Analysis of totally implantable venous access port systems (TIVAPS) related adverse events (AEs) in metastatic colorectal cancer (mCRC) patients treated with and without bevacizumab.

e14623 Background: TIVAPS are widely used for cancer chemotherapy. Bevacizumab, a key drug for mCRC, associates with AEs such as thromboembolism, bleeding, and impaired wound healing. Bevacizumab may complicit in increasing incidence of TIVAPS related AEs. To assess the incidence of TIVAPS related AEs in mCRC patients who received chemotherapy with and without bevacizumab. Methods: We retrospectively reviewed the medical records of consecutive patients whose TIVAPS were placed at our institution between Apr. 2004 and Apr. 2009. Major selection criteria were histologically proven colorectal adenocarcinoma, metastatic disease, and receiving chemotherapy after TIVAPS placement. We assessed the incidence of AEs occurred from the first administration of chemotherapy via TIVAPS to TIVAPS removal, death, or the last follow-up. We compared the incidence of TIVAPS related AEs in the cases bevacizumab was administered (group A) with that in the cases without bevacizumab administration (group B). Results: TIVAPS was placed 549 times for 505 patients, and 544 TIVAPS placements for 501 patients were analyzed. Bevacizumb was administered in 174 patients (32%), and median duration of bevacizumab therapy was 9.2 months. Characteristics of the cases in the group A and B were: male (60% and 59%); primary site colon (60% and 57%); catheterized in left subclavian vein (85% and 81%); history of prior chemotherapy (53% and 60%); median time from TIVAPS placement to administration of chemotherapy (1 day and 1 day). Incidence of common AEs in the group A and B were: infection (7.5% and 6.8%); venous thromboembolism (3.4% and 1.4%); TIVAPS occlusion (2.3% and 1.9%); delay of wound healing (1.1% and 0.5%); hematoma (0.6% vs 0%). Median time to AE in the group A and B was 21 months and 9 months. There was no significant difference in the incidence of TIVAPS related AEs between group A and B. During median observation period of 40.5 months, no arterial thrombotic event or AE resulted in death occurred. Conclusions: Addition of bevacizumab did not increase TIVAPS related AEs during chemotherapy for mCRC.

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Totally Implantable Venous Access Port Systems: Implant Depth-based Complications in Breast Cancer Therapy - A Comparative Study

Current Pharmaceutical Design ◽

10.2174/1381612827666210901170522 ◽

2021 ◽

Vol 27 ◽

Author(s):

Kuo Chen ◽

Narasimha M. Beeraka ◽

Yuanting Gu ◽

Jingruo Li ◽

Mikhail Sinelnikov ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Therapy ◽

Venous Access ◽

Breast Cancer Patients ◽

Breast Cancer Therapy ◽

Access Port ◽

Group A ◽

Venous Access Port ◽

Group B ◽

Group D

Background: Totally implantable venous access port system (TIVAPS) is widely used in breast cancer therapy; TIVAPS has several associated complications depending on the depth of implantation in breast cancer (BC) patients during continuous infusional chemotherapy regimens. The purpose of this study is to find out the optimal depth of TIVAPS implantation to reduce the incidence of complications during infusional chemotherapy. Methods: This study reviewed the depth TIVAPS implantation in the internal jugular vein in 1282 breast cancer patients over a ten-year period (2009-2019), and associated complications. We segregated the patients as 5 groups: ‘Group A (depth < 4 mm), Group B (depth of 4-8 mm), Group C (depth of 8-12 mm), and Group D (depth of 12-16 mm), and Group E (depth of > 16 mm)’. Consequently, the ‘internal complications’ such as infection, venous thrombotic syndrome, catheter folding & migration, extravasation, whereas the ‘external complications’ viz., inflammation, local hematoma, local cutaneous reactions, and port exteriorization were significantly analyzed during TIVAPS implantation at different depths in BC patients. Results: Overall incidence of ‘internal complications’ such as infections, venous thrombotic syndrome, catheter folding & migration, and extravasation was comparatively lesser in Group C (8-12 mm) than Group A, Group B, Group D, and Group E, respectively. Mainly, the external complications such as inflammation Group C (8-12 mm) (p<0.01) were lesser (6.8%, 3/44 cases) than Group A, Group B, Group D, Group E. On a similar note, the local hematoma, and local cutaneous reaction, and port exteriorization were observed as ‘5% (1/20 cases), 4.2% (2/47 cases), and (3.2%, 1/31 cases)’ in Group C patients (p<0.01), which were comparatively lesser than the other groups. Conclusion: Subcutaneous implantation of TIVAPS at a depth of 8-12 mm could be preferred due to the lowest incidence of internal and external complications compared to the incidence of these complications in other groups; this depth could be referred to as the safe and convenient implantation depth for the effective delivery of chemotherapy regimen in BC patients without difficulty in transcutaneous access to the port.

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Bisphosphonates and Osteonecrosis of the Jaw: Advantages of a New Schedule.

Blood ◽

10.1182/blood.v108.11.3590.3590 ◽

2006 ◽

Vol 108 (11) ◽

pp. 3590-3590

Author(s):

Patrizia Zappasodi ◽

Alessandro Corso ◽

Marzia Varettoni ◽

Catherine Klersy ◽

Gianmatteo Pica ◽

...

Keyword(s):

Median Time ◽

Standard Treatment ◽

Performance Status ◽

Pathologic Fracture ◽

Disease Status ◽

Osteonecrosis Of The Jaw ◽

Standard Group ◽

Significant Difference ◽

Group A ◽

Group B

Abstract Background: Bisphosphonates (Bi) have been proven to be effective in preventing or delaying skeletal complications in multiple myeloma (MM) with a significant improvement of the quality of life. The 2002 ASCO guidelines indicate that once initiated intravenous Bi should be continued until an evident substantial decline of performance status. Recently, osteonecrosis of the jaw (ONJ) has been reported as complication of intravenous Bi treatment, with an incidence ranging between 6 and 13% and a greater occurrence in patients (pts) receiving zoledronic acid (Zol) than in those treated with pamidronate (Pam). Aim. In this retrospective study we evaluated the incidence of ONJ and of skeletal related events (SRE) in a cohort of MM pts divided in two groups according to the schedule of administration of Bi; group A: monthly administrations until tolerated (standard), group B: monthly administrations during the first year and then every 3 months (reduced). Methods: One hundred and six MM pts (M: 63, F: 43) were included in this study: 51 pts received a standard treatment (group A) and 55 a reduced schedule (group B). Pam 90 mg i.v. was administered as a three hour infusion and Zol 4 mg i.v. as a 15 minutes infusion. SRE was defined as: pathologic fracture, radiation to bone, spinal cord compression with vertebral fracture, hypercalcemia. Results: No difference was found between the two groups concerning pts characteristics at the onset: age, sex, extension of bone disease, status of the disease (progressive or responsive). Twenty pts received only Pam, 42 only Zol and 44 pts Pam followed by Zol. The distribution of the different type of Bi was not different in the two groups. ONJ occurred in 7 pts (6.6%) with a significant difference between the two groups: 6 pts in standard schedule (11.7%) and 1 in the reduced (1.8%), p=0.01, after a median time of 22.8 months in group A, and 37.8 months in the case of group B. Four of out 7 ONJ occurred during the second year of treatment (12–24 months): that period resulted significantly related (p=0.000) to the occurrence of ONJ with respect to the others (24–38 months, 40–100 months). All ONJ occurred in pts treated with Zol alone (5 pts) or with Zol after Pam (2 pts), whereas no cases were observed in Pam alone pts (p= 0.005). The median number of infusions was 20 with comparable results in the two groups (20 in group A, 19 in group B). SRE was observed in 38 pts (35.8%): 16 pts in group A and 22 pts in group B without statistical difference (p=0.6), after a median time of 9.8 months. Conclusions: These results suggest that the reduced schedule of Bi is associated with a significant lower incidence of ONJ and, although the sample size is limited, the appearance of ONJ seems delayed with respect to the standard treatment. Moreover, the incidence of SRE is similar in the two groups. In conclusion, the reduced schedule, could be applied in order to combine the antiresorptive efficacy of Bi with a higher safety and a better compliance.

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A comparative study of the effect of piroxicam versus diclofenac on wound healing in clean abdominal wounds

International Surgery Journal ◽

10.18203/2349-2902.isj20180827 ◽

2018 ◽

Vol 5 (3) ◽

pp. 1041 ◽

Cited By ~ 2

Author(s):

Chandrashekar Reddy J. Madinur ◽

Prashant Tubachi ◽

A. S. Godhi ◽

A. S. Godhi

Keyword(s):

Wound Healing ◽

Controlled Trial ◽

Research Centre ◽

Female Ratio ◽

Factors Affecting ◽

Significant Difference ◽

Group A ◽

One Year ◽

Group B ◽

The Individual

Background: The primary function of the skin is to serve as a protective barrier against the environment. The process of wound healing constitutes an array of interrelated and concomitant events. Understanding these processes and various factors affecting these processes continue to expand. The present study was undertaken to compare and evaluate the effect of piroxicam versus diclofenac on wound healing in clean abdominal wounds.Methods: The present one year randomized controlled trial was conducted on all the patients undergoing appendicectomies for uncomplicated appendicitis and uncomplicated inguinal hernia repairs in the Department of Surgery, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum during the period of one year. Based on the thumb rule a total of 60 patients divided into two groups of 30 each were studied. Based on the computer-generated randomization patients were allocated to two groups that is group A (Inj. Piroxicam) and Group B (Inj. Diclofenac).Results: In the present study, males outnumbered females with male to female ratio between of 1.72 to 2:1. The mean age in group A was30.9±7.86 years and in group B it was 30.3±7.97 years. Both the groups that is Group A and B were graded under grade I (Good wound healing) from the POD 3 onwards. Overall the individual score and total scores had no influence of the final grading (outcome) of the wound.Conclusions: Overall, better results were seen on wound healing in patients who received Inj piroxicam with significantly less post-operative redness and edema. However, this did not have significant difference in the final outcome of the grading of the wound.

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Efficacy of Jatropha curcas Latex Cream in The Epithelialization Phase of Wound Healing in Mice Skin

E3S Web of Conferences ◽

10.1051/e3sconf/202015101038 ◽

2020 ◽

Vol 151 ◽

pp. 01038

Author(s):

Muhammad N. Salim ◽

Moma Silvia ◽

Dwinna Aliza ◽

Dian Masyitha ◽

Cut D. Iskandar ◽

...

Keyword(s):

Wound Healing ◽

Quantitative Data ◽

Statistical Test ◽

Wound Therapy ◽

Treatment Groups ◽

Significant Difference ◽

Group A ◽

Group B ◽

Incision Wound ◽

Made In

The objective of the present research was to find out the efficacy of Jatropha latex cream in the epithelialization phase of wound healing in mice skin. A total of 9 male mice aged 2-3 months old and the bodyweight of 25-40 g were divided into three treatment groups. Group A was given basic cream, group B was given Jatropha latex cream (10%), and group C was given sulfadiazine. The 2 cm incision wound was made in the paravertebral area. Wound therapy was carried out twice a day for 7 days. All quantitative data were measured using ANOVA then followed by the Duncan test. The number of angiogenesis on A, B, and C was 4.67±1.20; 12.78±2.52; and 11.33±2.33, while a number of fibroblasts were 179.56±12.69; 90.56±8.23; and 99.11±7.04, respectively. The average deposition of collagen was 1.46±0.12; 1.89±0.10; and 1.74±0.06, respectively. The statistical test showed that the number of angiogenesis, fibroblast, and deposition of collagen on group B was significantly different (P<0.05) compared to group A and showed no significant difference compared to group C (P>0.05). In conclusion, Jatropha latex cream (10%) able to accelerate the epithelialization phase of wound healing in mice skin.

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POST-OPERATTVE CHANGES IN PROIEINASE INHIBITORS IN NORMAL AND IMPAIRED WOUND HEALING

10.1055/s-0038-1644860 ◽

1987 ◽

Author(s):

M Reitz ◽

H Sauer ◽

G Witzke ◽

M Neher

Keyword(s):

Wound Healing ◽

Marked Reduction ◽

Mean Value ◽

Striking Difference ◽

Impaired Wound Healing ◽

Normal Wound Healing ◽

At Iii ◽

Group A ◽

Group B ◽

Tissue Trauma

Tissue trauma after surgery activates blood coagulation. This results in a change and in the consumption of important inhibitors.We investigated the oonoentraticn of antithrorfoin III (AT III), ∝ 1-antitrypsin (∝l-AT), ∝ 2- macrogloublin (∝ 2-M) and Cl-inactivator (Cl-INH) in the blood plasma by means ofradial iirmunodiffusicn in 16 patients before surgery, after surgery and cn the 1st, 3rd and 7th days after surgery. In 11 patients normal wound healing wasobserved (group A), while in 5 patients amplicationsoccurred (group B). AT III: Fall in concentration upto the 3rd day after surgery, then a rise in concentration. In the patients with impaired wound healing there was a particularly marked reduction in AT III cn the 3rd day.∝ 1-AT: Fall in concentration after surgery, followed by a rise in concentration. In impaired wound healing a lower mean value was determined on the 3rd day after surgery than in normal wound healing. ∝ 2-M: Fall in concentration up to the 3rd day after surgery, followed by a slight increase in concentration. No striking difference between the normal group and the group with complications. Cl-INH: Fall in concentration after surgery, followed by arise in concentration; in the patients with impaired wound healing there was adelayed rise in concentration.

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Comparing the role of subcision suction method with and without the injection of platelet-rich plasma in the treatment of depressed scars

Journal of Surgical Dermatology ◽

10.18282/jsd.v2.i2.90 ◽

2017 ◽

Vol 2 (2) ◽

Author(s):

Nouran Abd El-Aziz Abou Khedr ◽

Tarek Mahmoud Hussein ◽

Ayat Mohamed El-Sayed Abd El-Fatah

Keyword(s):

Wound Healing ◽

Platelet Rich Plasma ◽

Slight Improvement ◽

Moderate Improvement ◽

Acne Scars ◽

Significant Difference ◽

Group A ◽

Group B ◽

Short Time

<p class="BodyText1">Among wound-healing modalities, platelet-rich plasma (PRP) has been used for wound healing, through the release of multiple growth factors. The platelets mediate wound healing by initiating the clotting pathway and the subsequent matrix remodelisation. The aim of the work was to study the role of injection of platelet-rich plasma in the treatment of scars. This study was conducted on thirty patients who were divided into two groups (A and B). Each group included fifteen patients. The two groups were randomly distributed by using individual sealed envelopes. Group A was subjected to subcision of their acne scars using Nokor needle, followed by suction. Group B patients were subjected to the same treatment but followed by an injection of platelet-rich plasma once per month over three months. In Group A, 6 patients (40%) showed moderate improvement, 5 patients (33.3%) showed slight improvement and 4 patients (26.7%) showed significant improvement. In Group B, 7 patients (46.7%) showed moderate improvement, 5 patients (33.3%) showed marked improvement and 3 patients (20%) showed significant improvement. There was a statistically significant difference on the independent observer’s after-treatment assessment between the groups (P=0.014). In conclusion, subcision suction leads to a persistent improvement of acne scars in a short time, and the coupling with injection of PRP is the most effective in the treatment of depressed facial scars.</p>

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Effects of drying-off procedure of ewes’ udder, with intramammary antibiotic administration, in subsequent mammary infection and development of mastitis

Journal of the Hellenic Veterinary Medical Society ◽

10.12681/jhvms.15441 ◽

2017 ◽

Vol 63 (4) ◽

pp. 273 ◽

Cited By ~ 6

Author(s):

I. G. PETRIDIS (Ι.Γ. ΠΕΤΡΙΔΗΣ) ◽

V. S. MAVROGIANNI (Β.Σ. ΜΑΥΡΟΓΙΑΝΝΗ) ◽

D. A. GOUGOULIS (Δ.Α. ΓΟΥΓΟΥΛΗΣ) ◽

G. S. AMIRIDIS (Γ.Σ. ΑΜΟΙΡΙΔΗΣ) ◽

C. BROZOS (Χ. ΜΠΡΟΖΟΣ) ◽

...

Keyword(s):

Mammary Gland ◽

Median Time ◽

Post Partum ◽

Subclinical Mastitis ◽

Antibiotic Administration ◽

Lactation Period ◽

Significant Difference ◽

Group A ◽

Left And Right ◽

Group B

Objective of the study was to evaluate effects of the procedure followed for drying-off of ewes’ udder in subsequent mammary infection and development of mastitis, in an experiment, where intramammary antibiotic administration (procaine penicillin and neomycin) was performed into the right mammary gland of animals at end of lactation period. In ewes of group A, drying-off took place progressively during a period of 22 days; in ewes of group B, drying-off took place abruptly. Samples of teat duct material and milk for bacteriological and cytological examination were collected before start of the drying-off procedure and on two occasions after the subsequent lambing. Median time to first teat duct infection postpartum was 2 and 4.5 days (left and right, respectively) for group A and 6.5 and 3.5 days for group B (P > 0.38); median time to first mammary infection post-partum was 4.5 and 7 days (left and right, respectively) for group A and 6.5 and 3.5 days for groupB (P > 0.22). Principal bacterial isolates were coagulase-negative staphylococci. No significant differences were observed between the two groups in post-partum frequency of: teat duct infection (P > 0.17), mammary infection (P > 0.36), subclinical mastitis (P > 0.36), abnormal findings in a mammary gland (P > 0.17). No significant differences were seen between the two groups in post-partum incidence risk of the following outcomes: teat duct infection (P > 0.75), mammary infection (P > 0.42), subclinical mastitis (P > 0.39), abnormal findings in a mammary gland (P > 0.85). No significant differences were evident between the two groups in cure rate of abnormal findings in a mammary gland (P >0.89); a significant difference was evident between left and right mammary glands (P < 0.045). The results support a hypothesis that the procedure for udder drying-off (i.e., progressive or abrupt cessation of lactation) does not appear to affect the risk of subsequent mammary infection and development of mastitis, in cases of intramammary administration of antibiotics at the end of a lactation period. Intramammary administration of antibiotics improved cure rates of mammary abnormalities, independently of the procedure followed for udder drying-off.

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Perbandingan Penyembuhan Luka Insisi Menggunakan Pisau Bedah dan Pisau Elektrokauter Dinilai dengan Vancouver scar score pada Operasi Luka Bersih

JURNAL BIOMEDIK (JBM) ◽

10.35790/jbm.9.3.2017.17342 ◽

2017 ◽

Vol 9 (3) ◽

Author(s):

Diadon Mitaart ◽

Mendy Hatibie ◽

Djarot Noersasongko

Keyword(s):

Experimental Study ◽

Wound Healing ◽

Healing Process ◽

Skin Incision ◽

Risk Of Infection ◽

Significant Difference ◽

Group A ◽

Male Patients ◽

Group B ◽

Scar Score

Abstract: Skin incision is usually performed by using a scalpel. It is assumed that electrocautery knife, a more recent alternative, can increase the risk of infection, impair healing, and result in poor cosmetic scar. This study was aimed to compare the healing process of incision wounds performed by using sclapels and electrocautery knives assessed with Vancouver Scar Score (VSS) at three months after operation. This was an experimental study. Subjects were 17 male patients, aged 18-55 years old, with elective operation (categorized as clean wound operation) from March through June 2016 at Prof. Dr. R. D. Kandou Hospital Manado. Each incision was performed with a scalpel first (Group A) and continued with an electrocautery knife (Group B). After 3 months of operation, the wound scars were assessed with VSS. The Wilcoxon signed ranks test showed no significant difference between the VSS of the two groups (P > 0.05). Conclusion: There was no difference in wound healing of incised wounds performed by using scalpels and by using electrocautery knives.Keywords: VSS, electrocautery, wound healing, scarAbstrak: Insisi kulit biasanya dilakukan dengan menggunakan pisau bedah. Peralatan elektrokauter merupakan alternatif baru yang dianggap meningkatkan risiko infeksi, memperlambat penyembuhan, dengan hasil secara kosmetik yang buruk. Penelitian ini bertujuan untuk membandingkan proses penyembuhan dari luka insisi menggunakan pisau bedah dan pisau elektrokauter yang dinilai dengan Vancouver Scar Score (VSS) pada operasi dengan luka bersih. Jenis penelitian ialah eksperimental. Penelitian dilakukan selama periode Maret 2016 s/d Juni 2016 pada 17 orang pasien berjenis kelamin laki-laki, berusia 18-55 tahun yang memerlukan operasi elektif di RSUP Prof. Dr. R. D. Kandou Manado dan dikategorikan operasi dengan luka bersih. Setiap insisi selalu dilakukan terlebih dahulu dengan pisau bedah (kelompok A) dan sisanya dilakukan dengan pisau elektrokauter (kelompok B), kemudian luka dinilai dengan VSS setelah 3 bulan kemudian. Hasil uji Wilcoxon signed ranks terhadap hasil VSS saat 3 bulan setelah operasi memperlihatkan tidak terdapat perbedaan bermakna antara hasil perlakuan A dan B (P > 0,05). Simpulan: Tidak terdapat perbedaan dalam penyembuhan dari kedua bagian luka insisi yang menggunakan pisau bedah dan pisau elektrokauter pada operasi dengan luka bersih.Kata kunci: VSS, elektrokauter, penyembuhan luka, jaringan parut

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Negative nasopharyngeal SARS-CoV-2 PCR conversion in Response to different therapeutic interventions

10.1101/2020.05.08.20095679 ◽

2020 ◽

Cited By ~ 2

Author(s):

Mohammed Hassan Shabrawishi ◽

Abdallah Y Naser ◽

Hassan Alwafi ◽

Ahmad Mansoor Aldobyany ◽

Abdelfattah Ahmed Touman

Keyword(s):

Supportive Care ◽

Median Time ◽

Tertiary Hospital ◽

Convincing Evidence ◽

Therapeutic Interventions ◽

Care Group ◽

Significant Difference ◽

Secondary Endpoints ◽

Group A ◽

Group B

ABSTRACTBACKGROUNDDespite lack of convincing evidence of the efficacy of hydroxychloroquine, it has been suggested to be used for the treatment of SARS-CoV-2 to accelerate the negative virus conversion. We aimed to explore the association between negative nasopharyngeal SARS-CoV-2 PCR clearance and different therapeutic interventions.METHODOLOGYThis was a retrospective cohort study of 93 patients who were admitted to medical ward with a PCR confirmed diagnosis of COVID-19 and met the inclusion criteria in a tertiary hospital in Mecca, Saudi Arabia. There were three interventional subgroups (group A (n=45): who received antimalarial drug only classified as (A1), combined with azithromycin (A2) or combined with antiviral drugs (A3)), and one supportive care group (group B) (n=48). The primary and secondary endpoints of the study were achieving negative SARS-CoV-2 nasopharyngeal PCR sample within five days or less from the start of the intervention and 12 days or less from the diagnose, respectively.RESULTSThe mean age of the patients was 43.9 years (SD:15.9). A median time of 3.00 days (IQR:2.00-6.50) needed from the time of starting the intervention/supportive care to the first negative PCR sample. There was no statistically significant difference neither between the percentage of patients in the interventional group and the supportive care group who achieved the primary or the secondary endpoint, nor in the median time needed to achieve the first negative PCR sample (p>0.05).CONCLUSIONPrescribing antimalarial medications was not shown to shorten the disease course nor to accelerate the negative PCR conversion rate.

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EFFICACY OF STEROID AND PROTON PUMP INHIBITORS IN PATIENTS UNDERGOING TONSILLECTOMY - A COMPARATIVE STUDY

10.36106/ijsr/6525938 ◽

2020 ◽

pp. 4-5

Author(s):

Somu Lakshmanan ◽

Sathishkumar Jayagandhi ◽

Tasneem Syed Fiaz Ahmed

Keyword(s):

Wound Healing ◽

Pharmacological Agents ◽

Secondary Hemorrhage ◽

Secondary Intention ◽

Post Operative Pain ◽

Significant Difference ◽

Group A ◽

Secondary Haemorrhage ◽

Group B ◽

Operative Recovery

INTRODUCTION: All tonsillectomy techniques share the same characteristics of producing an avulsion wound exposing the underlying tissues which requires extensive healing by secondary intention. our study aims to compare two pharmacological agents and analyze their clinical outcome in post operative recovery of tonsillectomy patients. MATERIALS AND METHODS: Patients were randomly divided into two groups- Group A and Group B. Group A received Injection Dexamathasone, while group B received oral pantoprazole. Post operatively patients were assessed for post operative pain, wound healing and incidence of secondary hemorrhage on Post operative Day (POD) 0, 1, 7, 14. RESULTS: Group A (steroid) had comparatively less pain on POD 0 and POD 1. However there was no significant differnence between both the groups on POD 7 and 14. Incidence of secondary haemorrhage was seen in Group A (2%), but no incidence of haemorrhage was recorded in Group B. Both the groups did not show statistically significant difference in regards to wound healing. DISCUSSION: Tonsillectomy as a surgical procedure has evolved over the years. Our study took into account two pharmacological agents, dexamethasone and pantoprazole which act by different mechanism and measured their clinical outcomes in managing post tonsillectomy patients. CONCLUSION: The study concluded that there was no significant statistical difference between the two drugs in alleviating postoperative pain, wound healing and secondary haemorrhage.

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