scholarly journals Effects of the association between APOE rs405509 polymorphisms and gene-environment interactions on hand grip strength among middle-aged and elderly people in a rural population in southern China

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Haoyu He ◽  
Huaxiang Lu ◽  
Shuzhen Liu ◽  
Jiansheng Cai ◽  
Xu Tang ◽  
...  
Keyword(s):  
Grip Strength ◽  
Elderly People ◽  
Rural Population ◽  
Southern China ◽  
Hand Grip Strength ◽  
Environment Interaction ◽  
Middle Aged ◽  
Hand Grip ◽  
Gene Environment ◽  
Significant Gene

Abstract Background Hand grip strength is a complex phenotype. The current study aimed to identify the effects of the association between APOE rs405509 polymorphisms and gene-environment interactions on hand grip strength among middle-aged and elderly people in a rural population in Gongcheng, southern China. Methods APOE rs405509 polymorphisms in 1724 participants (695 men and 1029 women, aged 45–97 years old) were genotyped using the Sequenom MassARRAY platform. Statistical analysis was conducted using SPSS 21.0 and Plink 1.90. Results The APOE rs405509 G allele was associated with lower hand grip strength in all participants (β = −1.04, P value <0.001), and the correlation seemed to be even stronger among women. A significant gene-environment interaction was observed between APOE rs405509 and smoking, especially in men. The hand grip strength of male smokers carrying the GG genotype was significantly higher than that of nonsmokers (P value = 0.004). Conclusions APOE rs405509 polymorphisms might be genetic factors that affect hand grip strength in a rural population in Gongcheng, southern China. The APOE rs405509-smoking interaction has an impact on hand grip strength.

scholarly journals Lower Percentage of Fat Mass among Tai Chi Chuan Practitioners

2020 ◽  
Vol 17 (4) ◽  
pp. 1232
Author(s):  
Silvia Stagi ◽  
Azzurra Doneddu ◽  
Gabriele Mulliri ◽  
Giovanna Ghiani ◽  
Valeria Succa ◽  
...  
Keyword(s):  
Body Composition ◽  
Grip Strength ◽  
Muscle Mass ◽  
Fat Mass ◽  
Tai Chi ◽  
Hand Grip Strength ◽  
Middle Aged ◽  
Tai Chi Chuan ◽  
Hand Grip ◽  
Total Body

The aim of the study was to analyze total and regional body composition in Tai Chi Chuan (TCC) middle-aged and elderly practitioners. A cross-sectional study on 139 Italian subjects was realized: 34 TCC practitioners (14 men, 20 women; 62.8 ± 7.4 years) and 105 sedentary volunteers (49 men, 56 women; 62.8 ± 6.4 years). Anthropometric measurements (height, weight, arm, waist, and calf circumferences), hand-grip strength, and physical capacity values were collected. Total and regional (arm, leg, and trunk) body composition was analyzed by means of specific bioelectrical impedance vector analysis (specific BIVA). TCC practitioners of both sexes were characterized by a normal nutritional status, normal levels of physical capacity, and normal values of hand-grip strength. Compared to controls, they showed lower percentages of fat mass (lower specific resistance) in the total body, the arm, and the trunk, and higher muscle mass (higher phase angle) in the trunk, but lower muscle mass in the arm. Sexual dimorphism was characterized by higher muscle mass (total body, arm, and trunk) and lower %FM (arm) in men; sex differences were less accentuated among TCC practitioners than in the control. TCC middle-aged and elderly practitioners appear to be less affected by the process of physiological aging and the associated fat mass changes, compared to sedentary people.

scholarly journals Total Dietary Antioxidant Capacity and Longitudinal Trajectories of Body Composition

Antioxidants ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 728
Author(s):  
Niels van der Schaft ◽  
Katerina Trajanoska ◽  
Fernando Rivadeneira ◽  
M. Arfan Ikram ◽  
Josje D. Schoufour ◽  
...  
Keyword(s):  
Body Composition ◽  
Antioxidant Capacity ◽  
Grip Strength ◽  
Multinomial Logistic Regression ◽  
Hand Grip Strength ◽  
Middle Aged ◽  
Hand Grip ◽  
Dietary Antioxidant ◽  
Multivariable Adjustment ◽  
Dietary Antioxidant Capacity

Although there is some evidence that total dietary antioxidant capacity (TDAC) is inversely associated with the presence of obesity, no longitudinal studies have been performed investigating the effect of TDAC on comprehensive measures of body composition over time. In this study, we included 4595 middle-aged and elderly participants from the Rotterdam Study, a population-based cohort. We estimated TDAC among these individuals by calculating a ferric reducing ability of plasma (FRAP) score based on data from food-frequency questionnaires. Body composition was assessed by means of dual X-ray absorptiometry at baseline and every subsequent 3–5 years. From these data, we calculated fat mass index (FMI), fat-free mass index (FFMI), android-to-gynoid fat ratio (AGR), body fat percentage (BF%) and body mass index (BMI). We also assessed hand grip strength at two time points and prevalence of sarcopenia at one time point in a subset of participants. Data were analyzed using linear mixed models or multinomial logistic regression models with multivariable adjustment. We found that higher FRAP score was associated with higher FFMI (0.091 kg/m2 per standard deviation (SD) higher FRAP score, 95% CI 0.031; 0.150), lower AGR (−0.028, 95% CI −0.053; −0.003), higher BMI (0.115, 95% CI 0.020; 0.209) and lower BF% (−0.223, 95% CI −0.383; −0.064) across follow-up after multivariable adjustment. FRAP score was not associated with hand grip strength or sarcopenia. Additional adjustment for adherence to dietary guidelines and exclusion of individuals with comorbid disease at baseline did not change our results. In conclusion, dietary intake of antioxidants may positively affect the amount of lean mass and overall body composition among the middle-aged and elderly.

scholarly journals The Combined Impact of Low Hand Grip Strength and Co-morbidity on the Risk of All-cause Mortality in Korean Middle-aged and Older Adults

2020 ◽  
Vol 29 (1) ◽  
pp. 40-50
Author(s):  
Inhwan Lee ◽  
Hyunsik Kang
Keyword(s):  
Grip Strength ◽  
Hand Grip Strength ◽  
Upper Body ◽  
Middle Aged ◽  
Hand Grip ◽  
Increased Risk ◽  
Co Morbidity ◽  
All Cause Mortality ◽  
Combined Impact

PURPOSE: This study investigated the combined impact of low hand grip strength (HGS) and number of comorbidities on the risk of all-cause mortality in Korean middle-aged and older adults.METHODS: Data from the 2006 baseline and 2016 follow-up assessments of the Korean longitudinal study of aging (KLoSA) involving 9,270 Korean adults aged ≥45 years (55.6% women) were used in the study. Study participants were classified as zero, one, and two or more categories based on number of co-morbidities and as high, middle, and low categories based on HGS distributions. The Cox proportional hazard models were used to estimate the hazard ratio (HR) and 95% confidence interval (CI) of all-cause mortality according to HGS categories and number of comorbidities.RESULTS: During the 9.7±2.7 year follow-up period, 1,285 deaths from all causes occurred. In both middle and low HGS categories, one and two or more comorbidities resulted in an increased risk of all-cause mortality (HR=1.493; 95% CI=1.220-1.828; <i>p</i><.001 and HR=1.427; 95% CI=1.190-1.711; <i>p</i><.001, respectively) compared to no comorbidity (HR=1). Furthermore, the increased risks of all-cause mortality remained significant even after adjustments for a number of confounders such as age, sex, socio-economic status, and parameters of health behaviors and conditions. In high HGS category, there were no significant differences in the risk of all-cause mortality according to number of co-morbidities.CONCLUSIONS: The current finding suggested that promotion of upper body muscular strength may play an important role in preventing premature death from all causes, especially among those who suffer from co-morbidities.

scholarly journals Associations between gut microbiota and hand grip strength: a polygenetic scoring analysis and genome-wide environmental interaction study

2020 ◽  
Author(s):  
Li Liu ◽  
Bolun Cheng ◽  
Yan Wen ◽  
Yumeng Jia ◽  
Shiqiang Cheng ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Grip Strength ◽  
Genome Wide Association Study ◽  
Significant Snps ◽  
Hand Grip Strength ◽  
Environment Interaction ◽  
Interaction Study ◽  
Phenotypic Data ◽  
Hand Grip ◽  
Genome Wide

Abstract Background We aim to explore the genetic association between hand grip strength (HGS) and gut microbiota (GM). Methods The genome-wide association study (GWAS) data of GM was obtained from a recently published study, involving 2,646 individuals. Phenotypic data of left HGS (n = 375,229) and right HGS (n = 375,279) were derived from the UK Biobank. Firstly, PLINK 2.0 was used to calculate 114 GM related polygenetic risk score (PRS) of each subject based on GWAS result. Regression analysis was then conducted to evaluate the possible association of GM-PRS and HGS. Then genome-wide by environment interaction study (GWEIS) of GM related traits was then performed using a regression model adjusted for age, gender, BMI and 10 principal components. Results For PRS analysis, 13 candidate GM were identified to be associated with left HGS (P < 0.05), including G_Bifidobacterium (P = 8.36 × 10− 4), G_Clostridium_sensu_stricto (P = 2.69 × 10− 3), and 10 significant GM for right HGS, such as G_Acidaminococcus (P = 1.29 × 10− 2), G_Streptococcus (P = 1.79 × 10− 2). In addition, 4 GM were found to be overlapped in association with both left and right HGS, including G_Bifidobacterium (P right HGS = 2.78 × 10− 2, P left HGS = 8.36 × 10− 4). Furthermore, several genome-wide significant GWEIS associations were detected for HGS, including 3 significant SNPs interacted with G_Butyricicoccus (P < 5 × 10− 8) for right HGS (rs41310432, P = 3.86 × 10− 8; closest gene: NASP; rs1053941, P = 4.71 × 10− 8; closest gene: NASP; rs6671239, P = 4.73 × 10− 8, closest gene: GPBP1L1), and 1 suggestive intronic SNP in CACNA1H on chromosome 16 interacted with G_Butyricicoccus (rs139206507, P = 8.68 × 10− 8 ) for left HGS. Conclusions Our study holds great potential gaining a better understanding of the relationship between GM and HGS.

scholarly journals Hand grip strength: Reference values for adults and elderly people of Rio Branco, Acre, Brazil

PLoS ONE ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. e0211452 ◽  
Author(s):  
Cledir Araújo Amaral ◽  
Thatiana Lameira Maciel Amaral ◽  
Gina Torres Rego Monteiro ◽  
Mauricio Teixeira Leite Vasconcellos ◽  
Margareth Crisóstomo Portela
Keyword(s):  
Grip Strength ◽  
Elderly People ◽  
Reference Values ◽  
Hand Grip Strength ◽  
Hand Grip

scholarly journals Benefits of Volunteering for Middle-Aged and Older Adults: Comparison Between Types of Volunteering Activities

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 405-406
Author(s):  
Edwin K H Chung ◽  
Alfred H K Lam ◽  
Dannii Yeung ◽  
Ka Hung Edwin Chung
Keyword(s):  
Older Adults ◽  
Life Satisfaction ◽  
Depressive Symptoms ◽  
Health Outcomes ◽  
Cognitive Functioning ◽  
Grip Strength ◽  
Hand Grip Strength ◽  
Middle Aged ◽  
Hand Grip ◽  
Effect Of Age

Abstract More middle-aged and older adults are often encouraged to volunteer (Gray et al., 2012). However, the effects of various volunteering activities on physical, psychological and cognitive health remain unknown. This study thereby aims to investigate such effects and the moderating effect of age in such associations. Data of 501 middle-aged and older Hong Kong Chinese adults (Mage = 53.06, SD = 4.55; and Mage = 70.46, SD = 7.34, respectively; range = 45 – 96) from a survey on Adult Development and Aging were analysed. Engagements in instrumental (e.g., food preparation, fundraising) and cognitively demanding volunteering (e.g., counselling, mentoring), hand-grip strength, life satisfaction, depressive symptoms, and cognitive functioning were measured. Factorial ANOVA revealed significant main effects of age group and volunteering type (F = 29.71, and F = 3.96, respectively, ps &lt; .001), and an interaction effect of age and volunteering type (F =1.80, p = .03) on health outcomes. Comparisons among the four volunteering types (no volunteering, instrumental volunteering, cognitively demanding volunteering, and both types) revealed that individuals engaging in cognitively demanding volunteering had better hand-grip strength, life satisfaction, and cognitive functioning, and lower depressive symptoms than those who engaged in instrumental volunteering (all ps &lt; .05). The health outcomes of instrumental volunteering were even worse than those who did not volunteer at all. These patterns were more prevalent in the middle-aged adults than in the older adults. Findings of this study indicated the beneficial effects of cognitively demanding volunteering, providing valuable directions for future programs on volunteering.

scholarly journals Body Composition Symmetry in Long-Term Active Middle-Aged and Older Individuals

2021 ◽  
Vol 18 (11) ◽  
pp. 5956
Author(s):  
Silvia Stagi ◽  
Alessia Moroni ◽  
Margherita Micheletti Cremasco ◽  
Elisabetta Marini
Keyword(s):  
Body Composition ◽  
Grip Strength ◽  
Tai Chi ◽  
Bioelectrical Impedance ◽  
Hand Grip Strength ◽  
The Body ◽  
Control Group ◽  
Older Individuals ◽  
Middle Aged ◽  
Hand Grip

This study aimed to analyze body composition and strength symmetry in a sample of 165 middle-aged and elderly Italian volunteers, which included 97 active (67 men and 30 women; 61.17 ± 7.56 years) individuals regularly engaged in Tai Chi Chuan, tennis, or running, and a control group of 59 age-matched sedentary (27 men and 32 women) individuals. Anthropometric and bioelectrical measurements and hand grip strength of both sides were collected. Segmental body composition was analyzed through specific bioelectrical impedance vector analysis. The body composition of the right and left limbs was similar among active individuals (arms: T2 = 6.3, n.s.; legs: T2 = 5.0, n.s.), with a similar pattern in the three different disciplines. By contrast, the control group showed bilateral asymmetry (arms: T2 = 6.8, p < 0.001; legs: T2 = 8.8, p < 0.001), mainly because of the higher values of specific reactance (t = 2.4; p = 0.018) and phase angle (t = 2.0; p = 0.054) in the dominant arm, and the higher specific vector length (t = −3.0; p = 0.027) in the left leg. All of the groups showed a higher hand grip strength in the dominant arm (active: t = 7.0, p < 0.001; control: t = 2.9; p < 0.01). In conclusion, the active individuals showed stronger body composition symmetry than the controls, thus indicating a previously undetected positive effect of sport in middle-aged and older adults.

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