scholarly journals More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Qianmin Ou ◽  
Shaohan Zhang ◽  
Chuanqiang Fu ◽  
Le Yu ◽  
Peikun Xin ◽  
...  
Keyword(s):  
Wound Healing ◽  
Ferulic Acid ◽  
Natural Antioxidants ◽  
Wound Dressings ◽  
Polyethylene Glycol Diacrylate ◽  
Glycol Diacrylate ◽  
Antioxidant Function ◽  
Healing Tissue ◽  
Anti Oxidant ◽  
Gel Network

Abstract Background During wound healing, the overproduction of reactive oxygen species (ROS) can break the cellular oxidant/antioxidant balance, which prolongs healing. The wound dressings targeting the mitigation of ROS will be of great advantages for the wound healing. puerarin (PUE) and ferulic acid (FA) are natural compounds derived from herbs that exhibit multiple pharmacological activities, such as antioxidant and anti-inflammatory effects. Polydopamine (PDA) is made from natural dopamine and shows excellent antioxidant function. Therefore, the combination of natural antioxidants into hydrogel dressing is a promising therapy for wound healing. Results Hydrogel wound dressings have been developed by incorporating PUE or FA via PDA nanoparticles (NPs) into polyethylene glycol diacrylate (PEG-DA) hydrogel. This hydrogel can load natural antioxidant drugs and retain the drug in the gel network for a long period due to the presence of PDA NPs. Under oxidative stress, this hydrogel can improve the activity of superoxide dismutase and glutathione peroxidase and reduce the levels of ROS and malondialdehyde, thus preventing oxidative damage to cells, and then promoting wound healing, tissue regeneration, and collagen accumulation. Conclusion Overall, this triple antioxidant hydrogel accelerates wound healing by alleviating oxidative injury. Our study thus provides a new way about co-delivery of multiple antioxidant natural molecules from herbs via antioxidant nanoparticles for wound healing and skin regeneration. Graphic Abstract

Degradable conductive injectable hydrogels as novel antibacterial, anti-oxidant wound dressings for wound healing

2019 ◽  
Vol 362 ◽  
pp. 548-560 ◽  
Author(s):  
Jin Qu ◽  
Xin Zhao ◽  
Yongping Liang ◽  
Yameng Xu ◽  
Peter X. Ma ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressings ◽  
Injectable Hydrogels ◽  
Anti Oxidant

scholarly journals MXene-Integrated Microneedle Patches with Innate Molecule Encapsulation for Wound Healing

Research ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Lingyu Sun ◽  
Lu Fan ◽  
Feika Bian ◽  
Guopu Chen ◽  
Yuetong Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Phenylboronic Acid ◽  
Covalent Bonding ◽  
Polyethylene Glycol Diacrylate ◽  
Glycol Diacrylate ◽  
Effective Delivery ◽  
Microneedle Patch ◽  
Biomedical Fields

Wound healing is a complex physiological process that involves coordinated phases such as inflammation and neovascularization. Attempts to promote the healing process tend to construct an effective delivery system based on different drugs and materials. In this paper, we propose novel MXene-integrated microneedle patches with adenosine encapsulation for wound healing. Owing to the dynamic covalent bonding capacity of boronate molecules with adenosine, 3-(acrylamido)phenylboronic acid- (PBA-) integrated polyethylene glycol diacrylate (PEGDA) hydrogel is utilized as the host material of microneedle patches. Benefitting from photothermal conversion capacity of MXene, the release of loaded adenosine could be accelerated under NIR irradiation for maintaining the activation signal around injury site. In vitro cell experiments proved the effect of MXene-integrated microneedle patches with adenosine encapsulation in enhancing angiogenesis. When applied for treating animal models, it is demonstrated that the microneedle patches efficiently promote angiogenesis, which is conductive to wound healing. These features make the proposed microneedle patch potential for finding applications in wound healing and other biomedical fields.

scholarly journals Honey Accelerates Wound Healing in Pressure Ulcer: A Review

2020 ◽  
Vol 7 (1) ◽  
pp. 35-43
Author(s):  
Jessica Halim ◽  
Noto Dwimartutie
Keyword(s):  
Wound Healing ◽  
Pressure Ulcer ◽  
Tissue Injury ◽  
Antibacterial Properties ◽  
Wound Dressings ◽  
Promising Alternative ◽  
Online Databases ◽  
Literature Source ◽  
Anti Oxidant ◽  
Dressing Change

Introduction: Pressure ulcer (PU) is a result of prolonged pressure and shear over a bony prominence resulting in tissue injury of varying depth. To date, there is no standardized wound dressings for PU. Due to its availability and affordability, honey is suitable as PU wound dressing considering its anti-oxidant, anti-inflammatory, and antibacterial properties. This review article will provide evidence of the superiority of honey dressing.Methods: Literature source was searched through online databases with relevant keywords and then appraised for their validity, importance, and applicability. Total of three articles were appraised.Results: All articles agreed that application of honey on PU wounds reduced wound size and alleviate pain. Honey-impregnated gauze dressing promoted faster pain relief throughout treatment and less discomfort during each dressing change. Healing rate was proven 4 times faster with honey compared to other topical ointments. However, the antibacterial effect of honey was not significantly confirmed in the study. Nonetheless, topical application of honey successfully accelerates wound healing in PU.Conclusion: Honey is a promising alternative for topical dressings in patients with PU.

Phytotherapy for wound healing: The most important herbal plants in wound healing based on Iranian etnobotanical documents

2020 ◽  
Vol 20 ◽  
Author(s):  
Kamal Solati ◽  
Mehrdad Karimi ◽  
Mahmoud Rafieian-Kopaei ◽  
Naser Abbasi ◽  
Saber Abbaszadeh ◽  
...  
Keyword(s):  
Wound Healing ◽  
Medicinal Plants ◽  
Aloe Vera ◽  
Datura Stramonium ◽  
New Drugs ◽  
Mentha Pulegium ◽  
Accelerate Wound Healing ◽  
Healing Tissue ◽  
Herbal Plants ◽  
Echium Amoenum

: Wound healing is a process which starts with inflammatory response after damage occurrence. This process happens by restoring the wound surface coating tissue, migrating fibroblasts to form the needed collagen, forming a healing tissue and finally contortion and extraction of the wound. Today, various drugs are used to heal the wound. However, the used drugs to repair wounds have some defects and side effects. In spite of all attempts to accelerate wound healing definitely, no safe drug has been introduced for this purpose. Therefore, the necessity of identifying herbal plants in ethnopharmacology and ethnobotany documents with healing effect is felt essential. In this article we tried to review and present Iranian effective medicinal plants and herbal compounds used for wound healing. Searching was performed on databases including ISI Web of Science, PubMed, PubMed Central, Scopus, ISC, SID, Magiran and some other databases. The keywords used included wound healing, skin treatment, medicinal plants, ethnobotany, and phytotherapy. In this regard, 139 effective medicinal plants on wound healing were identified based on ethnopharmacology and ethnobotanical sources of Iran. Medicinal plants such as Salvia officinalis, Echium amoenum, Verbascum spp., G1ycyrrhiza glabra, Medicago sativa, Mentha pulegium, Datura stramonium L., Alhagi spp., Aloe vera, Hypericum perforatum, Pistacia atlantica and Prosopis cineraria were the most important and effective medicinal plants on wound healing in Iran. These native Iranian medicinal plants are full of antioxidants and biological compounds and might be used for wound healing and preparation of new drugs.

scholarly journals Elucidating the Molecular Mechanisms for the Interaction of Water with Polyethylene Glycol-Based Hydrogels: Influence of Ionic Strength and Gel Network Structure

Polymers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 845
Author(s):  
Xin Yang ◽  
Bronwin Dargaville ◽  
Dietmar Hutmacher
Keyword(s):  
Polyethylene Glycol ◽  
Ionic Strength ◽  
Molecular Mechanisms ◽  
Repeat Unit ◽  
Bound Water ◽  
Weight Fraction ◽  
Swelling Ratio ◽  
Polyethylene Glycol Diacrylate ◽  
Glycol Diacrylate ◽  
Hydrogel System

The interaction of water within synthetic and natural hydrogel systems is of fundamental importance in biomaterial science. A systematic study is presented on the swelling behavior and states of water for a polyethylene glycol-diacrylate (PEGDA)-based model neutral hydrogel system that goes beyond previous studies reported in the literature. Hydrogels with different network structures are crosslinked and swollen in different combinations of water and phosphate-buffered saline (PBS). Network variables, polyethylene glycol (PEG) molecular weight (MW), and weight fraction are positively correlated with swelling ratio, while “non-freezable bound water” content decreases with PEG MW. The presence of ions has the greatest influence on equilibrium water and “freezable” and “non-freezable” water, with all hydrogel formulations showing a decreased swelling ratio and increased bound water as ionic strength increases. Similarly, the number of “non-freezable bound water” molecules, calculated from DSC data, is greatest—up to six molecules per PEG repeat unit—for gels swollen in PBS. Fundamentally, the balance of osmotic pressure and non-covalent bonding is a major factor within the molecular structure of the hydrogel system. The proposed model explains the dynamic interaction of water within hydrogels in an osmotic environment. This study will point toward a better understanding of the molecular nature of the water interface in hydrogels.

scholarly journals Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2104
Author(s):  
Sibusiso Alven ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Cellular Adhesion ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
High Porosity ◽  
Hybrid Nanofibers

The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (ε-caprolactone) display interesting properties, including good biocompatibility, improved biodegradation, good mechanical properties and antimicrobial effects, promote tissue regeneration, etc. Formulation of these wound dressings via electrospinning technique is cost-effective, useful for uniform and continuous nanofibers with controllable pore structure, high porosity, excellent swelling capacity, good gaseous exchange, excellent cellular adhesion, and show a good capability to provide moisture and warmth environment for the accelerated wound healing process. Based on the above-mentioned outstanding properties of nanofibers and the unique properties of hybrid wound dressings prepared from poly (vinyl alcohol) and poly (ε-caprolactone), this review reports the in vitro and in vivo outcomes of the reported hybrid nanofibers.

Elastic Janus film for Wound Dressings: Unidirectional Biofluid Transport and Effectively Promoting Wound Healing

2021 ◽  
pp. 2105265
Author(s):  
Bing Xu ◽  
Ang Li ◽  
Rui Wang ◽  
Juan Zhang ◽  
Yinlong Ding ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressings
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