scholarly journals Current trends in tendinopathy: consensus of the ESSKA basic science committee. Part II: treatment options

2018 ◽  
Vol 5 (1) ◽  
Author(s):  
F. Abat ◽  
H. Alfredson ◽  
M. Cucchiarini ◽  
H. Madry ◽  
A. Marmotti ◽  
...  
Keyword(s):  
Basic Science ◽  
Treatment Options ◽  
Current Trends ◽  
Science Committee

scholarly journals Corporoplasty in Peyronie’s Disease: a Literature Review

2021 ◽  
Vol 11 (3) ◽  
pp. 209-219
Author(s):  
V. N. Pavlov ◽  
A. A. Bakirov ◽  
R. A. Kazikhinurov ◽  
A. A. Kazikhinurov ◽  
M. A. Agaverdiev ◽  
...  
Keyword(s):  
Treatment Options ◽  
Penile Prosthesis ◽  
Peyronie’S Disease ◽  
Usual Practice ◽  
Current Trends ◽  
Penile Deviation ◽  
Pros And Cons ◽  
Peyronie's Disease ◽  
Correction Surgery ◽  
Review Current

Corporoplasty is urological correction surgery for penile deviation that causes copulatory dysfunction or aesthetic discomfort. Penile deviation can be congenital or acquired (Peyronie’s disease, penile fracture). Congenital penile deviation is relatively rare and manifests in the curvature of erect penis ventrally and/or laterally, in most cases. According to many studies, patients with curvatures of 30° or more eventually seek surgical treatment. Congenital curvature may be mistaken for Peyronie’s disease for similar manifestations that, however, differ in aetiology and pathophysiology. Excisional, incisional corporoplasty or plication are commonly engaged to treat congenital curvatures, in various techniques and modifications. Augmentation transplantation (grafting) and penile prosthesis implantation with variant deviation treatment options are the usual practice in Peyronie’s disease. Unequivocal judgment of pros and cons in any particular technique is nevertheless implausible to make. This article aims to review current trends, protocols and their relative advantages in corporoplasty.

scholarly journals Current trends and future perspectives in pelvic reconstructive surgery

2018 ◽  
Vol 14 ◽  
pp. 174550651877649 ◽  
Author(s):  
Mélanie Aubé ◽  
Le Mai Tu
Keyword(s):  
Pelvic Organ Prolapse ◽  
Surgical Repair ◽  
Treatment Options ◽  
Pelvic Organ ◽  
Review Article ◽  
Pelvic Reconstructive Surgery ◽  
Future Perspectives ◽  
Vast Array ◽  
The Past ◽  
Current Trends

Pelvic organ prolapse is a prevalent disorder with a high lifetime incidence of surgical repair. Pelvic organ prolapse surgery has greatly evolved over the past years, and pelvic floor reconstructive surgeons are faced with a vast array of treatment options for their patients. Our review article illustrates the current trends and future perspectives for the surgical treatment of pelvic organ prolapse.

Current practice of BHS members in the treatment of osteonecrosis of the femoral head in adults

2017 ◽  
Vol 28 (1) ◽  
pp. 90-95 ◽  
Author(s):  
Henry B. Colaço ◽  
Jerome A. Davidson ◽  
Dominic Davenport ◽  
Mark. C. Norris ◽  
Marcus J.K. Bankes ◽  
...  
Keyword(s):  
Femoral Head ◽  
Treatment Options ◽  
Core Decompression ◽  
Operative Management ◽  
Operative Intervention ◽  
Older Patient ◽  
Old Patients ◽  
Current Trends ◽  
Clinical Scenarios ◽  
The Uk

Introduction: The management of osteonecrosis (ON) of the femoral head remains controversial. It is unclear the extent to which non-arthroplasty procedures are used and there has been no previous report of the trends in operative management of ON in the UK. Our objective is to report current trends in management of ON of the femoral head amongst specialist hip surgeons in the UK. Methods: A single-stage internet-based survey was e-mailed to 352 eligible members of the British Hip Society (BHS). This consisted of 10 question stems including 16 hypothetical clinical scenarios with imaging. Results: 115 active Consultant members of the BHS completed the survey. For symptomatic pre-collapse ON we found core decompression (CD) was the most common operative intervention and for post-collapse ON we found that total hip arthroplasty (THA) was the most common operative intervention. We found no difference in the rate of operative intervention between 24 and 48-year-old patients at any stage of ON but joint preserving procedures were more often selected for the younger patient and arthroplasty for the older patient. Surgeons were more likely to offer arthroplasty to a 48-year-old patient at an earlier stage of disease. Conclusions: Our respondents would offer different operative interventions dependent on stage of ON and patient age. Core decompression (CD) and arthroplasty were common but variation in treatment options offered suggests a lack of consensus amongst UK hip surgeons. We suggest that further research such as a prospective RCT is needed to gain consensus on management of this condition.

Basic Science and Treatment Options for Articular Cartilage Injuries

2006 ◽  
Vol 36 (10) ◽  
pp. 717-727 ◽  
Author(s):  
Paul B. Lewis ◽  
L. Pearce McCarty ◽  
Richard W. Kang ◽  
Brian J. Cole
Keyword(s):  
Articular Cartilage ◽  
Basic Science ◽  
Treatment Options ◽  
Cartilage Injuries ◽  
Articular Cartilage Injuries

scholarly journals Prevention, identification, and treatment of perioperative spinal cord injury

2008 ◽  
Vol 25 (5) ◽  
pp. E15 ◽  
Author(s):  
Henry Ahn ◽  
Michael G. Fehlings
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Clinical Outcome ◽  
Clinical Studies ◽  
Basic Science ◽  
Treatment Options ◽  
Arterial Blood ◽  
Secondary Damage ◽  
Increased Risk ◽  
Cord Injury

Object In this report, the authors suggest evidence-based approaches to minimize the chance of perioperative spinal cord injury (POSCI) and optimize outcome in the event of a POSCI. Methods A systematic review of the basic science and clinical literature is presented. Results Authors of clinical studies have assessed intraoperative monitoring to minimize the chance of POSCI. Furthermore, preoperative factors and intraoperative issues that place patients at increased risk of POSCI have been identified, including developmental stenosis, ankylosing spondylitis, preexisting myelopathy, and severe deformity with spinal cord compromise. However, no studies have assessed methods to optimize outcomes specifically after POSCIs. There are a number of studies focussed on the pathophysiology of SCI and the minimization of secondary damage. These basic science and clinical studies are reviewed, and treatment options outlined in this article. Conclusions There are a number of treatment options, including maintenance of mean arterial blood pressure > 80 mm Hg, starting methylprednisolone treatment preoperatively, and multimodality monitoring to help prevent POSCI occurrence, minimize secondary damage, and potentially improve the clinical outcome of after a POSCI. Further prospective cohort studies are needed to delineate incidence rate, current practice patterns for preventing injury and minimizing the clinical consequences of POSCI, factors that may increase the risk of POSCI, and determinants of clinical outcome in the event of a POSCI.

Antimicrobial innovation: a current update and perspective on the antibiotic drug development pipeline

2020 ◽  
Vol 12 (22) ◽  
pp. 2035-2065
Author(s):  
Liam J Stephens ◽  
Melissa V Werrett ◽  
Adam C Sedgwick ◽  
Steven D Bull ◽  
Philip C Andrews
Keyword(s):  
Drug Development ◽  
Bacterial Infections ◽  
Treatment Options ◽  
Press Releases ◽  
Current Trends ◽  
Antibiotic Drug ◽  
If Current ◽  
Development Pipeline ◽  
Insight Into ◽  
A Current

As bacteria continue to develop resistance to our existing treatment options, antibiotic innovation remains overlooked. If current trends continue, then we could face the stark reality of a postantibiotic era, whereby routine bacterial infections could once again become deadly. In light of a warning signaled by the WHO, a number of new initiatives have been established in the hope of reinvigorating the antibiotic drug development pipeline. In this perspective, we aim to summarize some of these initiatives and funding options, as well as providing an insight into the predicament that we face. Using clinical trials data, company website information and the most recent press releases, a current update of the antibiotic drug development pipeline is also included.

scholarly journals Therapeutic Vaccination for HPV Induced Cervical Cancers

2007 ◽  
Vol 23 (4) ◽  
pp. 337-352 ◽  
Author(s):  
Joeli A. Brinkman ◽  
Sarah H. Hughes ◽  
Pamela Stone ◽  
Angela S. Caffrey ◽  
Laila I. Muderspach ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Clinical Trials ◽  
Viral Vectors ◽  
Treatment Options ◽  
Invasive Cervical Cancer ◽  
Hpv Infection ◽  
Therapeutic Vaccination ◽  
Current Trends ◽  
Lesion Regression ◽  
Advanced Stage Cancer

Cervical Cancer is the second leading cause of cancer–related deaths in women worldwide and is associated with Human Papillomavirus (HPV) infection, creating a unique opportunity to treat cervical cancer through anti-viral vaccination. Although a prophylactic vaccine may be available within a year, millions of women, already infected, will continue to suffer from HPV-related disease, emphasizing the need to develop therapeutic vaccination strategies. A majority of clinical trials examining therapeutic vaccination have shown limited efficacy due to examining patients with more advanced-stage cancer who tend to have decreased immune function. Current trends in clinical trials with therapeutic agents examine patients with pre-invasive lesions in order to prevent invasive cervical cancer. However, longer follow-up is necessary to correlate immune responses to lesion regression. Meanwhile, preclinical studies in this field include further exploration of peptide or protein vaccination, and the delivery of HPV antigens in DNA-based vaccines or in viral vectors. As long as pre-clinical studies continue to advance, the prospect of therapeutic vaccination to treat existing lesions seem good in the near future. Positive consequences of therapeutic vaccination would include less disfiguring treatment options and fewer instances of recurrent or progressive lesions leading to a reduction in cervical cancer incidence.

Free Radicals

2002 ◽  
Vol 21 (7) ◽  
pp. 33-37 ◽  
Author(s):  
Jobeth Pilcher
Keyword(s):  
Free Radicals ◽  
Brain Injury ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
Basic Science ◽  
Treatment Options ◽  
Potential Treatment ◽  
Neonatal Complications ◽  
Injury Treatment

Free radicals may be the cause of many neonatal complications, such as chronic lung disease and brain injury. Treatment options for these complications using antioxidants are being evaluated through research. This article begins with a review of the basic science of free radicals. It then discusses neonatal complications potentially caused by free radicals. A brief description of research into potential treatment options is also included.

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