Investigation of common risk factors between polycystic ovary syndrome and Alzheimer's disease

Abstract The most common endocrine disorder among women is Polycystic ovary syndrome (PCOS), characterized by hyperandrogenism, chronic ovulation, and/or ultrasound evidence of small ovarian cysts. Obesity and insulin resistance are also the main factors influencing the clinical manifestations of this syndrome. High intakes of fat have been linked to more significant cognitive decline in old age, and due to the growing elderly population, maintaining long-term optimal cognitive function is very important. Alzheimer's disease (AD) is the most typical progressive neurodegenerative disorder of the brain, and recent studies suggest a relationship between endocrinal dysregulation and neuronal loss during AD pathology. In this narrative review, the international databases, including Google Scholar, Scopus, PubMed, and Web of Science databases, were searched for retrieving the relevant studies. According to the factors involved in Alzheimer's and PCOS, it seems that both disorders may share some common risk factors. In this study, the relevant studies' summaries were categorized to discuss the possible pathways that may explain the association between Alzheimer's and PCOS signs/symptoms and complications. Future preclinical studies are needed to investigate the exact underlining mechanisms related to PCOS and Alzheimer's association.

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Investigation of common risk factors between polycystic ovary syndrome and Alzheimer’s disease: a narrative review

Reproductive Health ◽

10.1186/s12978-021-01203-x ◽

2021 ◽

Vol 18 (1) ◽

Author(s):

Nahid Sarahian ◽

Hosna Sarvazad ◽

Elham Sajadi ◽

Nasrin Rahnejat ◽

Narges Eskandari Roozbahani

Keyword(s):

Risk Factors ◽

Alzheimer’S Disease ◽

Insulin Resistance ◽

Alzheimer's Disease ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Narrative Review ◽

Ovary Syndrome ◽

Common Risk Factors ◽

The Common

Abstract Background The most common endocrine and metabolic disorders in premenopausal women is polycystic ovary syndrome (PCOS), characterized by hyperandrogenism, chronic anovulation, and/or ultrasound evidence of small ovarian cysts. Obesity and insulin resistance are also the main factors influencing the clinical manifestations of this syndrome. Alzheimer’s disease (AD) is the most typical progressive neurodegenerative disorder of the brain, and recent studies suggest a relationship between endocrinal dysregulation and neuronal loss during AD pathology. Aim This study aimed to evaluate the common risk factors for Alzheimer’s and PCOS based on previous studies. Knowing the common risk factors and eliminating them may prevent neurodegenerative Alzheimer’s disease in the future. Method In this narrative review, international databases, including Google Scholar, Scopus, PubMed, and the Web of Science, were searched to retrieve the relevant studies. The relevant studies’ summaries were categorized to discuss the possible pathways that may explain the association between Alzheimer’s and PCOS signs/symptoms and complications. Results According to our research, the factors involved in Alzheimer’s and PCOS disorders may share some common risk factors. In patients with PCOS, increased LH to FSH ratio, decreased vitamin D, insulin resistance, and obesity are some of the most important factors that may increase the risk of Alzheimer’s disease.

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Cardiovascular risk factors in polycystic ovary syndrome

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-2005-862980 ◽

2005 ◽

Vol 113 (S 1) ◽

Author(s):

S Tan ◽

S Hahn ◽

K Pleger ◽

S Sack ◽

BL Herrmann ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Polycystic Ovary Syndrome ◽

Cardiovascular Risk Factors ◽

Polycystic Ovary ◽

Ovary Syndrome

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Association of polycystic ovary syndrome with cardiovascular risk factors

Gynecological Endocrinology ◽

10.1080/09513590903159565 ◽

2009 ◽

pp. 1-7

Author(s):

Tanzeela Akram ◽

Shahid Hasan ◽

Muhammad Imran ◽

Asima Karim ◽

Muhammad Arslan

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Polycystic Ovary Syndrome ◽

Cardiovascular Risk Factors ◽

Polycystic Ovary ◽

Ovary Syndrome

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Impact of rs2414096 polymorphism of CYP19 gene on susceptibility of polycystic ovary syndrome and hyperandrogenism in Kashmiri women

Scientific Reports ◽

10.1038/s41598-021-92265-1 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Sairish Ashraf ◽

Shayaq Ul Abeer Rasool ◽

Mudasar Nabi ◽

Mohd Ashraf Ganie ◽

Shariq R. Masoodi ◽

...

Keyword(s):

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Clinical Manifestations ◽

Additive Model ◽

Genotypic Frequency ◽

Ovary Syndrome ◽

Significant Difference ◽

Cyp19 Gene ◽

Reproductive Endocrine ◽

The Impact

AbstractPolycystic ovary syndrome (PCOS) is the most common reproductive endocrine disorder in pre-menopausal women having complex pathophysiology. Several candidate genes have been shown to have association with PCOS. CYP19 gene encodes a key steroidogenic enzyme involved in conversion of androgens into estrogens. Previous studies have reported contradictory results with regard to association of SNP rs2414096 in CYP19 gene with PCOS and hyperandrogenism in different ethnic populations. Present study was aimed to investigate the impact of SNP rs2414096 polymorphism of CYP19 gene on susceptibility of PCOS and hyperandrogenism in Kashmiri women. Further we also studied the genotypic-phenotypic association for various clinical and biochemical parameters of this polymorphism. Case control study. 394 PCOS cases diagnosed on the basis of Rotterdam criteria and age matched 306 healthy women. We found a significant differences in genotypic frequency (χ2 = 18.91, p < 0.05) as well as allele frequency (OR 0.63, CI 0.51–0.78, χ2 = 17.66, p < 0.05) between PCOS women and controls. The genotype–phenotype correlation analysis showed a significant difference in FG score (p = 0.047) and alopecia (p = 0.045) between the three genotypes. Also, the androgen excess markers like DHEAS (p < 0.001), Androstenedione (p < 0.001), Testosterone (p < 0.001) and FAI (p = 0.005) were significantly elevated in GG genotype and showed a significant difference in additive model in PCOS women. rs2414096 polymorphism of CYP19 gene is associated with the risk of PCOS as well as with clinical and biochemical markers of hyperandrogenism, hence suggesting its role in clinical manifestations of PCOS in Kashmiri women.

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