scholarly journals The impact of reporting magnetic resonance imaging incidental findings in the Canadian alliance for healthy hearts and minds cohort

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Judy M. Luu ◽  
Anand K. Sergeant ◽  
Sonia S. Anand ◽  
Dipika Desai ◽  
Karleen Schulze ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Incidental Findings ◽  
Resonance Imaging ◽  
Structural Abnormalities ◽  
The Impact ◽  
Hearts And Minds ◽  
The Brain

Abstract Background In the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies. Methods Between 2013 and 2019, 8252 participants (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported. Results Severe structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy. Conclusion The management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies. Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT02220582.

scholarly journals Postoperative Quality of Life Outcome and Employment in Patients Undergoing Resection of Epileptogenic Lesions Detected by Magnetic Resonance Imaging

2009 ◽  
Vol 49 (7) ◽  
pp. 281-286 ◽  
Author(s):  
Kouzo MORITAKE ◽  
Nobuhiro MIKUNI ◽  
Yasuhiko AKIYAMA ◽  
Hidemasa NAGAI ◽  
Nobuyuki MARUYAMA ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Postoperative Quality

scholarly journals Rationale and design of the cardiovascular status in patients with endogenous cortisol excess study (CV-CORT-EX): a prospective non-interventional follow-up study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kristina Ehrlich ◽  
Caroline Morbach ◽  
Theresa Reiter ◽  
Peter Ulrich Heuschmann ◽  
Anke Hannemann ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Magnetic Resonance Imaging ◽  
Cardiac Magnetic Resonance ◽  
Health Status ◽  
Magnetic Resonance ◽  
Transthoracic Echocardiography ◽  
Resonance Imaging ◽  
Psychosocial Status ◽  
Endogenous Cortisol

Abstract Background Endogenous Cushing’s syndrome (CS) results in increased cardiovascular (CV) morbidity and mortality. So far, most studies focussed on distinct disease entities rather than the integrity of the CV system. We here describe the design of the Cardiovascular Status in Endogenous Cortisol Excess Study (CV-CORT-EX), a study aiming to comprehensively investigate the health status of patients with endogenous CS (with a particular focus on CV phenotypes, biochemical aspects, quality of life, and psychosocial status). Method A prospective non-interventional cohort study performed at a German tertiary referral centre. At the time of enrolment, patients will be categorised as: (1) newly diagnosed overt CS, (2) recurrent overt CS, (3) CS in remission, (4) presence of mild autonomous cortisol excess (MACE). The target cohorts will be n = 40 (groups 1 + 2), n = 80 (group 3), and n = 20 (group 4). Patients with overt CS at the time of enrolment will be followed for 12 months after remission (with re-evaluations after 6 and 12 months). At each visit, patients will undergo transthoracic echocardiography, cardiac magnetic resonance imaging, 24-h electrocardiogram, 24-h blood pressure measurement, and indirect evaluation of endothelial function. Furthermore, a standardised clinical investigation, an extensive biochemical workup, and a detailed assessment of quality of life and psychosocial status will be applied. Study results (e.g. cardiac morphology and function according to transthoracic echocardiography and cardiac magnetic resonance imaging; e.g. prevalence of CV risk factors) from patients with CS will be compared with matched controls without CS derived from two German population-based studies. Discussion CV-CORT-EX is designed to provide a comprehensive overview of the health status of patients with endogenous CS, mainly focussing on CV aspects, and the holistic changes following remission. Trail registration ClinicalTrials.gov (https://clinicaltrials.gov/) NCT03880513, registration date: 19 March 2019 (retrospectively registered). Protocol Date: 28 March 2014, Version 2.

scholarly journals The Impact of Undiagnosed Synaesthesia on the Interpretation of Structural and Functional MRI Images Connectivity Maps and Resulting Diagnoses

2016 ◽  
Vol 15 (11) ◽  
pp. 7227-7234
Author(s):  
Nourhan Zayed
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
Sensory Modality ◽  
Structural Connectivity ◽  
Brain Regions ◽  
Resonance Imaging ◽  
Functional Connections ◽  
The Impact ◽  
The Brain

Synathesia is a condition in which stimulation of a sensory modality triggers another sensation in the alike or an unalike sensory modality. Currently, synaesthesia is deemed a neurological condition that engages unwanted transfer of signals between brain regions from one sense to another “crosstalk activation”. The probability that undiagnosed synaesthesia may impact the results of structural magnetic resonance imaging (MRI), Diffusion Tensor imaging (DTI), functional magnetic resonance imaging (fMRI) and resting state connectivity studies is high, given the multiple anatomical and functional connections within the brain. In this paper, the currently available literature to mark which sensations adjured by synaesthesia and how could this impact MRI different modalities. Our study found that synaesthesia can have an opaque impact on fMRI studies of sensory, memory and cognitive functions, and there is testimony to suggest structural connections in the brain are also mutated DTI measurements especially, it shows enhanced structural connectivity for synesthetes between brain regions, higher Fractional anisotropy (FA), as well as increased in the white matter integrity between some regions.. Given the low dispersal of synaesthesia, the likelihood of synaesthesia being a perplexing factor in DTI, fMRI studies of patient groups is small; however, determining the existence of synaesthesia is paramount for investigating individual patients especially Shizoherenia, and autistic patients.

The Management of Incidental Findings in Neuro-Imaging Research: Framework and Recommendations

2010 ◽  
Vol 38 (1) ◽  
pp. 117-126 ◽  
Author(s):  
Erica K. Rangel
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Incidental Findings ◽  
Incidental Finding ◽  
Human Subjects ◽  
Research Participant ◽  
Diagnostic Techniques ◽  
Resonance Imaging ◽  
Potential Health ◽  
The Brain

With improved diagnostic capability and accuracy, the fields of medicine, neuroscience, psychiatry, and psychology have benefitted remarkably from the dramatic advancements in neuroimaging technology. Not only can surface and subsurface structures of the brain be mapped with incredible anatomical detail (with magnetic resonance imaging), now neural activity can be imaged across time as the brain responds to different stimuli (with functional magnetic resonance imaging). These sophisticated techniques have been a vital element in the recent increase in neuroimaging-based research. This increase, while producing new diagnostic techniques and improved treatment mechanisms for neurological disease, has also led to a new dilemma for human subjects researchers: how should incidental findings be managed? An incidental finding (IF) is a finding concerning an individual research participant that has potential health or reproductive importance and is discovered in the course of conducting research but is beyond the aims of this study.

scholarly journals Hyperpolarized3He Functional Magnetic Resonance Imaging of Bronchoscopic Airway Bypass in Chronic Obstructive Pulmonary Disease

2012 ◽  
Vol 19 (1) ◽  
pp. 41-43 ◽  
Author(s):  
Lindsay Mathew ◽  
Miranda Kirby ◽  
Donald Farquhar ◽  
Christopher Licskai ◽  
Giles Santyr ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Magnetic Resonance Imaging ◽  
Chronic Obstructive Pulmonary Disease ◽  
Magnetic Resonance ◽  
Pulmonary Disease ◽  
Disease Stage ◽  
Chronic Obstructive ◽  
Resonance Imaging ◽  
Obstructive Pulmonary Disease

A 73-year-old exsmoker with Global initiative for chronic Obstructive Lung Disease stage III chronic obstructive pulmonary disease underwent airway bypass (AB) as part of the Exhale Airway Stents for Emphysema (EASE) trial, and was the only EASE subject to undergo hyperpolarized3He magnetic resonance imaging for evaluation of lung function pre- and post-AB.3He magnetic resonance imaging was acquired twice previously (32 and eight months pre-AB) and twice post-AB (six and 12 months post-AB). Six months post-AB, his increase in forced vital capacity was <12% predicted, and he was classified as an AB nonresponder. However, post-AB, he also demonstrated improvements in quality of life scores, 6 min walk distance and improvements in3He gas distribution in the regions of stent placement. Given the complex relationship between well-established pulmonary function and quality of life measurements, the present case provides evidence of the value-added information functional imaging may provide in chronic obstructive pulmonary disease interventional studies.

Quality of life assessments in the evaluation of magnetic resonance imaging

1994 ◽  
Vol 3 (1) ◽  
pp. 29-37 ◽  
Author(s):  
R. Mackenzie ◽  
W. Hollingworth ◽  
A. K. Dixon
Keyword(s):  
Quality Of Life ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Resonance Imaging
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