Association of rs2282679 A>C polymorphism in vitamin D binding protein gene with colorectal cancer risk and survival: effect modification by dietary vitamin D intake

Abstract Objectives Vitamin D has anticarcinogenic properties. Vitamin D metabolism-related gene polymorphisms can influence vitamin D levels and its impact on carcinogenesis. This study aimed to explore the independent and combined effects of dietary vitamin D and vitamin D metabolism-related gene polymorphisms on colorectal cancer risk in a Chinese population. Methods Incident cases with histologically confirmed colorectal cancer, and sex and age-matched controls were recruited in this ongoing case-control study. Of them, 488 cases and 496 controls were both successfully interviewed and collected blood samples. Vitamin D intake was assessed by a validated food frequency questionnaire. Genotyping was performed for CYP2R1 rs10741657, CYP2R1 rs12794714, CYP24A1 rs6013897, CYP24A1 rs6068816, CYP27B1 rs4646536 and GC rs7041 by using an improved multiplex ligation detection reaction (iMLDR) technique. Unconditional multivariable logistic regression was used to calculate odds ratio (OR) and 95% confidence interval (CI) after adjusting for various confounders. Results Higher intake of dietary vitamin D was associated with 47% reduction in colorectal cancer with OR of 0.53 (95% CI: 0.34, 0.82) for the highest quartile (vs. lowest quartile) intake. Compared with persons with CYP24A1 rs6068816 CC genotype, lower risk of colorectal cancer was observed among carriers of TT genotype (OR = 0.57, 95%CI 0.36, 0.89). No significant association was found between CYP2R1 rs10741657, CYP2R1 rs12794714, CYP24A1 rs6013897, CYP27B1 rs4646536, GC rs7041 and colorectal cancer risk. No significant interaction was observed between dietary vitamin D intake and six examined single nucleotide polymorphisms on the risk of colorectal cancer. Conclusions Our study supports a protective effect of high intake of dietary vitamin D on colorectal cancer. CYP24A1 rs6068816 TT genotype was significantly associated with a decreased risk of colorectal cancer. No interaction was observed between dietary vitamin D intake and six examined single nucleotide polymorphisms in a Chinese population. Funding Sources Guangdong Natural Science Foundation (No: 2019A1515011931).

Download Full-text

Vitamin D Intake and the Risk of Colorectal Cancer: An Updated Meta-Analysis and Systematic Review of Case-Control and Prospective Cohort Studies

Cancers ◽

10.3390/cancers13112814 ◽

2021 ◽

Vol 13 (11) ◽

pp. 2814

Author(s):

Hatim Boughanem ◽

Silvia Canudas ◽

Pablo Hernandez-Alonso ◽

Nerea Becerra-Tomás ◽

Nancy Babio ◽

...

Keyword(s):

Colorectal Cancer ◽

Vitamin D ◽

Confidence Interval ◽

Prospective Studies ◽

Meta Analysis ◽

Case Control ◽

Dietary Vitamin ◽

Case Control Studies ◽

Vitamin D Intake ◽

Dietary Vitamin D

Obesity, a sedentary lifestyle, high red meat consumption and alcohol, and tobacco are considered the driving factors behind colorectal cancer (CRC) worldwide. Both diet and lifestyle are recognized to play an important role in the prevention of CRC. Forty years later, the vitamin D–cancer hypothesis is considered consistent. However, the relationship between low vitamin D intake and CRC is still controversial. The aim of this meta-analysis is to determine the associations between Vitamin D intake and CRC. MEDLINE-PubMed and Cochrane databases were searched up to May 2020 for studies evaluating the association between vitamin D intake (from foods and supplements) and CRC. Two reviewers, working independently, screened all titles and abstracts to identify the studies that met the inclusion criteria (case-control or prospective cohort (PC) studies published in English). Data were pooled by the generic inverse variance method using a random or fixed effect model. Heterogeneity was identified using the Cochran Q-test and quantified by the I2 statistic. A total of 31 original studies were included for the quantitative meta-analysis, comprising a total 47.540 cases and 70.567 controls in case-control studies, and a total of 14.676 CRC-incident cases (out of 808.130 subjects in PC studies) from 17 countries. A significant 25% lower risk was reported comparing the highest vs. the lowest dietary vitamin D consumption and CRC risk (odds ratio (95% confidence interval): 0.75 (0.67; 0.85)) in case-control studies, whereas a non-significant association was reported in case of prospective studies (hazard ratio (95% confidence interval): 0.94 (0.79; 1.11). The present meta-analysis demonstrates that high dietary vitamin D is associated to CRC prevention. However, larger and high-quality prospective studies and clinical trials are warranted to confirm this association.

Download Full-text

Dietary vitamin D intake and colorectal cancer risk: a longitudinal approach within the PREDIMED study

European Journal of Nutrition ◽

10.1007/s00394-021-02585-1 ◽

2021 ◽

Author(s):

Pablo Hernández-Alonso ◽

Silvia Canudas ◽

Hatim Boughanem ◽

Estefanía Toledo ◽

Jose V. Sorlí ◽

...

Keyword(s):

Colorectal Cancer ◽

Vitamin D ◽

Cancer Risk ◽

Colorectal Cancer Risk ◽

Dietary Vitamin ◽

Vitamin D Intake ◽

Longitudinal Approach ◽

Dietary Vitamin D ◽

Predimed Study

Download Full-text

Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by aFokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding

International Journal of Cancer ◽

10.1002/ijc.23769 ◽

2008 ◽

Vol 123 (9) ◽

pp. 2170-2179 ◽

Cited By ~ 41

Author(s):

Evropi Theodoratou ◽

Susan M. Farrington ◽

Albert Tenesa ◽

Geraldine McNeill ◽

Roseanne Cetnarskyj ◽

...

Keyword(s):

Colorectal Cancer ◽

Vitamin D ◽

Cancer Risk ◽

Colorectal Cancer Risk ◽

Dietary Vitamin ◽

Inverse Association ◽

Vitamin D Intake ◽

Dietary Vitamin D

Download Full-text

A Polymorphism within the Vitamin D-Binding Protein Gene Is Associated with Graves’ Disease but Not with Hashimoto’s Thyroiditis

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem.87.6.8562 ◽

2002 ◽

Vol 87 (6) ◽

pp. 2564-2567 ◽

Cited By ~ 3

Author(s):

Michael A. Pani ◽

Karoline Regulla ◽

Maria Segni ◽

Stefan Hofmann ◽

Michael Hüfner ◽

...

Keyword(s):

Vitamin D ◽

Hashimoto’S Thyroiditis ◽

Protein Gene ◽

Binding Protein ◽

Hashimoto's Thyroiditis ◽

Graves Disease ◽

Vitamin D Binding Protein ◽

Binding Protein Gene

Download Full-text

Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: the EPIC-InterAct study

European Journal of Clinical Nutrition ◽

10.1038/ejcn.2013.235 ◽

2013 ◽

Vol 68 (2) ◽

pp. 196-202 ◽

Cited By ~ 10

Author(s):

S Abbas ◽

J Linseisen ◽

S Rohrmann ◽

J W J Beulens ◽

B Buijsse ◽

...

Keyword(s):

Type 2 Diabetes ◽

Vitamin D ◽

Dietary Vitamin ◽

Vitamin D Intake ◽

Dietary Vitamin D ◽

Prospective Investigation

Download Full-text

Association of vitamin D with incident glaucoma: findings from the Women’s Health Initiative

Journal of Investigative Medicine ◽

10.1136/jim-2020-001645 ◽

2021 ◽

pp. jim-2020-001645

Author(s):

Laura D Carbone ◽

Karen Johnson ◽

Joseph C Larson ◽

Fridtjof Thomas ◽

Jean Wactawski-Wende ◽

...

Keyword(s):

Vitamin D ◽

Women's Health ◽

Postmenopausal Women ◽

Serum Levels ◽

Dietary Vitamin ◽

Health Initiative ◽

Vitamin D Intake ◽

Vitamin D Supplements ◽

Dietary Vitamin D ◽

The Women’S Health Initiative

The relationship between vitamin D and glaucoma is controversial. The objective of this study was to examine women from the Women’s Health Initiative (WHI) to determine if there is an association between vitamin D and incident glaucoma in postmenopausal women. We examined the association between dietary vitamin D intake, vitamin D supplements and serum 25 hydroxyvitamin D (25(OH)D) levels and the risk of developing glaucoma. 143,389 postmenopausal women from the WHI including a subset with serum 25(OH) D measurements were examined to determine the association of dietary, supplemental and serum levels of vitamin D to the development of glaucoma. Dietary intakes of vitamin D, use of vitamin D supplements and serum levels of 25(OH) D were predictors examined for the main outcome of incident glaucoma. In multivariable models adjusted for demographic, clinical variables and medication use, dietary vitamin D, vitamin D supplements, total vitamin D intake (diet plus supplements) and serum 25 (OH) D measurements were not significantly associated with incident glaucoma. In the CaD placebo-controlled intervention clinical trial, there was also no association in the active intervention arm with glaucoma. We conclude that dietary vitamin D intake, supplements and serum levels are not significantly related to the risk of developing glaucoma in postmenopausal women.

Download Full-text

High Prevalence of Vitamin D Inadequacy During Late Postpartum in Canadian Mothers

Current Developments in Nutrition ◽

10.1093/cdn/nzab046_087 ◽

2021 ◽

Vol 5 (Supplement_2) ◽

pp. 790-790

Author(s):

Sarah Montgomery ◽

Angella Lee ◽

Nasime Sarbar ◽

Deborah Zibrik ◽

Yvonne Lamers

Keyword(s):

Vitamin D ◽

British Columbia ◽

Dietary Intake ◽

Dietary Vitamin ◽

Nutrient Deficiencies ◽

Cross Sectional ◽

Convenience Sample ◽

Vitamin D Intake ◽

Pregnancy And Postpartum ◽

Dietary Vitamin D

Abstract Objectives To assess maternal dietary intake and adequacy at postpartum and to determine whether lifestyle characteristics and breastfeeding status are related to nutrient intakes. Methods We analyzed cross-sectional data from a convenience sample of 129 mothers at 18-mo postpartum, whose families were enrolled into a randomized toddler intervention trial, in the Lower Mainland, British Columbia, Canada. The Canadian Diet History Questionnaire II (C-DHQ II) was used to estimate usual dietary intake in the mothers during the preceding 12 months (i.e., between 6- to 18-mo postpartum). Implausible energy intakes were defined as <600 kcal/day or >3500 kcals/day, and excluded from analysis. Demographic and lifestyle characteristic data about the pregnancy and postpartum time period were collected using a questionnaire. Results Maternal mean (SD) age at birth was 33.5 (4.0) years and most women were of European (46%) or Asian (38%) ethnicity, and had Bachelor's degree or higher education (70%). About 75%, 88%, and 89% did not meet their dietary requirements (i.e., intake below the EAR) for fiber, potassium, and vitamin D intakes, from food only, respectively. Considering total dietary intake from food and supplements, the prevalence of dietary vitamin D inadequacy was 25%. Women of European ethnicity had higher vitamin D intake (median (IQR) in mg/1000kcal/day: 19.5 (7.26,101)) compared to Asian women (10.8 (3.87, 21.1); P < 0.05). Dietary vitamin D intake was higher in breastfeeding (i.e., providing breastmilk as primary milk source, i.e., ³2 times/day, to their 18-mo old toddlers) compared to non- or occasionally breastfeeding mothers (20.0 (10.5, 61.1) versus 14.9 (4.28, 26.7) mg/1000kcal/day; P < 0.05). Conclusions While most Canadian mothers in this sample met the EARs for most nutrients, the prevalence of dietary inadequacy was very high for vitamin D, potassium, and fiber. Some population groups may be especially at risk of developing nutrient deficiencies in this period of life characterized by postpartum recovery and transition; targeted public health strategies may be needed to address these deficiencies. Funding Sources This study is supported by The University of British Columbia, and the British Columbia Children's Hospital Research Institute, Canada, and is funded by Société des Produits Nestlé S.A.

Download Full-text