scholarly journals Global Alliance for Genomics and Health Meets Bioconductor: Toward Reproducible and Agile Cancer Genomics at Cloud Scale

2020 ◽  
pp. 472-479 ◽  
Author(s):  
Vincent J. Carey ◽  
Marcel Ramos ◽  
Benjamin J. Stubbs ◽  
Shweta Gopaulakrishnan ◽  
Sehyun Oh ◽  
...  
Keyword(s):  
Best Practices ◽  
Cancer Genomics ◽  
Cost Benefit ◽  
Unit Testing ◽  
Use Case ◽  
Global Alliance ◽  
Workflow Execution ◽  
The One ◽  
Experimental Use ◽  
Scale Data

PURPOSE Institutional efforts toward the democratization of cloud-scale data and analysis methods for cancer genomics are proceeding rapidly. As part of this effort, we bridge two major bioinformatic initiatives: the Global Alliance for Genomics and Health (GA4GH) and Bioconductor. METHODS We describe in detail a use case in pancancer transcriptomics conducted by blending implementations of the GA4GH Workflow Execution Services and Tool Registry Service concepts with the Bioconductor curatedTCGAData and BiocOncoTK packages. RESULTS We carried out the analysis with a formally archived workflow and container at dockstore.org and a workspace and notebook at app.terra.bio. The analysis identified relationships between microsatellite instability and biomarkers of immune dysregulation at a finer level of granularity than previously reported. Our use of standard approaches to containerization and workflow programming allows this analysis to be replicated and extended. CONCLUSION Experimental use of dockstore.org and app.terra.bio in concert with Bioconductor enabled novel statistical analysis of large genomic projects without the need for local supercomputing resources but involved challenges related to container design, script archiving, and unit testing. Best practices and cost/benefit metrics for the management and analysis of globally federated genomic data and annotation are evolving. The creation and execution of use cases like the one reported here will be helpful in the development and comparison of approaches to federated data/analysis systems in cancer genomics.

MMPI-2 Scores of Puerto Rican, Mexican, and U.S. Latino College Students: A Research Note

2000 ◽  
Vol 87 (1) ◽  
pp. 266-268 ◽  
Author(s):  
Jose J. Cabiya ◽  
Denise A. Chavira ◽  
Francisco C. Gomez ◽  
Emilia Lucio ◽  
Jeanett Castellanos ◽  
...  
Keyword(s):  
United States ◽  
College Students ◽  
Puerto Rico ◽  
Standard Deviation ◽  
Puerto Rican ◽  
The United States ◽  
Clinical Scale ◽  
The Mean ◽  
The One ◽  
Scale Data

In this brief report, we present MMPI-2 basic validity and clinical scale data of Latino-descent persons from Puerto Rico ( n = 290), Mexico ( n = 1,920), and the United States ( n = 28). All were administered one of three Spanish translations of the MMPI-2. A review of the mean scores of these respective groups indicates similarities across all scales. Differences among these three groups, with the exception of the Mf scale (which is keyed to sex), were well within the one standard deviation band. More importantly, these findings are promising given the fact that three different translations of the MMPI-2 were applied.

From the boundaries of management to the management of boundaries

2019 ◽  
Vol 25 (3) ◽  
pp. 391-413 ◽  
Author(s):  
Andrea Caputo ◽  
Raffaele Fiorentino ◽  
Stefano Garzella
Keyword(s):  
Best Practices ◽  
Business Processes ◽  
Relevant Literature ◽  
Firm Boundaries ◽  
Content Type ◽  
Multiple Partners ◽  
The One ◽  
Development And Management ◽  
Practical Implications

PurposeThe purpose of this paper is to examine some of the new capabilities that are required for the facilitation of business processes management (BPM) in the current political and technological landscape. Specifically, the goal is to investigate the role of firm boundaries, from a business processes perspective, in new contexts in which the affirmation of digitalization requires more integration across a complex network of partners.Design/methodology/approachThe paper is based on a review of relevant literature on BPM, firm boundaries and negotiation. By critically integrating this literature, a framework is developed with the objective of supporting the management of boundaries.FindingsBPM, new competitive contexts, and the technological landscape require the development and management of boundary capabilities. Among these capabilities, “boundary management” – how managers coordinate resources, activities and business processes on the boundaries of the firm – should play a key role. Moreover, as managers must continuously interact with multiple partners in digital supply chains, the organizational model of negotiation serves as a means of effectively managing firm boundaries.Practical implicationsThe framework offers insights and guidelines that can help practitioners manage the boundaries of business processes. The authors encourage a focus on business processes occurring at firm boundaries. Furthermore, the authors encourage the development of new capabilities in response to the needs of practitioners to ensure best practices of negotiation.Originality/valueThis study shifts the emphasis of BPM from the boundaries of management to the management of boundaries. By shedding light on new capabilities required, this paper enriches the BPM literature and can assist, on the one hand, in reconfiguring business processes in the new political and technological landscape and, on the other hand, in facilitating effective negotiation.

Why They Fight: How Perceived Motivations for Military Service Shape Support for the Use of Force

2021 ◽  
Author(s):  
Ronald R Krebs ◽  
Robert Ralston ◽  
Aaron Rapport
Keyword(s):  
Military Service ◽  
Cost Benefit Analysis ◽  
Public Support ◽  
Cost Benefit ◽  
Good Citizen ◽  
Political Partisanship ◽  
Nationally Representative ◽  
And Gender ◽  
The One ◽  
The Relationship

Abstract What shapes public support for military missions? Existing scholarship points to, on the one hand, individuals’ affiliations and predispositions (such as political partisanship and gender), and, on the other hand, factors that shape a rational cost–benefit analysis (notably, mission objectives, the prospects for victory, and the magnitude and distribution of costs). We argue that public opinion is also shaped by beliefs about why soldiers voluntarily enlist. Using novel survey data and an experiment, deployed to a nationally representative sample of Americans, we test how four conceptions of soldiering affect support for a prospective military operation. We find, in observational data, that believing that a soldier is a good citizen or patriot bolsters support for the mission, while believing that a soldier has enlisted because he wants the material benefits of service or has “no other options” undermines support. These results support our causal argument: Americans’ attitudes toward military missions are shaped by their perception of whether the soldier has consented to deployment rather than by feelings of social obligation. This article has implications for debates on the determinants of public support for military missions and the relationship between military service and citizenship in democracies.

scholarly journals Developing cybersecurity education and awareness programmes for small- and medium-sized enterprises (SMEs)

2019 ◽  
Vol 27 (3) ◽  
pp. 393-410 ◽  
Author(s):  
Maria Bada ◽  
Jason R.C. Nurse
Keyword(s):  
Best Practices ◽  
Research Literature ◽  
Content Type ◽  
Security Education ◽  
Education And Awareness ◽  
The One ◽  
High Level ◽  
And Training ◽  
Insight Into

PurposeThe purpose of this study is to focus on organisation’s cybersecurity strategy and propose a high-level programme for cybersecurity education and awareness to be used when targeting small- and medium-sized enterprises/businesses (SMEs/SMBs) at a city-level. An essential component of an organisation’s cybersecurity strategy is building awareness and education of online threats and how to protect corporate data and services. This programme is based on existing research and provides a unique insight into an ongoing city-based project with similar aims.Design/methodology/approachTo structure this work, a scoping review was conducted of the literature in cybersecurity education and awareness, particularly for SMEs/SMBs. This theoretical analysis was complemented using a case study and reflecting on an ongoing, innovative programme that seeks to work with these businesses to significantly enhance their security posture. From these analyses, best practices and important lessons/recommendations to produce a high-level programme for cybersecurity education and awareness were recommended.FindingsWhile the literature can be informative at guiding education and awareness programmes, it may not always reach real-world programmes. However, existing programmes, such as the one explored in this study, have great potential, but there can be room for improvement. Knowledge from each of these areas can, and should, be combined to the benefit of the academic and practitioner communities.Originality/valueThe study contributes to current research through the outline of a high-level programme for cybersecurity education and awareness targeting SMEs/SMBs. Through this research, literature in this space was examined and insights into the advances and challenges faced by an on-going programme were presented. These analyses allow us to craft a proposal for a core programme that can assist in improving the security education, awareness and training that targets SMEs/SMBs.

scholarly journals Comparing Approaches for Evaluating Digital Interventions on the Shop Floor

Technologies ◽  
2018 ◽  
Vol 6 (4) ◽  
pp. 116 ◽  
Author(s):  
Francisco Lacueva-Pérez ◽  
Lea Hannola ◽  
Jan Nierhoff ◽  
Stelios Damalas ◽  
Soumyajit Chatterjee ◽  
...  
Keyword(s):  
Industry 4.0 ◽  
Shop Floor ◽  
Use Case ◽  
Individual Level ◽  
Ict System ◽  
The One ◽  
Comparison Of The Results ◽  
Future Work ◽  
Self Learning ◽  
Smart Factories

The introduction of innovative digital tools for supporting manufacturing processes has far-reaching effects at an organizational and individual level due to the development of Industry 4.0. The FACTS4WORKERS project funded by H2020, i.e., Worker-Centric Workplaces in Smart Factories, aims to develop user-centered assistance systems in order to demonstrate their impact and applicability at the shop floor. To achieve this, understanding how to develop such tools is as important as assessing if advantages can be derived from the ICT system created. This study introduces the technology of a workplace solution linked to the industrial challenge of self-learning manufacturing workplaces. Subsequently, a two-step approach to evaluate the presented system is discussed, consisting of the one used in FACTS4WORKERS and the one used in the “Heuristics for Industry 4.0” project. Both approaches and the use case are introduced as a base for presenting the comparison of the results collected in this paper. The comparison of the results for the presented use case is extended with the results for the rest of the FACTS4WORKERS use cases and with future work in the framework.

WELFARE-REDUCING GROWTH AND COST-BENEFIT ANALYSIS: ESSAY IN MEMORY OF E.J. MISHAN

2016 ◽  
Vol 61 (03) ◽  
pp. 1640013 ◽  
Author(s):  
YEW-KWANG NG
Keyword(s):  
Cost Benefit Analysis ◽  
Cost Benefit ◽  
Environmental Concerns ◽  
Benefit Analysis ◽  
Negative Effects ◽  
Positive Effects ◽  
One Child Policy ◽  
Child Policy ◽  
Biased Sex Ratio ◽  
The One

Mishan’s emphasis on the costs of economic growth half a century ago is becoming more important in this era of environmental concerns. More recently, another possible source of immiserizing growth is the one-child policy (recently relaxed) of China. This resulted in a biased sex-ratio and higher competition to earn incomes (to increase the probability of getting a wife), resulting in positive effects on GDP but negative effects on welfare. The implications of welfare-reducing growth for cost-benefit analysis and the legalization of prostitution are also discussed.

scholarly journals Contribución de la educación superior a los Objetivos de Desarrollo Sostenible desde la docencia

2020 ◽  
pp. 89
Author(s):  
Débora Isabel Ramos Torres
Keyword(s):  
Higher Education ◽  
Sustainable Development ◽  
Case Studies ◽  
International Association ◽  
Global Alliance ◽  
The Sustainable Development ◽  
World Survey ◽  
Development Goals ◽  
Teaching Function ◽  
The One

The Sustainable Development Goals (SDGs) have become entrenched in higher education institutions (HEIs) for their commitment to training people with relevant key competencies to address them. The article examines how teaching has been configured as the dimension with the greatest potential to incorporate sustainable development and how, together with research, it is considered one of the main areas of contribution to the achievement of the SDGs, concretized in the integration of these objectives to the study plans of the official degrees that, as a training action, are carried out. From the review of the Report of the Second World Survey of the International Association of Universities on Higher Education, Research and Sustainable Development, the annual Report of the Agreement on the SDGs of the Global Alliance and the Dossier of the Spanish Network for Development Sustainable, each SDG analyzes the relevant actions of integration of these Global Objectives in the teaching function and references to experiences as case studies. The analysis of the results shows a high variability between the universities regarding the degree of approach of each of the SDGs and the tendency to identify as well-established work, the one carried out with SDG 4, as a priority from teaching. The case studies analyzed show a significant differentiation regarding the types of actions they carry out and their trends. The use of surveys such as those analyzed are insufficient to observe the development of integration in the curricula, more experiences such as that developed by REDS are needed, as well as online platforms in which teachers present their experiences of curricular redesigns and incorporation from the SDGs to the curricula and mapping of the new degrees that are emerging.   

scholarly journals Continual Career Change

2007 ◽  
Vol 129 (07) ◽  
pp. 30-33 ◽  
Author(s):  
Steven Kerno
Keyword(s):  
Best Practices ◽  
Work Environment ◽  
Learning And Development ◽  
Individual Motivation ◽  
Protean Career ◽  
Job Title ◽  
Contemporary Reality ◽  
The One ◽  
Engineering Career ◽  
Future Project

This article explains the need of being versatile, flexible, adaptable, or capable of assuming forms for career demands that confront modern day engineers. The protean career, with the growing need for individual motivation and continuous, career-related learning and development, is indeed a contemporary reality for many engineers. The article also highlights that present and future engineering jobs will involve more challenge, more skilled expertise, and the ability to ‘network’ with others who possess similarly valuable knowledge, skills, and abilities. An engineer must be able to define and clearly articulate the nature and scope of current and future project assignments, as opposed to individual jobs. As work becomes more project-oriented, engineering career success will increasingly depend on the ability to move from project to project, and to absorb the learning and ‘best practices’ from each assignment, as opposed to retaining a relatively static job title and work environment. The successful engineer will more and more frequently be the one capable of using the tools at his or her disposal to effectively orient or map their knowledge and abilities to the current and future needs of their current organization, remaining flexible, adaptable, and versatile.

scholarly journals Horizons in Veterinary Precision Oncology: Fundamentals of Cancer Genomics and Applications of Liquid Biopsy for the Detection, Characterization, and Management of Cancer in Dogs

2021 ◽  
Vol 8 ◽  
Author(s):  
Jason Chibuk ◽  
Andi Flory ◽  
Kristina M. Kruglyak ◽  
Nicole Leibman ◽  
Alexis Nahama ◽  
...  
Keyword(s):  
Veterinary Medicine ◽  
Liquid Biopsy ◽  
Cancer Genomics ◽  
Residual Disease ◽  
Clinical Signs ◽  
Human Medicine ◽  
Response Monitoring ◽  
Precision Oncology ◽  
Technological Advances ◽  
The One

Cancer is the leading cause of death in dogs, in part because many cases are identified at an advanced stage when clinical signs have developed, and prognosis is poor. Increased understanding of cancer as a disease of the genome has led to the introduction of liquid biopsy testing, allowing for detection of genomic alterations in cell-free DNA fragments in blood to facilitate earlier detection, characterization, and management of cancer through non-invasive means. Recent discoveries in the areas of genomics and oncology have provided a deeper understanding of the molecular origins and evolution of cancer, and of the “one health” similarities between humans and dogs that underlie the field of comparative oncology. These discoveries, combined with technological advances in DNA profiling, are shifting the paradigm for cancer diagnosis toward earlier detection with the goal of improving outcomes. Liquid biopsy testing has already revolutionized the way cancer is managed in human medicine – and it is poised to make a similar impact in veterinary medicine. Multiple clinical use cases for liquid biopsy are emerging, including screening, aid in diagnosis, targeted treatment selection, treatment response monitoring, minimal residual disease detection, and recurrence monitoring. This review article highlights key scientific advances in genomics and their relevance for veterinary oncology, with the goal of providing a foundational introduction to this important topic for veterinarians. As these technologies migrate from human medicine into veterinary medicine, improved awareness and understanding will facilitate their rapid adoption, for the benefit of veterinary patients.

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