Maternal toxoplasmosis and the risk of childhood autism: serological and molecular small-scale studies

Abstract Background Toxoplasmosis resulting from infection with the Toxoplasma parasite has become an endemic disease worldwide. Recently, a few studies have reported a high prevalence of Toxoplasmosis infections among Saudi Arabian women. This disease could become life threatening for pregnant women and for immunodeficient people. There is evidence that infections during pregnancy, especially in the early stages, are associated with neurodevelopmental disorders. Autism disorder represents one of the most common neurodevelopmental disorders worldwide; it is associated with delayed language development, weak communication interaction, and repetitive behavior. The relationship between prenatal toxoplasmosis and autism in childhood remains unclear. The present study aims to report a link between maternal toxoplasmosis and autistic offspring among Saudi Arabian women. Method Blood samples (36 maternal, 36 from their non-autistic children, and 36 from their autistic children) were collected for serological and molecular evaluation. Results A toxoplasmosis infection was reported for 33.34% of participants using an ELISA assay (5.56% IgG+/IgM+, 11.11% IgG−/IgM+, and 16.67% IgG+/IgM-); however, a nested PCR assay targeting B1 toxoplasmosis specific genes recorded positive tests for 80.56% of the samples. In addition, the present study detected several points of mutation of mtDNA including NADH dehydrogenase (ND1, ND4) and Cyt B genes and the nDNA pyruvate kinase (PK) gene for autistic children infected with toxoplasmosis. Conclusion Considering previous assumptions, we suggest that a maternal toxoplasmosis infection could have a role in the development of childhood autism linked to mtDNA and nDNA impairment.

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STRATEGI KOPING ORANG TUA TERHADAP ANAK AUTIS DAN POLA ASUH ORANG TUA

Journal of Health Sciences ◽

10.33086/jhs.v11i2.113 ◽

2018 ◽

Vol 11 (2) ◽

pp. 196-204

Author(s):

Asirotul Ma’rifah ◽

Naning Puji Suryantini Suryantini ◽

Rina Mardiyana

Keyword(s):

Coping Strategies ◽

Sampling Technique ◽

Children With Autism ◽

Adaptive Coping ◽

Autistic Children ◽

Cross Sectional ◽

Authoritarian Parenting ◽

Cross Tabulation ◽

Relationship Of ◽

The Relationship

Autism is still a nightmare for most parents. Parents with autism can be very stressful when dealing with a hyperactive child's behavior, aggressive and passive. Stress experienced by parents of children with autism will affect the ability of parents in the parenting role, especially in relation to coping strategies have in dealing with problems of children. The participation of parents is crucial the success of socializing with children with autism in the general population. This study aims to determine the relationship of coping strategies parents of autistic children and parenting parents. This type of research is an analytic correlation with cross sectional approach. The population in this study were all parents of autistic children in SLB Muhammadiyah Mojokerto numbering 15 people. Samples in this study were all parents of autistic children in SLB Muhammadiyah Mojokerto which totaled 15 people by using total sampling technique. Collecting data using questionnaires. Data analized use cross tabulation, presented in a frequency distribution. On cross-tabulation obtained results tend to use maladaptive coping strategies permissive parenting that is 8 (53.3%), there are also respondents who use adaptive coping strategies using authoritarian parenting as much as one person (16.7%), and adaptive coping strategies tend using democratic parenting style as much as 5 people (33.3%). Expected parents still seeking information to broaden their parents on coping strategies of parents of autistic children and parenting parents as well as parents to give special attention for children with autism to the development and advancement of their lives because they have the same rights as any other normal child.

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The Relationship between Worker's Health Status and Work Ability Index in Small Scale Factories

Korean Journal of Occupational and Environmental Medicine ◽

10.35371/kjoem.1998.10.2.149 ◽

1998 ◽

Vol 10 (2) ◽

pp. 149 ◽

Cited By ~ 2

Author(s):

Young Ha Lee ◽

Sung Chul Hong ◽

Jong Young Lee

Keyword(s):

Health Status ◽

Work Ability ◽

Small Scale ◽

Work Ability Index ◽

Ability Index ◽

The Relationship

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Acute pulmonary embolism in COVID-19 patient: a case report of free-floating right heart thrombus successfully treated with fibrinolysis

European Heart Journal - Case Reports ◽

10.1093/ehjcr/ytaa388 ◽

2020 ◽

Author(s):

Fernando Scudiero ◽

Antonino Pitì ◽

Roberto Keim ◽

Guido Parodi

Keyword(s):

Pulmonary Embolism ◽

High Risk ◽

Retrospective Studies ◽

Right Heart ◽

Clinical Issue ◽

Systemic Thrombolysis ◽

Case Summary ◽

High Prevalence ◽

Life Threatening ◽

Complex Scenario

Abstract Background Despite the fast-growing understanding of the coronavirus disease 2019 (COVID-19), patient management remains largely empirical or based on retrospective studies. In this complex scenario, an important clinical issue appears to be represented by the high prevalence of thromboembolic events, but the data regarding high-risk pulmonary embolism (PE) is still not available. Case summary A patient with COVID-19 developed sudden shortness of breath and hypoxia. Early echocardiographic diagnosis of high-risk PE related to right heart thrombus was performed. Systemic thrombolysis was administered with excellent clinical and haemodynamic response. Discussion Pulmonary thromboembolism is a common occurrence in severe COVID-19 infection. In our experience, systemic thrombolysis proved to be effective and for this reason may be considered for life-threatening PE in COVID-19 patients.

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High prevalence of ascending aortic dilation in adults with repaired coarctation of the aorta

Cardiology in the Young ◽

10.1017/s1047951121000111 ◽

2021 ◽

pp. 1-6

Author(s):

Daniel Rinnström ◽

Mikael Dellborg ◽

Ulf Thilén ◽

Peder Sörensson ◽

Niels-Erik Nielsen ◽

...

Keyword(s):

Blood Pressure ◽

Aortic Valve ◽

Aortic Valve Disease ◽

Congenital Heart ◽

Coarctation Of The Aorta ◽

Valve Disease ◽

Aortic Dilation ◽

Factors Associated ◽

High Prevalence ◽

Life Threatening

Abstract Background: Ascending aortic dilation is a feared complication in adults with repaired coarctation of the aorta, as the condition is associated with life-threatening complications such as aortic dissection and rupture. However, the data are currently limited regarding factors associated with ascending aortic dilation in these patients. Methods and results: From the national register of congenital heart disease, 165 adult patients (≥ 18 years old) with repaired coarctation of the aorta, and echocardiographic data on aortic dimensions, were identified (61.2% male, mean age 35.8 ± 14.5 years). Aortic dilation (aortic diameters > 2 SD above reference mean) was found in 55 (33.3%) of the 165 included patients, and was associated with manifest aortic valve disease in univariable logistic regression analysis (OR 2.44, 95% CI [1.23, 4.83]). Conclusions: Aortic dilation is common post-repair of coarctation of the aorta, and is associated with manifest aortic valve disease and thus indirectly with the presence of a bicuspid aortic valve. However, no association was found between aortic dilation and age or blood pressure.

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Community-Level Sports Group Participation and Health Behaviors Among Older Non-Participants in a Sports Group: A Multilevel Cross-Sectional Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18020531 ◽

2021 ◽

Vol 18 (2) ◽

pp. 531

Author(s):

Taishi Tsuji ◽

Satoru Kanamori ◽

Yasuhiro Miyaguni ◽

Katsunori Kondo

Keyword(s):

Behavior Change ◽

Transtheoretical Model ◽

Community Level ◽

Older Individuals ◽

Multilevel Regression ◽

Cross Sectional ◽

Partial Regression Coefficient ◽

Group Participation ◽

High Prevalence ◽

The Relationship

This study validates the relationship between community-level sports group participation and the frequency of leaving the house and transtheoretical model stages of behavior change for exercise among older individuals who did not participate in a sports group. We used cross-sectional data from the 2016 Japan Gerontological Evaluation Study. The proportion of sports group participants at the community level was calculated using the data from 157,233 older individuals living in 1000 communities. We conducted a multilevel regression analysis to examine the relationship between the proportion of sports group participants and the frequency of leaving the house (1 day/week or less) and the transtheoretical model stages of behavior change for exercise. A statistically significant relationship was observed between a high prevalence of sports group participation and lower risk of homeboundness (odds ratio: 0.94) and high transtheoretical model stages (partial regression coefficient: 0.06) as estimated by 10 percentage points of participation proportion. Older individuals, even those not participating in a sports group, living in a community with a high prevalence of sports group participation are less likely to be homebound; they are highly interested and have numerous opportunities to engage in exercise.

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Displacement of Scope: A Problem of the Relationship Between Small-Scale and Large-Scale Sociological Theories

American Journal of Sociology ◽

10.1086/223689 ◽

1964 ◽

Vol 69 (6) ◽

pp. 571-584 ◽

Cited By ~ 31

Author(s):

Helmut R. Wagner

Keyword(s):

Large Scale ◽

Small Scale ◽

The Relationship

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The relationship between 99mTc-HMPAO brain SPECT and the scores of real life rating scale in autistic children

Brain and Development ◽

10.1016/s0387-7604(02)00006-2 ◽

2002 ◽

Vol 24 (2) ◽

pp. 77-81 ◽

Cited By ~ 21

Author(s):

Meryem Kaya ◽

Serap Karasalihoğlu ◽

Funda Üstün ◽

Aziz Gültekin ◽

Tevfik Fikret Çermik ◽

...

Keyword(s):

Rating Scale ◽

Real Life ◽

Brain Spect ◽

Autistic Children ◽

The Relationship ◽

99Mtc Hmpao

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The relationship between habitat physical complexity and recruitment of the coral reef damselfish, Pomacentrus amboinensis : an experimental study using small-scale artificial reefs

Ichthyological Research ◽

10.1007/s102280300010 ◽

2003 ◽

Vol 50 (1) ◽

pp. 73-77 ◽

Cited By ~ 13

Author(s):

Hiroyuki Kawasaki ◽

Mitsuhiko Sano ◽

Takuro Shibuno

Keyword(s):

Experimental Study ◽

Coral Reef ◽

Artificial Reefs ◽

Small Scale ◽

Pomacentrus Amboinensis ◽

The Relationship ◽

Physical Complexity

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Relationship between levels of salivary cortisol with depression and suicidal ideation

European Psychiatry ◽

10.1016/s0924-9338(11)73335-1 ◽

2011 ◽

Vol 26 (S2) ◽

pp. 1631-1631 ◽

Cited By ~ 1

Author(s):

P. De Usabel Guzmán ◽

M.J. Mota Rodríguez ◽

A. Pampin Alfonso ◽

J.B. Brenlla Gonzalez ◽

M.J. Núñez ◽

...

Keyword(s):

Suicidal Ideation ◽

Salivary Cortisol ◽

Public Health Problem ◽

Demographic Variables ◽

Major Public Health Problem ◽

Santiago De Compostela ◽

High Prevalence ◽

Cortisol Levels ◽

The Relationship

IntroductionSuicide is a major public health problem in most of the countries because it has a high prevalence in young people. It has been studied that high levels of cortisol are associated with depression and increase of the suicidal risk.ObjectiveTo analyze the relationship between cortisol levels in a population of university students and the questionnaire results for the Beck Depression Inventory (BDI).MethodThe sample was composed by 106 students of the Nursing School of Santiago de Compostela University. The 88.7% of the sample are women with a mean age of 21.50 + /−2.52, the 99% are unmarried. The protocol consisted in 3 sections: demographic variables, BDI questionnaire with spanish scale and determination of salivary cortisol levels. Statistical analysis was done with SPSS 15.ResultsThe are higher levels of salivary cortisol in students with a greater or equal score to 13 on the BDI with statistically significances differences (p = .000). Students with suicidal ideation (item 9 of the BDI) have highest rates of cortisol, with statistically significant differences (p = 0.001).ConclusionsThis study supports other researchs about the association between biological neuroendocrine markers and affective disorders. Explaining suicidal behavior could help us to prevent it by using early intervention strategies for vulnerable populations. They could also identify markers to establish the risk of suicide.

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