scholarly journals Time-synchronized immune-guided SBRT partial bulky tumor irradiation targeting hypoxic segment while sparing the peritumoral immune microenvironment

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Slavisa Tubin ◽  
Martin Ashdown ◽  
Branislav Jeremic
Keyword(s):  
Immune Response ◽  
Data Analysis ◽  
Response Rate ◽  
Treatment Time ◽  
System Response ◽  
Immune Microenvironment ◽  
Tumor Irradiation ◽  
The Right ◽  
The Impact ◽  
Biomarker Data

Abstract Background A novel unconventional SBRT-based PArtial Tumor irradiation targeting HYpoxic clonogenic cells (SBRT-PATHY) for induction of the tumoricidal bystander (BE) and abscopal effects (AE) was developed by translating our preclinical findings to a clinic in 2016. In order to further improve BE/AE response rate, SBRT-PATHY was upgraded in 2018 by the sparing of peritumoral immune microenvironment as a new OAR, defined by its own dose-constraints. Considering the anti-tumor immune response homeostatic fluctuation, which is cyclically suppressed and incited (“switched off and on”), we synchronized SBRT-PATHY with its most excitable phase, in order to overcome tumor tolerance locally and systemically. The aim of this study, therefore, was to report on the initial results of our latest innovation aimed to further improve BE/AE response rate by testing the effectiveness of the time-synchronized immune-guided SBRT-PATHY. Materials and methods In order to serially map the homeostatic anti-tumor immune response-fluctuations, High Sensitive C-Reactive Protein (HS-CRP), Lactate Dehydrogenase (LDH) and Lymphocyte/Monocyte Ratio (LMR) were analyzed using high-order polynomial trend analysis as surrogate of immune system response. After the biomarker data analysis detected the immune fluctuations and related idiosyncratic immune cycle periodicity, we determined the “most favourable” and “least favourable” treatment time-positions in the immune cycle. In order to evaluate the impact of an idiosyncratic immune cycle on treatment outcomes, our first consecutive four patients were treated on the “most favourable” while the remaining four on the “least favourable” day. Results The median follow-up was 11.8 months. The biomarker data analysis showed periodic immune response fluctuations of regular frequency. The “right” synchronization of SBRT-PATHY with the “most favorable day” of anti-tumor immune response was accompanied with improved clinical outcomes in terms of BE/AE-response rate. Conclusion We believe the right synchronization of radiotherapy with the homeostatically oscillating immune response may improve the probability of inducing BE/AE. Present study has been retrospectively registered on 18th of October 2019 by the ethic committee for Austrian region „Kärnten “in Klagenfurt (AUT), under study number A 37/19.

scholarly journals The Impact of Investment Decision and Funding on Financial Performance and Firm Value

2019 ◽  
Vol 8 (2) ◽  
pp. 103
Author(s):  
Hadi Santoso
Keyword(s):  
Data Analysis ◽  
Financial Performance ◽  
Firm Value ◽  
Stock Exchange ◽  
Investment Decision ◽  
Investment Decisions ◽  
The Right ◽  
The Impact ◽  
Selection Of

Managers who are responsible for the management of companies are faced with two important decisions - investment and funding. The right investment decisions and choice of funding sources are important because they affect the company's financial performance. The selection of the types of assets to be invested and the right types of financing sources result in optimal returns for the company. It reflects good company performance and future prospects. In addition, optimal return is a good sign for investors. Companies that perform well experience increase in the value of their firm. This study examined the effect of investment decisions and the selection of appropriate sources of funds on the performance of the company and the consequent impact on the firm value. The study was conducted in two parts. The first part examined the effect of investment decisions on long-term assets with long-term funding on the rate of return and firm value. The second part examined the effect of investment decisions on the company's short-term assets and funding for financial performance and firm value. The case study used in this research is a consumer goods sub-sector company listed on the Indonesia Stock Exchange in the period 2010 to 2017. Path analysis is the data analysis tools that was used. The results of data analysis showed that the asset structure has an effect on financial performance and firm value. The capital structure affects the financial performance but does not affect the firm value of the company. Financial performance was measured by ROI.

scholarly journals POOR ACEH: THE IMPACT OF SPECIAL AUTONOMY AS EFFORT POVERTY REDUCTION IN ACEH

2020 ◽  
Vol 18 (2) ◽  
pp. 1-14
Author(s):  
Deni Setiawan ◽  
Khalida Ulfa ◽  
Titin Purwaningsih
Keyword(s):  
Data Analysis ◽  
Poverty Reduction ◽  
Statistical Data ◽  
Central Government ◽  
Analysis Data ◽  
Statistical Data Analysis ◽  
Literature Study ◽  
Aceh Province ◽  
The Right ◽  
The Impact

Special autonomy as one of the strategies in overcoming social welfare issues is one of them in Aceh Province. The implementation of regional autonomy after the reforms marked by the issuance of Law Number 33 of 2004 concerning the financial balance between the central government to the regions. The hope is to make the regions more autonomous or independent in government, and a more equal financial structure and the right to manage financial resources that are more transparent. This research focuses on the impact of the implementation of special autonomy in Aceh Province, limited from 2015 to 2019 in poverty alleviation efforts. This study uses a qualitative method with a descriptive approach to literature study and statistical data analysis. Data analysis techniques in this study were using statistical data analysis obtained from BPS. The results showed that special autonomy as an effort to reduce poverty in Aceh has a very good contribution because it has reduced poverty in Aceh from 819 thousand in March 2019 to 810 thousand people in September 2019. And the use of the special autonomy fund was channeled through programs made by the Aceh government in the fields of Education, Health, and the economy.

scholarly journals Improving client outcomes whilst maintaining scheme sustainability

2014 ◽  
Vol 9 ◽  
Author(s):  
Kate Kerr ◽  
David Gifford ◽  
Steven Fleming
Keyword(s):  
Data Analysis ◽  
Qualitative Data ◽  
Client Outcomes ◽  
Qualitative Data Analysis ◽  
Client Experience ◽  
Corporate Objective ◽  
The Right ◽  
The Impact

Improving client outcomes whilst maintaining scheme sustainability In 2010 the Transport Accident Commission commenced its journey in placing Client Outcomes as a corporate objective alongside those of Scheme Viability and Client Experience. It was widely agreed to be the right thing to do but also took a leap of faith in that the impact of this focus on the more established scheme measures was at that time unknown. Through the use of both quantitative and qualitative data analysis, this presentation aims to review the hypothesis that including Client Outcomes as a corporate objective would strengthen the management of scheme viability and client experience.

scholarly journals Satisfaction With Healthcare: The Changes And Features Of Patients Making Aknowledgements For Doctors And Nurses Wiews

2016 ◽  
Vol 26 (5) ◽  
pp. 5-12
Author(s):  
Vinsas Janušonis
Keyword(s):  
Response Rate ◽  
Healthcare Services ◽  
University Hospital ◽  
Women Patients ◽  
Persons With Disabilities ◽  
Patients Satisfaction ◽  
Number Of Patients ◽  
The Right ◽  
The Impact ◽  
Doctors And Nurses

The aim of the study – to estimate patients, who gave thanks for medics – doctors and nurses opinion changes and singularity of right healthcare, satisfaction and fruition their expectations. Material and methods. From January 2004 to December 2015 a survey was performed in Klaipeda University Hospital (KUH). The study included 197755 patients who were undergoing treatment in KUH. Information was collected via questionnaires (response rate 81,4%). The patients who gave thanks for medics group was analyzed apart. The survey was analyzed and compared for the periods 2004-2006 and 2013-2015. Results and discussion. The most part of patients who gave thanks for medics was aged 50-69 (15, 8%), at work, women. The time of healthcare services, information for patients, good contact and communication between patients and medics, patients’ satisfaction influenced the number of thanks. The number of thanksgiving have not direct correlation with healthcare quality. Conclusions. Patients thanksgiving has confirmed the KUH provided healthcare for the majority of patients are appropriate to meet their expectations and they are satisfied with it. Comparison of both analyzed periods has shown that over 10 years fell acknowledgments for medics. Age, gender and social status had the impact on the number of acknowledgments - more thanksgiving was from women, patients 50-59 year age, retired and persons with disabilities. The right cooperation between medics and patients, provision of healthcare information to patients increased the number of thanksgiving. The number of patients who satisfied with healthcare results and meet their expectations directly correlated with number of patients who gave thanks for medics.

scholarly journals The Effect of Job Transfer on Employee Performance With Motivation and Job Satisfaction as Intervening Variables

2021 ◽  
Vol 04 (09) ◽  
Author(s):  
Muslichah Muslichah ◽  
Keyword(s):  
Job Satisfaction ◽  
Data Analysis ◽  
Empirical Evidence ◽  
Response Rate ◽  
Employee Performance ◽  
Analysis Method ◽  
Job Transfer ◽  
Research Population ◽  
The Impact ◽  
Intervening Variables

This study aims to provide empirical evidence of the effect of job transfer on employee performance with motivation and job satisfaction as mediating variables. The research population was 52, all of whom were tax inspectors at KPP Madya Malang Indonesia. All members of the population are used as samples. A total of 52 questionnaires were distributed to tax inspectors, and 36 questionnaires were returned, resulting in a response rate of 69.23%. The data analysis method used is path analysis. The results showed that job transfer did not affect employee performance. Furthermore, it was also found that motivation did not mediate the effect of job transfer on employee performance. Finally, this study found that job satisfaction mediates the impact of job transfer on employee performance.

Nanomedicine Approach to Immunotherapy of Hepatocellular Carcinoma

2021 ◽  
Vol 17 (5) ◽  
pp. 771-792
Author(s):  
Hongbo Ni ◽  
Jian Xue ◽  
Fan Wang ◽  
Xiaohan Sun ◽  
Meng Niu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Immune Response ◽  
Tumor Cell ◽  
Response Rate ◽  
Advanced Technology ◽  
Antitumor Immune Response ◽  
Immune Microenvironment ◽  
Primary Resistance ◽  
Secondary Resistance ◽  
Immunosuppressive Microenvironment

In recent years, the growing studies focused on the immunotherapy of hepatocellular carcinoma and proved the preclinical and clinical promises of host antitumor immune response. However, there were still various obstacles in meeting satisfactory clinic need, such as low response rate, primary resistance and secondary resistance to immunotherapy. Tackling these barriers required a deeper understanding of immune underpinnings and a broader understanding of advanced technology. This review described immune microenvironment of liver and HCC which naturally decided the complexity of immunotherapy, and summarized recent immunotherapy focusing on different points. The ever-growing clues indicated that the instant killing of tumor cell and the subsequent relive of immunosuppressive microenvironment were both indis- pensables. The nanotechnology applied in immunotherapy and the combination with intervention technology was also discussed.

scholarly journals Case Report: Response to Immunotherapy, Can Radiotherapy Be a Troublemaker?

2021 ◽  
Vol 12 ◽  
Author(s):  
Patricia Martin-Romano ◽  
Julien Adam ◽  
Jean-Yves Scoazec ◽  
Sébastien Gouy ◽  
Antonin Levy ◽  
...  
Keyword(s):  
Immune Response ◽  
Case Report ◽  
Cell Carcinoma ◽  
Immune Microenvironment ◽  
Extensive Analysis ◽  
Immune Contexture ◽  
Previously Treated ◽  
Potential Impact ◽  
Tumor Types ◽  
The Impact

Immunotherapy has dramatically changed the treatment landscape for several tumor types. However, the impact of previous radiotherapy (RT) on response to immunotherapy is still unknown. We report the case of a 58-year-old female diagnosed with a squamous anal cell carcinoma previously treated with RT and having a dissociated response to anti-PD1 agent. An extensive analysis of the immune contexture performed on the tissue collected from both previously RT-treated and RT-untreated lesions confirmed differences on immune microenvironment, highlighting the potential impact of radiotherapy on the immune response.

scholarly journals How sticky should a virus be? The impact of virus binding and release on transmission fitness using influenza as an example

2014 ◽  
Vol 11 (92) ◽  
pp. 20131083 ◽  
Author(s):  
Andreas Handel ◽  
Victoria Akin ◽  
Sergei S. Pilyugin ◽  
Veronika Zarnitsyna ◽  
Rustom Antia
Keyword(s):  
Immune Response ◽  
Adaptive Immune Response ◽  
Virus Binding ◽  
Adaptive Immune ◽  
Cell Mediated Immune Response ◽  
Infected Cells ◽  
The Right ◽  
The Impact ◽  
Virus Fitness ◽  
Better Than

Budding viruses face a trade-off: virions need to efficiently attach to and enter uninfected cells while newly generated virions need to efficiently detach from infected cells. The right balance between attachment and detachment—the right amount of stickiness—is needed for maximum fitness. Here, we design and analyse a mathematical model to study in detail the impact of attachment and detachment rates on virus fitness. We apply our model to influenza, where stickiness is determined by a balance of the haemagglutinin (HA) and neuraminidase (NA) proteins. We investigate how drugs, the adaptive immune response and vaccines impact influenza stickiness and fitness. Our model suggests that the location in the ‘stickiness landscape’ of the virus determines how well interventions such as drugs or vaccines are expected to work. We discuss why hypothetical NA enhancer drugs might occasionally perform better than the currently available NA inhibitors in reducing virus fitness. We show that an increased antibody or T-cell-mediated immune response leads to maximum fitness at higher stickiness. We further show that antibody-based vaccines targeting mainly HA or NA, which leads to a shift in stickiness, might reduce virus fitness above what can be achieved by the direct immunological action of the vaccine. Overall, our findings provide potentially useful conceptual insights for future vaccine and drug development and can be applied to other budding viruses beyond influenza.

scholarly journals Beyond Tumor Mutation Burden: Tumor Neoantigen Burden as a Biomarker for Immunotherapy and Other Types of Therapy

2021 ◽  
Vol 11 ◽  
Author(s):  
Peipei Wang ◽  
Yueyun Chen ◽  
Chun Wang
Keyword(s):  
Immune Response ◽  
Clinical Outcome ◽  
Immune Cells ◽  
Response Rate ◽  
Tumor Mutation Burden ◽  
Patients With Cancer ◽  
Improved Outcomes ◽  
Mutation Burden ◽  
Future Challenges ◽  
The Impact

Immunotherapy has significantly improved the clinical outcome of patients with cancer. However, the immune response rate varies greatly, possibly due to lack of effective biomarkers that can be used to distinguish responders from non-responders. Recently, clinical studies have associated high tumor neoantigen burden (TNB) with improved outcomes in patients treated with immunotherapy. Therefore, TNB has emerged as a biomarker for immunotherapy and other types of therapy. In the present review, the potential application of TNB as a biomarker was evaluated. The methods of neoantigen prediction were summarized and the mechanisms involved in TNB were investigated. The impact of high TNB and increased number of infiltrating immune cells on the efficacy of immunotherapy was also addressed. Finally, the future challenges of TNB were discussed.

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