Development and Evaluation of Avanafil Self-nanoemulsifying Drug Delivery System with Rapid Onset of Action and Enhanced Bioavailability

Sublingual drug delivery system was a well-established platform for delivering the drug that need to exhibit quick action without any first-pass metabolic effect, but various pitfall in the regular sublingual drug delivery systems such as a tablet, capsule etc., that can be overcome by novel sublingual drug delivery technology such as particulate sublingual spray. Sublingual spray for drug administration has gained attention in the market since it proved its propensity to by-pass the first-pass metabolism and to initiate a rapid onset of action due to its atomized micro particulate nature, which is significantly higher than the other sublingual formulations. The approval of sublingual spray by the regulatory agencies may commence further research in this field by subsuming various essential drugs for indications such as cancer pain, cardiovascular issue etc. This article comprises a detailed study on the drawback of conventional sublingual drug delivery system and the approach by which these drawbacks can be overruled by spray technology in the sublingual area and the, in-depth mechanism of drug delivery through sublingual with the help of atomization followed by the entire formulation strategy along with evaluation and industrial perspective of the sublingual spray dosage form as a future tool of patient-friendly drug delivery.

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CHEWING GUM: CONFECTIONARY TO A POPULAR TRANSBUCCAL DOSAGE FORM

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i6.18307 ◽

2017 ◽

Vol 10 (6) ◽

pp. 39

Author(s):

Bharat Jhanwar ◽

Bhupendra Singh Tomar ◽

Surajpal Verma

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Water Soluble ◽

Chewing Gum ◽

Onset Of Action ◽

Release Studies ◽

Chewing Gums ◽

Energy Supplements ◽

Novel Drug

Chewing gum is a highly convenient and controlled release transbuccal drug delivery system taken without water. It is gaining popularity as a selfadministrable carrier for the medication used for motion sickness, smoke cessation, hypertension, xerostomia, dental caries, pain, as nutritive and energy supplements. Functional chewing gum favors both local and systemic effects intended to be chewed about half an hour. It has emerged out with a fast onset of action either by direct absorption or swallowed with saliva into gastrointestinal tract.It has better bioavailability that lowers the doses and reduces the gastric side-effects. Gums adhere with ease and compliance of administration to children and dysphagia patients. Chewing gums are formulated using a water-insoluble gum base with water-soluble excipients with the active ingredient in the case of medicated gums. European Pharmacopeia standards used for release studies, there are no other particular official standards. It has attracted the researchers as successful potential drug delivery system in coming future. The present article reviews it as novel drug delivery system including its merits and limitations, material and methods of formulation and evaluation.

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REVIEW ON PARENTRAL DRUG DELIVERY SYSTEM: A NOVEL APPROACH

International Journal of Recent Advances in Science and Technology ◽

10.30750/ijrast.321 ◽

2016 ◽

Vol 3 (2) ◽

Author(s):

Rakesh Roshan Mali ◽

Himanshu Tomar

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Active Drug ◽

Therapeutic Index ◽

The Body ◽

Parenteral Administration ◽

Onset Of Action ◽

Safety Issues ◽

Delivery Technology

Drug delivery is a process that includes dosage form and route of administration. It refers to procedures or approaches for transporting pharmaceutical compound in the body safely to achieve its therapeutic effect. The Parenteral drug delivery system is the most common and efficient for delivery of active drug substances with poor bio-availability and the drugs with a narrow therapeutic index. Though parenteral administration of drug is often critical and associated with problems such as limited number of acceptable excipients, stringent requirements of aseptic production process, safety issues, and patient noncompliance. Still this route maintains its value due to special advantages like quicker onset of action in case of emergency; target the drug quickly to desired site of action, prevention of first pass metabolism etc. The application of advanced drug delivery technology to parenteral administration lead to development of SLNs, liposomes, niosomes, lipid nano dispersions etc. to overcome limitations of conventional parenteral delivery.Drug delivery technology that can reduce the total number of injection throughout the drug therapy period will be truly advantageous not only in terms of compliance, but also to improve the quality of the therapy. Such reduction in frequency of drug dosing is achieved by the use of specific formulation technologies that guarantee the release of the active drug substance in a slow and predictable manner. The development of new injectable drug delivery system has received considerable attention over the past few years.

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Characterization and Optimization of Oral Solid Supersaturable Self-emulsifying Drug Delivery System of Cilostazol

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.00586 ◽

2021 ◽

pp. 3371-3376

Author(s):

Ali N. Wannas ◽

Nidhal K. Maraie

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Immediate Release ◽

Drug Dissolution ◽

Dissolution Profile ◽

Onset Of Action ◽

Different Types

Objective: This study aimed to prepare tablets containing solid supersaturable self-emulsifying drug delivery system (S-SEDD) of cilostazol for oral use. Method: To improve drug dissolution and so bioavailability for cilostazol (calss II drug) as well as reducing the amount of additives (except for drug =50 mg), liquid S-SEDD of cilostazol were prepared. In this study the liquid supersaturable formula was converted into a solid supersaturable self-emulsifying form using different amounts of two different types of the adsorbents (avicel 101 and aerosil 200). Accordingly; six-formulas (SS1-SS6) were prepared and evaluated applying pre-compression evaluation and the best formula was SS3 formula having an amorphous homogenous free-flowing property and used to prepare tablets using direct compression method. Consequently; six tablet formulas (T1-T6) containing different types and amounts of additives were prepared and evaluated applying post-compression parameters and in-vitro drug release. Result: The best tablet formula was T2 formula which showed high dissolution profile under sink and non-sink condition in comparison to conventional marketed tablet indicating that it kept its supersaturable self-emulsification in-vitro with faster drug release which may lead to improve drug absorption and bioavailability with a fast onset of action. Conclusion: This work succeeded in converting the prepared cilostazol liquid S-SEDD to solid SEDD which is compressed into an immediate release tablets that disintegrate and spontaneously emulsified to form supersaturable system in the GIT which improved drug solubility, release and consequently may enhance its absorption and bioavailability leading to reducing dose size and drug/excipient size effects.

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