scholarly journals Investigation of common risk factors between polycystic ovary syndrome and Alzheimer’s disease: a narrative review

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Nahid Sarahian ◽  
Hosna Sarvazad ◽  
Elham Sajadi ◽  
Nasrin Rahnejat ◽  
Narges Eskandari Roozbahani
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Alzheimer's Disease ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Narrative Review ◽  
Ovary Syndrome ◽  
Common Risk Factors ◽  
The Common

Abstract Background The most common endocrine and metabolic disorders in premenopausal women is polycystic ovary syndrome (PCOS), characterized by hyperandrogenism, chronic anovulation, and/or ultrasound evidence of small ovarian cysts. Obesity and insulin resistance are also the main factors influencing the clinical manifestations of this syndrome. Alzheimer’s disease (AD) is the most typical progressive neurodegenerative disorder of the brain, and recent studies suggest a relationship between endocrinal dysregulation and neuronal loss during AD pathology. Aim This study aimed to evaluate the common risk factors for Alzheimer’s and PCOS based on previous studies. Knowing the common risk factors and eliminating them may prevent neurodegenerative Alzheimer’s disease in the future. Method In this narrative review, international databases, including Google Scholar, Scopus, PubMed, and the Web of Science, were searched to retrieve the relevant studies. The relevant studies’ summaries were categorized to discuss the possible pathways that may explain the association between Alzheimer’s and PCOS signs/symptoms and complications. Results According to our research, the factors involved in Alzheimer’s and PCOS disorders may share some common risk factors. In patients with PCOS, increased LH to FSH ratio, decreased vitamin D, insulin resistance, and obesity are some of the most important factors that may increase the risk of Alzheimer’s disease.

scholarly journals Investigation of common risk factors between polycystic ovary syndrome and Alzheimer's disease

2021 ◽  
Author(s):  
Nahid Sarahian ◽  
Hosna Sarvazad ◽  
Elham Sajadi ◽  
Nasrin Rahnejat ◽  
Narges Eskandari-Roozbahani
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Polycystic Ovary Syndrome ◽  
Neurodegenerative Disorder ◽  
Polycystic Ovary ◽  
Clinical Manifestations ◽  
Neuronal Loss ◽  
Ovary Syndrome ◽  
Common Risk Factors

Abstract The most common endocrine disorder among women is Polycystic ovary syndrome (PCOS), characterized by hyperandrogenism, chronic ovulation, and/or ultrasound evidence of small ovarian cysts. Obesity and insulin resistance are also the main factors influencing the clinical manifestations of this syndrome. High intakes of fat have been linked to more significant cognitive decline in old age, and due to the growing elderly population, maintaining long-term optimal cognitive function is very important. Alzheimer's disease (AD) is the most typical progressive neurodegenerative disorder of the brain, and recent studies suggest a relationship between endocrinal dysregulation and neuronal loss during AD pathology. In this narrative review, the international databases, including Google Scholar, Scopus, PubMed, and Web of Science databases, were searched for retrieving the relevant studies. According to the factors involved in Alzheimer's and PCOS, it seems that both disorders may share some common risk factors. In this study, the relevant studies' summaries were categorized to discuss the possible pathways that may explain the association between Alzheimer's and PCOS signs/symptoms and complications. Future preclinical studies are needed to investigate the exact underlining mechanisms related to PCOS and Alzheimer's association.

scholarly journals Analyzing the Risk factors of Polycystic Ovary Syndrome (PCOS) with Insulin Resistance (IR)

IJARCCE ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 81-84
Author(s):  
Bakkiyalakshmi R ◽  
Jenifer T ◽  
Gayathri Premanand
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome

Cardiometabolic risk factors in adolescents with polycystic ovary syndrome

2020 ◽  
Vol 26 ◽  
Author(s):  
Anastasia Vatopoulou ◽  
Maria-Eleni Dionelli ◽  
Alexis Papanikolaou ◽  
Sonia Grover
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Polycystic Ovary Syndrome ◽  
Cardiometabolic Risk ◽  
Polycystic Ovary ◽  
Cardiometabolic Risk Factors ◽  
Ovary Syndrome

: It is well-established that adults with polycystic ovary syndrome (PCOS) have increased prevalence of several cardiometabolic risk factors, including obesity, insulin resistance, type 2 diabetes mellitus and dyslipidemia. Accumulating data suggest that these risk factors are already present in adolescence in patients with PCOS. This has major implications for the management of this population, since the timely identification of these risk factors is essential for preventing cardiovascular disease in adulthood. The present review summarizes the existing evidence regarding the prevalence of both traditional and non-traditional cardiometabolic risk factors in adolescents with PCOS.

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