An association between lung cancer and gastroesophageal reflux

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 18195-18195
Author(s):  
Z. Ghanem ◽  
A. Sedfawy ◽  
V. Debari ◽  
M. Maroules
Keyword(s):  
Lung Cancer ◽  
Gastroesophageal Reflux ◽  
Cell Carcinoma ◽  
Cancer Patients ◽  
Wide Spectrum ◽  
Care Center ◽  
Tertiary Care ◽  
Control Group ◽  
Upper Aerodigestive Tract ◽  
Lung Cancer Patients

18195 Background: Many studies have demonstrated the association between gastroesophageal reflux and a wide spectrum of extra-esophageal complications of the upper aerodigestive tract. A major risk factor for adenocarcinoma of the esophagus is intestinal metaplasia, which occurs as a consequence of GERD. In addition to that, laryngoscopy and bronchoscopy can reveal findings with a high positive predictive value for the presence of GERD. The probable role of this chronic irritative disorder as a causative agent in carcinoma of the lung has not been studied. The aim of our study is to determine the correlation between GERD and lung cancer. Methods: A hospital based retrospective age, sex, ethnicity and smoking matched case control study was performed in a tertiary care center. The medical records of 325 patients diagnosed with lung cancer and 325 matched control cases were reviewed between January 2003 and December 2005. We looked at many aspects at the presentation of the disease including right or left sided lung cancer, pathology of the tumor and the presence of other co-morbid conditions. GERD diagnosis was determined either by endoscopy, manometry or clinical diagnosis retrospectively. Results: Among the 325 lung cancer patients 75 (23%) were found to have GERD at the time of diagnosis. On the other hand, only 46 (15%) patients were found in the control group. By using the Fisher Exact Probability Test there was a statistically significant increase in the incidence of GERD among lung cancer patients compared to the control group at the time of diagnosis (p=0.0046, 95% CI = 1.21- 2.73 and Odds Ratio =1.82). Patients with lung cancer were also divided into 5 major categories: Adenocarcinoma (n=110, 34%), Squamous cell carcinoma (n=70, 22%), Small cell carcinoma (n=40, 12%), NSCLCA (n=52, 16%) and Others (e.g. large cell, neuroendocrine...etc) (n=53, 16%). Conclusion: Our analyses suggest an association between GERD and lung cancer. For this reason we may consider GERD as a possible co-promoting factor of lung cancer in some patients. No significant financial relationships to disclose.

scholarly journals Clinicopathological Profile of Patients with Lung Carcinoma in a Tertiary Care Center

2020 ◽  
Author(s):  
M.T. Chandramouli ◽  
Giridhar Belur Hosmane
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Lung Carcinoma ◽  
Care Center ◽  
Tertiary Care ◽  
Smoking History ◽  
Tertiary Care Center ◽  
Cell Type ◽  
Lung Cancer Patients ◽  
Incidence And Mortality

Abstract Introduction Among malignant diseases, lung carcinoma is the most common cancer in men worldwide in terms of both incidence and mortality. Its increasing incidence in developing countries like India is an important public health problem. This work aimed to study the demographic, clinical, radiological, and histological features of patients with confirmed lung cancer. Materials and Methods A total of 50 patients with histologically confirmed lung cancer at a tertiary care center in India from August 2016 to September 2018 were studied and analyzed. Results Out of 50 diagnosed lung cancer patients, 86% were men and 14% women; 31 (62%) patients were aged more than 60 years. Majority were smokers (84%) and all were men. Cough (94%) was the most common presenting symptom followed by dyspnea (68%), chest pain (48%), and hemoptysis (38%). Of the 50 patients, 29 (58%) had soft tissue density mass lesion on radiograph. Squamous cell carcinoma (SCC) was the diagnosed histological cell type in 24 (48%) patients and adenocarcinoma in 21 (42%) patients. Distant metastasis was observed in 20 (40%) patients. Conclusion In this study, the most common histopathological cell type is SCC. Patients aged more than 50 years and smokers are at high risk of lung cancer. Patients with a smoking history and persistent respiratory symptoms should be promptly evaluated for lung malignancy.

scholarly journals Trends in prevalence of prognostic factors and survival in lung cancer patients from 1985 to 2004 at a tertiary care center

2008 ◽  
Vol 32 (2) ◽  
pp. 101-108 ◽  
Author(s):  
Sumesh Kachroo ◽  
L. Tong ◽  
Margaret R. Spitz ◽  
Yun Xing ◽  
Kelly Merriman ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Prognostic Factors ◽  
Cancer Patients ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Lung Cancer Patients

scholarly journals P1.12-16 Management of Elderly Small-Cell Lung Cancer Patients in a Romanian Tertiary Care Center

2018 ◽  
Vol 13 (10) ◽  
pp. S579
Author(s):  
T. Alexa-Stratulat ◽  
B. Gafton ◽  
M.V. Marinca ◽  
M. Paduraru ◽  
A. Luca ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Patients ◽  
Cell Lung Cancer ◽  
Care Center ◽  
Tertiary Care ◽  
Small Cell ◽  
Tertiary Care Center ◽  
Small Cell Lung ◽  
Lung Cancer Patients

scholarly journals Pleuropulmonary Tuberculosis Following Chemotherapy for Lung Cancer at a Tertiary Care Center in India

2013 ◽  
Vol 47 (4) ◽  
pp. 177-180
Author(s):  
Ashim Das ◽  
Digambar Behera ◽  
Navneet Singh ◽  
Ashutosh N Aggarwal
Keyword(s):  
Lung Cancer ◽  
Overall Survival ◽  
Cancer Patients ◽  
Cancer Chemotherapy ◽  
Care Center ◽  
Tertiary Care ◽  
Time Interval ◽  
Tertiary Care Center ◽  
Lung Cancer Patients ◽  
Response To Chemotherapy

ABSTRACT Background Chemotherapy is a risk factor for occurrence of infections. Tuberculosis is a common infection in high prevalence countries. Data on incidence of tuberculosis following lung cancer chemotherapy is limited. The current study was conducted to assess the spectrum and clinical profile of pleuro-pulmonary tuberculosis following lung cancer chemotherapy at a tertiary care institute in North India. Methods Retrospective data analysis of newly diagnosed lung cancer patients undergoing chemotherapy over a three-and-half year period. Diagnosis of tuberculosis was made by presence of suggestive clinicoradiological features (fever, cough, pleuritic chest pain, new parenchymal infiltrates or new onset pleural effusion on chest imaging) along with demonstration of acid fast bacilli (AFB) in sputum/pleural fluid/bronchoalveolar lavage (BAL) fluid and/or growth of Mycobacterium tuberculosis on culture. For biopsy/cytology specimens, tuberculosis was diagnosed by demonstration of granulomatous inflammation with AFB. Results Overall six (0.9%) of 662 lung cancer patients developed tuberculosis [four pulmonary (PTB) and two pleural (TB-PE)]. Occurrence of PTB/TB-PE and of smear-positive PTB after lung cancer chemotherapy was at a rate of 2.59 per 1000 patients/year and 1.73 per 1000 patients/year respectively, compared with national incidences of 1.85 per 1000 population/year and 0.75 per 1000 population/year respectively. Four patients had objective response to chemotherapy. Diagnosis of PTB/TB-PE was established by sputum microscopy, BAL fluid microscopy and pleural biopsy in two patients each. All patients developed tuberculosis on same side as primary tumor. All patients received standard four-drug anti-tubercular therapy (ATT). Median time interval between diagnosis of lung cancer and that of tuberculosis was 144 (56-317) days while time interval between last chemotherapy cycle and diagnosis of tuberculosis was 55 (36-182) days. Median overall survival and survival after diagnosis of tuberculosis were 312 (141-504) days and 174 (41-199) days respectively. Conclusion Occurrence of PTB/TB-PE after lung cancer chemotherapy is higher than the corresponding incidence of tuberculosis observed in the general Indian population. Overall survival of these patients is similar to lung cancer patients in general if clinical suspicion of tuberculosis is actively pursued and ATT initiated promptly following diagnosis of tuberculosis. How to cite this article Singh N, Madan K, Aggarwal AN, Gupta N, Das A, Behera D. Pleuropulmonary Tuberculosis Following Chemotherapy for Lung Cancer at a Tertiary Care Center in India. J Postgrad Med Edu Res 2013;47(4):177-180.

scholarly journals miRNA-486 and miRNA-499 in human plasma evaluate the clinical stages of lung cancer and play a role as a tumor suppressor in lung tumorigeneisis not pathogenesis

2016 ◽  
Vol 11 (1) ◽  
pp. 264 ◽  
Author(s):  
Youchao Jia ◽  
Aimin Zang ◽  
Yanguang Feng ◽  
Xiao-Fang Li ◽  
Ke Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Patients ◽  
Cell Lung Cancer ◽  
Statistical Significance ◽  
Small Cell ◽  
Expression Level ◽  
Control Group ◽  
Small Cell Lung ◽  
Lung Cancer Patients

<p class="Abstract">It was aimed to explore the expression level of miRNA-486 and miRNA-499 in the plasma of lung cancer patients and analysis their differences in expre-ssion. The expression level of both miRNA-486 and miRNA-499 in the plasma of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) were lower than that of the control group (p&lt;0.05) and the decrease was more obvious in NSCLC. Compare with the miRNA-499，expression quantity in NSCLC patients plasma. There was statistical significance difference (p&lt;0.05) between III～Ⅳstage and I～II stage. The expression quantity of miRNA in plasma of patients with extensive-stage SCLC was lower than that of patients with limited-stage SCLC (p&lt;0.05). The sensitivity and specificity of plasms miRNA-486 respectively were 88.5% and 83.3%. The expression of miRNA-499 and miRNA-486 in lung cancer patients were up-regulated, and might be closely related to the occurrence and prognosis of lung cancer, and might be used as potential screening and prognosis index for lung cancer.</p><p> </p>

scholarly journals Effect of respiratory training apparatus and vibration expectoration vest on expectoration in patients with lung cancer resection

2018 ◽  
Vol 5 (4) ◽  
pp. 285-289
Author(s):  
Xiao-Jing Guo ◽  
Li-Li Wei ◽  
Xin-Hui Li ◽  
Ning- Ning Yu ◽  
Shao-Bo Gao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Respiratory Function ◽  
Perioperative Period ◽  
Control Group ◽  
Observation Group ◽  
Pulmonary Atelectasis ◽  
Cancer Resection ◽  
Lung Cancer Patients ◽  
Respiratory Training

Abstract Objective The aim of this study was to explore the safe and effective method of expectoration in the preoperative period of patients with lung cancer resection and to promote the rehabilitation of patients. Methods A total of 100 cases of lung cancer patients undergoing elective surgery were divided into the observation group and the control group, with 50 cases in each group. The control group was treated with vibration expectoration vest for expectoration during the perioperative period, and the observation group was treated with respiratory function exerciser that has expectoration function in the perioperative period, three times a day, and the effect was evaluated after 5 days. Results The number of patients in the observation group after the first expectoration time was significantly less than that of the control group (P<0.001). Pain score, pulmonary atelectasis, and pulmonary infection rate of the observation group were significantly lower than those of the control group; the hospitalization time was significantly shorter than that of the control group; and the difference was statistically significant (P<0.05). Conclusions Lobectomy for lung cancer patients with perioperative respiratory training for respiratory function exercise, compared with conventional methods, is helpful for postoperative expectoration and to reduce the incidence of adverse events.

scholarly journals Low adherence to pneumococcal vaccination in lung cancer patients in a tertiary care university hospital in Southern Germany

2021 ◽  
Author(s):  
Arno Mohr ◽  
Mia Kloos ◽  
Christian Schulz ◽  
Michael Pfeifer ◽  
Bernd Salzberger ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Medical Records ◽  
Hepatitis A ◽  
Tertiary Care ◽  
Pneumococcal Vaccination ◽  
University Hospital ◽  
Lung Cancer Patients ◽  
Tick Borne Encephalitis ◽  
The University

Abstract IntroductionThe aim of this study was to investigate the adherence to vaccinations, especially pneumococcal vaccinations, in lung cancer patients.MethodsThe study was performed at the University Hospital Regensburg, Germany. All patients with a regular appointment scheduled between December 1, 2020, and April 29, 2021, and who provided informed consent were included. Available medical records, vaccination certificates and a questionnaire were analyzed.Results136 lung cancer patients (NSCLC n = 113, 83.1%, SCLC n = 23, 16.9%) were included. A correct pneumococcal vaccination according to national recommendations was performed in 9.4% (12/127) of patients.A correct vaccination was performed for tetanus in 50.4% (6/131), diphtheria in 34.4% (44/128), poliomyelitis in 25.8% (33/128), tick-borne encephalitis in 40.7% (24/59), hepatitis A in 45.5% (7/11), hepatitis B in 38.5% (5/13), shingles in 3.0% (3/101), measles in 50.0% (3/6), pertussis in 47.7% (62/130), influenza in 54.4% (74/136) and meningococcal meningitis in 0% (0/2).ConclusionAdherence to pneumococcal vaccinations, as well as other vaccinations, is rather low in lung cancer patients.

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