population. Of those affected, 86 were receiving haemodialysis or peritoneal dialysis and 24 had a renal transplant. Patients who tested positive were older and more likely to reside in more deprived postcodes. Mortality was high at 26.7% in the dialysis patients and 29.2% in the transplant patients. Conclusion The rate of detected SARS-CoV-2 in people receiving KRT in Scotland was relatively low but with a high mortality for those demonstrating infection. Although impossible to confirm, it appears that the measures taken within dialysis units coupled with the national shielding policy, have been effective in protecting this population from infection.

scholarly journals COVID-19 in patients undergoing renal replacement therapy in Scotland: findings and experience from the Scottish Renal Registry

2020 ◽  
Author(s):  
Samira Bell ◽  
Jacqueline Campbell ◽  
Jackie McDonald ◽  
Martin O'Neill ◽  
Chrissie Watters ◽  
...  
Keyword(s):  
Public Health ◽  
Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Study Data ◽  
Data Sets ◽  
The Public ◽  
Transplant Patients ◽  
High Incidence ◽  
Observational Cohort ◽  
Respiratory Coronavirus

Background Infection with the severe acute respiratory coronavirus 2 (SARS-CoV-2) has led to a worldwide pandemic with coronavirus disease 2019 (COVID-19), the disease caused by SARS-CoV-2, overwhelming healthcare systems globally. Preliminary reports suggest a high incidence of infection and mortality with SARS-CoV-2 in patients receiving renal replacement therapy (RRT). The aims of this study are to report characteristics, rates and outcomes of all patients affected by infection with SARS-CoV-2 undergoing RRT in Scotland. Methods Study design was an observational cohort study. Data were linked between the Scottish Renal Registry, Health Protection Scotland and the Scottish Intensive Care Society Audit Group national data sets using a unique patient identifier (Community Health Index (CHI)) for each individual by the Public Health and Intelligence unit of Public Health, Scotland. Descriptive statistics and survival analyses were performed. Results During the period 1st March 2020 to 31st May 2020, 110 patients receiving RRT tested positive for SARS-CoV-2 amounting to 2% of the prevalent RRT population. Of those affected, 87 were receiving haemodialysis or peritoneal dialysis and 24 had a renal transplant. Patients who tested positive were older and more likely to reside in more deprived postcodes. Mortality was high at 26.7% in the dialysis patients and 29.2% in the transplant patients. There was consistency between Scottish renal units of the measures implemented to prevent or reduce transmission but timing varied. Conclusion The rate of detected SARS-CoV-2 in people receiving RRT in Scotland was relatively low but with a high mortality for those demonstrating infection. Although impossible to confirm, it appears that the measures taken within dialysis units coupled with the national shielding policy, have been effective in protecting this population from infection.

scholarly journals Rubella Immunity among Pregnant Women in a Canadian Provincial Screening Program

2009 ◽  
Vol 20 (3) ◽  
pp. 73-77 ◽  
Author(s):  
Mark J Kearns ◽  
Sabrina S Plitt ◽  
Bonita E Lee ◽  
Joan L Robinson
Keyword(s):  
Public Health ◽  
Screening Program ◽  
Study Data ◽  
Test Results ◽  
Childbearing Age ◽  
Younger Women ◽  
The Public ◽  
Health Significance ◽  
Health Database ◽  
Northern Alberta

BACKGROUND: There are limited recent data on rubella immunity in women of childbearing age in Canada. In the present paper, the proportion of rubella seroreactivity and redundant testing (testing of women previously seropositive when tested by the same physician) in the Alberta prenatal rubella screening program were studied.METHODS: In the present retrospective observational study, data on all specimens submitted for prenatal screening in Alberta between August 2002 and December 2005 were extracted from the Provincial Laboratory for Public Health database. The proportion of rubella screening and immunoglobulin G (IgG) seroreactivity were determined. Demographic variables were compared between rubella seroreactors and nonseroreactors. The proportion of redundant testing was determined.RESULTS: Of 159,046 prenatal specimens, 88.3% (n=140,473) were screened for rubella immunity. In total, 8.8% of specimens tested negative for rubella IgG. Younger women (23.2% of women younger than 20 years of age versus 4.7% of women between 35 and 39 years of age; P<0.001) and women from northern Alberta (11.9% versus 8.1% [overall]; P<0.001) were significantly more likely to have seronegative specimens. Of the 20,044 women who had multiple rubella immunity screenings, 88.1% (n=17,651) had multiple positive test results. In total, 20.7% of the 42,274 specimens submitted from women with multiple screenings were deemed redundant.DISCUSSION: Younger women were most likely to be seronegative for rubella. The public health significance of women entering their childbearing years with low or undetectable rubella IgG levels remains to be determined. A large number of women with documented rubella immunity were unnecessarily retested.

scholarly journals FC 028COVID-19 RELATED MORTALITY IN KIDNEY TRANSPLANT AND DIALYSIS PATIENTS: A COMPARATIVE, PROSPECTIVE REGISTRY BASED STUDY

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Alexandre Candellier ◽  
Eric Jean Goffin ◽  
Priya Vart ◽  
Marlies Noordzij ◽  
Miha Arnol ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Replacement Therapy ◽  
Kidney Transplant ◽  
Hemodialysis Patients ◽  
Cox Proportional Hazards ◽  
Elderly Subjects ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Kidney Replacement Therapy ◽  
Adjusted Model

Abstract Background and Aims Studies examining kidney failure patients with COVID-19 reported higher mortality in hemodialysis patients than in kidney transplant recipients. However, hemodialysis patients are often older and have more comorbidities. This study investigated the association of type of kidney replacement therapy with COVID-19 severity adjusting for differences in characteristics. Method Data were retrieved from the European Renal Association COVID-19 Database (ERACODA), which includes kidney replacement therapy patients diagnosed with COVID-19 from all over Europe. We included all kidney transplant recipients and hemodialysis patients who presented between February 1st and December 1st 2020 and had complete information reason for COVID-19 screening and vital status at day 28. The diagnosis of COVID-19 was made based on a PCR of a nasal or pharyngeal swab specimens and/or COVID-19 compatible findings on a lung CT scan. The association of kidney transplantation or hemodialysis with 28-day mortality was examined using Cox proportional-hazards regression models adjusted for age, sex, frailty and comorbidities. Additionally, this association was investigated in the subsets of patients that were screened because of symptoms or have had routine screening. Results A total of 1,670 patients (496 functional kidney transplant recipients and 1,174 hemodialysis patients) were examined. 16.9% of kidney transplant recipients and 23.9% of hemodialysis patients died within 28 days of presentation. In an unadjusted model, the risk of 28-day mortality was 33% lower in kidney transplant recipients compared with hemodialysis patients (hazard ratio (HR): 0.67, 95% CI: 0.52, 0.85). However, in an age, sex and frailty adjusted model, the risk of 28-day mortality was 29% higher in kidney transplant recipients (HR=1.29, 95% CI: 1.00, 1.68), whereas in a fully adjusted model the risk was even 43% higher (HR=1.43, 95% CI: 1.06, 1.93). This association in patients who were screened because of symptoms (n=1,145) was similar (fully adjusted model HR=1.46, 95% CI: 1.05, 2.04). Results were similar when other endpoints were studied (e.g. risk for hospitalization, ICU admission or mortality beyond 28 days) as well as across subgroups. Only age was found to interact significantly, suggesting that the increased mortality risk associated with kidney transplantation was especially present in elderly subjects. Conclusion In this study, kidney transplant recipients had a greater risk of a more severe course of COVID-19 compared with hemodialysis patients when adjusted for age, sex and comorbidities.

scholarly journals Knowledge and conduct of public health system dentist about atraumatic restorative treatment

2017 ◽  
Vol 46 (2) ◽  
pp. 82-89
Author(s):  
Josué Junior Araújo PIEROTE ◽  
Maria Hellen Sâmia Fortes BRITO ◽  
Larissa Campos Rodrigues PINHEIRO ◽  
Lúcia de Fátima Almeida de Deus MOURA ◽  
Marina de Deus Moura de LIMA ◽  
...  
Keyword(s):  
Public Health ◽  
Health System ◽  
Public Service ◽  
Public Health System ◽  
Family Health ◽  
Study Data ◽  
Atraumatic Restorative Treatment ◽  
Significance Level ◽  
The Public ◽  
Restorative Treatment

Abstract Objective To evaluate the knowledge and conduct of dentists of the Public Health System (Family Health Strategy – FHS) regarding Atraumatic Restorative Treatment (ART). Material and method A census survey was conducted and all FHS dentists from the urban area of the city of Teresina, Piauí, Brazil were visited in their workplaces and invited to participate in this study. Data collection was carried out between July and October, 2014 through self-administered questionnaires. For statistical analysis the chi-square test with a significance level of 5% and the linear association test were applied. Result One hundred and eighty-three professionals participated in the study (with a response rate of 89.7%), mostly women (71.0%), aged twenty to thirty-nine years (49.2%), with twenty or more years’ experience since graduation (45.9%), working only in the public service (70.5%), and with expertise in the clinical area (44.3%). Most of them believe in ART (82.7%) and 95.8% of them apply it (of those, 58.9% apply it only in public service). The professionals’ individual knowledge of ART was measured and most of them have correct information regarding the treatment. The knowledge level evaluation was significantly associated with age and time since graduation (p<0.05). Conclusion Most of the dentistsworking in the public health system of Teresina, Piauí, Brazil have a good knowledge of and show positive behavior towardentists ART, but improvement is needed regarding the technique and its correct indication.

scholarly journals Oscillations in U.S. COVID-19 Incidence and Mortality Data Reflect Diagnostic and Reporting Factors

mSystems ◽  
2020 ◽  
Vol 5 (4) ◽  
Author(s):  
Aviv Bergman ◽  
Yehonatan Sella ◽  
Peter Agre ◽  
Arturo Casadevall
Keyword(s):  
Public Health ◽  
United States ◽  
Public Health System ◽  
Epidemiological Data ◽  
The United States ◽  
Mortality Data ◽  
Data Sets ◽  
Periodic Oscillations ◽  
The Public ◽  
Incidence And Mortality

ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic currently in process differs from other infectious disease calamities that have previously plagued humanity in the vast amount of information that is produced each day, which includes daily estimates of the disease incidence and mortality data. Apart from providing actionable information to public health authorities on the trend of the pandemic, the daily incidence reflects the process of disease in a susceptible population and thus reflects the pathogenesis of COVID-19, the public health response, and diagnosis and reporting. Both new daily cases and daily mortality data in the United States exhibit periodic oscillatory patterns. By analyzing New York City (NYC) and Los Angeles (LA) testing data, we demonstrate that this oscillation in the number of cases can be strongly explained by the daily variation in testing. This seems to rule out alternative hypotheses, such as increased infections on certain days of the week, as driving this oscillation. Similarly, we show that the apparent oscillation in mortality in the U.S. data are mostly an artifact of reporting, which disappears in data sets that record death by episode date, such as the NYC and LA data sets. Periodic oscillations in COVID-19 incidence and mortality data reflect testing and reporting practices and contingencies. Thus, these contingencies should be considered first prior to suggesting biological mechanisms. IMPORTANCE The incidence and mortality data for the COVID-19 data in the United States show periodic oscillations, giving the curve a distinctive serrated pattern. In this study, we show that these periodic highs and lows in incidence and mortality data are due to daily differences in testing for the virus and death reporting, respectively. These findings are important because they provide an explanation based on public health practices and shortcomings rather than biological explanations, such as infection dynamics. In other words, when oscillations occur in epidemiological data, a search for causes should begin with how the public health system produces and reports the information before considering other causes, such as infection cycles and higher incidences of events on certain days. Our results suggest that when oscillations occur in epidemiological data, this may be a signal that there are shortcomings in the public health system generating that information.

scholarly journals FC 027COVID-19 IN PATIENTS ON KIDNEY REPLACEMENT THERAPY - CLINICAL CHARACTERISTICS AT TRIAGE ASSOCIATED WITH ADMISSION, READMISSION AND SHORT-TERM OUTCOMES

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Sandip Mitra ◽  
Anu Jayanti ◽  
Priya Vart ◽  
Armando Coca ◽  
Maurizio Gallieni ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Kidney Transplant ◽  
Care Pathway ◽  
Initial Assessment ◽  
Pulmonary Insufficiency ◽  
Clinical Approach ◽  
Kidney Transplant Recipients ◽  
Short Term ◽  
Clinical Frailty Scale ◽  
Kidney Replacement Therapy

Abstract Background and Aims Patients on kidney replacement therapy (KRT) are at high risk of developing severe COVID-19 illness and often require high intensity care and utilisation of hospital resources. During the ongoing pandemic, the optimal care pathway and triage for KRT patients presenting with varying severity of COVID-19 illness is unknown. We studied clinical factors and outcomes associated with admission, readmission and short-term outcomes. Method Data from the European Renal Association COVID-19 Database (ERACODA) was analysed. This database includes granular data on dialysis patients and kidney transplant recipients with COVID-19 from all over Europe. The clinical and laboratory features at first presentation of hospitalized and non-hospitalized patients and those who returned for second presentation were studied. In addition, possible predictors of outcome in those who were not hospitalized at first presentation were identified. Results Among 1,423 KRT patients (haemodialysis; 1017/kidney transplant; 406) with COVID-19, 25% (n=355) were not hospitalized at first presentation. Of them, only 10% (n=36), presented for a second time in the hospital. The median interval between the first and second presentation was 5 days (Interquartile interval: 2-7 days). Patients who re-presented had worsening of pulmonary symptoms, a fall in oxygen saturation (97% to 90%), and an increase in C-reactive protein (26 mg/L to 73 mg/L) between their attendances. Patients who re-presented after initial assessment were older (72 vs. 63 years) and initially more often had pulmonary symptoms and abnormalities on lung imaging compared with those who did not present for a second time. The 28-day mortality rate of patients admitted at the second presentation was similar to that of patients admitted at first presentation (26.5% vs. 29.7%, p=0. 61). Among patients who were not hospitalized at first presentation (mortality 6%), age, prior smoking, clinical frailty scale, and shortness of breath at first presentation were identified as predictors of mortality. Conclusion KRT patients with COVID-19 and mild pulmonary abnormalities and no signs of pulmonary insufficiency can be safely returned without hospitalization. These patients should be advised to seek immediate contact when they develop respiratory distress. Our findings provide support for a risk-stratified clinical approach to admissions of KRT patients presenting with COVID-19. The study findings may be valuable for clinical triage and optimising hospital capacity utilisation during the ongoing pandemic.

scholarly journals Evaluation of PROMIS Preference Scoring System (PROPr) in Patients Undergoing Hemodialysis or Kidney Transplant

2021 ◽  
pp. CJN.01880221
Author(s):  
Jing Zhang ◽  
Barry Dewitt ◽  
Evan Tang ◽  
Daniel Breitner ◽  
Mohammed Saqib ◽  
...  
Keyword(s):  
Construct Validity ◽  
Replacement Therapy ◽  
Kidney Transplant ◽  
Short Form ◽  
Health Condition ◽  
Measurement Information ◽  
Kidney Transplant Recipients ◽  
Cross Sectional ◽  
Patient Reported ◽  
Kidney Replacement Therapy

Background and Objectives A preference-based health utility score (PROPr) can be calculated using Patient-Reported Outcomes Measurement Information System domain scores. We assessed the construct validity of PROPr among patients treated with kidney replacement therapy (hemodialysis or kidney transplant). Design, setting, participants and measurements Secondary analysis of data collected in multicenter, cross-sectional studies of adults treated with kidney replacement therapy, recruited between April 2016 to March 2020 in Toronto, Canada. All participants provided informed consent. The outcome was PROPr score. Co-administered outcome variables included the Short form 6-domain (SF-6D) and EuroQol 5-domain 5-level (EQ-5D-5L) scores. Socioeconomic and clinical variables included age, sex, diabetes, estimated Glomerular Filtration Rate (eGFR), serum albumin, hemoglobin, kidney replacement therapy and Charlson-comorbidity index. Construct validity was assessed through correlations between PROPr and SF-6D or EQ-5D-5L and associations between PROPr and other exposure variables. Health condition impact estimates (coefficients for health conditions compared to a referent category: e.g. dialysis vs kidney transplant) were calculated using multivariable linear regression. Results Mean (SD) age of the 524 participants was 57 (17) years, 58% were male and 45% white. Median (IQR) score was 0.39 (0.24-0.58) for PROPr, 0.69 (0.58-0.86) for SF-6D and 0.85 (0.70-0.91) for EQ-5D-5L. Large correlations were observed between PROPr vs SF-6D (0.79, 95%CI: 0.76 - 0.82) and EQ-5D-5L (0.71, 95%CI: 0.66 - 0.75). Both PROPr and the other utility indices demonstrated health condition impact in the expected direction. For example, the estimate for PROPr was -0.17 (95%CI: -0.13, -0.21) for dialysis (versus kidney transplant), -0.05 (95%CI: -0.11, 0.01, P=0.08) for kidney transplant recipients with eGFR <45 vs ≥45 ml/min/1.73m2 and -0.28 (95%CI: -0.22, -0.33) for moderate/severe versus no/mild depressive symptoms. Conclusions Our results support the validity of PROPr among patients treated with kidney replacement therapy.

scholarly journals Household Response to Inadequate Sewerage and Garbage Collection Services in Abuja, Nigeria

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Ismaila Rimi Abubakar
Keyword(s):  
Public Health ◽  
Developing Countries ◽  
Qualitative Study ◽  
Environmental Sustainability ◽  
Garbage Collection ◽  
Study Data ◽  
Personal Observation ◽  
The Public ◽  
The City ◽  
Depth Interviews

Provision of sanitation and garbage collection services is an important and yet challenging issue in the rapidly growing cities of developing countries, with significant human health and environmental sustainability implications. Although a growing number of studies have investigated the consequences of inadequate delivery of basic urban services in developing countries, few studies have examined how households cope with the problems. Using the Exit, Voice, Loyalty, and Neglect (EVLN) model, this article explores how households respond to inadequate sewerage and garbage collection services in Abuja, Nigeria. Based on a qualitative study, data were gathered from in-depth interviews with sixty households, complemented with personal observation. The findings from grounded analysis indicated that majority (62%) and about half (55%) of the respondents have utilized the informal sector for sewerage services and garbage collection, respectively, to supplement the services provided by the city. While 68% of the respondents reported investing their personal resources to improve the delivery of existing sewerage services, half (53%) have collectively complained to the utility agency and few (22%) have neglected the problems. The paper concludes by discussing the public health and environmental sustainability implications of the findings.

scholarly journals The unaccomplished mission of reducing mortality in patients on kidney replacement therapy

2020 ◽  
Vol 13 (6) ◽  
pp. 948-951
Author(s):  
Alberto Ortiz
Keyword(s):  
Risk Factors ◽  
Kidney Disease ◽  
Replacement Therapy ◽  
Early Death ◽  
Gene Encoding ◽  
Mineral And Bone Disorder ◽  
Transplant Patients ◽  
Kidney Replacement Therapy ◽  
End Stage ◽  
The Impact

Abstract Six years ago, a comprehensive review by the EURECA-m working group of the ERA-EDTA thoroughly addressed the drivers of mortality in patients with end-stage kidney disease. Not unexpectedly, the key global driver of early death in these patients was the lack of access to kidney replacement therapy. However, and contrary to the expectations of non-nephrologists, mortality was still high when kidney replacement therapy was provided. This was due to excess cardiovascular and non-cardiovascular mortality, and the need to further characterize correctable risk factors and eventually test the impact of correcting them was emphasized. In this issue of ckj, seven reports address risk factors for death in non-dialysis chronic kidney disease (CKD), dialysis and kidney transplant patients. They characterize irreversible (e.g. sex; age; genetic variants of the KL gene encoding the anti-ageing protein Klotho) and reversible (obesity; mineral and bone disorder parameters; anti-depressant drugs, especially those that increase the QT; amputation; public health investments) factors associated with mortality of CKD patients on or off kidney replacement therapy.

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