scholarly journals Polymorphic variants in genes related to stress coping are associated with the awake bruxism

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zofia Maciejewska-Szaniec ◽  
Marta Kaczmarek-Ryś ◽  
Szymon Hryhorowicz ◽  
Agnieszka Przystańska ◽  
Tomasz Gredes ◽  
...  

Abstract Background Chronic stress is one of the leading predisposing factors in bruxism aetiology, but the influence of genetic factors is also suggested. We aimed to study whether sequence variants in genes involved in stress regulation pathways: NTRK2 and BDNF, may be associated with awake bruxism susceptibility, clinical presentation, and patients’ perceived stress level. Methods The study group included 104 patients with probable awake bruxism and 191 population controls. Patients underwent dental examination concerning the symptoms of bruxism and psychological testing. Genotyping was performed using HRMA and sequencing. Statistical analyses were conducted, and P values below 0.05 were considered statistically significant. Results We observed a positive correlation of measured stress level and pathological teeth attrition in the anterior segment (r = 0.45, P < 0.001), enamel attritions (r = 0.44, P < 0.001), tongue impressions (r = 0.50, P < 0.001) and posterior teeth attrition (r = 0.27, P = 0.005). Moreover, the c.196A variant (p.66Met) of the BDNF gene and c.1397-31392G allele of the NTRK2 gene were present with elevated frequency, comparing to controls. Conclusions This study hence the thesis that perceived stress level is a substantial contributing factor to awake bruxism occurrence and its clinical manifestations. Moreover, sequence variants in genes related to stress coping may be correlated with awake bruxism’s susceptibility via elevated perceived stress level.

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Silvia Fisch ◽  
Suzana Trivaković-Thiel ◽  
Stephanie Roll ◽  
Theresa Keller ◽  
Sylvia Binting ◽  
...  

Abstract Background The aim of the trial was to investigate the effect of a hypnotherapeutic group program in healthy persons with increased levels of perceived stress. Methods In a randomized controlled multicenter trial participants with a self-assessed subjective stress level ≥ 40 mm on a visual analogue scale (0–100 mm; VAS) for the previous week and a stable state of health were randomized to either 5 weekly sessions of 120-min duration of a hypnotherapeutic group program for stress reduction and improved stress coping plus 5 hypnosis audiorecords for individual practice at home plus an educational booklet for stress coping (hypnosis group) versus an educational booklet only (control group). The primary outcome parameter was the VAS stress level for the previous week after 5 weeks. Secondary outcome parameters included the VAS stress level after 12 weeks, perceived stress (CPSS), depression (ADS-K), self efficacy (SWE) and quality of life (SF 36) after 5 weeks and 12 weeks. Analysis of covariance with a significance level of 5% using the full analysis set was used for analysis; the model included treatment (fixed effect), VAS baseline value (fixed covariate), and center (random effect). Results A total of 95 participants were randomized; 47 (40 female, 45 ± 13.4 years of age) were allocated to the hypnosis group, and 48 (41 female, 46.9 ± 14.3 years) were allocated to the control group. Regarding VAS stress level after 5 weeks, the adjusted VAS mean in the hypnosis group was 41.8 mm [95% confidence interval (CI): 35.2; 48.4] compared to 62.9 mm [56.2; 69.7] in the control group, and the group difference was − 21.2 mm [− 30.1; − 12.2] (P < 0.001). After 12 weeks, the stress intensity on the VAS showed a between-group difference of − 14.7 mm [− 25.1; − 4.4] (P = 0.006), and the adjusted means were 41.1 mm [33.4; 48.8] in the hypnosis group and 55.9 mm [48.4; 63.5] in the control group. Improvements were also reported for CPSS, SF-36, SWE and ADS-K after 5 and 12 weeks. Conclusion Compared to the control group, the hypnosis group showed reduced perceived stress after 5 and 12 weeks. Trial registration ClinicalTrials.gov NCT03525093; date of registration: May 15, 2018.


2020 ◽  
Author(s):  
Xu Chen ◽  
Cheng-Bo Zeng ◽  
Shuai-Feng Liu ◽  
Xiao-Ming Li ◽  
Shan Qiao ◽  
...  

Abstract To compare the psychological stress level and hair cortisol level of people living with HIV (PLWH) with those without HIV. A total of 220 subjects were initially enrolled in the study, including 20 subjects living without HIV and 200 PLWH. Psychological stress level, including quality of life, anxiety, perceived stress and mental resilience, was self-reported in both groups with related scales. The cortisol in hair were extracted and assessed by LC-APCI-MS/MS method. Propensity score matching analysis was performed to balance the baseline covariates of the two groups, whereas the difference in psychological stress level and hair cortisol level between the two groups were compared. Furthermore, the associations between psychological stress level and cortisol level were examined. Two comparison groups were matched by 1:3 propensity score matching, which yield 20 subjects living without HIV and 60 PLWH. Ultimately, in regarding to the psychological stress, the levels of the anxiety, perceived stress and mental resilience were higher among PLWH than those living without HIV, but the people without HIV showed higher quality of life. The hair cortisol level in PLWH was higher than those living without HIV. However, there were no significant associations between psychological stress level and cortisol level. The PLWH showed higher level of psychological stress and cortisol than those without HIV. No relationship was seen between psychological stress level and cortisol level in PLWH.


Author(s):  
Muhammad Fijar Rotul Akbar ◽  
Achmad Rizki ◽  
Maulida Nur

Academic demands including examinations are found to bethe major contributor of stress development among students.Current research is purposed to investigate the prevalence ofperceived stress level among Madrasah Aliyah studentsduring examination week. This study was a descriptive andcross-sectional design applying quantitative method for datacollection. With respect to the sample, 107 students formMadrasah Aliyah Pasirjambu, Kab. Bandung wereproportionally selected from class 10 to class 12. To measurethe degree to which particular situations and conditionshappening in student’s life are appraised or perceived asstressful situation, Perceived Stress Scale developed bySheldon Cohen was administered. After which, havinggained ethical approval from the foundation board andschool director, the data were collected and analyzed usingstatistical program of SPSS. Result showed that duringexamination, majority of them were experiencing moderatelevel of stress accounting for more than 80% and nosignificant differences of stress level were found withrespect to gender, age and study year (class).


2020 ◽  
Vol 9 (2) ◽  
pp. 117-125
Author(s):  
Eka Wahyuni ◽  
Yustia Nova Annisa

Abstrak Penelitian ini bertujuan untuk mengetahui tingkat stres remaja dan kebutuhan untuk mengembangkan video tutorial mindfulness-breathing meditation sebagai strategi dalam mengurangi stres remaja. Convenience sampling yang digunakan untuk mengumpulkan data pada 165 peserta didik. Alat ukur yang digunakan adalah perceived stress scale (PSS) dan studi kebutuhan video mindfulness-breathing meditation. Hasil penelitian menunjukkan bahwa tingkat stres remaja yang tinggi (27 dari skor total 40). Perempuan memiliki tingkat stres yang lebih tinggi daripada laki-laki (27,2 vs 26,6), persentase perempuan yang mengalami stres tingkat tinggi lebih banyak daripada laki-laki (54,1%vs 41,3%). Meskipun prevalensi stres sangat tinggi di kalangan remaja, sebagian besar peserta didik sangat minim memiliki paparan materi mengenai cara mengurangi stres (80,15%) serta mengenai latihan bernafas dengan baik. Peserta didik juga sangat antusias untuk mempelajari meditasi pernafasan melalui video (100%). Diketahui juga bahwa pengembangan video mindfulness-breathing meditation sangat penting untuk membantu peserta didik dalam mengurangi stres mereka. Kata Kunci: Stres, Remaja, Mindfulness, Breathing Meditation   Abstract This research aims to determine the stress level of adolescents and the need to develop a mindfulness-breathing meditation video as a strategy to reduce adolescents’ stress. The convenience sampling was used to collect data form was 165 students. The measures are the perceived stress scale (PSS) and the needs of mindfulness-breathing meditation video. The results shows that the adolescent’ stress level is high (27 out of 40). Female has higher level stress than male (27,2 vs 26,6), the percentage of female who experience high level stress was outnumber male (54,1% vs 41,3%). Despite the high prevalence of stress among adolescent, most of students has minimum exposure to stress reduction (80,15%) as well as breathing exercises. All students enthusiastic to learn mindfulness-breathing meditation through video. It is recommended that development of mindfulness-breathing meditation video is crucial to help students in reducing their stress. Keywords: Stress, Adolescent, Mindfulness, Breathing Meditation


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