scholarly journals The association between neutrophil-to-lymphocyte ratio and treatment response in nasopharyngeal cancer patients of Cipto Mangunkusumo General Hospital in 2015-2018: A retrospective cohort study.

2019 ◽  
Vol 5 (suppl) ◽  
pp. 123-123
Author(s):  
Rahmat Cahyanur ◽  
Cosphiadi Irawan ◽  
Sari Rahmawati ◽  
Nadia Nasman
Keyword(s):  
Treatment Response ◽  
General Hospital ◽  
Nasopharyngeal Cancer ◽  
Neutrophil To Lymphocyte Ratio ◽  
Advanced Stage ◽  
First Line ◽  
Lymphocyte Ratio ◽  
Poor Treatment ◽  
The Mean ◽  
Poor Treatment Response

123 Background: Nasopharyngeal Cancer (NPC) is the most common head and neck cancer in Indonesia and mostly diagnosed at advanced stage. The patients with same stage of the disease have shown variety of responses against first line chemotherapy, suggesting other factors that could play a role in determining the treatment outcome. Meanwhile, neutrophil-to-lymphocyte ratio (NLR) has been studied to be a prognostic factor in many malignancies. Objective: This study aimed to determine the association between NLR and treatment response in advanced-stage NPC patients of Cipto Mangunkusumo General Hospital (RSCM) in 2015-2018. Methods: We evaluated the medical record of 45 advanced-stage NPC patients that visited RSCM in 2015-2018 retrospectively. The NLR was calculated using the neutrophil and lymphocyte count prior the first chemotherapy. We categorized NLR ≥ 4 as high. We categorized the treatment response by response (CR and PR) and non-response (SD and PD). Results: There were 45 patients included in this study. Demographic profile of the patients were dominated by male (80,0%) with mean age 45.58 (±14.5) years old. The mean of NLR was 7.396 (±5.182). We found 32 (71.1%) patients had high NLR (cut off > 4). Majority of patients with high NLR (71.9%) did not respond to first line treatment. The association between NLR and treatment response was statistically significant ( p = 0.048). Conclusions: We found that high NLR values are associated with poor treatment response in NPC patients. Keywords: Nasopharyngeal cancer, neutrophil-to-lymphocyte ratio, treatment response.

scholarly journals Platelet-to-Lymphocyte Ratio (PLR) Profile and Neutrophil-to-Lymphocyte Ratio (NLR) in Lung Cancer Patients in Ulin General Hospital Banjarmasin 2017-2018

2020 ◽  
Vol 16 (1) ◽  
pp. 25
Author(s):  
Haryati Haryati ◽  
Holly Diany
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
General Hospital ◽  
Neutrophil To Lymphocyte Ratio ◽  
Advanced Stage ◽  
Platelet To Lymphocyte Ratio ◽  
Lung Cancer Patients ◽  
Lymphocyte Ratio ◽  
Anatomy Laboratory ◽  
End Stage

Abstract: Lung cancer is the leading cause of malignancy in the world reaching up to 13% of all cancer diagnoses. Platelet-to-Lymphocyte Ratio (PLR) and Neutrophil-to-Lymphocyte Ratio (NLR), are promising markers of inflammatory prognosis, clinical decisions for proper management of lung cancer patients. The research used a retrospective analytic observational study as its research method. Samples were taken from Pathology Anatomy Laboratory, and the medical record data of lung cancer patients in Ulin General Hospital Banjarmasin from 2017 to 2018. Male lung cancer patients have percentage of 72% with PLR NLR values by sex are not much different p>0.05. 23% of patients were aged ≥ 65 years and 77% were aged £ 65 years with value p>0.05. Adenocarcinoma reaches 65% with p>0.05. Most metastases are 44% pleural effusion with value p>0.05. Percentage of advanced stage is 90% with a higher PLR NLR value at the end stage. There is a meaningful relationship of NLR with lung cancer stage p<0.05, but no relantionship with PLR p>0.05. PRL and NRL are increased at advanced stage. NRL and PRL did not differ significantly based on age, sex and histology of lung cancer. Keywords: Platelet-to-lympho­cyte ratio (PLR), Neutrophil-to-lymphocyte ratio (NLR), lung cancer

scholarly journals Can Platelet and Leukocyte Indicators Give Us an Idea about Distant Metastasis in Nasopharyngeal Cancer?

2017 ◽  
Vol 118 (1) ◽  
pp. 49-59 ◽  
Author(s):  
Mitat Arıcıgil ◽  
Mehmet Akif Dündar ◽  
Abitter Yücel ◽  
Hamdi Arbağ ◽  
Suhayb Kuria Aziz
Keyword(s):  
Distant Metastasis ◽  
Nasopharyngeal Cancer ◽  
Neutrophil To Lymphocyte Ratio ◽  
Control Group ◽  
Platelet Distribution Width ◽  
Distribution Width ◽  
Lymphocyte Ratio ◽  
Cancer Group ◽  
The Mean ◽  
The Relationship

This study aimes to evaluate platelet and leucocyte indicators, such as the mean platelet volume, platelet distribution width, plateletcrit, white blood cell count, neutrophil to lymphocyte ratio in nasopharyngeal cancer patients and also to evaluate the relationship between these indicators and nasopharyngeal cancer with distant metastasis. The medical records of 118 patients diagnosed with nasopharyngeal cancer in our hospital between January 2006 and August 2015 were reviewed. The nasopharyngeal cancer group was further sub grouped according to the presence or absence of distant metastasis and TNM (tumour – T, node – N, metastasis – M) classification. A control group consisted of 120 healthy patients. The platelet and leucocyte values at the time of the initial diagnosis were recorded. Neutrophil to lymphocyte ratio and platelet distribution width values were significantly higher in the nasopharyngeal cancer group. But only platelet distribution width values were significantly higher in the nasopharyngeal cancer group with distant metastasis compared to the nasopharyngeal cancer group without distant metastasis. Neutrophil to lymphocyte ratio and platelet distribution width values may increase in nasopharyngeal cancer. But only the platelet distribution width values may give us an idea about the distant metastasis in nasopharyngeal cancer.

scholarly journals Intralesional Bleomycin for the Treatment of Resistant Palmoplantar and Periungual Warts

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Suchana Marahatta ◽  
Dhan Keshar Khadka ◽  
Sudha Agrawal ◽  
Arpana Rijal
Keyword(s):  
Retrospective Study ◽  
Side Effects ◽  
Treatment Response ◽  
Efficacy And Safety ◽  
Poor Treatment ◽  
Systemic Side Effects ◽  
The Mean ◽  
Plantar Warts ◽  
Poor Treatment Response

Introduction. Periungual, palmar, and plantar warts are difficult to treat with poor treatment response. Intralesional (IL) bleomycin has shown promising results for their treatment in a few reports. However, we need further evidence before opting it for treating difficult sites and resistant warts. Hence, we conducted this study to assess the efficacy and safety of IL bleomycin for the treatment of resistant palmoplantar and periungual warts. Methods. In this retrospective study, we included all patients who were given IL bleomycin for warts over a year. Maximum three sittings of bleomycin (1 mg/ml) were given monthly, and they were followed up for 3 months after the procedure. The response was categorized as complete, near-complete, significant, moderate, mild, and no clearance for 100%, 75–99%, 50–74%, 25–49%, 1–25%, and 0% clearance, respectively. Results. Out of 29 patients, follow-up details were available only in 19 patients (53 warts). The mean duration was 2.5 ± 1.47 years. The number of past interventions ranged from 2–4. Wart clearance after the first intervention was complete in 36.84%, near-complete in 26.31%, significant in 26.31%, and moderate in 10.53%. Wart clearance after the last intervention was complete in 89.47% and near-complete in 10.52% of patients. However, during 3 months of follow-up after the last injection, 15.78% had a recurrence. None of them had severe local and systemic side effects. Conclusions. IL bleomycin could be a better treatment option for the treatment of resistant and difficult warts. However, we observed a higher recurrence rate even in a shorter follow-up. Hence, we need further studies with larger samples.

Elevation of Neutrophil-to-Lymphocyte Ratio before First-Line Chemotherapy Predicts a Poor Prognosis for Second-Line Chemotherapy in Gastric Cancer

Oncology ◽  
2018 ◽  
Vol 96 (3) ◽  
pp. 140-146 ◽  
Author(s):  
Dai Inoue ◽  
Shuhei Sekiguchi ◽  
Wataru Yamagata ◽  
Gen Maeda ◽  
Daiki Yamada ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Poor Prognosis ◽  
Neutrophil To Lymphocyte Ratio ◽  
Second Line ◽  
First Line ◽  
Lymphocyte Ratio ◽  
Second Line Chemotherapy ◽  
Line Chemotherapy

scholarly journals Correlation of neutrophil-to-lymphocyte ratio and clinical outcome of acute thrombotic stroke in patients with COVID-19

Narra J ◽  
2021 ◽  
Vol 1 (3) ◽  
Author(s):  
Rizky Sarengat ◽  
Mohammad S. Islam ◽  
Mohammad S. Ardhi
Keyword(s):  
Ischemic Stroke ◽  
Clinical Outcome ◽  
Acute Ischemic Stroke ◽  
National Institutes Of Health ◽  
Neutrophil To Lymphocyte Ratio ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Lymphocyte Ratio ◽  
Life Threatening ◽  
The Mean

The coronavirus disease 2019 (COVID-19) pandemic has caused millions of deaths worldwide. Acute ischemic stroke is a life-threatening risk factor for COVID-19 infection. Neutrophil-to-lymphocyte ratio (NLR) is one of the predictors of poor prognosis in acute ischemic stroke. The aim of this study was to assess the correlation between NLR values and the clinical outcome of acute thrombotic stroke patients with COVID-19 that was measured using the National Institutes of Health Stroke Scale (NIHSS). A cross-sectional hospital-based study was conducted in Dr. Soetomo General Hospital Surabaya, Indonesia. Patients with acute thrombotic stroke and COVID-19 admitted between 1 March 2020 and 31 May 2021 were recruited. The NLR values and the NIHSS scores were assessed during the admission and the correlation between NLR and NIHSS scores was calculated. This study included 21 patients with acute thrombotic stroke and COVID-19, consisting of 12 males and 9 females. The mean age was 57.6 years old. The mean NLR values was 8.33±6.7 and the NIHSS scores ranging from 1 to 33. Our data suggested a positive correlation between NLR values and NIHSS scores, r=0.45 with p=0.041. In conclusion, the NLR value is potentially to be used as a predictor of the clinical outcome in acute thrombotic stroke patients with COVID-19. However, further study is warranted to validate this finding.

scholarly journals Antipsychotic plasma levels in the assessment of poor treatment response in schizophrenia

2017 ◽  
Vol 137 (1) ◽  
pp. 39-46 ◽  
Author(s):  
R. McCutcheon ◽  
K. Beck ◽  
E. D'Ambrosio ◽  
J. Donocik ◽  
C. Gobjila ◽  
...  
Keyword(s):  
Treatment Response ◽  
Plasma Levels ◽  
Poor Treatment ◽  
Poor Treatment Response
Sign in / Sign up

Export Citation Format

Share Document