scholarly journals Association of 25-hydroxyvitamin D with cardiometabolic risk factors and metabolic syndrome: a mendelian randomization study

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Chi Chen ◽  
Yi Chen ◽  
Pan Weng ◽  
Fangzhen Xia ◽  
Qin Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Cardiometabolic Risk ◽  
Mendelian Randomization ◽  
Cardiometabolic Risk Factors ◽  
Metabolic Traits ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
Genetically Determined

Abstract Background Low circulating vitamin D levels have been associated with increased risk of metabolic syndrome (MS) and cardiometabolic risk factors in multiple epidemiology studies. However, whether this association is causal is still unclear. We aimed to test whether genetically lowered vitamin D levels were associated with MS and its metabolic traits, using mendelian randomization (MR) methodology. Methods Ten thousand six hundred fifty-five participants were enrolled from the SPECT-China study, which was performed in 23 sites in East China during 2014 to 2016. Using four single-nucleotide polymorphisms (SNPs) in the DHCR7, CYP2R1, GC and CYP24A1 genes with known effects on 25(OH) D concentrations, we created a genetic risk score (GRS) as instrumental variable (IV) to estimate the effect of genetically lowered 25(OH) D on MS and cardiometabolic risk factors. MS was defined according to the International Diabetes Federation criteria. Results Lower measured 25(OH)D levels were associated with MS (OR 0.921, 95% CI 0.888, 0.954) after multivariable adjustment. However, the MR-derived odds ratio of genetically determined 25(OH) D for risk of MS was 0.977 (95% CI 0.966, 1.030). The MR-derived estimates for raised fasting plasma glucose was 0.578 (95% CI 0.321, 0.980) per 10 nmol/L GRSsynthesis determined increase of 25(OH) D levels. Conclusions We found no evidence that genetically determined reduction in 25(OH)D conferred an increased risk of MS and its metabolic traits. However, we created our GRS only on the basis of common variants, which represent limited amount of variance in 25(OH)D. MR studies using rare variants, and large-scale well-designed RCTs about the effect of vitamin D supplementation on MS are warranted to further validate the findings.

scholarly journals Vitamin D levels and cardiometabolic risk factors in Portuguese adolescents

2016 ◽  
Vol 220 ◽  
pp. 501-507 ◽  
Author(s):  
Maria Cabral ◽  
Joana Araújo ◽  
Joana Teixeira ◽  
Henrique Barros ◽  
Sandra Martins ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Vitamin D Levels ◽  
Portuguese Adolescents

scholarly journals Irregularity of energy intake at meals: prospective associations with the metabolic syndrome in adults of the 1946 British birth cohort

2015 ◽  
Vol 115 (2) ◽  
pp. 315-323 ◽  
Author(s):  
Gerda K. Pot ◽  
Rebecca Hardy ◽  
Alison M. Stephen
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Energy Intake ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Logistic Regression Models ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Health And Development

AbstractIrregularity in eating patterns could be a potential cardiometabolic risk factor. We aimed to study the associations of irregular intake of energy at meals in relation to cardiometabolic risk factors 10 and 17 years later. Variability of energy intake data – derived from 5-d estimated diet diaries of cohort members of the National Survey for Health and Development collected at ages 36 (n1416), 43 (n1505) and 53 years (n1381) – was used as a measure for irregularity. Associations between meal irregularity scores with cardiometabolic risk factors measured 10 and 17 years later were investigated using linear mixed models and logistic regression models. The results showed that irregularity scores changed significantly over the years (P<0·05). At age 36 years, subjects with a more irregular intake of energy at lunch (OR 1·42; 95 % CI 1·05, 1·91) and between meals (OR 1·35; 95 % CI 1·01, 1·82) had an increased risk for the metabolic syndrome 17 years later; at lunch was also associated with an increased waist circumference (OR 1·58; 95 % 1·27, 1·96) and TAG levels (OR 1·33; 95 % CI 1·02, 1·72). At age 43 years, subjects with a more irregular intake at breakfast had an increased risk of the metabolic syndrome 10 years later (OR 1·53; 95 % CI 1·15, 2·04), as well as an increased BMI (OR 1·66; 95 % CI 1·31, 2·10), waist circumference (OR 1·53; 95 % CI 1·23, 1·90) and diastolic blood pressure (OR 1·42; 95 % CI 1·13, 1·78). In conclusion, subjects with a more irregular intake of energy, mostly at breakfast and lunch, appeared to have an increased cardiometabolic risk 10 and 17 years later.

Abstract P171: Vitamin D and Cardiometabolic Risk Factors: The Jerusalem Perinatal Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Amy Moore ◽  
Hagit Hochner ◽  
Colleen Sitlani ◽  
Michelle A Williams ◽  
David S Siscovick ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Young Adults ◽  
Cardiometabolic Risk ◽  
Hdl Cholesterol ◽  
Cardiometabolic Risk Factors ◽  
P Value ◽  
Total Vitamin ◽  
P Values ◽  
Vitamin D Levels

Background: Vitamin D, a pleotropic hormone, influences cellular and tissue functions that are potentially related to cardiometabolic risk. Vitamin D deficiency and insufficiency have also been related to cardiovascular diseases. However, relationships between vitamin D and cardiometabolic risk factors in young adults are not well-characterized. Methods: We examined associations of vitamin D with cardiometabolic risk factors among a subset of the Jerusalem Perinatal Study (JPS) population, a birth cohort of Jerusalem residents born between 1974 and 1976. Offsprings aged 30-35 years, sampled based on maternal pre-pregnancy body mass index (BMI) and offspring birth weight, and their mothers were recruited as part of the JPS-1 study. Data were collected using interviews and field physical examinations. Fasting blood specimens were obtained for vitamin D and biomarker (glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides) measurements. We used liquid chromatography-tandem mass spectroscopy to measure total vitamin D (25-[OH] D). Sample-weighted multiple regression models, adjusted for potential confounders, were used to examine associations, and determine coefficients and 95% confidence intervals. Results: Mean total vitamin D levels were 22.27ng/ml, 23.48ng/ml and 21.03ng/ml among all study participants, males (N=617) and females (N=588), respectively. Vitamin D levels were statistically different between males and females (p-value <0.001). Current smokers had higher vitamin D levels compared with non-smokers, even after adjustment for current BMI, ethnicity, occupation and other potential confounders (β=1.41, p-value= 0.039). Overall, higher vitamin D levels were associated with lower BMI (p-values 0.002) and lower diastolic blood pressure (p-values 0.011). Conclusion: Vitamin D is associated with cardiometabolic risk factors in young adults. The unexpected association between current smoking and higher vitamin D in our study needs replication and further investigation.

scholarly journals 25-Hydroxyvitamin D insufficiency is associated with cardiometabolic risk in Korean adolescents: the 2008–2009 Korea National Health and Nutrition Examination Survey (KNHANES)

2012 ◽  
Vol 17 (1) ◽  
pp. 186-194 ◽  
Author(s):  
Ga Eun Nam ◽  
Do Hoon Kim ◽  
Kyung Hwan Cho ◽  
Yong Gyu Park ◽  
Kyung Do Han ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cardiometabolic Risk ◽  
Vitamin D Insufficiency ◽  
Cardiometabolic Risk Factors ◽  
Korean Adolescents ◽  
Hydroxyvitamin D ◽  
Health And Nutrition ◽  
Increased Risk ◽  
25 Hydroxyvitamin D

AbstractObjectiveVitamin D insufficiency is known to be related to cardiometabolic disorders; however, the associations among serum 25-hydroxyvitamin D (25(OH)D) concentration and metabolic syndrome and cardiometabolic risk factors in children and adolescents have not yet been clearly delineated. For this reason, we investigated the relationship among serum 25(OH)D concentration and metabolic syndrome and cardiometabolic risk factors among Korean adolescents.DesignWe performed a cross-sectional analysis and used hierarchical multivariate logistic regression analysis models to adjust for confounding variables.SettingWe used the data gathered during the 2008–2009 Korea National Health and Nutrition Examination Survey (KNHANES).SubjectsOur subjects included 1504 Korean adolescents aged 12–18 years who participated in the KNHANES.ResultsVitamin D insufficiency, defined as 25(OH)D concentration <50 nmol/l, was found in 75·3 % of Korean adolescents and was associated with an increased risk of the prevalence of metabolic syndrome. Waist circumference and BMI were the most closely correlated cardiometabolic components of metabolic syndrome according to serum 25(OH)D status, but no significant relationship was found between serum 25(OH)D concentration and insulin resistance or for the risks for high blood pressure, hyperglycaemia, reduced HDL-cholesterol or hypertriacylglycerolaemia, with or without adjustment for confounding variables.ConclusionsLow serum 25(OH)D concentration appears to be associated with several cardiometabolic risk factors and an increased risk of the prevalence of metabolic syndrome in Korean adolescents.

scholarly journals Association between vitamin D status, cardiometabolic risk factors and metabolic syndrome in Puerto Rican adults

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Cristina Palacios ◽  
Cynthia Perez ◽  
Manuel Guzman ◽  
Ana Patricia Ortiz ◽  
Erick Suarez
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Puerto Rican ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Vitamin D Status

scholarly journals Association between physical activity, cardiometabolic risk factors and vitamin D in children and adolescents: a systematic review

2019 ◽  
Vol 24 ◽  
pp. 1-12
Author(s):  
Patricia Ribeiro Paes Corazza ◽  
Maiara Cristina Tadiotto ◽  
Derick Andrade Michel ◽  
Jorge Mota ◽  
Neiva Leite
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Systematic Review ◽  
Vitamin D ◽  
Children And Adolescents ◽  
Cardiometabolic Risk ◽  
Density Lipoprotein ◽  
Cardiometabolic Risk Factors ◽  
Cross Sectional ◽  
Vitamin D Levels

This systematic review aimed to synthesize evidence of cross-sectional studies on the associations between physical activity, cardiometabolic risk factors and vitamin D concentrations in children and adolescents. The search was performed in PubMed, SciELO, LILACS, Scopus, MEDLINE and SPORTDiscus. Cardiometabolic risk factors included obesity, insulin resistance, systemic arterial hypertension and unfavorable changes in the lipid profile (low levels of high-density lipoprotein, elevated low-density lipoprotein and triglycerides). Cross-sectional design studies published between 2007 and 2019 were included whether they evaluated the relationship between vitamin D and physical activity and/or vitamin D and cardiometabolic risk factors. Fourteen studies were selected, involving 8340 children and adolescents. The main results found were a significant inverse relationship between vitamin D levels and cardiometabolic risk factors. All studies (n = 8) that tested association between physical activity and 25-hydroxyvitamin D (25 (OH) D) concentrations showed a significant and direct relationship between them. In addition, nine out of eleven studies that tested the association between 25 (OH) D and body mass index reported an inverse and significant relationship between 25 (OH) D and obesity. In conclusion, sufficient concentrations of vitamin D are related to a more favorable cardiometabolic profile, and children and adolescents who are obese or insufficiently active have a higher risk of present hypovitaminosis D.

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