scholarly journals Survey of ethnobotanical cocktails commonly used in the treatment of malaria in southwestern Nigeria

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Rachel Omagha ◽  
Emmanuel Taiwo Idowu ◽  
Chibuisi Gideon Alimba ◽  
Adetoro Olubunmi Otubanjo ◽  
Adeniyi Kazeem Adeneye
Keyword(s):  
Herbal Medicines ◽  
Oral Route ◽  
Malaria Treatment ◽  
Herbal Remedies ◽  
Southwestern Nigeria ◽  
Traditional Treatment ◽  
South West ◽  
Pharmacological Screening ◽  
Selection Of ◽  
Structured Questionnaire

Abstract Background Combination of different antimalarials has become the popular method of care for malaria morbidity in conventional and traditional treatment approaches due to the need to increase the efficacy and reduce the selection of drug resistance. A worrisome concern is the critical gaps with regards to the information available on antimalarial herbal cocktails. This study presents cocktail herbal remedies in ethnomedicinal approaches to malaria treatment in Oyo and Ogun states, South West Nigeria. Ethnobotanical information on indigenous antimalarials used in combination remedies was collected from herbal practitioners using a semi-structured questionnaire. Results Findings showed majority of respondents treat malaria with combination herbal remedies. They sighted their beliefs and customs, the efficacy, affordability and availability of these herbs as reasons for their adoption of herbal medicines as their preferred mode of treating malaria. Enquiry revealed 26 sets of cocktail antimalarials from a variety of plant species. The plants and ingredients are extracted and used as decoction, infusion or steam baths. Oral route was the most popular mode of administration. Respondents reported they drink one to two medium-sized cups of the recipe on an average of two times daily within a duration of about 10 days. Conclusions Herbal antimalarial remedies continue to be the popular treatments option in our localities. This study provides knowledge of the diverse ways respondents combine medicinal herbs and other local ingredients for malaria treatment. Pharmacological screening is urgently needed to validate their safety and efficacy in order to protect the health of our locals heavily relying on them to combat high burdens of malaria.

scholarly journals Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 530
Author(s):  
Oliviero Bruni ◽  
Luigi Ferini-Strambi ◽  
Elena Giacomoni ◽  
Paolo Pellegrino
Keyword(s):  
Gaba Receptors ◽  
Herbal Medicines ◽  
Well Being ◽  
Herbal Remedies ◽  
Gamma Aminobutyric Acid ◽  
Systematic Analysis ◽  
Inhibitory Neurotransmitter ◽  
Alternative Medicines ◽  
Molecular Components ◽  
The Brain

Sleep is an essential component of physical and emotional well-being, and lack, or disruption, of sleep due to insomnia is a highly prevalent problem. The interest in complementary and alternative medicines for treating or preventing insomnia has increased recently. Centuries-old herbal treatments, popular for their safety and effectiveness, include valerian, passionflower, lemon balm, lavender, and Californian poppy. These herbal medicines have been shown to reduce sleep latency and increase subjective and objective measures of sleep quality. Research into their molecular components revealed that their sedative and sleep-promoting properties rely on interactions with various neurotransmitter systems in the brain. Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter that plays a major role in controlling different vigilance states. GABA receptors are the targets of many pharmacological treatments for insomnia, such as benzodiazepines. Here, we perform a systematic analysis of studies assessing the mechanisms of action of various herbal medicines on different subtypes of GABA receptors in the context of sleep control. Currently available evidence suggests that herbal extracts may exert some of their hypnotic and anxiolytic activity through interacting with GABA receptors and modulating GABAergic signaling in the brain, but their mechanism of action in the treatment of insomnia is not completely understood.

scholarly journals Heterogeneity of mesenchymal stem cells in cartilage regeneration: from characterization to application

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Kangkang Zha ◽  
Xu Li ◽  
Zhen Yang ◽  
Guangzhao Tian ◽  
Zhiqiang Sun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Articular Cartilage ◽  
Cartilage Repair ◽  
Cartilage Damage ◽  
Cartilage Regeneration ◽  
Great Promise ◽  
Traditional Treatment ◽  
Different Types ◽  
Selection Of

AbstractArticular cartilage is susceptible to damage but hard to self-repair due to its avascular nature. Traditional treatment methods are not able to produce satisfactory effects. Mesenchymal stem cells (MSCs) have shown great promise in cartilage repair. However, the therapeutic effect of MSCs is often unstable partly due to their heterogeneity. Understanding the heterogeneity of MSCs and the potential of different types of MSCs for cartilage regeneration will facilitate the selection of superior MSCs for treating cartilage damage. This review provides an overview of the heterogeneity of MSCs at the donor, tissue source and cell immunophenotype levels, including their cytological properties, such as their ability for proliferation, chondrogenic differentiation and immunoregulation, as well as their current applications in cartilage regeneration. This information will improve the precision of MSC-based therapeutic strategies, thus maximizing the efficiency of articular cartilage repair.

A South-West Dublin Glossary: A Selection of South-West County Dublin Words, Idioms and Phrases

Béaloideas ◽  
1944 ◽  
Vol 14 (1/2) ◽  
pp. 162 ◽  
Author(s):  
Liam Ua Broin ◽  
J. J. Hogan
Keyword(s):  
South West ◽  
Selection Of

Herbal Remedies and Children: Do They Work? Are They Harmful?

PEDIATRICS ◽  
2003 ◽  
Vol 112 (Supplement_1) ◽  
pp. 240-246 ◽  
Author(s):  
Alan D. Woolf
Keyword(s):  
Primary Care ◽  
Herbal Medicine ◽  
Herbal Medicines ◽  
Good Health ◽  
Herbal Remedies ◽  
Herbal Products ◽  
Safety And Efficacy ◽  
Primary Care Clinicians

More parents are considering the use of herbal remedies to maintain their children’s good health and to treat their illnesses. They look to pediatricians and other primary care clinicians for advice concerning the safety and efficacy of herbal products for children. This article reviews principles for the clinician to keep in mind while investigating the literature on herbal medicine and addressing the use of herbal medicines with parents.

A comprehensive review on the medicinal importance; biological and therapeutic efficacy of Lagenaria siceraria (Mol.) (bottle gourd) Standley fruit

2021 ◽  
Vol 21 ◽  
Author(s):  
Muhammad Zahoor ◽  
Muhammad Ikram ◽  
Nausheen Nazir ◽  
Sumaira Naz ◽  
Gaber El-Saber Batiha ◽  
...  
Keyword(s):  
Herbal Medicines ◽  
High Water ◽  
Bottle Gourd ◽  
Herbal Remedies ◽  
Lagenaria Siceraria ◽  
Synthetic Drugs ◽  
Domestic Plant ◽  
Phytochemical Constituents ◽  
Cucurbitaceae Family ◽  
Water Contents

: Herbal remedies have been employed for the treatment and management of different diseases for ages. Herbal medicines are a promising choice over modern synthetic drugs because of their low side effects and are thus considered safe and effective in treating human diseases. Lagenaria siceraria (Mol.) Standley fruit (Bottle gourd) belongs to the Cucurbitaceae family that has been used in a different system of traditional medication to treat various diseases. This is a domestic plant that provides food as well as medication. This vegetable has low caloric values and high water contents. The edible portion of it contains phytochemicals like vitamins, proteins, choline, minerals, terpenoids, flavonoids etc. Several bioactive compounds have been isolated from L. siceraria, including triterpenoids, sterols, cucurbitacins, flavones, C-glycosides and β-glycosides. Researchers have evaluated various parts of this plant viz., fruit, root, flowers, and leaves for pharmacological activities like antianxiety, antidepressant, diuretic, antimicrobial, cytotoxic, antihyperlipidemic, cardioprotective, analgesic, anti-inflammatory, anthelmintic, anti-hyperglycemic, antihepatotoxic, anti-urolithiatic, antistress, antiulcer, anticancer, hepatoprotective, anthelmintic, immunomodulatory, and antioxidant. In this review, an attempt has been made to explore its phytochemical constituents, traditional, medicinal, and pharmacological uses to highlight the therapeutic importance of this well-known plant. This would be helpful in reviving its importance and highlight its several promising aspects to encourage researchers for further research on L. siceraria.

Formulation and Evaluation of Benidipine Nanosuspension

2021 ◽  
pp. 4111-4116
Author(s):  
Sejal Patel ◽  
Anita P. Patel
Keyword(s):  
Particle Size ◽  
Water Solubility ◽  
Polymer Concentration ◽  
Oral Route ◽  
Water Soluble ◽  
In Vitro Dissolution ◽  
Scanning Calorimetry ◽  
23 Factorial Design ◽  
Selection Of

In the interest of administration of dosage form oral route is most desirable and preferred method. After oral administration to get maximum therapeutic effect, major challenge is their water solubility. Water insoluble drug indicate insufficient bioavailability as well dissolution resulting in fluctuating plasma level. Benidipine (BND) is poorly water soluble antihypertensive drug has lower bioavailability. To improve bioavailability of Benidipine HCL, BND nanosuspension was formulated using media milling technique. HPMC E5 was used to stabilize nanosuspension. The effect of different important process parameters e.g. selection of polymer concentration X1(1.25 mg), stirring time X2 (800 rpm), selection of zirconium beads size X3 (0.4mm) were investigated by 23 factorial design to accomplish desired particle size and saturation solubility. The optimized batch had 408 nm particle size Y1, and showed in-vitro dissolution Y2 95±0.26 % in 30 mins and Zeta potential was -19.6. Differential scanning calorimetry (DSC) and FT-IR analysis was done to confirm there was no interaction between drug and polymer.

scholarly journals Effect of River Salinity on Crop Diversity: A Case Study of South West Coastal Region of Bangladesh

2014 ◽  
Vol 8 ◽  
pp. 29-37 ◽  
Author(s):  
Animesh K. Gain ◽  
Kul P. Aryal ◽  
Pritish Sana ◽  
Md Nazim Uddin
Keyword(s):  
Negative Impact ◽  
Saline Water ◽  
Coastal Region ◽  
Saline Water Intrusion ◽  
South West ◽  
Agricultural Diversity ◽  
Structured Questionnaire ◽  
Local Farmers ◽  
Saline Zone

Saline water intrusion is a major problem and conflicting issue in south-west coastal region of Bangladesh. The increased salinity has negative impact on agricultural diversity in this region. The present study provides an assessment of perception of local farmers about changes of agricultural diversity mainly diversity of vegetable species (both summer and winter) and standing plants with the changes of salinity level in the nearby river. This study was carried out in January to August 2005 through semi-structured questionnaire in selected villages of different salinity prone areas such as high saline zone and moderate saline zone, namely Paikgacha and Rampal, respectively. The study has revealed that in Paikgacha, the salinity varies approximately within the range from 20,000 to 45,000 micro-mhos and in Rampal it is from 10,000 to 30,000 micro-mhos. Due to increased salinity, the summer vegetable species in Paikgacha and Rampal have been reduced from 16 to 2 and 15 to 9 respectively during the period 1975-2005. For winter vegetable species, this figure wasreduced from 13 to 9 in Paikgacha but in Rampal this number remained unchanged. Standing plant species in Paikgacha and Rampal have been reduced from 31 to 14 and 35 to21 respectively during that period. Agricultural diversity is reducing in substantial rate both spatially and temporally.Nepal Agric. Res. J. Vol. 8, 2007, pp. 29-37 DOI: http://dx.doi.org/10.3126/narj.v8i0.11576

scholarly journals Ethnobotanical Research of Plants Used in Traditional Medicine for The Treatment of Epilepsy in Southern Mozambique

2021 ◽  
Author(s):  
Helena Correia ◽  
Maria Wanda Emanuelson ◽  
Moisés Nhantumbo ◽  
Paulo Andrassone ◽  
Graça Cumbi ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Traditional Medicine ◽  
Oral Route ◽  
Anticonvulsant Drugs ◽  
Treatment Of Epilepsy ◽  
Primary Health ◽  
Pharmacological Studies ◽  
Preparation Mode ◽  
Strychnos Spinosa ◽  
Structured Questionnaire

Abstract Background Epilepsy is a chronic brain disease that affects about 50 million people worldwide, mainly in developing countries. It is treated with anticonvulsant drugs, but in some cases, conventional anticonvulsants have not been effective, leading patients to turn to alternative herbal treatments. The study aimed to identify plants used in traditional medicine for the treatment of epilepsy in southern Mozambique, record the parts used, the method of preparation as well as the mode of administration. Methodology: The study was conducted between April to June 2019. 53 Traditional Medicine Practitioners were interviewed using a semi-structured questionnaire. The data was analyzed by calculating the Percentage of Citation (%FC) and Informant Factor Consensus (IFC). Results A total of 32 medicinal plants belonging to 18 botanical families were identified for the treatment of epilepsy in the southern part of Mozambique. The species, Hugonia orientalis Engl (22.64%), Maclura africana Bur (16.98%), Strychnos spinosa Lam (13.21%), Terminalia sericea Bruch ex DC (13.21%) and Manilkara mochisia (Bark) Dubard (11.32%) were the most cited. The families Annonaceae and Menispermaceae (4 species) were the most representative in number of species. The root was the most commonly used plant part (54.2%), the frequently used preparation mode was decoction (71%), and administration of the remedies was often by oral route. Conclusion Medicinal plants still play an important role in primary health care in the study area. However there is a need to develop pharmacological studies based on these plants to understand the mechanism of action of the bioactive compounds and for the future development of new and more effective anticonvulsant drugs

scholarly journals Effect of Employer Brand Image on Application Intentions of Final Year Management Undergraduates: Unfolding Employer Branding Determinants

2018 ◽  
Vol 5 (1) ◽  
Author(s):  
SRM Jayasinghe
Keyword(s):  
Sri Lanka ◽  
Undergraduate Students ◽  
Study Data ◽  
Corporate Image ◽  
Male Students ◽  
Development Economic ◽  
Social Dimensions ◽  
Employer Branding ◽  
Selection Of ◽  
Structured Questionnaire

Area of the StudyAs a significant determinant of the competitiveness and effectiveness of the entity, this study is to discuss what attributes of employer or determinants of Employer Branding (EB) are paramount for the attraction of final year management undergraduates towards the employer in Sri Lanka. Problem of the Study Theoretical and empirical gap of the knowledge available, especially in Sri Lanka with regard to determinants of EB which effect to the selection of future employer of the final year management undergraduates. Method of the study For the purpose of the study, data were collected from a randomly selected 300 final year management undergraduate students from 03 government universities in Sri Lanka by administrating a structured questionnaire, which consisted of 32 questions/statements with 7 point scale. The data analysis included the univariate and bivariate analyses. Findings of the Study The findings of the study are undergraduates more concern over the development, economic and social dimensions when they choose their future employer. The preference over the factors does not have significant impact based on the gender while there is significant differences of perceptions occur on factors of EB based on the level of academic achievement of the students. Furthermore the preferences over the EB factors have some differences based on the academic institution. Female students more prefer to be employed in public sector than the private sector compared to the male students. Conclusion of the Study It is concluded that in order to attract young talented graduates towards the employer, the organization must have a climate which fulfill the developmental, social and economic needs of the employees. Keywords: Employer Branding, Application Intension, Job Appealing Decision, Potential employees, Corporate Image

Sign in / Sign up

Export Citation Format

Share Document