scholarly journals Induction of virus-specific effector immune cell response limits virus replication and severe disease in mice infected with non-lethal West Nile virus Eg101 strain

2015 ◽  
Vol 12 (1) ◽  
Author(s):  
Mukesh Kumar ◽  
Kelsey Roe ◽  
Maile O’Connell ◽  
Vivek R. Nerurkar
Keyword(s):  
West Nile Virus ◽  
Virus Replication ◽  
Cell Response ◽  
Immune Cell ◽  
Severe Disease ◽  
West Nile ◽  
Specific Effector ◽  
Immune Cell Response

scholarly journals RhoA Signaling in Immune Cell Response and Cardiac Disease

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1681
Author(s):  
Lucia Sophie Kilian ◽  
Derk Frank ◽  
Ashraf Yusuf Rangrez
Keyword(s):  
Cardiac Disease ◽  
Cell Response ◽  
Cell Activation ◽  
Immune Cell ◽  
Inflammatory Diseases ◽  
Heart Diseases ◽  
Small Gtpase ◽  
Cardiac Inflammation ◽  
Immune Cell Activation ◽  
Immune Cell Response

Chronic inflammation, the activation of immune cells and their cross-talk with cardiomyocytes in the pathogenesis and progression of heart diseases has long been overlooked. However, with the latest research developments, it is increasingly accepted that a vicious cycle exists where cardiomyocytes release cardiocrine signaling molecules that spiral down to immune cell activation and chronic state of low-level inflammation. For example, cardiocrine molecules released from injured or stressed cardiomyocytes can stimulate macrophages, dendritic cells, neutrophils and even T-cells, which then subsequently increase cardiac inflammation by co-stimulation and positive feedback loops. One of the key proteins involved in stress-mediated cardiomyocyte signal transduction is a small GTPase RhoA. Importantly, the regulation of RhoA activation is critical for effective immune cell response and is being considered as one of the potential therapeutic targets in many immune-cell-mediated inflammatory diseases. In this review we provide an update on the role of RhoA at the juncture of immune cell activation, inflammation and cardiac disease.

scholarly journals IMMU-68. SINGLE-CELL PROTEOMIC ANALYSIS OF IMMUNE CELL RESPONSE TO CHECKPOINT BLOCKADE USING 30-PARAMETER FLOW CYTOMETRY

2018 ◽  
Vol 20 (suppl_6) ◽  
pp. vi137-vi137
Author(s):  
Amber Giles ◽  
Leonard Nettey ◽  
Thomas Liechti ◽  
Margaret Beddall ◽  
Elizabeth Vera ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Single Cell ◽  
Cell Response ◽  
Proteomic Analysis ◽  
Immune Cell ◽  
Checkpoint Blockade ◽  
Immune Cell Response

scholarly journals Postoperative cellular stress in the kidney is associated with an early systemic γδ T-cell immune cell response

Critical Care ◽  
2018 ◽  
Vol 22 (1) ◽  
Author(s):  
Ivan Göcze ◽  
Katharina Ehehalt ◽  
Florian Zeman ◽  
Paloma Riquelme ◽  
Karin Pfister ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Immune Cell ◽  
Cellular Stress ◽  
Γδ T Cell ◽  
Immune Cell Response

scholarly journals Upregulation of IL15RA in Triple Negative Breast Cancer (TNBC) Promotes Tumour Cell Growth and Motility and Can Activate an Immune Cell Response

2013 ◽  
Vol 24 ◽  
pp. iii38
Author(s):  
P. Marra ◽  
S. Mathew ◽  
A. Grigoriadis ◽  
Y. Wu ◽  
F. Kyle-Cezar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Triple Negative Breast Cancer ◽  
Tumour Cell ◽  
Cell Response ◽  
Triple Negative ◽  
Immune Cell ◽  
Immune Cell Response ◽  
Tumour Cell Growth

scholarly journals The recently identified flavivirus Bamaga virus is transmitted horizontally by Culex mosquitoes and interferes with West Nile virus replication in vitro and transmission in vivo

2018 ◽  
Vol 12 (10) ◽  
pp. e0006886 ◽  
Author(s):  
Agathe M. G. Colmant ◽  
Sonja Hall-Mendelin ◽  
Scott A. Ritchie ◽  
Helle Bielefeldt-Ohmann ◽  
Jessica J. Harrison ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Virus Replication ◽  
West Nile ◽  
Culex Mosquitoes

Monocyte immune cell response and copper status in beef steers that grazed endophyte-infected tall fescue.

1998 ◽  
Vol 76 (10) ◽  
pp. 2694 ◽  
Author(s):  
K E Saker ◽  
V G Allen ◽  
J Kalnitsky ◽  
C D Thatcher ◽  
W S Swecker ◽  
...  
Keyword(s):  
Tall Fescue ◽  
Cell Response ◽  
Immune Cell ◽  
Beef Steers ◽  
Copper Status ◽  
Immune Cell Response ◽  
And Copper Status

scholarly journals The Host Response to West Nile Virus Infection Limits Viral Spread through the Activation of the Interferon Regulatory Factor 3 Pathway

2004 ◽  
Vol 78 (14) ◽  
pp. 7737-7747 ◽  
Author(s):  
Brenda L. Fredericksen ◽  
Maria Smith ◽  
Michael G. Katze ◽  
Pei-Yong Shi ◽  
Michael Gale
Keyword(s):  
West Nile Virus ◽  
Virus Replication ◽  
Host Response ◽  
Molecular Mechanisms ◽  
Target Genes ◽  
West Nile Virus Infection ◽  
Null Mouse ◽  
Regulatory Factor ◽  
West Nile ◽  
Viral Spread

ABSTRACT Recent outbreaks of West Nile Virus (WNV) have been associated with an increase in morbidity and mortality in humans, birds, and many other species. We have initiated studies to define the molecular mechanisms by which a recent pathogenic isolate of WNV evades the host cell innate antiviral response. Biochemical and microarray analyses demonstrated that WNV induced the expression of beta interferon (IFN-β) and several IFN-stimulated genes late in infection of cultured human cells. The late expression of these antiviral genes was due to the delayed activation of the transcription factor IFN regulatory factor 3 (IRF-3). Despite this host response, WNV was still able to replicate efficiently. The effect of the IRF-3 pathway on WNV replication was assessed by examining virus replication and spread in cultures of wild-type or IRF-3-null mouse embryo fibroblasts. The absence of IRF-3 was marked by a significant increase in plaque size and a sustained production of infectious particles. Although the activation of the IRF-3 pathway was not sufficient to block virus replication, our results suggest that IRF-3 target genes function to constrain WNV infection and limit cell-to-cell virus spread.

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