FBXW7 gene polymorphism is associated with type 2 diabetes in the Uygur population in Xinjiang, China

Abstract Background FBXW7 gene expression is positively correlated with glycolipid metabolism and is associated with diabetes in animal models. In the current study, we focused on exploring whether genetic variants of the FBXW7 gene were associated with type 2 diabetes (T2DM) and the risk factors for T2DM in Uygur people in Xinjiang, China. Methods A total of 2164 Chinese Uygur subjects (673 T2DM patients and 1491 controls) were recruited for our case–control study, and four SNPs (rs10033601, rs2255137, rs2292743 and rs35311955) of the FBXW7 gene were genotyped using the improved multiplex ligation detection reaction (iMLDR) technique. Results Our study showed that the genotypes using the overdominant model (GA vs AA + GG) of rs10033601 and using the overdominant model (TA vs TT + AA) of rs2292743 were significantly different between T2DM patients and the controls (P = 0.005 and P = 0.012, respectively). After multivariate adjustments for confounders, the rs10033601 and rs2292743 SNPs were still independent risk factors for T2DM [GA vs AA + GG: odds ratio = 1.35, 95% confidence interval (CI) = 1.12–1.64, P = 0.002; TA vs TT + AA: OR = 1.28, 95% CI = 1.06–1.55, P = 0.011]. Participants within the Chinese Uygur populations and who with the GA genotype of rs10033601 and the TA genotype of rs2292743 were associated with significantly elevated glucose levels. Conclusions Our study revealed that both rs10033601 and rs2292743 of the FBXW7 gene were associated with T2DM in the Uygur populations in Xinjiang.

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Risk factors associated with the development of diabetic kidney disease in Sudanese patients with type 2 diabetes mellitus: A case-control study

Diabetes & Metabolic Syndrome Clinical Research & Reviews ◽

10.1016/j.dsx.2021.102320 ◽

2021 ◽

pp. 102320

Author(s):

Mazin MT. Shigidi ◽

Wieam N. Karrar

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Diabetic Kidney Disease ◽

Case Control Study ◽

Case Control ◽

Factors Associated ◽

Control Study

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Differences in risk factors of malignancy between men and women with type 2 diabetes: A retrospective case-control study

Oncotarget ◽

10.18632/oncotarget.17716 ◽

2017 ◽

Vol 8 (40) ◽

pp. 66940-66950 ◽

Cited By ~ 1

Author(s):

Mariusz Dąbrowski ◽

Elektra Szymańska-Garbacz ◽

Zofia Miszczyszyn ◽

Tadeusz Dereziński ◽

Leszek Czupryniak

Keyword(s):

Risk Factors ◽

Type 2 Diabetes ◽

Case Control Study ◽

Case Control ◽

Retrospective Case ◽

Men And Women ◽

Control Study

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Association Between 3'APOB-VNTR Polymorphism and Plasma Lipid Profiles in Type 2 Diabetes Patients

Iranian journal of diabetes and obesity ◽

10.18502/ijdo.v12i3.4447 ◽

2020 ◽

Author(s):

Jamshid Mehrzad ◽

Elahe Kargozar ◽

Mohammadreza Erfanian-Khorasani ◽

Mahdieh Mohammaditabar

Keyword(s):

Risk Factors ◽

Type 2 Diabetes ◽

Plasma Lipid ◽

Lipid Profiles ◽

Control Group ◽

Cholesterol Accumulation ◽

Vntr Polymorphism ◽

Vntr Polymorphisms ◽

Control Study

Objective: Apolipoprotein B (APOB) plays an important role in the metabolism of cholesterol and impairment in its function can lead to cholesterol accumulation in the pancreatic islets. It can then reduce insulin secretion and lead to Type 2 diabetes (T2DM). The purpose of this study was to investigate the association of 3chr('39')APOB-VNTR polymorphism with plasma lipid profiles in T2DM individuals in Khorasan Razavi province, Iran. Materials and Methods: In this case-control study, 204 patients with T2DM and 207 non-diabetic volunteers were examined as a control group. All samples were analyzed for plasma lipid profiles. Genotypes were determined by PCR and electrophoresis. Differences in lipid variables between genotypes were assessed using one-way analysis of variance (ANOVA) with SPSS 20.0. Results: We found 18 different alleles of the APOB gene 3chr('39')VNTR comprising from 26 to 45 hypervariable elements (HVEs) in the control groups and 21 alleles ranging from 30 to 51 repeats in the T2DM patients. Short alleles (26 to 29 HVEs) were only in controls and large alleles (46 to 51 HVEs) were only in T2DM patients. Our results showed that in people with long HVE polymorphism, HDL-C levels decreased, but LDL-C increased. Therefore, longer alleles for T2DM are considered risk factors. It was also observed that the TC / HDL-C ratio was significantly lower in shorter genotypes than the longer genotypes in T2DM patients. Conclusion: It is concluded that 3chr('39')APOB-VNTR polymorphisms, especially longer alleles, affect plasma lipid levels in individuals with T2DM and are risk factors for this disease.

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Bottom-up proteomics analysis of the secretome of murine islets of Langerhans in elevated glucose levels

The Analyst ◽

10.1039/c6an02268e ◽

2017 ◽

Vol 142 (2) ◽

pp. 284-291 ◽

Cited By ~ 1

Author(s):

Andrew Schmudlach ◽

Jeremy Felton ◽

Robert T. Kennedy ◽

Norman J. Dovichi

Keyword(s):

Type 2 Diabetes ◽

Endoplasmic Reticulum ◽

Endoplasmic Reticulum Stress ◽

Oxidative Damage ◽

Islets Of Langerhans ◽

High Glucose ◽

Proteomics Analysis ◽

Glucose Levels ◽

Elevated Glucose

Glucotoxicity is a causative agent of type-2 diabetes, where high glucose levels damage the islets of Langerhans resulting in oxidative damage and endoplasmic reticulum stress.

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A Case-Control Study on Risk Factors affected Peripherals Neuropathic complication in Elderly with Type 2 Diabetes Mellitus

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.00700 ◽

2021 ◽

pp. 4040-4046

Author(s):

Made Krisna Adi Jaya ◽

Dewa Ayu Swastini ◽

Baiq Leny Nopitasari ◽

Putu Rika Veryanti

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Case Control Study ◽

The Elderly ◽

Case Control ◽

Smoking History ◽

Control Study

Background: Diabetic Peripheral Neuropathy (DPN) is a microvascular complication that commonly occurs in people with diabetes mellitus. Geriatrics with type 2 diabetes mellitus is one of the populations most vulnerable to this complication. An epidemiological study states that geriatrics has a 32% greater risk of developing this complication compared to other age groups. There have not been many studies conducted to evaluate the risk factors that influence this DPN complication, so it needs to be done an individual evaluation for the elderly population. Objective: This study aims to explore the risk factors that influence the incidence of DPN in elderly patients with type 2 diabetes mellitus. Methods: A case-control study design was carried out on 70 geriatrics with type 2 diabetes mellitus. The outcome determined was the incidence of DPN to track the cause of DPN exposure retrospectively. Influential risk factors are determined by the Odds Ratio (OR) with a 95% confidence interval (CI). All statistical analyzes were two-tailed, and p-values <0.05 were considered as statistically significant. Results: Seven factors influence the incidence of DPN in the elderly consisting of smoking history (OR=13.1), uncontrolled lipid profile (OR=5.1), non-neuroprotector users (OR=5.6), uncontrolled blood glucose (OR=42.7), history of heart disease (OR=9.0), uncontrolled blood pressure (OR=4.3), and BMI above normal (OR=5.1). Conclusion: Strong recommendation for medical personnel to focus attention on seven significant risk factors affected complications of DPN to reduce its progression or prevent upcoming complications.

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Identification of the risk factors for the high prevalence of type 2 diabetes and its complications in a Punjabi population: North Indian Diabetes Study: A case-control study

International Journal of Diabetes in Developing Countries ◽

10.4103/0973-3930.38629 ◽

2007 ◽

Vol 27 (4) ◽

pp. 108 ◽

Cited By ~ 9

Author(s):

Rupinder Tewari ◽

JasvinderS Bhatti ◽

GurjitK Bhatti ◽

Amit Joshi ◽

Seema Rai ◽

...

Keyword(s):

Risk Factors ◽

Type 2 Diabetes ◽

Case Control Study ◽

Case Control ◽

High Prevalence ◽

Control Study

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Urinary NGAL and RBP Are Biomarkers of Normoalbuminuric Renal Insufficiency in Type 2 Diabetes Mellitus

Journal of Immunology Research ◽

10.1155/2019/5063089 ◽

2019 ◽

Vol 2019 ◽

pp. 1-11 ◽

Cited By ~ 5

Author(s):

Aimei Li ◽

Bin Yi ◽

Yan Liu ◽

Jianwen Wang ◽

Qing Dai ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Renal Insufficiency ◽

Urinary Ngal ◽

Independent Risk Factors ◽

Pai 1 ◽

E Cadherin

Objectives. As a screening index of diabetic kidney disease (DKD), urinary albumin/creatine ratio (UACR) is commonly used. However, approximately 23.3%-56.6% of DKD patients with estimated glomerular filtration rate eGFR<60 ml/min per 1.73 m2 are normoalbuminuric. Thus, urinary biomarkers of nonalbuminuric renal insufficiency in type 2 diabetes mellitus (T2DM) patients are urgently needed. Methods. This cross-sectional study enrolled 209 T2DM patients with normoalbuminuria whose diabetes duration was more than 5 years. The patients were classified into two groups, NO-CKD (eGFR≥60 ml/min per 1.73 m2, n=165) and NA-DKD (eGFR<60 ml/min per 1.73 m2, n=44). Levels of urinary neutrophil gelatinase-associated lipocalin (NGAL), retinol-binding protein (RBP), plasminogen activator inhibitor-1 (PAI-1), vascular cell adhesion molecule-1 (VCAM-1), and E-cadherin were detected, and their correlations with eGFR, plasma TNF-α, IL-6, endothelin-1 (ET-1), and 8-hydroxydeoxyguanosine (8-OHdG) were assessed. Results. Among patients with renal insufficiency, 26.0% was normoalbuminuric. Compared to the NO-CKD group, the NA-DKD group was older with lower hemoglobin (HB) levels and higher systolic blood pressure (SBP), plasma TNF-α, IL-6, and 8-OHdG levels. Logistic regression analysis suggested that age, TNF-α, and 8-OHdG were independent risk factors for nonalbuminuric renal insufficiency. Compared to the NO-CKD group, the NA-DKD group exhibited significant increases in urinary NGAL and RBP levels but not PAI-1, VCAM-1, and E-cadherin. Urinary NGAL and RBP both correlated negatively with eGFR and positively with plasma IL-6 and 8-OHdG. Multiple linear regression indicated NGAL (β=−0.287, p=0.008) and RBP (β=−44.545, p<0.001) were independently correlated with eGFR. Conclusion. Age, plasma TNF-α, and 8-OHdG are independent risk factors for renal insufficiency in T2DM patients with normoalbuminuria. Urinary NGAL and RBP can serve as noninvasive biomarkers of normoalbuminuric renal insufficiency in T2DM.

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