scholarly journals Effectiveness of saline water and lidocaine injection treatment of intractable plantar keratoma: a randomised feasibility study

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Marie-Philippe Mercier ◽  
Virginie Blanchette ◽  
Vincent Cantin ◽  
Magali Brousseau-Foley

Abstract Background An intractable plantar keratoma (IPK) is a conical thickening of the epidermis’ stratum corneum and a common cause of foot pain which can have a significant, detrimental impact on the mobility, quality of life and independence of individuals. Conservative treatments are currently offered to patients with IPK, but they are unsatisfactory since they do not offer a sufficient or permanent reduction of symptoms. The purpose of this study was the evaluation of the feasibility, safety and effectiveness of innovative treatments for intractable plantar keratoma (IPK). Methods A randomized single blind trial with 40 patients divided with block randomization in four parallel groups was conducted to compare treatment combinations: conservative sharp debridement only or sharp debridement with needle insertion, physiological water injection or lidocaine injection. All patients obtained the same treatment four times at a four-week interval. At each visit, visual analog scale (VAS), Foot Function Index (FFI) and IPK size were evaluated. VAS and FFI were also completed at a six and twelve-month follow-up. Results Our findings in regards to feasibility demonstrated recruitment challenges because of the anticipated pain that would be provoked by needle insertion may not be worth the potential pain relief compared to debridement alone from the patient’s perspective. This was also the principal cause of drop out. Our preliminary results show no main effect of group for any of the clinical outcomes: pain felt on VAS, FFI score, IPK’s size (p > 0.05). However, the analysis revealed a statistically significant effect of time on VAS (p < 0.001), FFI score (p < 0.001) and IPK’s size (width and depth (p < 0.001); length (p = 0.001)), but no group x time interaction was found (p > 0.05). Conclusions This study demonstrates that IPK treatment consisting of sharp debridement with needle insertion, physiological saline water injection or lidocaine injection is feasible and safe. There was a non-statistically significant trend toward diminishing pain intensity compared to scalpel debridement alone. The pain provoked by needle insertion and injection treatments must be addressed with a scientifically proven protocol to make it more comfortable for patients before these treatments could be considered in further studies. Trial registration ClinicalTrials.gov, NCT04777227. 2 March, 2021 - Retrospectively registered (All participants were recruited prior to registration).

Agronomy ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 796
Author(s):  
Mohamed A. Mattar ◽  
Said S. Soliman ◽  
Rashid S. Al-Obeed

A field experiment was conducted on date palm trees (Phoenix dactylifera ‘Succary’) cultivated on sandy loam soil from 2017 to 2018. This study investigated the effects of providing water of three different qualities, namely freshwater (FR) and two saline water sources: reclaimed wastewater (RW) and well-water (WE) applied through three irrigation levels representing 50% (I50), 100% (I100), and 150% (I150) of crop evapotranspiration (ETc), on the soil water and salt distribution patterns, yield, water productivity (WP), and fruit quality of the ′Succary′ date palm. The electrical conductivity (ECw) of FR, RW, and WE were 0.18, 2.06, and 3.94 dS m−1, respectively. Results showed that WE applied by the I150 treatment had the highest soil water content, followed by RW used in the I100 irrigation level and FR with I50, whereas the soil salt content was high for WE applied in the I50 level and low for FR applied by the I150 treatment. Deficit irrigation (I50) of date palms with either RW or WE reduced date yields on average 86 kg per tree, whereas the yield increased under over-irrigation (I150) with FR to 123.25 kg per tree. High WP values were observed in the I50 treatments with FR, RW, or WE (on average 1.82, 1.68, and 1.67 kg m−3, respectively), whereas the I150 treatment with each of the three water types showed the lowest WP values. Fruit weight and size were the lowest in the full irrigation (I100) with WE, whereas the I150 treatment with RW showed the highest values. There were no significant differences in either total soluble solids (TSS) or acidity values when the irrigation level decreased from 100% to 50% ETc. Compared with both I50 and I100 treatments, reduced values of both TSS and acidity were observed in the I150 treatment when ECw decreased from 3.94 to 0.18 dS m−1,. Fruit moisture content decreased with the application of saline irrigation water (i.e., RW or WE). Total sugar and non-reducing sugar contents in fruits were found to be decreased in the combination of RW and I150, whereas the 50% ETc irrigation level caused an increment in both parameters. These results suggest that the application of deficit irrigation to date palm trees grown in arid regions, either with FR or without it, can sufficiently maximize WP and improve the quality of fruits but negatively affects yield, especially when saline water is applied. The use of saline water for irrigation may negatively affect plants because of salt accumulation in the soil in the long run.


2021 ◽  
pp. 62-63
Author(s):  
Neha Thakur ◽  
B.L. Mehra ◽  
Sunil Thakur ◽  
Anil Bhardwaj

Osteoporosis is an alarming issue in the society today. It is continuously increasing its signicance with increasing elderly population and is affecting both the sexes at different degrees. It is characterized by low bone mass with microarchitectural deterioration of bone leading to enhanced bone fragility, thus increasing the susceptibility to fracture. Taking into account the references available in various Ayurvedic classics it can be correlated to Asthikshaya. Asthikshaya occurs due to decrease in strength of Asthi Dhatu chiey due to Kala, Swabhava and Vata Prakopa. International Osteoporosis Foundation estimated that the annual direct cost of treating osteoporotic fractures has increased grossly. In India the general population is not much aware about the hazardous complications of osteoporosis. The modern pharmacological treatment is long and beyond the nancial reach of common people. Therefore the best way to deal with it is to prevent this as early as possible. To achieve this aim a clinical study was conducted to evaluate the effect of an Ayurvedic Formulation known as Eleg Fem capsules (Asthishrinkhalaadi Yoga) in osteoporotic patients. In the clinical trial 30 patients above the age of 40 years with low BMD T-Score were registered from OPD and IPD of Kayachikitsa department of Rajiv Gandhi Govt. Post Graduate Ayurvedic College and Hospital Paprola, Kangra. Out of 30 patients, 27 completed the trial and 3 patients were drop out. Criteria of assessment of patients was change in bone mineral density (BMD T- Score) and change in the score of Quality of Life Index Questionnaire for Osteoporosis (QUALEFFO-41). All the registered patients were given the formulation for 6 weeks. Improvement was observed with statistically signicant results on mean BMD TScore and moderately signicant result on Quality of Life Index scoring. The study revealed that the Eleg Fem capsules (Asthishrinkhalaadi Yoga) is a safe and effective therapy in the Osteoporotic patients.


Author(s):  
Leandro de P. Souza ◽  
Reginaldo G. Nobre ◽  
Evandro M. da Silva ◽  
Geovani S. de Lima ◽  
Francisco W. A. Pinheiro ◽  
...  

ABSTRACT The objective of this research was to evaluate the growth and formation of fresh and dry weight of ‘Crioula’ guava rootstock irrigated with waters of different saline levels and nitrogen (N) doses, in an experiment conducted in plastic tubes under greenhouse conditions. The experimental design was randomized blocks, in a 5 x 4 factorial scheme with four replicates, and the treatments consisted of five levels of water electrical conductivity - ECw (0.3, 1.1, 1.9, 2.7 and 3.5 dS m-1) and four N doses (70, 100, 130 and 160% of the N dose recommended for the cultivation of guava seedlings, cv. ‘Paluma’). The dose referring to 100% corresponds to 773 mg of N dm-3. The highest growth of ‘Crioula’ guava rootstock was obtained with ECw of 0.3 dS m-1 and fertilization of 541.1 mg N dm-3 of soil; increasing N doses did not reduce the deleterious effect of the salt stress on the growth and phytomass formation of ‘Crioula’ guava rootstock; irrigation with water of up to 1.75 dS m-1, in the production of guava rootstocks, promotes acceptable reduction of 10% in growth and quality of the seedlings.


1998 ◽  
Vol 7 (6) ◽  
pp. 487-494 ◽  
Author(s):  
J. M. Raboud ◽  
J. Singer ◽  
A. Thorne ◽  
M. T. Schechter ◽  
S. D. Shafran

2017 ◽  
Vol 46 (4) ◽  
pp. 463-478
Author(s):  
Rita Younan ◽  
Joan Farrell ◽  
Tamara May

Background: Group schema therapy is an emerging treatment for personality and other psychiatric disorders. It may be particularly suited to individuals with complex trauma given that early abuse is likely to create maladaptive schemas. Aims: This pilot study explored the feasibility and effectiveness of a 4-week in-patient group schema therapy programme for adults with complex trauma in a psychiatric hospital setting. Method: Thirty-six participants with complex trauma syndrome participated in this open trial. Treatment consisted of 60 hours of group schema therapy and 4 hours of individual schema therapy administered over 4 weeks. Feasibility measures included drop-out rates, qualitative interviews with participants to determine programme acceptability and measures of psychiatric symptoms, self-esteem, quality of life and schema modes pre-, post- and 3 months following the intervention. Results: Drop-out rate for the 4-week program was 11%. Thematic analysis of interview transcripts revealed four major themes: connection, mode language explained emotional states, identifying the origin of the problem and the emotional activation of the programme. Measures of psychiatric symptoms, self-esteem and quality of life showed improvement post-treatment and at 3 months post-treatment. There was a reduction in most maladaptive schema modes pre-/post-treatment. Conclusions: A group schema therapy approach for complex trauma is feasible and demonstrates positive effects on psychiatric symptoms and maladaptive schemas.


Irriga ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 549-561
Author(s):  
RAFAEL RAMOS MORAIS ◽  
JOÃO PAULO SILVA MACÊDO ◽  
LOURIVAL FERREIRA CAVALCANTE ◽  
JACKSON TEIXEIRA LOBO ◽  
ANTÔNIO GUSTAVO LUNA SOUTO ◽  
...  

ARRANJO ESPACIAL E PODA NA PRODUÇÃO E QUALIDADE QUÍMICA DE MARACUJÁ IRRIGADO COM ÁGUA SALINA     RAFAEL RAMOS MORAIS1; JOÃO PAULO SILVA MACÊDO2; LOURIVAL FERREIRA CAVALCANTE3; JACKSON TEIXEIRA LOBO1; ANTÔNIO GUSTAVO LUNA SOUTO1 E EVANDRO FRANKLIN MESQUITA4   1 Programa de pós-graduação em Agronomia, Departamento de Fitotecnia e Ciências Ambientais do Centro de Ciências Agrárias, Universidade Federal da Paraíba, Rodovia PB 079, SN, Km 12, 58.397-000, Areia, Paraíba, Brasil, [email protected]; [email protected], [email protected]. 2 Empresa Paraibana de Pesquisa, Extensão Rural e Regularização Fundiária, Rodovia BR 230, S/N, Km 13, Morada Nova, 58.108-502, Cabedelo, Paraíba, Brasil, [email protected]. 3 Professor do Departamento de Solos e Engenharia Rural, Universidade Federal da Paraíba, Rodovia PB 079, S/N, Km 12, 58.397-000, Areia, Paraíba, Brasil, [email protected]. 4 Professor do Centro de Ciências Humanas e Agrárias, Universidade Estadual da Paraíba, Sitio Cajueiro, S/N, Zona Rural, 58.884-000, Catolé do Rocha, Paraíba, Brasil, [email protected].     1 RESUMO   Um experimento foi desenvolvido no município de Coronel Ezequiel, Estado do Rio Grande do Norte, Brasil, para avaliar os efeitos da densidade de plantio e poda da haste principal em plantas de maracujazeiro amarelo, acesso Guinezinho, sob irrigação com água salina de 3,4 dS m-1. Os tratamentos, com distância de 2,0 m entre linhas, foram distribuídos em blocos ao acaso, com quatro repetições de 12 plantas por parcela, em esquema fatorial 4 × 2, correspondente as distâncias de 3, 6, 9 e 12 m entre plantas nas linhas com e sem poda da haste principal, ao atingir o sistema de sustentação. Os componentes avaliados foram número de frutos colhidos, produção por planta, produtividade e na polpa dos frutos, os valores de sólidos solúveis, acidez titulável, pH e a relação sólidos solúveis/ acidez titulável. A interação entre os fatores estudados exerceu efeitos significativos no número de frutos colhidos, produção por planta, teor de sólidos solúveis e acidez titulável. A produtividade foi influenciada pelos dois fatores de forma isolada. O pH da polpa respondeu apenas ao espaçamento entre plantas nas linhas e a relação SS/AT não foi influenciada por nenhuma das fontes de variação estudadas. O aumento das distâncias de plantio nas linhas promove ganho de produção por planta, mas reduz a produtividade. Plantas podadas na haste principal apresentam maior produtividade. A irrigação com água de qualidade restritiva à agricultura não inibiu a capacidade produtiva do maracujazeiro amarelo acesso Guinezinho e não prejudicou a qualidade química dos frutos.   Palavras-chave: acesso Guinezinho, densidade de plantio, Passiflora edulis Sims.     MORAIS, R. R.; MACÊDO, J. P. S.; CAVALCANTE, L. F.; LOBO, J. T.; SOUTO, A. G. L.; MESQUITA, E. F. SPATIAL ARRANGEMENT AND PRUNING IN THE PRODUCTION AND CHEMICAL QUALITY OF YELLOW PASSIONFRUIT IRRIGATED WITH SALINE WATER       2 ABSTRACT   An experiment was carried out in  Coronel Ezequiel municipality, Rio Grande do Norte State, Brazil, to evaluate the effects of planting density and pruning of the main stem on yellow passion fruit plants access Guinezinho under irrigation with saline water (3.4 dS m-1). The treatments, with inter-row distance of 2 m, were distributed in randomized blocks, with four replications of 12 plants per plot, in a 4 × 2 factorial scheme, corresponding to intra-row distances of 3, 6, 9 and 12 m for plants with and without pruned main stem, upon reaching the support system. The evaluated components were number of fruit harvested, production per plant, fruit yield and in the fruit pulp, the analyzed components were soluble solid content, titratable acidity, pH and soluble solid content/ titratable acidity ratio. The interaction between the factors studied significantly affected the number of fruit harvested, production per plant, solids content and titratable acidity. The fruit yield was influenced by the two isolated factors, but the pH of the pulp responded only to the intra-row plant spacing, and the solids content/ titratable acidity ratio was not influenced by any of the sources of variation studied. Increasing the distances intra-row raises the production per plant, but reduces fruit yield. Plants pruned on the main stem have higher fruit yield. Irrigation with restrictive water quality to agriculture did not inhibit the productive capacity of yellow passion fruit access Guinezinho and did not impair the chemical quality of the fruits.   Keywords: Guinezinho access, planting density, Passiflora edulis Sims.


2019 ◽  
Vol 5 (15) ◽  
pp. 343-351
Author(s):  
Iip Saripah ◽  
Nike Kamarubiani ◽  
D. Nunu Heryanto ◽  
Holva Lovana Siregar ◽  
Ari Putra ◽  
...  

The research specifically discussed PKBM as an institution that could facilitate the needs of the community and could increase more empowered human resources with a variety of capabilities through economic strengthening. The researchers want to know how does the PKBM institution as a strong institution that is able to partner and be able to assist disadvantaged communities. The purpose of this study in general is to obtain a clear picture of determinant in institutional strengthening, improving the quality of PKBM services, and human resource development through a participatory partnership model in PKBM. The conceptual framework of the research refers to the concept of PKBM, the concept of capacity building and the concept of partnership. This research used a qualitative approach with descriptive method. The location is chosen in Cimahi, Tasikmalaya,, and Karawang Regency. The results obtained are: (1) the first determinant factor is educators, in general, the objective conditions of educators in PKBM are few and there are educators who do not meet the competency standards that they must have. (2) Students become the next determinant factor, PKBM recruits students by opening registration and registering students who drop out of school in formal schools then asks the school to refer students to continue their education at PKBM. (3) PKBM, which is stablished based on community self-help certainly has limitations in facilities and infrastructure, starting from the inadequate amount and quality that is no longer good. (4) In meeting the needs of program sustainability, PKBM has attended by carrying out a variety of businesses, but this has not been able to meet overall needs. (5) PKBM has business activities such as selling products made by students in the form of food or handicrafts, but has limitations in the marketing process. Keywords Determinant Factors, Capacity Building, Partipatory Partnership, Quality of PKBM Service


2015 ◽  
Vol 1 ◽  
pp. 62-66
Author(s):  
Noor Jung Shah

Nepal government and non-governmental organization are working in the field of education and focusing to ensure the quality of education with total enrolment of children in school. However, there is lacking to address the children affected by AIDS (CABA) to ensure the education rights and CABA compel to drop out from education. HIV issues are existing since 1998 but government of Nepal developed the policy on education to CABA in 2011; therefore we can analyze the status of government concentration on education to children affected by AIDS. The article is based on field experiences and secondary sources because I have been involving in this field since 1995 and focusing in children affected by AIDS. Stigma and discrimination is the main cause to drop the school by children affected by AIDS and there are no specific strategies to intervene to continue the education of children affected by AIDS. Government of Nepal has program to other children like children with disability or scheduled caste or geographical based but do not have the program to support the children affected by AIDS. Children affected by AIDS have always challenges to face the stigma and discrimination at schools and society which directly affect on their education.DOI: http://dx.doi.org/10.3126/jtd.v1i0.13092 Journal of Training and Development Vol.1 2015: 62-66


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