Trends in prevalence of prognostic factors and survival in lung cancer patients from 1985 to 2004 at a tertiary care center

Abstract Introduction Among malignant diseases, lung carcinoma is the most common cancer in men worldwide in terms of both incidence and mortality. Its increasing incidence in developing countries like India is an important public health problem. This work aimed to study the demographic, clinical, radiological, and histological features of patients with confirmed lung cancer. Materials and Methods A total of 50 patients with histologically confirmed lung cancer at a tertiary care center in India from August 2016 to September 2018 were studied and analyzed. Results Out of 50 diagnosed lung cancer patients, 86% were men and 14% women; 31 (62%) patients were aged more than 60 years. Majority were smokers (84%) and all were men. Cough (94%) was the most common presenting symptom followed by dyspnea (68%), chest pain (48%), and hemoptysis (38%). Of the 50 patients, 29 (58%) had soft tissue density mass lesion on radiograph. Squamous cell carcinoma (SCC) was the diagnosed histological cell type in 24 (48%) patients and adenocarcinoma in 21 (42%) patients. Distant metastasis was observed in 20 (40%) patients. Conclusion In this study, the most common histopathological cell type is SCC. Patients aged more than 50 years and smokers are at high risk of lung cancer. Patients with a smoking history and persistent respiratory symptoms should be promptly evaluated for lung malignancy.

Download Full-text

P1.12-16 Management of Elderly Small-Cell Lung Cancer Patients in a Romanian Tertiary Care Center

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2018.08.851 ◽

2018 ◽

Vol 13 (10) ◽

pp. S579

Author(s):

T. Alexa-Stratulat ◽

B. Gafton ◽

M.V. Marinca ◽

M. Paduraru ◽

A. Luca ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cancer Patients ◽

Cell Lung Cancer ◽

Care Center ◽

Tertiary Care ◽

Small Cell ◽

Tertiary Care Center ◽

Small Cell Lung ◽

Lung Cancer Patients

Download Full-text

Prevalence of T790M mutation among TKI-therapy resistant Lebanese lung cancer patients based on liquid biopsy analysis: a first report from a major tertiary care center

Molecular Biology Reports ◽

10.1007/s11033-019-04797-5 ◽

2019 ◽

Vol 46 (4) ◽

pp. 3671-3676

Author(s):

Hazem Assi ◽

Arafat Tfayli ◽

Nada Assaf ◽

Sarah Abou Daya ◽

Aram H. Bidikian ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Patients ◽

Liquid Biopsy ◽

Care Center ◽

Tertiary Care ◽

Tertiary Care Center ◽

T790m Mutation ◽

First Report ◽

Lung Cancer Patients

Download Full-text

Pleuropulmonary Tuberculosis Following Chemotherapy for Lung Cancer at a Tertiary Care Center in India

Journal of Postgraduate Medicine Education and Research ◽

10.5005/jp-journals-10028-1082 ◽

2013 ◽

Vol 47 (4) ◽

pp. 177-180

Author(s):

Ashim Das ◽

Digambar Behera ◽

Navneet Singh ◽

Ashutosh N Aggarwal

Keyword(s):

Lung Cancer ◽

Overall Survival ◽

Cancer Patients ◽

Cancer Chemotherapy ◽

Care Center ◽

Tertiary Care ◽

Time Interval ◽

Tertiary Care Center ◽

Lung Cancer Patients ◽

Response To Chemotherapy

ABSTRACT Background Chemotherapy is a risk factor for occurrence of infections. Tuberculosis is a common infection in high prevalence countries. Data on incidence of tuberculosis following lung cancer chemotherapy is limited. The current study was conducted to assess the spectrum and clinical profile of pleuro-pulmonary tuberculosis following lung cancer chemotherapy at a tertiary care institute in North India. Methods Retrospective data analysis of newly diagnosed lung cancer patients undergoing chemotherapy over a three-and-half year period. Diagnosis of tuberculosis was made by presence of suggestive clinicoradiological features (fever, cough, pleuritic chest pain, new parenchymal infiltrates or new onset pleural effusion on chest imaging) along with demonstration of acid fast bacilli (AFB) in sputum/pleural fluid/bronchoalveolar lavage (BAL) fluid and/or growth of Mycobacterium tuberculosis on culture. For biopsy/cytology specimens, tuberculosis was diagnosed by demonstration of granulomatous inflammation with AFB. Results Overall six (0.9%) of 662 lung cancer patients developed tuberculosis [four pulmonary (PTB) and two pleural (TB-PE)]. Occurrence of PTB/TB-PE and of smear-positive PTB after lung cancer chemotherapy was at a rate of 2.59 per 1000 patients/year and 1.73 per 1000 patients/year respectively, compared with national incidences of 1.85 per 1000 population/year and 0.75 per 1000 population/year respectively. Four patients had objective response to chemotherapy. Diagnosis of PTB/TB-PE was established by sputum microscopy, BAL fluid microscopy and pleural biopsy in two patients each. All patients developed tuberculosis on same side as primary tumor. All patients received standard four-drug anti-tubercular therapy (ATT). Median time interval between diagnosis of lung cancer and that of tuberculosis was 144 (56-317) days while time interval between last chemotherapy cycle and diagnosis of tuberculosis was 55 (36-182) days. Median overall survival and survival after diagnosis of tuberculosis were 312 (141-504) days and 174 (41-199) days respectively. Conclusion Occurrence of PTB/TB-PE after lung cancer chemotherapy is higher than the corresponding incidence of tuberculosis observed in the general Indian population. Overall survival of these patients is similar to lung cancer patients in general if clinical suspicion of tuberculosis is actively pursued and ATT initiated promptly following diagnosis of tuberculosis. How to cite this article Singh N, Madan K, Aggarwal AN, Gupta N, Das A, Behera D. Pleuropulmonary Tuberculosis Following Chemotherapy for Lung Cancer at a Tertiary Care Center in India. J Postgrad Med Edu Res 2013;47(4):177-180.

Download Full-text

An association between lung cancer and gastroesophageal reflux

Journal of Clinical Oncology ◽

10.1200/jco.2007.25.18_suppl.18195 ◽

2007 ◽

Vol 25 (18_suppl) ◽

pp. 18195-18195

Author(s):

Z. Ghanem ◽

A. Sedfawy ◽

V. Debari ◽

M. Maroules

Keyword(s):

Lung Cancer ◽

Gastroesophageal Reflux ◽

Cell Carcinoma ◽

Cancer Patients ◽

Wide Spectrum ◽

Care Center ◽

Tertiary Care ◽

Control Group ◽

Upper Aerodigestive Tract ◽

Lung Cancer Patients

18195 Background: Many studies have demonstrated the association between gastroesophageal reflux and a wide spectrum of extra-esophageal complications of the upper aerodigestive tract. A major risk factor for adenocarcinoma of the esophagus is intestinal metaplasia, which occurs as a consequence of GERD. In addition to that, laryngoscopy and bronchoscopy can reveal findings with a high positive predictive value for the presence of GERD. The probable role of this chronic irritative disorder as a causative agent in carcinoma of the lung has not been studied. The aim of our study is to determine the correlation between GERD and lung cancer. Methods: A hospital based retrospective age, sex, ethnicity and smoking matched case control study was performed in a tertiary care center. The medical records of 325 patients diagnosed with lung cancer and 325 matched control cases were reviewed between January 2003 and December 2005. We looked at many aspects at the presentation of the disease including right or left sided lung cancer, pathology of the tumor and the presence of other co-morbid conditions. GERD diagnosis was determined either by endoscopy, manometry or clinical diagnosis retrospectively. Results: Among the 325 lung cancer patients 75 (23%) were found to have GERD at the time of diagnosis. On the other hand, only 46 (15%) patients were found in the control group. By using the Fisher Exact Probability Test there was a statistically significant increase in the incidence of GERD among lung cancer patients compared to the control group at the time of diagnosis (p=0.0046, 95% CI = 1.21- 2.73 and Odds Ratio =1.82). Patients with lung cancer were also divided into 5 major categories: Adenocarcinoma (n=110, 34%), Squamous cell carcinoma (n=70, 22%), Small cell carcinoma (n=40, 12%), NSCLCA (n=52, 16%) and Others (e.g. large cell, neuroendocrine...etc) (n=53, 16%). Conclusion: Our analyses suggest an association between GERD and lung cancer. For this reason we may consider GERD as a possible co-promoting factor of lung cancer in some patients. No significant financial relationships to disclose.

Download Full-text