Layer by Layer Microencapsulate Technology as Basis for Fabrication of Drug Delivery Nanosystems with Remote Controlling Properties

2011 ◽  
pp. 131-168
Author(s):  
Olga A. Inozemtseva ◽  
Sergey A. Portnov ◽  
Tatyana A. Kolesnikova ◽  
Dmitry A. Gorin ◽  
Gleb B. Sukhorukov
Keyword(s):  
Drug Delivery ◽  
Layer By Layer

scholarly journals Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS production

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7735-7748 ◽  
Author(s):  
Jordan E. Read ◽  
Dong Luo ◽  
Tina T. Chowdhury ◽  
Rod J. Flower ◽  
Robin N. Poston ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Migration ◽  
Drug Release ◽  
Layer By Layer ◽  
Ros Production ◽  
Flow Conditions ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Migration Assays ◽  
In Cells

Magnetically responsive LbL microcapsules are biologically inert, magnetically retained in flow and cell migration assays so are retainable drug delivery vehicles.

scholarly journals Versatile Layer-By-Layer Highly Stable Multilayer Films: Study of the Loading and Release of FITC-Labeled Short Peptide in the Drug Delivery Field

Materials ◽  
2019 ◽  
Vol 12 (8) ◽  
pp. 1206 ◽  
Author(s):  
Kun Nie ◽  
Xiang Yu ◽  
Navnita Kumar ◽  
Yihe Zhang
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Multilayer Films ◽  
Layer By Layer ◽  
Guest Molecules ◽  
Potential Applications ◽  
Spatio Temporal ◽  
Release Speed

A viable short FITC-peptide immobilization is the most essential step in the fabrication of multilayer films based on FITC-peptide. These functional multilayer films have potential applications in drug delivery, medical therapy, and so forth. These FITC-peptides films needed to be handled with a lot of care and precision due to their sensitive nature. In this study, a general immobilization method is reported for the purpose of stabilizing various kinds of peptides at the interfacial regions. Utilizing Mesoporous silica nanoparticles can help in the preservation of these FITC-peptides by embedding themselves into these covalently cross-linked multilayers. This basic outlook of the multilayer films is potent enough and could be reused as a positive substrate. The spatio-temporal retention property of peptides can be modulated by varying the number of capping layers. The release speed of guest molecules such as tyrosine within FITC-peptide or/and adamantane (Ad)-in short peptides could also be fine-tuned by the specific arrangements of the multilayers of mesoporous silica nanoparticles (MSNs) and hyaluronic acid- cyclodextrin (HA-CD) multilayer films.

scholarly journals 3D Printed Laminated CaCO3-Nanocellulose Films as Controlled-Release 5-Fluorouracil

Polymers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 986 ◽  
Author(s):  
Denesh Mohan ◽  
Nur Fatin Khairullah ◽  
Yan Ping How ◽  
Mohd Shaiful Sajab ◽  
Hatika Kaco
Keyword(s):  
Drug Delivery ◽  
Chemical Properties ◽  
Pharmaceutical Compounds ◽  
The Body ◽  
Therapeutic Effects ◽  
Layer By Layer ◽  
3D Printed ◽  
Time Required ◽  
Uptake And Release ◽  
And Chemical Properties

Drug delivery constitutes the formulations, technologies, and systems for the transport of pharmaceutical compounds to specific areas in the body to exert safe therapeutic effects. The main criteria for selecting the correct medium for drug delivery are the quantity of the drug being carried and the amount of time required to release the drug. Hence, this research aimed to improve the aforementioned criteria by synthesizing a medium based on calcium carbonate-nanocellulose composite and evaluating its efficiency as a medium for drug delivery. Specifically, the efficiency was assessed in terms of the rates of uptake and release of 5-fluorouracil. Through the evaluation of the morphological and chemical properties of the synthesized composite, the established 3D printing profiles of nanocellulose and CaCO3 took place following the layer-by-layer films. The 3D printed double laminated CaCO3-nanocellulose managed to release the 5-fluorouracil as an effective single composition and in a time-controlled manner.

Layer-by-layer polyelectrolyte complex coated poly(methacrylic acid) nanogels as a drug delivery system for controlled release: structural effects

RSC Advances ◽  
2014 ◽  
Vol 4 (99) ◽  
pp. 56323-56331 ◽  
Author(s):  
Xiaorui Li ◽  
Pengcheng Du ◽  
Peng Liu
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Methacrylic Acid ◽  
Polyelectrolyte Complex ◽  
Core Shell ◽  
Layer By Layer ◽  
Structural Effects

The structure of core–shell nanogels@polyelectrolyte complex microspheres was optimized as a drug delivery system for controlled release.

3D Printing Technology in Drug Delivery: Recent Progress and Application

2019 ◽  
Vol 24 (42) ◽  
pp. 5039-5048 ◽  
Author(s):  
Sabna Kotta ◽  
Anroop Nair ◽  
Nimer Alsabeelah
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Pharmaceutical Manufacturing ◽  
Layer By Layer ◽  
Printing Technology ◽  
Drug Dosing ◽  
3D Printing Technology ◽  
3D Printed

Background: 3D printing technology is a new chapter in pharmaceutical manufacturing and has gained vast interest in the recent past as it offers significant advantages over traditional pharmaceutical processes. Advances in technologies can lead to the design of suitable 3D printing device capable of producing formulations with intended drug release. Methods: This review summarizes the applications of 3D printing technology in various drug delivery systems. The applications are well arranged in different sections like uses in personalized drug dosing, complex drugrelease profiles, personalized topical treatment devices, novel dosage forms and drug delivery devices and 3D printed polypills. Results: This niche technology seems to be a transformative tool with more flexibility in pharmaceutical manufacturing. Typically, 3D printing is a layer-by-layer process having the ability to fabricate 3D formulations by depositing the product components by digital control. This additive manufacturing process can provide tailored and individualized dosing for treatment of patients different backgrounds with varied customs and metabolism pattern. In addition, this printing technology has the capacity for dispensing low volumes with accuracy along with accurate spatial control for customized drug delivery. After the FDA approval of first 3D printed tablet Spritam, the 3D printing technology is extensively explored in the arena of drug delivery. Conclusion: There is enormous scope for this promising technology in designing various delivery systems and provides customized patient-compatible formulations with polypills. The future of this technology will rely on its prospective to provide 3D printing systems capable of manufacturing personalized doses. In nutshell, the 3D approach is likely to revolutionize drug delivery systems to a new level, though need time to evolve.

scholarly journals Alginate Nanoformulation: Influence of Process and Selected Variables

2020 ◽  
Vol 13 (11) ◽  
pp. 335
Author(s):  
Hazem Choukaife ◽  
Abd Almonem Doolaanea ◽  
Mulham Alfatama
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Effective Properties ◽  
Matrix Material ◽  
Cost Effective ◽  
Biological Properties ◽  
Layer By Layer ◽  
Therapeutic Outcomes ◽  
Manufacturing Techniques ◽  
Formulation Parameters

Nanocarriers are defined as structures and devices that are constructed using nanomaterials which add functionality to the encapsulants. Being small in size and having a customized surface, improved solubility and multi-functionality, it is envisaged that nanoparticles will continue to create new biomedical applications owing to their stability, solubility, and bioavailability, as well as controlled release of drugs. The type and physiochemical as well as morphological attributes of nanoparticles influence their interaction with living cells and determine the route of administration, clearance, as well as related toxic effects. Over the past decades, biodegradable polymers such as polysaccharides have drowned a great deal of attention in pharmaceutical industry with respect to designing of drug delivery systems. On this note, biodegradable polymeric nanocarrier is deemed to control the release of the drug, stabilize labile molecules from degradation and site-specific drug targeting, with the main aim of reducing the dosing frequency and prolonging the therapeutic outcomes. Thus, it is essential to select the appropriate biopolymer material, e.g., sodium alginate to formulate nanoparticles for controlled drug delivery. Alginate has attracted considerable interest in pharmaceutical and biomedical applications as a matrix material of nanocarriers due to its inherent biological properties, including good biocompatibility and biodegradability. Various techniques have been adopted to synthesize alginate nanoparticles in order to introduce more rational, coherent, efficient and cost-effective properties. This review highlights the most used and recent manufacturing techniques of alginate-based nanoparticulate delivery system, including emulsification/gelation complexation, layer-by-layer, spray drying, electrospray and electrospinning methods. Besides, the effects of the main processing and formulation parameters on alginate nanoparticles are also summarized.

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