scholarly journals Urethral cancer managed with phallus preserving surgery: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Emily Walsh ◽  
Niall Kelly ◽  
Padraig Daly ◽  
Nigam Shah ◽  
Ivor Cullen
Keyword(s):  
Inguinal Lymph Node ◽  
Anatomical Location ◽  
Essential Factor ◽  
Papilloma Virus ◽  
Case Presentation ◽  
Male Predominance ◽  
Urethral Carcinoma ◽  
Tumour Biopsy ◽  
Rare Malignancy ◽  
Contemporary Management

AbstractBackgroundPrimary urethral carcinoma (PUC) is rare and accounts for < 1% of all genito-urinary cancers. There is a male predominance of 3:1 and a peak incidence in the 7th and 8th decades. The aetiology of this cancer is similar to penile cancer, and the human papilloma virus (HPV) is thought to be an essential factor in tumorigenesis. Urethral cancer should be diagnosed and staged with a combination of tumour biopsy, MRI, and CT with treatment involving a multimodal approach. Contemporary management emphasises phallus-preserving surgery where feasible.Case presentationHere, we describe a case of distal urethral carcinoma, which presented as a metastatic groin mass and identifying the primary lesion proved challenging. Diagnostic flexible cystoscopy identified a tiny lesion in the navicular fossa, which was biopsied and confirmed to be a squamous cell carcinoma. The patient then underwent phallus preserving surgery, including distal urethrectomy with bilateral inguinal lymph node dissections. The final stage was pT1N1M0, and adjuvant chemotherapy was started. The distal urethrectomy involved the surgical creation of a hypospadic meatus in the midshaft of the penis. Normal voiding and sexual function were preserved.ConclusionsUrethral cancer is a rare malignancy and clinicians should bear in mind that early diagnosis of this disease can be very difficult depending on the anatomical location of the tumour. Treatment currently favours penis-preserving surgery.

scholarly journals Metastatic Adenocarcinoma of Para-urethral Gland Presenting as Inguinal Lymph Node and Recurrent Bulbar Urethral Stricture

2020 ◽  
Vol 3 (2) ◽  
pp. e1-e4
Author(s):  
Adam Jones ◽  
Samuel Mills ◽  
Sinthuja Naguleswaran ◽  
Tom Newton ◽  
Mohan Pillai
Keyword(s):  
Lymph Node ◽  
Urethral Stricture ◽  
Inguinal Lymph Node ◽  
Case Reports ◽  
Treatment Options ◽  
Male Predominance ◽  
Urethral Carcinoma ◽  
Gland Carcinoma ◽  
Adjusted Incidence

Para-urethral gland carcinoma is a rare urological malignancy that has a male predominance and has an age-adjusted incidence of 1.5–4.3/million. There are various histological subtypes of para-urethral carcinoma, with adenocarcinoma representing only 16.4% of these. Treatment is dependent on site, stage and patient factors. A multimodal approach is often adopted for the treatment of this malignancy. This includes radical surgery based on site of malignancy and there have been various case reports describing the role of adjuvant chemotherapy. However, there is still no agreed recommendation or available evidence for treatment of this infrequently encountered malignancy. The majority of patients present with symptoms of advanced disease and outcomes remain poor. We report a case of para-urethral gland adenocarcinoma presenting as recurrent bulbar urethral stricture and inguinal lymph node metastasis. This case report aims to highlight the rarityof the disease and discuss treatment options for this uncommon urological malignancy.

Distal urethral carcinoma: Contemporary management with phallus preserving techniques

The Surgeon ◽  
2022 ◽  
Author(s):  
J.A. O'Kelly ◽  
E. Browne ◽  
P. Murray ◽  
J. Keane ◽  
P. Daly ◽  
...  
Keyword(s):  
Urethral Carcinoma ◽  
Contemporary Management

scholarly journals Intraoral Sebaceous Carcinoma: Case Report of a Rare Tumor Emphasizing the Histopathological Differential Diagnosis

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Manveen Kaur Jawanda ◽  
R. V. Subramanyam ◽  
Harshaminder Grewal ◽  
Chitra Anandani ◽  
Ravi Narula
Keyword(s):  
Differential Diagnosis ◽  
Oral Cavity ◽  
Sebaceous Carcinoma ◽  
Rare Tumor ◽  
Radiographic Findings ◽  
Case Presentation ◽  
Clinical Appearance ◽  
Cutaneous Malignancy ◽  
The Face ◽  
Rare Malignancy

Background. Sebaceous carcinoma (SC) is an uncommon cutaneous malignancy, usually occurring predominantly in the eyelids and only occasionally involving the oral cavity. Sebaceous carcinoma (SC) is a rare malignancy. Only 10 cases of sebaceous carcinoma of the oral cavity have been reported so far. Case Presentation. A 40-year-old female presented with a mass on the left side of the middle third of the face. Radiographic findings were inconclusive. Resection of the mass was consistent with the diagnosis of primary sebaceous carcinoma. Conclusion. Intraoral sebaceous carcinoma is uncommon. Due to its varied clinical appearance and presence of a diverse histopathologic appearance, the diagnosis is quite often confounding and elusive. Hence, it is imperative to familiarize oneself about various aspects of this rare tumor for earlier diagnosis, to improve the chances of patient’s survival.

scholarly journals Ovarian ependymoma presenting in pregnancy: a case report and literature review

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Bo Jin ◽  
Jingjing Jiang ◽  
Hongfa Peng
Keyword(s):  
Early Stage ◽  
Progesterone Receptors ◽  
Ovarian Neoplasm ◽  
Ependymal Cells ◽  
Positive Staining ◽  
Case Presentation ◽  
Pathological Type ◽  
Mother And Child ◽  
Rare Malignancy

Abstract Background Ovarian ependymoma is a rare malignancy. Because of the extreme rarity, certain features of the neoplasm, including its clinical behaviour and optimal therapy, are incompletely characterized. Case presentation A 32-year-old pregnant woman at term presented with a left ovarian neoplasm that occurred in the early stage of pregnancy. She underwent left adnexectomy during the caesarean section, and the neoplasm was histologically and immunohistochemically identified to be ovarian ependymoma. Immunohistochemical staining with oestrogen receptors and progesterone receptors showed strong positive staining. According to reports in the literature, the pathological type of ovarian ependymoma in our patient was the extra-axial type. Interestingly, the foetus was also found to have bilateral ependymal cysts during pregnancy. The patient received no further surgical treatment or adjuvant therapy. She and her 14-month-old baby both have no evidence of disease at present. The follow-up of both mother and child is still continuing. Conclusions The case presented here illustrates high levels of oestrogen during pregnancy may stimulate viable malignant ependymal cells to proliferate. Hence, young women with extra-axial-type ependymomas may not be suitable for fertility preservation. Moreover, hormone-based therapies can be a potentially effective treatment for women with extra-axial ependymomas.

scholarly journals Scalp Metastasis of Cervical Cancer With Favorable Outcome

2020 ◽  
Vol 8 (3) ◽  
pp. 333-335
Author(s):  
Elham Saffarieh ◽  
Setare Nassiri ◽  
Maedeh Brahman ◽  
Soheila Amini Moghaddam ◽  
Shima Hosseini
Keyword(s):  
Cervical Cancer ◽  
Multidisciplinary Approach ◽  
Uterine Cervical Cancer ◽  
Radical Excision ◽  
Hematogenous Spread ◽  
Papilloma Virus ◽  
Case Presentation ◽  
Frontal Part ◽  
Scalp Metastasis

Introduction: Carcinoma of the uterine cervix is the most common gynecological malignancies in developing countries. Human papilloma virus is known as the main etiology. In addition, the spread of uterine cervical cancer often occurs through direct local extension and the lymphatics although the hematogenous spread is uncommon. Further, the scalp metastasis of cervical cancer is extremely rare. Case Presentation: In this regard, a 50-year-old woman with scalp metastasis of previous cervical cancer was discussed in the present study. She was suffering from a fast-growing and painful nodule, located on the frontal part of the scalp as a sole site of metastasis. A multidisciplinary approach was considered for her, which consisted of radical excision, followed by radiotherapy and chemotherapy. Given the lack of abundant evidence for the efficacy of this treatment, our patient has fortunately survived for more than two years. Conclusions: During the follow-up period after the completion of treatment, it is not sensible to only focus on the primary site of the tumor and thus entire examination is mandatory in this regard.

scholarly journals Primary Manifestation of Sarcoidosis Involving the Gingivae

2012 ◽  
Vol 1 (2) ◽  
pp. 102-105 ◽  
Author(s):  
Catherine Saylor ◽  
Nabil Beaini ◽  
James Rokos ◽  
Keerthana Satheesh ◽  
Charles Cobb
Keyword(s):  
Clinical Signs ◽  
Signs And Symptoms ◽  
Definitive Diagnosis ◽  
Anatomical Location ◽  
Case Presentation ◽  
Histologic Analysis ◽  
Appropriate Treatment ◽  
Clinical Signs And Symptoms

ABSTRACT Sarcoidois of the gingiva is rarely the primary manifestation of the disease. The following case presentation highlights clinical signs and symptoms that are not uncommon or unusual except for the anatomical location of the initial expression. Appropriate treatment must be based on a definitive diagnosis which, in turn, requires a biopsy for histologic analysis. How to cite this article Saylor C, Beaini N, Rokos J, Satheesh K, Cobb C. Primary Manifestation of Sarcoidosis Involving the Gingivae. Int J Experiment Dent Sci 2012;1(2):102-105.

scholarly journals Endoscopic management of foreign bodies from the upper gastrointestinal tract in the hills of Himachal Pradesh, India: A 5-year tertiary care experience

2016 ◽  
Vol 07 (04) ◽  
pp. 144-147
Author(s):  
Brij Sharma ◽  
Sujeet Raina ◽  
Neetu Sharma ◽  
Rajesh Sharma ◽  
Neelam Grover ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Tertiary Care ◽  
Clinical Problem ◽  
Upper Gastrointestinal Tract ◽  
Endoscopic Management ◽  
Anatomical Location ◽  
Upper Endoscopy ◽  
Care Experience ◽  
Male Predominance ◽  
Upper Gastrointestinal

Abstract Background and Aim: Foreign body (FB) ingestion is a common clinical problem in medical practice. Endoscopy is the therapeutic method of choice for the management of FBs with minimal complications. The aim of this study is to report our experience and outcome in a 5-year period in dealing with FBs in the upper gastrointestinal tract (GIT) using upper endoscopy. Materials and Methods: The records of all the patients who presented to the Department of Gastroenterology and who underwent endoscopic management between January, 2010, and December, 2014, were reviewed with details on age, sex, type of FBs and its anatomical location, treatments, and outcomes. Results: A total of 59 patients were analyzed. Their age ranged from 2 years to 87 years. A male predominance was noticed (59.4%). Coins and chicken bone shared the most commonly encountered FBs. Esophagus was the most common site of trapping (49/59). Upper endoscopy successfully resolved the problem by FB removal in all patients, thus the overall success rate was 100%. No complications or mortalities due to FB ingestion or removal were observed throughout the study. Conclusion: In our experience, endoscopic management of FBs in upper GIT is a safe and highly effective procedure.

Comprehensive genomic profiling in malignant myoepithelioma to suggest potential alternative diagnosis.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e23530-e23530
Author(s):  
Brittany Siontis ◽  
Jonathan B. McHugh ◽  
Alexa Betzig Schrock ◽  
Dean Pavlick ◽  
Jeffrey S. Ross ◽  
...  
Keyword(s):  
Genomic Profiling ◽  
University Of Michigan ◽  
Male Predominance ◽  
Molecular Alterations ◽  
Common Location ◽  
Ewsr1 Rearrangement ◽  
Ffpe Samples ◽  
Comprehensive Genomic Profiling ◽  
Histopathologic Evaluation ◽  
Rare Malignancy

e23530 Background: Malignant myoepithelioma of soft tissue (MM) is a rare tumor affecting patients (pts) of any age without sex predilection. MM has varied histopathologic findings, with epithelioid and spindle components and differentiation along osseous, chondroid or other lineages. Morphologic features suggest MM, however histologic overlap with other lesions exists. Diagnosis requires ancillary immunohistochemical &/or molecular studies; EWSR1 rearrangement with various fusion partners has been reported. Clinical behavior is varied and poorly understood due to disease rarity. Here, we undertook comprehensive genomic profiling (CGP) of MM to evaluate for potential targetable molecular alterations and report clinical outcomes. Methods: We identified pts with MM treated at University of Michigan (UM) from 2000-2017, obtained clinical data and reviewed pathology on 10 available samples and performed integrative sequencing through Michigan Oncology Sequencing Program (MI-ONCOSEQ) on 6. For 31 additional FFPE samples, hybrid capture-based DNA CGP (n = 16) or DNA+RNA CGP (n = 15) was performed (Foundation Medicine, FM). Results: 13 pts were treated at UM; median age at diagnosis was 52 (22-88) with male predominance (9/13). Primary tumor size was 3 cm (2-9.5) and most common location was trunk (4/13) and extremity (3/13). Four pts with metastatic disease (mets) underwent systemic chemotherapy with 0 responses. Median progression free and overall survival in mets was 20 (5-75) and 57 (12-91) months, respectively. CGP analyses of all samples (Table) revealed EWSR1 rearrangement in 8.1% (3/37) and presence of PHF1-TFE3 and CIC:DUX4 rearrangements in 16% (6/37). Independent blinded histopathology review of whole slides and tissue is underway. Conclusions: MM is a rare malignancy with variable clinical course. In our series, pts with mets derived little benefit from systemic therapy. CGP revealed CDKN2A/B alteration as the most prevalent with few harboring EWSR1 rearrangement. PHF1-TFE3 was recently described in ossifying fibromyxoid tumor (OFMT) that may represent a subset of OFMT not yet expressing bone markers. The presence of hypermutation and CIC:DUX4 fusions also suggests potential alternate diagnosis. These results indicate that CGP could complement histopathologic evaluation to aid in diagnoses and treatment of this entity. [Table: see text]

Neuro-imaging findings in children with developmental delay and cerebral palsy: experience from a tertiary medical center of Bangladesh

2021 ◽  
Vol 11 (2) ◽  
pp. 112-115
Author(s):  
Naheed Nabi ◽  
Jannatara Shefa ◽  
Shaheen Akhter
Keyword(s):  
Cerebral Palsy ◽  
Ct Scan ◽  
Developmental Delay ◽  
Medical Center ◽  
Common Finding ◽  
Anatomical Location ◽  
Cross Sectional ◽  
Female Ratio ◽  
Male Predominance ◽  
Neuro Imaging

Background: Cerebral palsy (CP) is the most common developmental disability in children. Neuro-imaging in CP is widely used investigation. Imaging study can visualize the anatomical location of lesion in brain. The aim of this study was to find out the extent of non-progressive damage in brain among children with CP. Methods: This was a cross-sectional study. Data were collected from the out-patient department of Institute of Pediatric Neurodisorders & Autism (IPNA), Bangabandhu Sheikh Mujib Medical University (BSMMU) from December, 2019 to March, 2020. Results: Total 88 cases (age up to 14 years) were reviewed. There was male predominance and male to female ratio was 2:1. Computed tomography (CT) scan was done in majority of patients (71 cases) and magnetic resonance imaging (MRI) in 17 cases. Major abnormalities were atrophy in 34.1% cases, ventricular dilatation in 14.8% cases, encephalomalacia in 19.3% cases and basal ganglia lesion in 11.4% cases. Overall in CT scan group, 95.77% cases were abnormal and in MRI group, 88.23% were abnormal. Conclusion: Atrophy of the brain was the most common finding in neuro-imaging of patients with CP and developmental disabilities. Neuro-imaging is very useful and recommended for the children with developmental delay and CP cases. It may help to classify the CP and may give a clue for further investigations such as metabolic screening and genetic testing. Birdem Med J 2021; 11(2): 112-115

Sign in / Sign up

Export Citation Format

Share Document