scholarly journals The impact of high intensity care around birth on long-term neurodevelopmental outcomes

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Corneliu Bolbocean ◽  
Michael Shevell
Keyword(s):  
High Intensity ◽  
Neurodevelopmental Outcomes ◽  
The Impact

scholarly journals TwinLIFE: The Twin Longitudinal Investigation of FEtal Discordance

2019 ◽  
Vol 22 (6) ◽  
pp. 617-622 ◽  
Author(s):  
Sophie G. Groene ◽  
Pia Todtenhaupt ◽  
Erik W. van Zwet ◽  
Melissa van Pel ◽  
Romy J. M. Berkhout ◽  
...  
Keyword(s):  
High Risk Group ◽  
Future Health ◽  
Neurodevelopmental Outcomes ◽  
Prospective Longitudinal Study ◽  
Prenatal Environment ◽  
Prenatal Growth ◽  
Additional Funding ◽  
Prospective Longitudinal ◽  
The Impact

AbstractLifelong health is thought to be partially set during intrauterine life by persistent epigenetic changes induced by the prenatal environment. To evaluate this hypothesis, we initiated a prospective longitudinal study in monochorionic (MC) twins: the TwinLIFE study. MC twins are monozygotic, thus in origin genetically identical, and share a single placenta. Although MC twins have many environmental factors in common, in one-third of the MC twin pairs, one fetus has significantly less access to nutrients and resources during pregnancy than its co-twin often resulting in a significant discordance in prenatal growth. Hence, MC twins constitute a unique natural experiment to study the influence of the prenatal environment on health. In TwinLIFE, we will chart intrapair differences in DNA methylation focusing on mesenchymal stromal cells isolated from cord as an advanced proxy of epigenetic dysregulation relevant for long-term health consequences. Next, we will follow up the MC twins for growth, cardiovascular and neurodevelopmental outcomes during childhood and evaluate the impact of an epigenetic signature at birth on future health. The current target is to include 100 MC twin pairs, but we aim to continue enrollment after procuring additional funding. TwinLIFE will not only address an unmet clinical need in the high-risk group of MC twins, but may also advance early-life strategies to prevent adverse growth, cardiovascular and neurodevelopmental outcomes in the general population.

scholarly journals Long-Term Geomorphological Evolution of the Mouth Bar in the Modaomen Estuary of the Pearl River over the Last 55 Years (1964–2019)

Water ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 90
Author(s):  
Zhiyuan Han ◽  
Huaiyuan Li ◽  
Hualiang Xie ◽  
Bing Yan ◽  
Mingxiao Xie
Keyword(s):  
Human Activities ◽  
High Intensity ◽  
Pearl River ◽  
Bathymetric Data ◽  
The Past ◽  
Modaomen Estuary ◽  
Mouth Bar ◽  
The Pearl River ◽  
The Impact

Based on mass bathymetric data and remote sensing data in the Modaomen Estuary, this study explored the long-term evolutionary characteristics of the mouth bar in the Modaomen Estuary of the Pearl River from 1964 to 2019. In the past 55 years, due to the impact of human activities, such as shoal reclamation and estuarine regulation in the Modaomen Estuary, the river mouth moved out of the shallow sea covered by several islands and faced the South China Sea directly. Therefore, the mouth bay became a siltation center in the estuarine region and expanded outwards, gradually evolving a geomorphic pattern with three shallow shoals and two distributary branches; a west branch as the main branch accompanied by a small east branch. Over the past decade, high-intensity sand dredging activities in the mouth bar have led to a considerable deepening of the water depth and a significant refinement of bed sediments, forming a discharge pattern of a wide and shallow channel flowing into the sea. Therefore, the evolutionary characteristics of the mouth bar have become abnormal in recent years, so additional field bathymetric data and hydrological data are required for further research regarding the subsequent evolution of the mouth bar, against the background of a significant reduction of sediment discharge and high-intensity human activities.

scholarly journals Exclusive breastfeeding and its impact on neurodevelopment

2021 ◽  
Vol 8 (8) ◽  
pp. 4128
Author(s):  
Saeed Salem Alghamdi ◽  
Mansour Sultan Alruwaili ◽  
Mansour Sultan Alruwaili ◽  
Nafea Hamoud Alanazi ◽  
Nafea Hamoud Alanazi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Breast Milk ◽  
Brain Development ◽  
Exclusive Breastfeeding ◽  
Essential Fatty Acids ◽  
Long Term Outcomes ◽  
Neurodevelopmental Outcomes ◽  
Physical Interactions ◽  
The Impact

Many advantages have been reported among the various studies in the literature about the efficacy of breastfeeding on brain development, which is mainly attributable to the abundant presence of the bioactive compounds and the essential fatty acids in breast milk. Moreover, it has been proven that breastfeeding enhanced long-term outcomes in children. In this context, arachidonic acid and docosahexaenoic acid are two fatty acids that were previously reported to be associated with the developmental outcomes of the retina, nerve cells and brain. Both of these amino acids have also been found in breast milk, and they are not present in other milk formulas as cow’s milk which is usually administered to newborns. In the present literature review, we aim to discuss the impact of exclusive breastfeeding on neurodevelopment. The findings from various studies indicate the strong effect of breastfeeding on the neurodevelopmental outcomes as compared to the administration of other milk formulas. Another finding from previous literature, the favorable events that are obtained from breastfeeding were also found to be sustained to the school-age of these children. On the other hand, evidence regarding the efficacy of breastfeeding on brain development in preterm infants is still poor. As a result, further studies are needed to furtherly validate this point. The main mechanisms by which favorable neurodevelopmental outcomes are obtained following breastfeeding are the nutritional values that are found within the breast milk along with the physical interactions between the mothers and infants during breastfeeding.

Suppressed, but Not Forgotten

2011 ◽  
Vol 70 (1) ◽  
pp. 5-11 ◽  
Author(s):  
Beat Meier ◽  
Anja König ◽  
Samuel Parak ◽  
Katharina Henke
Keyword(s):  
Memory Trace ◽  
Thought Suppression ◽  
Test Phase ◽  
Indirect Test ◽  
Final Test ◽  
Test Experiment ◽  
And Control ◽  
Cue Words ◽  
The Impact

This study investigates the impact of thought suppression over a 1-week interval. In two experiments with 80 university students each, we used the think/no-think paradigm in which participants initially learn a list of word pairs (cue-target associations). Then they were presented with some of the cue words again and should either respond with the target word or avoid thinking about it. In the final test phase, their memory for the initially learned cue-target pairs was tested. In Experiment 1, type of memory test was manipulated (i.e., direct vs. indirect). In Experiment 2, type of no-think instructions was manipulated (i.e., suppress vs. substitute). Overall, our results showed poorer memory for no-think and control items compared to think items across all experiments and conditions. Critically, however, more no-think than control items were remembered after the 1-week interval in the direct, but not in the indirect test (Experiment 1) and with thought suppression, but not thought substitution instructions (Experiment 2). We suggest that during thought suppression a brief reactivation of the learned association may lead to reconsolidation of the memory trace and hence to better retrieval of suppressed than control items in the long term.

Examining the Impact of the Disabled Youth Peer Development Initiative: What are the Long-Term Outcomes?

2003 ◽  
Author(s):  
Teresa Garate-Serafini ◽  
Jose Mendez ◽  
Patty Arriaga ◽  
Larry Labiak ◽  
Carol Reynolds
Keyword(s):  
Long Term Outcomes ◽  
The Disabled ◽  
The Impact

The Impact of Different Treatments on Long-Term Symptoms in Vestibular Schwannoma

2014 ◽  
Vol 75 (S 02) ◽  
Author(s):  
Morten Lund-Johansen ◽  
Øystein Tveiten ◽  
Monica Finnkirk ◽  
Erling Myrseth ◽  
Frederik Goplen ◽  
...  
Keyword(s):  
Vestibular Schwannoma ◽  
The Impact

The influence of inflation targeting on the pass-through effect of the exchange rate

2018 ◽  
pp. 70-84
Author(s):  
Ph. S. Kartaev ◽  
Yu. I. Yakimova
Keyword(s):  
Developing Countries ◽  
Monetary Policy ◽  
Exchange Rate ◽  
Inflation Targeting ◽  
Policy Regime ◽  
Short And Long Term ◽  
The Exchange Rate ◽  
Pass Through ◽  
The Impact

The paper studies the impact of the transition to the inflation targeting regime on the magnitude of the pass-through effect of the exchange rate to prices. We analyze cross-country panel data on developed and developing countries. It is shown that the transition to this regime of monetary policy contributes to a significant reduction in both the short- and long-term pass-through effects. This decline is stronger in developing countries. We identify the main channels that ensure the influence of the monetary policy regime on the pass-through effect, and examine their performance. In addition, we analyze the data of time series for Russia. It was concluded that even there the transition to inflation targeting led to a decrease in the dependence of the level of inflation on fluctuations in the ruble exchange rate.

Secular stagnation in the modern world

2018 ◽  
pp. 125-141 ◽  
Author(s):  
S. M. Drobyshevsky ◽  
P. V. Trunin ◽  
A. V. Bozhechkova
Keyword(s):  
Public Debt ◽  
Capital Accumulation ◽  
Technological Development ◽  
Japanese Economy ◽  
Modern World ◽  
Key Factors ◽  
Destruction Process ◽  
Secular Stagnation ◽  
The Impact

The paper studies the factors of secular stagnation. Key factors of long-term slowdown in economic growth include the slowdown of technological development, aging population, human capital accumulation limits, high public debt, creative destruction process violation etc. The authors analyze key theoretical aspects of long-term stagnation and study the impact of these factors on Japanies economy. The authors conclude that most of the factors have significant influence on the Japanese economy for recent decades, but they cannot explain all dynamics. For Russia, on the contrary, we do not see any grounds for considering the decline in the economy since 2013 as an episode of secular stagnation.

Sign in / Sign up

Export Citation Format

Share Document