pH-Dependent Organocobalt Sources for Active Radical Species: A New Type of Anticancer Agents

2018 ◽  
pp. 485-519 ◽  
Author(s):  
Mark E. Vol’pin ◽  
Ilia Ya. Levitin ◽  
Sergei P. Osinsky
Keyword(s):  
Anticancer Agents ◽  
Radical Species ◽  
New Type ◽  
Ph Dependent

The pH-Dependent Interaction of Cinnamomin with Lipid Membranes Investigated by Fluorescence Methods

2000 ◽  
Vol 381 (7) ◽  
pp. 567-573 ◽  
Author(s):  
Rong-gui Hu ◽  
Shuang Tang ◽  
Wang-yi Liu
Keyword(s):  
Conformational Changes ◽  
Lipid Membranes ◽  
Type Ii ◽  
Ans Binding ◽  
Tryptophan Residues ◽  
New Type ◽  
Small Unilamellar Vesicles ◽  
Ph Dependent ◽  
Endocytic Vesicles

Abstract Cinnamomin, a new type II ribosomeinactivating protein (RIP), was found to be able to induce the release of calcein loaded in lecithin small unilamellar vesicles and the fusion or aggregation of the lecithin liposomes. Such induction could be promoted several fold by a pH 5.0 environment, a condition similar to that in endocytic vesicles. Lowering the pH from 7.5 to 5.0 evoked conformational changes of cinnamomin and unmasked its hydrophobic areas, including the exposure of 1-anilino-8-naphthalenesulfonate (1,8-ANS) binding sites of the molecule. Some tryptophan residues with affinity to acrylamide were demonstrated to participate in the lipidprotein interaction. The pH dependent fusogenicity of type II RIP might suggest its in vivo function as a fusogen to exert its cytotoxicity.

The pH-dependent contributions of radical species during the removal of aromatic acids and bases in light/chlorine systems

2021 ◽  
pp. 133493
Author(s):  
Zexiu An ◽  
Mingxue Li ◽  
Yanru Huo ◽  
Jinchan Jiang ◽  
Yuxin Zhou ◽  
...  
Keyword(s):  
Aromatic Acids ◽  
Radical Species ◽  
Acids And Bases ◽  
Ph Dependent

A novel type of active site at the surface of crystalline SiO2 (a-quartz) and its possible impact on pathogenicity

1991 ◽  
Vol 69 (9) ◽  
pp. 1427-1434 ◽  
Author(s):  
Dominique Costa ◽  
Bice Fubini ◽  
Elio Giamello ◽  
Marco Volante
Keyword(s):  
Active Site ◽  
Oxygen Radical ◽  
Oxygen Species ◽  
Surface Site ◽  
Mechanical Grinding ◽  
Radical Species ◽  
Crystalline Quartz ◽  
New Type ◽  
Type Radical

A new type of surface site, different from those previously described, which gives rise to a paramagnetic oxygen species upon adsorption of O2 at low temperature, has been found at the surface of crystalline quartz. This site is abundant on freshly cleaved surfaces or on chemically etched ones but absent on crystal growth faces or on samples annealed at high temperature. The abundance of this site is not related to the other surface radicals characteristic of the quartz surface originated by mechanical grinding in air. The EPR spectral features of the signal suggest an ozonide type radical O3−. The adsorption of oxygen onto quartz dusts variously treated in order to modulate their fibrogenic potential in vivo indicates that a relationship may exist between the presence of this site and quartz pathogenicity. Key words: quartz, oxygen radical species, ozonide, silicosis, EPR.

Multifunctional Ferritin Nanoparticles as Theranostics for Imaging-Guided Tumor Phototherapy

2019 ◽  
Vol 15 (7) ◽  
pp. 1546-1555 ◽  
Author(s):  
Jun Zhang ◽  
Yun Zeng ◽  
Min Su ◽  
Ming Yu ◽  
Yang Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Active Targeting ◽  
Tumor Localization ◽  
Ph Response ◽  
Theranostic Nanoparticles ◽  
New Type ◽  
Ph Dependent ◽  
Targeting Effect

The pH-response reassemble ability of the ferritin nanocage (Fn) presents the unique and facile Fn-based drug delivery systems, which enable the drug loaded into the cage of TFn. In this study, we constructed a targeting CGKRK peptides modified Fn (TFn) by genetic engineering. The TFn possessed the targeting effect of the peptide CGKRK, and could efficiently target to the tumor angiogenic blood vessels and tumor cells. In addition, the TFn could be applied in drug delivery system due to its pH-dependent depolymerization and self-assembly properties. A new type metalla-aromatics complex of NIR-absorbing organic agent named as "556-Ph" was loaded into the TFn. The developed TFn@556-Ph acted as theranostic nanoparticles for precise tumor localization via active targeting and simultaneously superior imaging-guided photothermal and photodynamic synergistic therapy.

A novel lurasidone hydrochloride–shikimic acid co-amorphous system formed by hydrogen-bonding interaction with the retained pH-dependent solubility behavior

CrystEngComm ◽  
2020 ◽  
Vol 22 (35) ◽  
pp. 5841-5853
Author(s):  
Yi Hu ◽  
Cuiping Jiang ◽  
Bin Li ◽  
Lijing Zhou ◽  
Renjie Xu ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Organic Acid ◽  
Shikimic Acid ◽  
Hydrogen Bonding Interaction ◽  
Amorphous System ◽  
Solubility Behavior ◽  
Bonding Interaction ◽  
New Type ◽  
Ph Dependent ◽  
Lurasidone Hydrochloride

The current study was aimed at investigating the lurasidone hydrochloride–shikimic acid co-amorphous system using a new type of organic acid.

scholarly journals A new type of signal peptide: central role of a twin-arginine motif in transfer signals for the delta pH-dependent thylakoidal protein translocase.

1995 ◽  
Vol 14 (12) ◽  
pp. 2715-2722 ◽  
Author(s):  
A.M. Chaddock ◽  
A. Mant ◽  
I. Karnauchov ◽  
S. Brink ◽  
R.G. Herrmann ◽  
...  
Keyword(s):  
Signal Peptide ◽  
New Type ◽  
Ph Dependent

scholarly journals NADPH binding and control of catalase compound II formation: comparison of bovine, yeast, and Escherichia coli enzymes

1994 ◽  
Vol 300 (2) ◽  
pp. 531-539 ◽  
Author(s):  
A Hillar ◽  
P Nicholls ◽  
J Switala ◽  
P C Loewen
Keyword(s):  
Escherichia Coli ◽  
Catalytic Activity ◽  
Free Radical ◽  
Compound I ◽  
Radical Species ◽  
New Type ◽  
Compound Ii ◽  
And Control ◽  
Original Classification

1. NADPH binds to bovine catalase and to yeast catalases A and T, but not to Escherichia coli catalase HPII. The association was demonstrated using chromatography and fluorimetry. Bound NADPH fluoresces in a similar way to NADPH in solution. 2. Bound NADPH protects bovine and yeast catalases against forming inactive peroxide compound II either via endogenous reductant action or by ferrocyanide reduction during catalytic activity in the presence of slowly generated peroxide. 3. Bound NADPH reduces neither compound I nor compound II of catalase. It apparently reacts with an intermediate formed during the decay of compound I to compound II; this postulated intermediate is an immediate precursor of stable compound II either when the latter is formed by endogenous reductants or when ferrocyanide is used. It represents therefore a new type of hydrogen donor that is not included in the original classification of Keilin and Nicholls [Keilin, D. and Nicholls, P. (1958) Biochim. Biophys. Acta 29, 302-307] 4. A model for NADPH action is presented in which concerted reduction of the ferryl iron and of a neighbouring protein free radical is responsible for the observed NADPH effects. The roles of migrant radical species in mammalian and yeast catalases are compared with similar events in metmyoglobin and cytochrome c peroxidase reactions with peroxides.

The Microstructure of Shock-Synthesized Diamond

1967 ◽  
Vol 25 ◽  
pp. 324-325
Author(s):  
Lucien F. Trueb
Keyword(s):  
Single Crystals ◽  
Preferred Orientation ◽  
High Magnification ◽  
Texture Pattern ◽  
Shock Process ◽  
New Type ◽  
Diffraction Diagram

A new type of synthetic industrial diamond formed by an explosive shock process has been recently developed by the Du Pont Company. This material consists of a mixture of two basically different forms, as shown in Figure 1: relatively flat and compact aggregates of acicular crystallites, and single crystals in the form of irregular polyhedra with straight edges.Figure 2 is a high magnification micrograph typical for the fibrous aggregates; it shows that they are composed of bundles of crystallites 0.05-0.3 μ long and 0.02 μ. wide. The selected area diffraction diagram (insert in Figure 2) consists of a weak polycrystalline ring pattern and a strong texture pattern with arc reflections. The latter results from crystals having preferred orientation, which shows that in a given particle most fibrils have a similar orientation.

New type electron gun with electrostatic and electromagnetic lenses

1978 ◽  
Vol 36 (1) ◽  
pp. 62-63
Author(s):  
T. Ichinokawa ◽  
H. Maeda
Keyword(s):  
Electron Microscopy ◽  
Electron Beam ◽  
Optimum Condition ◽  
Bias Voltage ◽  
Electron Gun ◽  
Charge Effect ◽  
Micro Fabrication ◽  
Maximum Brightness ◽  
New Type ◽  
The Ideal

I. IntroductionThermionic electron gun with the Wehnelt grid is popularly used in the electron microscopy and electron beam micro-fabrication. It is well known that this gun could get the ideal brightness caluculated from the Lengumier and Richardson equations under the optimum condition. However, the design and ajustment to the optimum condition is not so easy. The gun has following properties with respect to the Wehnelt bias; (1) The maximum brightness is got only in the optimum bias. (2) In the larger bias than the optimum, the brightness decreases with increasing the bias voltage on account of the space charge effect. (3) In the smaller bias than the optimum, the brightness decreases with bias voltage on account of spreading of the cross over spot due to the aberrations of the electrostatic immersion lens.In the present experiment, a new type electron gun with the electrostatic and electromagnetic lens is designed, and its properties are examined experimentally.

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