scholarly journals Prostate deformation during hypofractionated radiotherapy: an analysis of implanted fiducial marker displacement

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Lukas Knybel ◽  
Jakub Cvek ◽  
Tomas Blazek ◽  
Andrea Binarova ◽  
Tereza Parackova ◽  
...  

Abstract Background To report prostate deformation during treatment, based on an analysis of fiducial marker positional differences in a large sample. Material and methods This study included 144 patients treated with prostate stereotactic body radiation therapy after implantation in each of 4 gold fiducial markers (FMs), which were located and numbered consistently. The center of mass of the FMs was recorded for every pair of X-ray images taken during treatment. The distance between each pair of fiducials in the live X-ray images is calculated and compared with the respective distances as determined in the CT volume. The RBE is the difference between these distances. Mean RBE and intrafraction and interfraction RBE were evaluated. The intrafraction and intefraction RBE variability were defined as the standard deviation, respectively, of all RBE during 1 treatment fraction and of the mean daily RBE over the whole treatment course. Results We analyzed 720 treatment fractions comprising 24,453 orthogonal X-ray image acquisitions. We observed a trend to higher RBE related to FM4 (apex) during treatment. The fiducial marker in the prostate apex could not be used in 16% of observations, in which RBE was > 2.5 mm. The mean RBEavg was 0.93 ± 0.39 mm (range 0.32–1.79 mm) over the 5 fractions. The RBEavg was significantly lower for the first and second fraction compared with the others (P < .001). The interfraction variability of RBEavg was 0.26 ± 0.16 mm (range 0.04–0.74 mm). The mean intrafraction variability of all FMs was 0.45 ± 0.25 mm. The highest Pearson correlation coefficient was observed between FM2 and FM3 (middle left and right prostate) (R = 0.78; P < .001). Every combination with FM4 yielded lower coefficients (range 0.66–0.71; P < .001), indicating different deformation of the prostate apex. Conclusions Ideally, prostate deformation is generally small, but it is very sensitive to rectal and bladder filling. We observed RBE up to 11.3 mm. The overall correlation between FMs was affected by shifts of individual fiducials, indicating that the prostate is not a “rigid” organ. Systematic change of RBE average between subsequent fractions indicates a systematic change in prostate shape.

2017 ◽  
Vol 11 (1) ◽  
pp. 1041-1048 ◽  
Author(s):  
Mehmet Bekir Unal ◽  
Kemal Gokkus ◽  
Evrim Sirin ◽  
Eren Cansü

Objective: The main objective of this study is to evaluate the availability of lateral antebrachial cutaneous nerve (LACN) autograft for acute or delayed repair of segmented digital nerve injuries. Patients and Methods: 13 digital nerve defects of 11 patients; treated with interposition of LACN graft that harvested from ipsilateral extremity were included in the study. Mean follow up period was 35, 7 months. The mean time from injury to grafting is 53, 3 days. The results of the mean 2PDT and SWMT values of injured /uninjured finger at the end of follow up period were evaluated with Paired T test. The correlation between the defect length and the difference of 2PDT, SWMT values between the uninjured and injured finger at the end of follow up period; were evaluated with Pearson - correlation analysis. Results: The mean value of our 2PDT and SWMT results are ~5,923, ~3, 52, respectively in which can be interpreted between the normal and diminished light touch. The defect length and difference percentage of SWMT values is positively and significantly correlated statistically. Mean length of interposed nerve grafts was 18.5 mm. The age of the patient and the mean values of 2PDT and SWMT with the difference % of 2PDT and % of SWMT are not statistically correlated. Conclusion: Based on results regarding sensory regaining at recipient side and negligible sensory deficit at harvesting side, we suggest that lateral antebrachial cutaneous nerve might be a valuable graft option for digital nerve defects.


Perception ◽  
1989 ◽  
Vol 18 (2) ◽  
pp. 237-242 ◽  
Author(s):  
P Lánský ◽  
Naum Yakimoff ◽  
T Radil ◽  
L Mitrani

The error in estimating the orientation of a dot pattern was measured as the difference between the orientation of the least-squared-distances line (LS-line) of the pattern and the orientation of a line adjusted by the subject to match the perceived orientation of the pattern. Analysis of the mean errors (averaged over ten subjects) obtained for one hundred patterns confirmed that the orientation of the LS-line represents the orientation of elongated dot-patterns. It is shown that estimated orientation was systematically biased towards the nearest 45° oblique meridian. This bias points to the importance of the ±45° directions as natural norms for left- and right-side tilt in the frontoparallel plane.


1994 ◽  
Vol 375 ◽  
Author(s):  
C. T. Chen ◽  
Y. U. Idzerda ◽  
C.-C. Kao ◽  
L. H. Tjeng ◽  
H.-J. Lin ◽  
...  

AbstractSoft-x-ray magnetic circular dichroism (MCD) is the difference between the absorptivity or reflectivity of left and right circularly polarized soft-x-rays at the magnetically interesting L2,3- edges of 3d transition metals or the M4,5-edges of the 4f rare earth elements. Thanks to its large absorption cross-section and strong MCD effect, this technique has become a powerful new means for probing, in an element- and site-specific manner, the magnetic properties of ultra-thin films and multilayers. Soft-x-ray MCD experiments, recently conducted at the Dragon beamline, are utilized to demonstrate the recent progress in this technique and its applications in the research of magnetic thin films.


2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Adrijana Spasovska Vasilova ◽  
Lada Trajcheska ◽  
Mimoza Milenkova ◽  
Aleksandra Canevska ◽  
Angela Kabova ◽  
...  

Abstract Background and Aims Kidney size has been found to be correlated with anthropometric features and is different among different ethnicities. In this study, we used ultrasonography for measurement of kidney volumes in healthy individuals and evaluated the relationships with body height, age and gender. Method We conducted a cross-sectional observational study and evaluated 108 healthy individuals whose serum creatinine level was within reference range. Patients’ medical clinical and laboratory records were reviewed. Age, gender and height were recorded. Pearson correlation coefficients were used to evaluate the strength of association between ultrasonographic parameters with each other and with other parameters, and were expressed as r2. Variations in left and right renal dimensions between various age groups were compared using a one-way analysis of variance, followed by a post-hoc Tukey's test. Results Subjects’ age ranged from 16 to 84 years and the mean age was over 50 years. There was an equal distribution among genders. Strong and positive correlations were seen for the measured length, parenchyma thickness and also for both total and parenchymal volumes with subjects’ height for both kidneys. The strongest correlations were observed for the left and right kidney length and also for the right kidney parenchymal volume (r=0.536, p=0.001; r=0.469, p=0.001; r=0.44, p=0.001). On the opposite, most of the relations with age were negative, but week and insignificant. When we divided the study subjects into three age groups and compared them for the height, there was no significant difference among them. Regarding the parenchymal and total kidney volumes of both kidneys, the different age groups showed similar findings in the ultrasonographic measurements. The mean calculated volumes were slightly declining with age and showed the largest values in the first group of patients under 30 years and lowest values in patients over 70 years old. Ultrasonographic measurements were also compared among the two genders. Both (men and women) showed similar age (53.55 ± 18.22 vs. 50.79 ± 18.13 p= 0.430, respectively). As for the height, men were significantly taller than women (1.734 ± 0.007 vs.1.637 ± 0.005, p= 0.001). The kidney length, volume and parenchymal volumes of both kidneys were significantly larger in men. Conclusion Renal length and volume are strongly correlated with body height. This relation must be considered in clinical decisions on further investigations regarding kidney disease progression.


2008 ◽  
Vol 396-398 ◽  
pp. 179-182 ◽  
Author(s):  
Ana Cristina P. Machado ◽  
Marize Varella de Oliveira ◽  
Robson Pacheco Pereira ◽  
Yasmin R. Carvalho ◽  
Carlos Alberto Alves Cairo

The osseointegration of porous titanium implants was evaluated in the present work. Implants were fabricated from ASTM grade 2 titanium by a powder metallurgy method. Part of these implants were submitted to chemical and thermal treatment in order to deposit a biomimetic coating, aiming to evaluate its influence on the osseointegration of the implants. The implants were characterized by Scanning Electron Microscopy (SEM), Electron Dispersive X-Ray Spectroscopy (EDS) and Raman Spectroscopy. Three coated and three control (uncoated) implants were surgically inserted into thirty albino rabbits’ left and right tibiae, respectively. Tibiae samples were submitted to histological and histomorphometric analyses, utilizing SEM, optical microscopy and mechanical tests. EDS results indicated calcium (Ca) and phosphorous (P) at the surface and Raman spectra exhibited an intense peak, characteristic of hydroxyapatite (HA). Bone neoformation was detected at the bone-implant interface and inside the pores, including the central ones. The mean bone neoformation percentage in the coated implants was statistically higher at 15 days, compared to 30 and 45 days. The mechanical tests showed that coated implants presented higher resistance to displacement, especially after 30 and 45 days.


1988 ◽  
Vol 43 (2) ◽  
pp. 171-174 ◽  
Author(s):  
Siegfried Pohl ◽  
Wolfgang Saak ◽  
Peter Stolz

(Ph4P)2Mn2Br6 (1) and (Ph3PCH2Ph)2Mn2I6 (2) were prepared from the reaction of manganese dihalide with the corresponding phosphonium halide in CH2Cl2.The structures of 1 and 2 were determined from single crystal X-ray diffraction data.Both compounds crystallize in the triclinic space group P 1 with one formula unit per unit cell.1:a = 998.1(1), b = 1005.7(1), c = 1313.3(2) pm, α = 108.51(1), β = 94.25(1), γ = 100.36(1)°.2: a = 1058.6(2), b = 1236.3(2), c = 1248.4(3) pm, α = 63.53(1), β = 74.15(1), γ = 74.65(1)°.The structures of 1 and 2 exhibit discrete, dimeric anions formed by the fusion of two identical tetrahedral-like units with a common halogen-halogen edge. The mean Mn-Hal bond lengths were found to be 251.8 pm (Mn-Br) and 272.2 pm (Mn-I). The difference between the bridging and terminal Mn-Hal bond lengths is about 12-13 pm in both compounds


Author(s):  
Zahra Safavi Bayat ◽  
Wim Van Brakel ◽  
Hamideh Ebrahimi ◽  
Nadere Naderi Ravesh ◽  
Nezhat Shakeri ◽  
...  

Leprosy is one of the oldest chronic diseases, and similar to other infectious diseases, it causes long-term physical and social effects on the lives of patients and their families. This was a cross-sectional study conducted with 103 patients with leprosy in Mashhad in the Mehrab Khan region in March 2016. The sampling method was convenience sampling. The data was analyzed using SPSS version 19. Descriptive statistics (frequency, percentage, mean and standard deviation) and inferential tests (ANOVA, Pearson correlation, and independent t-test) were used. The results showed that the mean age of patients was 65.2±8.1 years and the mean age of developing leprosy was 15.3±7.03. There was an inverse correlation between the score of overall stigma, internal stigma, and all dimensions of quality of life that was statistically significant, except for the social dimension (r= -0.181…; P=0.067). There was an inverse correlation between the psychological dimension of quality of life and experienced stigma. The highest score of the overall quality of life was related to divorced patients with a mean score of 79.7, which was statistically significant (P=0.016) from those who were not divorced. In post-hoc test, just the difference between widow and divorced were significant regarding quality of life. According to results, there was a negative correlation between the quality of life and all aspects of stigma using the SARI tool.


2011 ◽  
Vol 29 (27_suppl) ◽  
pp. 126-126
Author(s):  
V. Krakobsky ◽  
D. Gwirc

126 Background: When it comes to breast-conserving surgery the boost volume becomes a critical target because it has the highest risk of residual cancer cells. At our institution the most common methods to contour the tumor bed are: the scar-based planning guided by fluoroscopy (2DP) and the one that relies on the visualization of the seroma under CT (3DP). We evaluated the accuracy of the breast boost volume treated with clinical mark-up compared with the volume delineated with CT planning. Additionally, we evaluated whether or not the lumpectomy scar is a suitable landmark to define the tumor bed. Methods: 20 patients diagnosed with breast cancer stage I-IIA underwent tumor bed boost planning using two techniques: 2DP and 3DP. All the information concerning to the 2DP was reproduced in a radiotherapy planning system. Statistical analysis: the match pair t-test and the coefficient of variation were used to test for an association among the two planning techniques for tumor bed coverage. The D95, D90, V15, volume, medium lung dose and geographic miss were analyzed. Pearson correlation analysis was used to assess the relationship between CVS, date of surgery, age and previous chemotherapy treatment. Other items taken into account were the match between the scar and the seroma, and how good the visualization of the seroma was by using the CVS. Results: 2DP was inaccurate: the mean D95, D90 and V15 were 3.12 Gy, 4.6 Gy and 29% respectively (variation coefficient: 135%, 107% and 65% respectively). The difference between the mean 2DP D95 and 3DP D95 was 11 Gy (95% CI, 9 Gy to 13 Gy, p< 0.001). The difference between the mean 2DP V15 and 3DP V15 was 59% (95% CI, 49% to 69%, p < 0.001).The percentage of geographic miss was: 80% (95% CI, 63% to 97%). All the seromas were finely visualized There was no correlation between CVS, age, prior chemotherapy and date of surgery. The volumes and the medium lung dose were larger for the 3D method: 373.1 cm3 vs. 248.8 cm3 and 0.27Gy vs. 0.14 Gy respectively. Only 45% of the lumpectomy scars matched the seroma. Conclusions: CT-based planning allows for optimal tumor bed coverage compared with scar-based planning which carries a significant risk of missing the target. The lumpectomy scar is often a poor indicator of the tumor bed.


2021 ◽  
pp. 76-82
Author(s):  
S.І. Doroshenko ◽  
I.S. Kuzmenko ◽  
K.V. Storozhenko ◽  
S.V. Irkha ◽  
Kh.M. Demianchuk

No tooth is as problematic for patients as it is for third molars. After erupting later than all teeth, they often have little space in the dentition, or rather in the retromolar space, which should appear, above all, with further growth of the jaws. Therefore, the timing of their eruption varies considerably and is often accompanied by the appearance of significant morphological and functional disorders. That is why it is necessary to take a balanced approach to the preservation of third molars in the dental arch, providing them with a place in the retromolar space by timely detecting their condition and position in the jawbones and thus preserving the integrity of the dentition and implementing the fourth and last stage of bite raising in orthodontic patients with dental anomalies. The purpose of the study. To substantiate a differentiated approach to the preservation of third molars in orthodontic treatment by determining their condition and position in the jaw. Material and methods of research. For this purpose, 44 patients aged 15-30 years with different dentofacial anomalies having full permanent dentition including third molars confirmed by clinical and X-ray data were examined and given orthodontic treatment. Additional methods of the study included analysis of diagnostic model measurements (by Pont Korkhaus method). Furthermore, retromolar space was measured to find out if there is a space for third molars in the row of teeth by measuring its length and height using a silicone index (by S.I. Doroshenko and Ye.A. Kulhinskyi's method, 2009). X-ray studies included analysis of orthopantomograms (OPG), teleradiography (TRG), computed tomography (CT) scan, etc. The OPG analysis was conducted using K.V. Storozhenko's method (2013) which involved measuring the inclination of teeth, especially third and second molars relative to the jaw base. OPG showed a lack of space for third molars using S.I. Doroshenko and Ye.A. Kulhinskyi's method (2009). Measurement data were processed using mathematical statistics. The mean and the confidence interval for the data sample were calculated according to GOST R 8.736 – 2011. Results. The analysis of data showed significant variability in inclination of third molars relative to the jaw base and second molars on both sides of the jaws (on the left and the right). The largest difference in inclinations of third and second molars was observed in the lower jaw (LJ) both on the left and the right, with an insignificant deviation of 0.3° ± 0.2°, and the least difference was in the upper jaw (UJ), especially on the left, but with a larger deviation of 3.6° ± 0.2°. The conducted studies suggested that the larger the difference in inclinations of third lower molars relative to second ones is, the more problematic their eruption is, since they erupt later. Lower third molars incline medially at their crowns and therefore they have a smaller angle of inclination relative to the LJ base. While erupting upper third molars incline distally at their crown with an increased angle of inclination relative to the UJ base. In 44 patients aged 15-30 years, 106 (60.2%) third molars were in retention, including 35 (33.1%) teeth in physiological retention in younger people, 40 (37,7%) teeth in half-retention, and 31 (29.2%) third molars in constant retention. An important factor in predicting the eruption of third molars became the presence of space for them in retromolar space, both sagittally and vertically. The presence of space in the row of teeth, i. e. sagittally, was observed in 25 (14.2%) of 176 third molars: in LJ in 15 (8.5%) molars, especially on the left in 7 (4.0%), and on the right in 8 (4.5%) teeth; in UJ in 10 (5.7%) teeth – 6 (3.4%) and 4 (2.3%) respectively. The presence of space for the third molars also depended on width at the equator, which appeared to be the smallest in UJ and varied from 10 mm to 15 mm with a mean of 11.7 mm, and the largest in LJ – from 12 mm to 19 mm, the mean was 14.17 mm. Differences in the means between left and right UJ third molars were not detected (11.8 mm and 11.8 mm respectively), and in LJ it was insignificant (14.2 mm and 14.1 mm). In individual cases, the difference was 2.0-4.0 mm, and 1.0 mm in LJ. The latter confirms some scientists’ conclusions that the sizes of upper third molars vary more widely. Retention of third molars in the subjects was associated with different dentofacial anomalies most commonly reported in 17 (38.6%) patients with distal occlusion (class ІІ) and in 13 (29.5%) persons with deep occlusion, and more rarely seen with medial (class ІІІ) – 4 (9.1%) – and open occlusion – 4 (9.1%). Clinical studies suggested that when selecting a tactic for treatment of retained teeth, apart from determining their position in jawbones and the presence of a sagittal space in the row of teeth, it is also necessary to determine the size of vertical retromolar space for them which was measured using silicone indexes. Persons with deep and distal occlusion had the narrowest alveolar space from 0.5 mm to 4 mm, while in those with neutral occlusion it was from 5 mm to 7 mm. Thus, the conducted studies showed the importance of the differentiated approach to the preservation of third molars, especially during orthodontic treatment.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ryuichiro Inaba ◽  
Satoshi Yamakawa ◽  
Takashi Kanamoto ◽  
Sho Ukimoto ◽  
Seira Sato ◽  
...  

AbstractThis study aimed to compare the physical activity (PA) measured by a wearable sensor device (WSD) and the step count measurement, and to investigate the association between PAs and lifestyle. Data of 301 participants were collected from March 2019 to March 2021. Step counts, sedentary behavior, performance time of light/moderate/vigorous PA, METs × hour of “Locomotive” and “Household” categorized activities, and energy expenditure (EE) were measured by the WSD, respectively. Furthermore, the participants were classified into student, standing worker, and sitting worker groups. Data were analyzed using the Steel–Dwass and Pearson correlation coefficient tests. The correlation between the performance time of each PA and step count was weak, except for moderate PA. “Household” EE and step count also had a weak correlation. In the comparison of lifestyle, there was a significant difference in the mean performance time of each type of PA between the groups. Additionally, the standing worker and sitting worker groups had a significant difference in METs × hour of "Household" activities, indicating that the difference between the occupations is reflected in “Household” activities. The WSD measurement can be used to evaluate detailed individual PA, whereas the step count measurement showed weakness in the PA estimation.


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