Long-Term Outcomes and Prognostic Factors in Patients with Indications for Particle Therapy in Sarcomas

Object. The authors conducted a study to evaluate the long-term outcomes and prognostic factors for survival in a large series of patients treated by gamma knife surgery (GKS) for non—small cell lung cancer (NSCLC) brain metastases. Methods. The study is based on the retrospective analysis of clinical and radiological records obtained during a 10-year period (1993–2003), concerning 836 lesions in 504 patients. The lesions were primary in 86% and recurrent 14% of the cases; they were solitary in 31%, single in 29%, and multiple in 40%. The mean follow-up period was 16 months (range 4–113 months). The most common histological types were adenocarcinoma (51%) and squamous cell carcinoma (27%). Dose planning parameters were as follows: mean target volume 6.2 cm3 (range 0.06–22.5 cm3); mean prescription dose 21.4 Gy (range 15.5–28 Gy); and mean number of isocenters 6.7 (range one–18). Progression-free and actuarial survival curves were calculated using the Kaplan—Meier method. The main factors affecting survival were determined by unimultivariate analysis (log-rank test and Cox proportional hazard models). Analysis of long-term outcomes seemed to confirm that GKS is a primary therapeutic option in these patients. The 1-year local tumor control rate was 94%. The overall median survival was 14.5 months, with extremely rewarding quality of life indices. The recursive partitioning analysis classification was the dominant prognostic factor. Conclusions. Gamma knife surgery is a useful treatment for brain metastases from NSCLC.

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Long-term outcomes and prognostic factors of young patients with mucinous and signet-ring cell colorectal cancer

Archives of Medical Science ◽

10.5114/aoms.2020.93342 ◽

2020 ◽

Vol 16 (2) ◽

pp. 359-365 ◽

Cited By ~ 1

Author(s):

Rui Zhang ◽

Jian Zhao ◽

Jian Xu ◽

Yuzhe Chen

Keyword(s):

Colorectal Cancer ◽

Prognostic Factors ◽

Young Patients ◽

Signet Ring Cell ◽

Long Term Outcomes ◽

Signet Ring ◽

Ring Cell

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Prognostic factors for long-term outcomes in relapsing–remitting multiple sclerosis

Multiple Sclerosis Journal - Experimental Translational and Clinical ◽

10.1177/2055217316666406 ◽

2016 ◽

Vol 2 ◽

pp. 205521731666640 ◽

Cited By ~ 2

Author(s):

Anthony L Traboulsee ◽

Peter Cornelisseª ◽

Magnhild Sandberg-Wollheim ◽

Bernard MJ Uitdehaag ◽

Ludwig Kappos ◽

...

Keyword(s):

Multiple Sclerosis ◽

Prognostic Factors ◽

Regression Models ◽

Brain Volume ◽

Univariate Analysis ◽

Medication Possession Ratio ◽

Stepwise Multiple Regression ◽

Long Term Outcomes ◽

Edss Score

Objective The objective of this article is to investigate potential clinical and MRI predictors of long-term outcomes in multiple sclerosis (MS). Methods This was a post hoc analysis using data from all 382 patients in the PRISMS long-term follow-up (LTFU) study collected up to eight years after randomisation. An additional analysis was performed including only those patients originally randomised to receive early subcutaneous interferon (IFN) β-1a ( n = 259). Baseline/prestudy variables, indicators of early clinical and MRI activity (baseline to month 24), and indicators of IFN β-1a treatment exposure (including medication possession ratio (MPR)) were investigated as candidate prognostic factors for outcomes measured from baseline and from month 24 to LTFU. Explanatory variables identified from univariate regression models ( p ≤ 0.15) were selected for inclusion in stepwise multiple regression models. Results Candidate prognostic factors selected by the univariate analysis ( p ≤ 0.15) included age, MS duration, baseline brain volume, EDSS score, and log(T2 burden of disease (BOD)). In most of the multivariate regression models applied, higher baseline brain volume and MPR predicted better long-term clinical outcomes, while higher baseline and greater early increase in EDSS score predicted worse outcomes. Conclusion Identification of markers that may be prognostic for long-term disability could help identify MS patients at higher risk of disability progression.

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Prognostic Factors of Long-Term Outcomes in Endodontic Microsurgery: A Retrospective Cohort Study over Five Years

Journal of Clinical Medicine ◽

10.3390/jcm9072210 ◽

2020 ◽

Vol 9 (7) ◽

pp. 2210

Author(s):

Yeon-Jee Yoo ◽

Dong-Won Kim ◽

Hiran Perinpanayagam ◽

Seung-Ho Baek ◽

Qiang Zhu ◽

...

Keyword(s):

Logistic Regression ◽

Prognostic Factors ◽

Periodontal Disease ◽

Maxillary Sinus ◽

Long Term Outcomes ◽

Chi Square ◽

Term Outcome ◽

Long Term Outcome ◽

Endodontic Microsurgery

The aim of this study was to analyze the long-term outcomes of endodontic microsurgeries in a cohort and identify their association with prognostic factors. A cohort of endodontic microsurgeries followed up periodically with complete clinical and radiographic records for at least 5 years were reviewed retrospectively. Their survival and healing status and profile characteristics were analyzed by Pearson chi-square test and logistic regression (α = 0.05) to identify prognostic factors that influenced outcomes. Of 652 cases in the cohort, 225 (34.5%) were included. The mean follow-up period was 90.4 months (range, 60–168 months). The long-term success rate was 80.5%, and the 5-year survival rate was 83.5%. Logistic regression showed higher success in anteriors compared to molars (OR = 5.405, (95% CI, 1.663–17.571; p = 0.005)) and in teeth with crown restorations (OR = 10.232, (95% CI, 3.374–31.024; p < 0.001)). Conversely, lower success was found in teeth with periodontal disease (OR = 0.170, (95% CI, 0.032–0.900; p = 0.037)) and maxillary sinus involvement (OR = 0.187, (95% CI, 0.035–0.994; p = 0.049)). Endodontic microsurgery has a highly favorable long-term outcome. Tooth position, crown restoration, periodontal disease, and maxillary sinus involvement were identified as main prognostic factors.

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