scholarly journals Tissue stiffness in BPH patients from magnetic resonance elastography

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Chalida Aphinives ◽  
Watcharaphon Kiatsayompoo ◽  
Kulyada Eurboonyanun ◽  
Prin Twinprai ◽  
Saranya Jaruchainiwat
Keyword(s):  
Magnetic Resonance ◽  
Prostate Gland ◽  
Magnetic Resonance Elastography ◽  
Prostate Tissue ◽  
Tissue Stiffness ◽  
Mri Findings ◽  
Mri Features ◽  
Urinary Tract Symptoms ◽  
Noninvasive Imaging Technique ◽  
The Mean

Abstract Background BPH is commonly found in older men which can lead to lower urinary tract symptoms. Magnetic resonance elastography (MRE) is an innovative, noninvasive imaging technique used to evaluate tissue stiffness. There has not been any study, however, that assessed the tissue stiffness in patients with BPH. A prospective descriptive study was performed to demonstrated MRI and MRE techniques of the prostate gland in ten patients with BPH to assess tissue stiffness, features of BPH on MRI and components of BPH in the area of increased stiffness. Results MRI and MRE examinations in all patients were successful without any complications. The mean tissue stiffness of the whole prostate gland was 4.40 ± 0.71 kPa with good reproducibility (ICC 0.82). Stromal components and mixed glandular-stromal components tended to be associated with the areas of increased stiffness on stiffness images, 50.6% for stromal components and 37.9% for mixed glandular-stromal components. Some MRI findings were seen on the patients with high mean stiffness values such as prostatic calcification, type-5 BPH pattern and large prostate volumes. Conclusions Prostate MRE is a useful noninvasive reproducible diagnostic tool for evaluating prostate tissue stiffness by both qualitative and quantitative assessments. The mean prostate tissue stiffness from MRE in patients with BPH in this study was 4.40 ± 0.71 kPa. Some MRI features might be associated with increased tissue stiffness. Trial registration: PID 229. Registered 4 October 2019. http://md.redcap.kku.ac.th

scholarly journals The Advance of Magnetic Resonance Elastography in Tumor Diagnosis

2021 ◽  
Vol 11 ◽  
Author(s):  
Jin-Ying Yang ◽  
Ben-Sheng Qiu
Keyword(s):  
Magnetic Resonance ◽  
Tumor Tissue ◽  
Tumor Development ◽  
Low Frequency ◽  
Treatment Method ◽  
Magnetic Resonance Elastography ◽  
Tumor Diagnosis ◽  
Tissue Stiffness ◽  
Noninvasive Imaging Technique ◽  
Selection Of

The change in tissue stiffness caused by pathological changes in the tissue’s structure could be detected earlier, prior to the manifestation of their clinical features. Magnetic resonance elastography (MRE) is a noninvasive imaging technique that uses low-frequency vibrations to quantitatively measure the elasticity or stiffness of tissues. In tumor tissue, stiffness is directly related to tumor development, invasion, metastasis, and chemoradiotherapy resistance. It also dictates the choice of surgical method. At present, MRE is widely used in assessing different human organs, such as the liver, brain, breast, prostate, uterus, gallbladder, and colon stiffness. In the field of oncology, MRE’s value lies in tumor diagnosis (especially early diagnosis), selection of treatment method, and prognosis evaluation. This article summarizes the principle of MRE and its research and application progress in tumor diagnosis and treatment.

scholarly journals Virtual magnetic resonance elastography has the feasibility to evaluate preoperative pituitary adenoma consistency

Pituitary ◽  
2021 ◽  
Author(s):  
Kerstin Lagerstrand ◽  
Nicholas Gaedes ◽  
Stig Eriksson ◽  
Dan Farahmand ◽  
Erica De Coursey ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Transsphenoidal Surgery ◽  
Tumor Heterogeneity ◽  
Magnetic Resonance Elastography ◽  
Diagnostic Methods ◽  
Great Promise ◽  
Tissue Stiffness ◽  
Surgery Outcome ◽  
The Mean ◽  
Transsphenoidal Resection

Abstract Purpose To evaluate the use of preoperative virtual Magnetic Resonance Elastography (vMRE) for patients undergoing transsphenoidal resection of pituitary adenomas (PA). Methods Ten patients (60.2 ± 19.6 years; 8 males) were prospectively examined with the vMRE-method prior to transsphenoidal surgery. vMRE-images, reflecting tissue stiffness were reconstructed. From these images, histograms as well as the mean stiffness values over the tumor body were extracted. Finally, vMRE-data was compared with the PA consistency at surgery blinded to vMRE. Results In all patients, successful vMRE-examination was performed enabling evaluation of even small PAs. For tumors with homogenous tissue, the mean stiffness value increased with surgical consistency grading. For heterogenous tumors, however, the mean stiffness value did not consistently reflect the grading at surgery. On the other hand, the vMRE-images and histograms were found to be able to characterize the tumor heterogeneity and display focal regions of high stiffness that were found to affect the surgery outcome in these PAs. The vMRE-images and histograms showed great promise in characterizing the consistency at surgery for these PAs. Conclusion Evaluation of PA consistency in preparation for surgery seems to be feasible using the vMRE-method. Our findings also address the need for high resolution diagnostic methods that can non-invasively display focal regions of increased stiffness, as such regions may increase the difficulty of transsphenoidal PA-resection.

A Logistic Regression Analysis for Tissue Stiffness Categorization Through Magnetic Resonance Elastography

2021 ◽  
Author(s):  
Mohammadreza Ramzanpour ◽  
Mohammad Hosseini-Farid ◽  
Jayse Mclean ◽  
Mariusz Ziejewski ◽  
Ghodrat Karami
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Magnetic Resonance ◽  
Logistic Regression Analysis ◽  
Magnetic Resonance Elastography ◽  
Tissue Stiffness

scholarly journals Breast Magnetic Resonance Imaging of Multicentric, Multifocal and Bilateral Cancer — A Case-based Review

2011 ◽  
Vol 07 (01) ◽  
pp. 24
Author(s):  
Virginia Pérez Dueñas ◽  
María Ruíz de Gopegui Andreu ◽  
Sara Morón Hodge ◽  
Asunción Suárez Manrique ◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
False Positive ◽  
Breast Magnetic Resonance Imaging ◽  
Breast Mri ◽  
Resonance Imaging ◽  
Mri Findings ◽  
Mri Features ◽  
Breast Magnetic Resonance

Multifocal or multicentric breast cancer can be difficult to detect on mammography or ultrasound, particularly in patients with dense breast tissue. A multimodality approach that includes breast magnetic resonance imaging (MRI) is indicated, particularly when conservative surgery is being considered as it is the most sensitive technique for identifying additional sites of disease. However, its influence on recurrence and survival rates has yet not been clearly established, and false-positive cases may lead to more aggressive management and treatment. Radiologists should therefore be aware of relevant breast MRI findings. Infiltrating carcinomas, contralateral unsuspected carcinomas, occult carcinomas, false-positive cases and post-chemotherapy changes. Several cases of multiple-site breast carcinomas and their corresponding mammographic, ultrasound and MRI features have been reviewed for this article, in which the definition and differences between multifocal, multicentric and contralateral breast carcinoma are explained and the most relevant imaging findings on MRI are illustrated and correlated with mammogram and ultrasound findings. Finally, the role of breast MRI in the pre-operative assessment of breast cancer is discussed.

scholarly journals 1.5 Tesla Magnetic Resonance Imaging Features of Canine Intracranial Intra-axial Hematomas

2021 ◽  
Vol 8 ◽  
Author(s):  
James Whitlock ◽  
Andrew Holdsworth ◽  
Carles Morales ◽  
Laurent Garosi ◽  
Inés Carrera
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Enhancement ◽  
Clinical Signs ◽  
Border Region ◽  
Imaging Features ◽  
Resonance Imaging ◽  
Mri Findings ◽  
Mri Features ◽  
Mri Study

The differentiation of solitary intra-axial hematomas from hemorrhagic neoplasms based on their magnetic resonance imaging (MRI) features is challenging. The treatment and prognosis for these two disease entities are vastly different and distinction between them is often based on MRI findings alone. The aim of this study was to describe the 1.5 tesla MRI features of canine intra-axial hematomas and correlate these findings with the evolution of hemorrhages described in human brains. Retrospective evaluation of patient details, clinical signs, and MRI findings of dogs with intra-axial hematomas that were histopathologically confirmed or determined via repeat MRI study and/or resolution of neurological signs. Ten dogs met the inclusion criteria. All 10 hematoma lesions were determined to be 2–7 days in age. On MRI, all 10 hemorrhagic lesions were comprised of two distinct regions; a relatively thin T1-weighted (T1W), T2-weighted (T2W) and gradient echo (GRE) hypointense (9/10) peripheral border region and a large central region that was heterogenous but predominantly T1W, T2W and GRE hyperintense (8/10). The peripheral border region was complete in its integrity in all 10 cases on T2W and GRE sequences. Contrast enhancement was present in (6/10) hematoma lesions and was always peripheral in nature with no evidence of central enhancement associated with any of the lesions. An intra-axial hematoma should be suspected in solitary hemorrhagic space occupying lesions that have a complete hypointense peripheral rim, elicit a peripheral contrast enhancement pattern, and display the expected temporal pattern of hematoma evolution.

Magnetic resonance fingerprinting in prostate cancer before and after contrast enhancement

2021 ◽  
pp. 20210479
Author(s):  
Young Sub Lee ◽  
Moon Hyung Choi ◽  
Young Joon Lee ◽  
Dongyeob Han ◽  
Dong-Hyun Kim
Keyword(s):  
Prostate Cancer ◽  
Magnetic Resonance ◽  
Prostate Gland ◽  
Prostate Tissue ◽  
Normal Prostate ◽  
Adc Value ◽  
Contrast Enhanced ◽  
Normal Prostate Tissue ◽  
Adc Values ◽  
T1 And T2

Objectives: To assess the apparent diffusion coefficient (ADC) values and the T1 and T2 values derived from nonenhanced (NE) and contrast-enhanced (CE) magnetic resonance fingerprinting (MRF) in the prostate gland and to evaluate differences in values among prostate cancer, the normal peripheral zone (PZ) and the normal transition zone (TZ). Methods: Fifty-seven patients (median age, 73 years; range, 48–86) with prostate cancer who underwent multiparametric MRI including NE and CE MRF were included in this study. T1 and T2 values were extracted from NE and CE MRF, respectively. Five quantitative values (the ADC, NE T1, NE T2, CE T1 and CE T2 values) were measured in three areas: prostate cancer, PZ and TZ. We compared the values among the three areas and evaluated the differences between NE MRF and CE MRF values. Results: ADC values and MRF-derived values were significantly higher in PZ than prostate cancer or TZ (p < 0.001). TZ had a significantly lower CE T1 but significantly higher values of the other variables than prostate cancer (p < 0.001). The T1 values in all three areas and the T2 values in prostate cancer and TZ were significantly lower on CE MRF than on NE MRF (p < 0.001). Conclusions: Quantitative analysis of NE and CE MRI can be conducted by using the MRF technique. The ADC value and the T1 and T2 values from CE MRF and NE MRF were found to be significantly different between prostate cancer and normal prostate tissue. Advances in knowledge The T1 and T2 values from contrast-enhanced MR fingerprinting are significantly different between prostate cancer and normal prostate tissue.

scholarly journals Different MRI patterns in MS worsening after stopping fingolimod

2019 ◽  
Vol 6 (4) ◽  
pp. e566 ◽  
Author(s):  
Caterina Lapucci ◽  
Damiano Baroncini ◽  
Maria Cellerino ◽  
Giacomo Boffa ◽  
Ilaria Callegari ◽  
...  
Keyword(s):  
Clinical Features ◽  
Brain Mri ◽  
Activity Level ◽  
Lesion Volume ◽  
Mri Findings ◽  
Volume Increase ◽  
Mri Features ◽  
Disability Status ◽  
The Mean

ObjectiveTo analyze MRI images in patients with MS who experienced worsening of neurologic status (WNS) after stopping fingolimod (FTY).MethodsIn this retrospective study, demographic, clinical, and radiologic data of patients with MS who experienced WNS after stopping FTY were retrospectively collected. We introduced the “δExpanded Disability Status Scale (EDSS)-ratio” to identify patients who, after FTY withdrawal, showed an inflammatory flare-up exceeding the highest lifetime disease activity level. Patients with δEDSS-ratio > 1 were enrolled in the study.ResultsEight patients were identified. The mean (SD) age of the 8 (7 female) patients was 35.3 (4.9) years. The mean FTY treatment duration was 3.1 (0.8) years. The mean FTY discontinuation–WNS interval was 4 (0.9) months. The 4 patients with δEDSS-ratio ≥ 2 developed severe monophasic WNS (EDSS score above 8.5), characterized by clinical features and MRI findings not typical of MS, which we classified as “tumefactive demyelination pattern” (TDL) and “Punctuated pattern” (PL). Conversely, patients whose δEDSS-ratio was between 1 and 2 had clinical features and brain MRI compatible with a more typical, even if aggressive, MS relapse. In patients with TDL and PL, the flare-up of inflammatory activity led to severe tissue damage resulting in T2 but also T1 lesion volume increase at 6-month follow-up.ConclusionsPeculiar MRI features (TDL and PL), different from a typical MS flare-up, might occur in some patients who experienced WNS after stopping FTY. Further studies, also involving immunologic biomarkers, are necessary to investigate TDL or PL pathophysiology.

Magnetic Resonance Imaging in Cavitary Choroidal Melanoma

2000 ◽  
Vol 10 (4) ◽  
pp. 335-337 ◽  
Author(s):  
G. Rebolleda ◽  
M. Suárez Figueroa ◽  
F.J. Muñoz-Negrete ◽  
A. Rocamora
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Choroidal Melanoma ◽  
Solid Mass ◽  
Resonance Imaging ◽  
Mri Findings ◽  
Nevus Of Ota ◽  
Spindle Cells ◽  
Mri Features ◽  
Magnetic Resonance Imaging Mri

Purpose To report the development of a cavitary choroidal melanoma in a patient with nevus of Ota and describe its magnetic resonance imaging (MRI) features. Patient A 66-year-old man with right oculodermal melanocytosis and an ipsilateral choroidal cavitary melanoma was seen. Diagnosis was suspected on the clinical, ultrasonographic and MRI findings. Results T1-weighted image showed a hyperintense solid mass containing hypointense cystic-like spaces delineated by hyperintense septa with respect to the vitreous. The reverse image was observed on T2-weighted images. A choroidal melanoma comprising epithelioid and spindle cells with multilocular cavities was documented histopathologically. Conclusions There may be an association between cavitary melanoma and nevus of Ota. Characteristic MRI findings could be helpful in the differential diagnosis of cavitary uveal melanoma.

scholarly journals Magnetic resonance imaging of vulvar dermatofibrosarcoma protuberans – report of a case

2013 ◽  
Vol 47 (3) ◽  
pp. 244-246 ◽  
Author(s):  
Evrim Ozmen ◽  
Güven Güney ◽  
Oktay Algin
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Soft Tissue ◽  
Dermatofibrosarcoma Protuberans ◽  
Lymph Node Involvement ◽  
Low Grade ◽  
Resonance Imaging ◽  
Mri Findings ◽  
First Case ◽  
Mri Features

Abstract Background. Dermatofibrosarcoma protuberans (DFSP) of the vulva is a rare low-grade soft tissue sarcoma. Magnetic resonance imaging (MRI) findings of vulvar DFSP were essentially unreported in the literature. Case report. We report a DFSP of vulva with its clinical, histological and MRI features. As far we know this is the first case of histologically confirmed vulvar DFSP presenting with MR images. The diagnosis of DFSP is usually made by histopathologic and clinical findings. Conclusions. MRI is useful both for the diagnosis of DFSP and following up the patients since it has high soft tissue resolution and no risk of radiation exposure. With MRI the relation to the adjacent anatomical structures, extension and depth of the tumour and possible lymph node involvement can also be demonstrated.

scholarly journals Pathologic Findings of Breast Lesions Detected on Magnetic Resonance Imaging

2017 ◽  
Vol 141 (11) ◽  
pp. 1513-1522 ◽  
Author(s):  
Seema B. Jabbar ◽  
Beverly Lynch ◽  
Stephen Seiler ◽  
Helena Hwang ◽  
Sunati Sahoo
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
High Sensitivity ◽  
Breast Cancer Patients ◽  
Resonance Imaging ◽  
Mri Findings ◽  
Mri Features ◽  
Pathologic Findings ◽  
Mri Guided ◽  
Kinetic Pattern

Context.— Breast magnetic resonance imaging (MRI) is now used routinely for high-risk screening and in the evaluation of the extent of disease in newly diagnosed breast cancer patients. Morphologic characteristics and the kinetic pattern largely determine how suspicious a breast lesion is on MRI. Because of its high sensitivity, MRI identifies a large number of suspicious lesions. However, the low to moderate specificity and the additional cost have raised questions regarding its frequent use. Objectives.— To identify the pathologic entities that frequently present as suspicious enhancing lesions and to identify specific MRI characteristics that may be predictive of malignancy. Design.— One hundred seventy-seven MRI-guided biopsies from 152 patients were included in the study. The indication for MRI, MRI features, pathologic findings, and patient demographics were recorded. The MRI findings and the pathology slides were reviewed by a dedicated breast radiologist and breast pathologists. Results.— Seventy-one percent (126 of 177) of MRI-guided breast biopsies were benign, 11% (20 of 177) showed epithelial atypia, and 18% (31 of 177) showed malignancy. The vast majority (84%; 62 of 74) of MRI lesions with persistent kinetics were benign. However, 57% (17 of 30) of lesions with washout kinetics and 65% (62 of 95) of mass lesions were also benign. Conclusions.— Magnetic resonance imaging detects malignancies undetected by other imaging modalities but also detects a wide variety of benign lesions. Benign and malignant lesions identified by MRI share similar morphologic and kinetic features, necessitating biopsy for histologic confirmation.

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