Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PREDIMED-Plus study

Abstract Background This study explored the association between inactive time and measures of adiposity, clinical parameters, obesity, type 2 diabetes and metabolic syndrome components. It further examined the impact of reallocating inactive time to time in bed, light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) on cardio-metabolic risk factors, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. Methods This is a cross-sectional analysis of baseline data from 2189 Caucasian men and women (age 55–75 years, BMI 27–40 Kg/m2) from the PREDIMED-Plus study (http://www.predimedplus.com/). All participants had ≥3 components of the metabolic syndrome. Inactive time, physical activity and time in bed were objectively determined using triaxial accelerometers GENEActiv during 7 days (ActivInsights Ltd., Kimbolton, United Kingdom). Multiple adjusted linear and logistic regression models were used. Isotemporal substitution regression modelling was performed to assess the relationship of replacing the amount of time spent in one activity for another, on each outcome, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. Results Inactive time was associated with indicators of obesity and the metabolic syndrome. Reallocating 30 min per day of inactive time to 30 min per day of time in bed was associated with lower BMI, waist circumference and glycated hemoglobin (HbA1c) (all p-values < 0.05). Reallocating 30 min per day of inactive time with 30 min per day of LPA or MVPA was associated with lower BMI, waist circumference, total fat, visceral adipose tissue, HbA1c, glucose, triglycerides, and higher body muscle mass and HDL cholesterol (all p-values < 0.05). Conclusions Inactive time was associated with a poor cardio-metabolic profile. Isotemporal substitution of inactive time with MVPA and LPA or time in bed could have beneficial impact on cardio-metabolic health. Trial registration The trial was registered at the International Standard Randomized Controlled Trial (ISRCTN: http://www.isrctn.com/ISRCTN89898870) with number 89898870 and registration date of 24 July 2014, retrospectively registered.

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The Relationship Between Objectively Measured Physical Activity, Salivary Cortisol, and the Metabolic Syndrome Score in Girls

Pediatric Exercise Science ◽

10.1123/pes.2013-0109 ◽

2014 ◽

Vol 26 (3) ◽

pp. 221-230 ◽

Cited By ~ 8

Author(s):

Katrina D. DuBose ◽

Andrew J. McKune

Keyword(s):

Physical Activity ◽

Blood Pressure ◽

Metabolic Syndrome ◽

Waist Circumference ◽

Body Fat ◽

Salivary Cortisol ◽

Sexual Maturity ◽

Vigorous Physical Activity ◽

The Metabolic Syndrome ◽

The Relationship

The relationship between physical activity levels, salivary cortisol, and the metabolic syndrome (MetSyn) score was examined. Twenty-three girls (8.4 ± 0.9 years) had a fasting blood draw, waist circumference and blood pressure measured, and wore an ActiGraph accelerometer for 5 days. Saliva samples were collected to measure cortisol levels. Previously established cut points estimated the minutes spent in moderate, vigorous, and moderate-to-vigorous physical activity. A continuous MetSyn score was created from blood pressure, waist circumference, high-density-lipoprotein (HDL), triglyceride, and glucose values. Correlation analyses examined associations between physical activity, cortisol, the MetSyn score, and its related components. Regression analysis examined the relationship between cortisol, the MetSyn score, and its related components adjusting for physical activity, percent body fat, and sexual maturity. Vigorous physical activity was positively related with 30 min post waking cortisol values. The MetSyn score was not related with cortisol values after controlling for confounders. In contrast, HDL was negatively related with 30 min post waking cortisol. Triglyceride was positively related with 30 min post waking cortisol and area under the curve. The MetSyn score and many of its components were not related to cortisol salivary levels even after adjusting for physical activity, body fat percentage, and sexual maturity.

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Provision of healthy school meals does not affect the metabolic syndrome score in 8–11-year-old children, but reduces cardiometabolic risk markers despite increasing waist circumference

British Journal Of Nutrition ◽

10.1017/s0007114514003043 ◽

2014 ◽

Vol 112 (11) ◽

pp. 1826-1836 ◽

Cited By ~ 42

Author(s):

Camilla T. Damsgaard ◽

Stine-Mathilde Dalskov ◽

Rikke P. Laursen ◽

Christian Ritz ◽

Mads F. Hjorth ◽

...

Keyword(s):

Physical Activity ◽

Insulin Resistance ◽

Metabolic Syndrome ◽

Body Composition ◽

Waist Circumference ◽

Control Diet ◽

Hdl Cholesterol ◽

School Meals ◽

The Metabolic Syndrome ◽

Cardiometabolic Markers

An increasing number of children are exhibiting features of the metabolic syndrome (MetS) including abdominal fatness, hypertension, adverse lipid profile and insulin resistance. Healthy eating practices during school hours may improve the cardiometabolic profile, but there is a lack of evidence. In the present study, the effect of provision of school meals rich in fish, vegetables and fibre on a MetS score (primary outcome) and on individual cardiometabolic markers and body composition (secondary outcomes) was investigated in 834 Danish school children. The study was carried out as a cluster-randomised, controlled, non-blinded, cross-over trial at nine schools. Children aged 8–11 years received freshly prepared school lunch and snacks or usual packed lunch from home (control) each for 3 months. Dietary intake, physical activity, cardiometabolic markers and body composition were measured at baseline and after each dietary period. The school meals did not affect the MetS score (P= 1·00). However, it was found that mean arterial pressure was reduced by 0·4 (95 % CI 0·0, 0·8) mmHg (P= 0·04), fasting total cholesterol concentrations by 0·05 (95 % CI 0·02, 0·08) mmol/l (P= 0·001), HDL-cholesterol concentrations by 0·02 (95 % CI 0·00, 0·03) mmol/l, TAG concentrations by 0·02 (95 % CI 0·00, 0·04) mmol/l (bothP< 0·05), and homeostasis model of assessment-insulin resistance by 0·10 (95 % CI 0·04, 0·16) points (P= 0·001) compared with the control diet in the intention-to-treat analyses. Waist circumference increased 0·5 (95 % CI 0·3, 0·7) cm (P< 0·001), but BMIz-score remained unaffected. Complete-case analyses and analyses adjusted for household educational level, pubertal status and physical activity confirmed the results. In conclusion, the school meals did not affect the MetS score in 8–11-year-olds, as small improvements in blood pressure, TAG concentrations and insulin resistance were counterbalanced by slight undesired effects on waist circumference and HDL-cholesterol concentrations.

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Evaluation of Metabolic Syndrome among Locomotive Drivers

Occupational Medicine ◽

10.18502/tkj.v11i3.2588 ◽

2020 ◽

Author(s):

M Saraei ◽

A Najafi ◽

E Heidarbagi ◽

A Rahimi-Golkhandan

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Metabolic Syndrome ◽

Waist Circumference ◽

Cross Sectional Study ◽

Cross Sectional ◽

High Waist Circumference ◽

The Metabolic Syndrome ◽

High Prevalence ◽

Train Drivers

Introduction: Screening of risk factors for metabolic syndrome among commercial and train drivers that are considered safety sensitive jobs, is an important issue in safety of transportation system. Metabolic syndrome is consisted of disturbed lipid profile, high blood pressure, and high waist circumference. It can lead to decrease the quality of life and higher health associated costs for these patients. This study aimed to assess risk factors for metabolic syndrome among train drivers. Methods: This cross-sectional study was conducted on 281 train drivers referred to their annual health examinations to Occupational Medicine Clinic of Baharloo Hospital, Tehran University of Medical Sciences. Demographic characteristics of participants were recorded. Blood pressure, body mass index and waist circumference of drivers were measured. Participants’ blood sample for fasting blood sugar, triglyceride, high and low density lipoproteins were collected. Metabolic syndrome was defined according to the NCEP ATP III criteria. Results: All of the participants were males. Their mean age and BMI was 43±10 year and 26.60±3.67 Kg/m2, respectively. Fifty three (21%) of the participants were diagnosed with metabolic syndrome. The more frequent risk factor for metabolic syndrome was triglyceride more than 150mg/dl. Conclusion: Findings of the present study revealed high prevalence of metabolic syndrome among train drivers. Further studies are needed for screening the metabolic syndrome in this occupational group as it is a sensitive occupation.

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Cross-sectional study of complement C3 as a coronary risk factor among men and women

Clinical Science ◽

10.1042/cs20040198 ◽

2005 ◽

Vol 108 (2) ◽

pp. 129-135 ◽

Cited By ~ 46

Author(s):

Altan ONAT ◽

Bülent UZUNLAR ◽

Gülay HERGENÇ ◽

Mehmet YAZICI ◽

Ibrahim SARI ◽

...

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Metabolic Syndrome ◽

Waist Circumference ◽

Family Income ◽

Smoking Status ◽

Complement C3 ◽

Linear Regression Models ◽

Cross Sectional ◽

The Metabolic Syndrome

In the present study, we examined (i) whether C3 (complement C3) was an independent marker of prevalent CHD (coronary heart disease), and (ii) which preferential associations existed between C3 and some cardiovascular risk factors when jointly analysed with CRP (C-reactive protein) and fibrinogen. In a cohort of 756 unselected adults, 39% of whom had the metabolic syndrome, C3 and other risk variables were evaluated in a cross-sectional manner. In a logistic regression model for the likelihood of CHD, a significant OR (odds ratio) of 3.5 [95% CI (confidence intervals), 1.27 and 9.62)] for C3 was obtained after adjustment for smoking status, TC (total cholesterol) and usage of statins. A similar model, also comprising systolic blood pressure, with a cut-off point of ≥1.6 g/l C3 exhibited a 1.9-fold risk (95% CI, 1.01 and 3.58) compared with individuals below the cut-off point. Both analyses displayed an adjusted OR of 1.37 for each S.D. increment in C3. The significant relationship of C3 with a likelihood of CHD also proved to be independent of CRP. In multiple linear regression models, associations were tested for each acute-phase protein with measures of obesity, fasting insulin, triacylglycerols (triglycerides), TC, HDL (high-density lipoprotein)-cholesterol, physical activity, smoking status, diagnosis of metabolic syndrome and family income. When both genders were combined, C3 was independently associated with serum triacylglycerols, waist circumference, BMI (body mass index) and TC. CRP was independently associated with waist circumference, TC, family income (inversely) and physical activity, and fibrinogen with BMI, TC, smoking status and metabolic syndrome. In summary, elevated levels of complement C3 are associated with an increased likelihood of CHD independent of standard risk factors and regardless of the presence of acute coronary events, suggesting that C3 might be actively involved in coronary atherothrombosis. Unlike CRP and fibrinogen, C3 was preferentially associated with waist girth and serum triacylglycerols.

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Prevalence of the metabolic syndrome in the Pech district

Archives of Public Health ◽

10.3889/aph.2018.2242 ◽

2018 ◽

Vol 10 (2) ◽

pp. 40-47

Author(s):

Ardita Kerveshi-Sulejmani ◽

Aferdita Selmanaj ◽

Igor Isjanovski ◽

Rozalinda Isjanovska

Keyword(s):

Public Health ◽

Blood Pressure ◽

Metabolic Syndrome ◽

Waist Circumference ◽

Systolic Blood Pressure ◽

Diastolic Blood Pressure ◽

Cross Sectional ◽

The Metabolic Syndrome ◽

The World ◽

The Mean

The metabolic syndrome (MS) is the main clinical and public health challenge in the world, in the wake of urbanization, excess energy intake, increased obesity, sedentary lifestyle and habits. MS leads to a 5-fold increase the risk of diabetes mellitus type 2 (T2DM) and 2 times the risk of cardiovascular disease (CVD) over the next 5 to 10 years. The aim of the research is to determine the prevalence of metabolic syndrome syndrome in the Pech District according to NCEP ATD III / 2001. Material and methods: Cross sectional study was carried out at the General Hospital in Pec, which represents a regional hospital for the Pec District. A total of 1667 patients from the Pech district were interviewed for a period of one year. Results: In the group, MS was present in 506 patients. In the majority of cases, we found the systolic blood pressure condition ≥ 130 mmHg -99.4%, followed by diastolic blood pressure ≥ 85 mmH-96.4%, elevated triglycerides ≥ 1.7 mmol / l- 94.7%, waist circumference> 88 cm in women-94.0% , increased glycemia ≥ 6.1mmol / L in 80.0%, waist circumference > 102cm in men-65.5%, HDL values <1.03mmol / L in men - 56.9% and HDL values <1.03mmol / L in females 51.5%. The mean value of systolic blood pressure in patients with MS is 151.1 ± 9.3 mmHg. The average value of diastolic blood pressure in patients with MS is 91.0 ± 4.7 mmHg. The average waist circumference of patients with MC was 103.6 ± 9.2 cm. The mean HDL of patients with MS is 1.1 ± 0.2 mmol / L. The average glycemic value in patients with MS is 6.5 ± 0.6 mmol / Average triglyceride value in patients with MS and is 2.5 ± 0.8 mmol / L. The most common in patients with MS is obesity / obesity - 70.8%, overweight is 27.8%, and 1.4% normal weight is registered. Conclusions: The prevalence of MS in the Pech district is 30.4% and was approximately as in Croatia 34% and Tetovo region with 28.25%, but it was dependent on the population and definitions used. The metabolic syndrome is one of the major public health problems, and a socioeconomic problem around the world and in Kosovo, too.

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METABOLIC SYNDROME IN DIALYSIS PATIENTS

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2016.5.1 ◽

2016 ◽

pp. 7-11

Author(s):

Vinh Phu Hoang ◽

Tam Vo ◽

Van Tien Le ◽

Thi Hoai Huong Vo

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Renal Failure ◽

Chronic Renal Failure ◽

Artificial Kidney ◽

Dialysis Patients ◽

Cross Sectional ◽

Average Value ◽

The Metabolic Syndrome ◽

End Stage

Objective: To review disorders elements of the metabolic syndrome in patients with end-stage chronic renal failure on dialysis cycle. Materials and methods: A cross sectional descriptive study of 85 patients including end-stage chronic renal failure in dialysis cycle from 5/2015 - 9/2016 at the Department of Artificial Kidney, Hue Central Hospital. Results: The prevalence of metabolic syndrome in dialysis patients was 37.65%. The prevalence of abdominal obesity was 30.6%; The prevalence of hypertension was 72.9%, the average value systolic blood pressure and diastolic blood pressure were 142.24 ± 27.53, 80.35 ± 12.48 mmHg; The prevalence of hyperglycemia was 28%, the average value blood glucose was 4.9 ± 1.19 mmol/l; The prevalence of triglyceride increase was 34.1%, the average value triglyceride was 1.59 ± 0.84 mmol/l. The prevalence of HDL-C increase was 47.1%, the average value HDL-C was 1.24 ± 0.33 mmol/l. Conclusion: The prevalence of metabolic syndrome in dialysis patients is very high, in which hypertension and HDL disturbances are the highest. Key words: chronic renal failure, dialysis, metabolic syndrome

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Individual Diet Modification Reduces the Metabolic Syndrome in Patients Before Pharmacological Treatment

Nutrients ◽

10.3390/nu13062102 ◽

2021 ◽

Vol 13 (6) ◽

pp. 2102

Author(s):

Małgorzata Elżbieta Zujko ◽

Marta Rożniata ◽

Kinga Zujko

Keyword(s):

Physical Activity ◽

Metabolic Syndrome ◽

Fatty Acids ◽

Waist Circumference ◽

Nutrition Education ◽

Dietary Habits ◽

Fasting Glucose ◽

Intervention Group ◽

Control Group ◽

The Metabolic Syndrome

Modification of lifestyle, including healthy nutrition, is the primary approach for metabolic syndrome (MetS) therapy. The aim of this study was to estimate how individual nutrition intervention affects the reduction of MetS components. Subjects diagnosed with MetS were recruited in the Lomza Medical Centre. The study group consisted of 90 participants and was divided into one intervention group (individual nutrition education group (INEG)) and one control group (CG). The research was conducted over 3 months. The following measurements were obtained during the first visit and after completion of the 3 months intervention: body mass, waist circumference, body composition, blood pressure, fasting glucose, and blood lipids. Dietary assessments were performed before and post-intervention using 3-day 24-h dietary recalls. Dietary knowledge was evaluated with the KomPAN questionnaire. The total polyphenol content of the diet was calculated. Sociodemographic and lifestyle characteristics were collected from a self-reported questionnaire. The physical activity was assessed by the short version of the International Physical Activity Questionnaire (IPAQ). It was found that the individual nutrition education was an effective method to improve the knowledge, dietary habits, and physical activity of the study participants. The modification of the diet in terms of higher intake of polyphenols (flavonoids and anthocyanins), fiber, polyunsaturated fatty acids (PUFA), PUFA n-3, and lower intake of saturated fatty acids (SFA) had a significant impact on the improvement of some MetS risk factors (waist circumference, fasting glucose, and HDL-cholesterol).

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Metabolic syndrome in people with a long-standing spinal cord injury: associations with physical activity and capacity

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2016-0269 ◽

2016 ◽

Vol 41 (11) ◽

pp. 1190-1196 ◽

Cited By ~ 11

Author(s):

Sonja de Groot ◽

Jacinthe J. Adriaansen ◽

Marga Tepper ◽

Govert J. Snoek ◽

Lucas H.V. van der Woude ◽

...

Keyword(s):

Physical Activity ◽

Metabolic Syndrome ◽

Spinal Cord ◽

Spinal Cord Injury ◽

Aerobic Capacity ◽

Cross Sectional Study ◽

Cross Sectional ◽

The Metabolic Syndrome ◽

Cord Injury ◽

Peak Aerobic Capacity

This study investigated (i) the prevalence of the metabolic syndrome (MetS) in people with a long-standing spinal cord injury (SCI); (ii) whether personal or lesion characteristics are determinants of the MetS; and (iii) the association with physical activity or peak aerobic capacity on the MetS. In a cross-sectional study, persons with SCI (N = 223; time since injury of ≥10 years) were tested. The individual components of the MetS were assessed together with the physical activity measured by the Physical Activity Scale for Individuals with Physical Disabilities (PASIPD), while peak aerobic capacity was tested during a graded wheelchair exercise test on a treadmill. Thirty-nine percent of the participants had MetS. In a multivariate logistic regression analyses and after performing a backward regression analysis, only age and education were significant determinants of the MetS. A 10-year increase in age leads to a 1.5 times more chance to have the MetS. Furthermore, people with a low education will multiply the relative risk of MetS compared with people with high education by almost 2. With and without correcting for confounders, no significant relationship was found between PASIPD or peak aerobic capacity and the MetS. It can be concluded that the prevalence of the MetS is high (39%) in people with a long-standing SCI but is comparable to the general Dutch population. Older people and those with a lower education level are most at risk for the MetS. Physical activity and peak aerobic fitness were not related to the MetS in this group with a long-standing SCI.

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METABOLIC SYNDROME PREVALENCE IS NOT ASSOCIATED WITH DIET QUALITY IN THE CHILEAN ELDERLY POPULATION: A CROSS SECTIONAL ANALYSIS FROM THE NATIONAL HEALTH SURVEY 2009-2010

Journal of Aging Research and Lifestyle ◽

10.14283/jarcp.2016.104 ◽

2016 ◽

pp. 1-7

Author(s):

C. Dussaillant ◽

G. Echeverría ◽

L. Villarroel ◽

C.B. Yu ◽

A. Rigotti ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Waist Circumference ◽

Food Intake ◽

Diet Quality ◽

Elderly Population ◽

The Elderly ◽

National Health Survey ◽

Cross Sectional ◽

Sectional Analysis

Objectives: To analyze the relationship between the prevalence of metabolic syndrome, food intake, and diet quality in elderly (≥65 years old) Chilean population. Design: Cross sectional analysis based on the last national health survey performed in the years 2009 and 2010 (ChNHS 2009-2010). Setting: Non-institutionalized individuals of 65 years or older were selected and visited at home. Participants: A subsample of 505 elderly adults from the ChNHS 2009-2010 who answered a food questionnaire and had appropriate information to diagnose metabolic syndrome following the ATPIII-NCEP guidelines. Measurements: Fasting blood samples were obtained in order to measure blood lipids and fasting blood glucose. Blood pressure, waist circumference, and body mass index (BMI) were also measured. A 5-item food frequency questionnaire was applied to all the participants of NHS 2009-2010. Results: The overall prevalence of metabolic syndrome in the Chilean adult population was 37.7%, increasing in frequency with advancing age. Among the elderly (≥65 years old), metabolic syndrome was found in 57.2% of the sample. Elevated blood pressure and increased waist circumference were the most prevalent metabolic syndrome components among this group (88% and 80%, respectively). Low intake of fruits, vegetables, whole cereals, fish, and dairy was seen among the elderly, and no association was found between food intake nor diet quality and metabolic syndrome prevalence. Conclusion: Metabolic syndrome is highly prevalent among the Chilean elderly population and its prevalence is not associated with food intake or diet quality in this age group.

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The metabolic syndrome – What is it and how should it be managed?

European Journal of Preventive Cardiology ◽

10.1177/2047487319886404 ◽

2019 ◽

Vol 26 (2_suppl) ◽

pp. 33-46 ◽

Cited By ~ 7

Author(s):

Peter M Nilsson ◽

Jaakko Tuomilehto ◽

Lars Rydén

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Metabolic Syndrome ◽

Waist Circumference ◽

Elevated Blood Pressure ◽

Elevated Blood ◽

Successful Management ◽

Unhealthy Lifestyle ◽

The Metabolic Syndrome ◽

Frail Elderly People

A cluster of metabolic factors have been merged into an entity named the metabolic syndrome. Although the characteristics of this syndrome have varied over time the presently used definition was established in 2009. The presence of three abnormal findings out of five components qualifies a person for the metabolic syndrome: elevated waist circumference, elevated triglycerides, reduced high-density lipoprotein cholesterol, elevated blood pressure and elevated fasting plasma glucose. Cut points have been defined for all components apart from waist circumference, for which national or regional values are used. The metabolic syndrome predicts cardiovascular disease and type 2 diabetes. This associated risk does not exceed its components whereof elevated blood pressure is the most frequent. A successful management should, however, address all factors involved. The management is always based on healthy lifestyle choices but has not infrequently to be supported by pharmacological treatment, especially blood pressure lowering drugs. The metabolic syndrome is a useful example of the importance of multiple targets for preventive interventions. To be successful management has to be individualized not the least when it comes to pharmacological therapy. Frail elderly people should not be over-treated. Knowledge transfer of how risk factors act should be accompanied by continuous trust building and motivation. In complex situations with a mix of biological risk factors, adverse social conditions and unhealthy lifestyle, everything cannot be changed at once. It is better to aim for small steps that are lasting than large, unsustainable steps with relapses to unhealthy behaviours. A person with the metabolic syndrome will always be afflicted by its components, which is the reason that management has to be sustained over a very long time. This review summarizes the knowledge on the metabolic syndrome and its management according to present state of the art.

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