scholarly journals Not Your Typical “Lipoma”; An Unusual Case of Thyroid Cancer Presenting With a Skull Lesion

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A894-A895
Author(s):  
Basma Abdulhadi ◽  
Deepti Bahl
Keyword(s):  
Thyroid Cancer ◽  
Total Thyroidectomy ◽  
Unusual Case ◽  
Bone Destruction ◽  
Nodular Goiter ◽  
Follicular Carcinoma ◽  
Primary Malignancy ◽  
Cervical Lymph Nodes ◽  
Skull Metastasis ◽  
Skull Lesion

Abstract Background: Bone metastases from thyroid cancers tends to more commonly afflict the long bones, pelvis, ribs, vertebrae and sternum. Skull metastases are exceedingly rare being found in only ~2.5% of patients with thyroid cancer, more commonly in patients with Follicular thyroid carcinomas. We present an unusual case of thyroid cancer presenting with skull metastasis. Clinical Case: A 55 year- old male with a slowly growing skull lesion was referred to our center after an attempt to remove this scalp lesion was aborted as the lesion extended through a calvarial defect. This lesion was noted by the patient 1 year prior to presentation and was slowly growing in size. He opted for watchful monitoring as this was presumed to be a lipoma at the time. Imaging revealed a 6.4 x 4.6 x 6.3 cm lesion in the left parietal region with a large extra-axial and soft tissue components with intervening bone destruction as well as adjacent dural thickening. Differential for the lesion given the radiological appearance included meningioma, hemangiopericytoma, or an osseous/dural metastasis with an unclear primary malignancy. Excision of the extra-axial parietal lesion was consistent with metastatic thyroid carcinoma (follicular variant of papillary carcinoma). Further imaging revealed a multi nodular goiter with a prominent 6 cm left thyroid nodule. Patient had no obstructive symptoms. He underwent a total thyroidectomy with findings of a 6.8 cm minimally invasive follicular carcinoma with multifocal capsular invasion and a focus of vascular invasion. The right lobe revealed 1.5 cm classic PTC. Notably, margins were free of disease and cervical lymph nodes were negative for disease. Imaging revealed no other metastatic lesions. Patient received RAI after his total thyroidectomy and was started on suppressive doses of levothyroxine. He has been followed with annual MRI Brain, USG thyroid and Thyroglobulin levels and remains free of recurrence for the past 36 months. Conclusion: Thyroid cancer can present with skull metastasis without causing significant morbidity. This is a rare manifestation of disease and can be easily misdiagnosed. This case highlights the importance of keeping a broad differential when evaluating skull lesions.

scholarly journals The relationship of thyroid cancer with dominant nodule in patients with nodular goiter who underwent total thyroidectomy and had thyroid carcinoma

2013 ◽  
Vol 28 (4) ◽  
pp. 182-185
Author(s):  
Koray Arisoy ◽  
Ferda Nihat Koksoy ◽  
Dogan Gonullu ◽  
Aysenur Ayyildiz Igdem ◽  
Bekir Kuru
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Carcinoma ◽  
Total Thyroidectomy ◽  
Nodular Goiter ◽  
Relationship Of ◽  
The Relationship

Thyroid Cancer in Children and Adolescents

1994 ◽  
Vol 80 (4) ◽  
pp. 257-262 ◽  
Author(s):  
Ambrogio S. Fassina ◽  
Maurizio Rupolo ◽  
Maria Rosa Pelizzo ◽  
Dario Casara
Keyword(s):  
Thyroid Cancer ◽  
Children And Adolescents ◽  
Total Thyroidectomy ◽  
Residual Disease ◽  
Lung Metastases ◽  
Follicular Carcinoma ◽  
Medullary Carcinoma ◽  
Recurrence Risk ◽  
University Hospital ◽  
Female Ratio

Aims and background It was the aim of this paper to report clinical and pathologic characteristics and outcome of treatment in terms of relapse-free and overall survival in 36 patients under 20 years of age and treated for thyroid cancer at Padua University Hospital from January 1968 to December 1988 and followed until December 1992. Methods The median follow-up was 112 months (range 3 to 228 months). Age at diagnosis ranged from 4 to 20 years with a mean age of 15 years and a male/female ratio of 1:2.9. A thyroid nodule or a laterocervical mass was the most frequent sign of presentation. The routine diagnosis schedule included thyroid scintigram, neck echotomography and in the last decade fine needle aspiration biopsy. Results Sixteen (28%) patients had a family history of thyroid disease. Histology revealed that papillary carcinoma was present in 43 patients (76.8%), follicular carcinoma in 9 (16%), medullary carcinoma in 2 (3.6%) and lymphoma in 2 (3.6%). Fifty-four patients were treated with total thyroidectomy, of these 34 had bilateral neck dissection and 20 unilateral nodal dissection; 2 patients underwent simple lobectomy with unilateral dissection. Nodal involvement was present in 41 (73%) cases, and synchronous visceral metastases were detected with scan and/or chest X-ray in 10 (18%) cases. In the case of differentiated thyroid carcinoma, patients with residual disease or thyroid remnants were treated with 131I metabolic therapy. All patients were put on suppressive hormone therapy. At this writing, 52 (93%) patients were in complete remission and 4 (7%) had persistent disease. Recurrences developed in 2 (3.5%) patients: one presented lung metachronus metastases and one local recurrence; no deaths have occurred. Conclusions From this experience, total thyroidectomy appears to be the appropriate approach for differentiated tumors in children and adolescents because the disease is often diffuse, secondary deposits may be easily detected, and the value of thyroglobulin measurement can be improved. Following this strategy, overall recurrence risk was low and 131I therapy was curative in patients with nodal and lung metastases.

scholarly journals A prospective observational study on thyroid malignancy

2021 ◽  
Vol 8 (4) ◽  
pp. 1155
Author(s):  
Bharath S. V. ◽  
Badareesh Lakshminarayana ◽  
Rishabh Mehta
Keyword(s):  
Thyroid Cancer ◽  
Follicular Carcinoma ◽  
Medullary Carcinoma ◽  
Needle Aspiration ◽  
Biological Behaviour ◽  
Cervical Lymph Nodes ◽  
Modes Of Presentation ◽  
The Common ◽  
Thyroid Malignancies ◽  
Success Of Treatment

Background: Thyroid cancers are a complex group of tumours with wide variety of histological presentation and biological behaviour, and prognosis range. In their early stages, they behave like other benign conditions of the thyroid. The success of treatment lies upon early diagnosis and proper management. The aim of the present study is to evaluate the modes of presentation, the incidence of various pathological types, and assess their clinical, behaviour and surgical management.Methods: The present study is observational, time-bound, consists of patients prospectively and consecutively diagnosed and histologically confirmed thyroid malignancy.Results: This study showed females 80.66% are commonly affected than males 19.44%. The most frequent malignancy is papillary 86.11%, followed by follicular carcinoma 11.11%, medullary carcinoma 2.78%. Cervical lymph nodes are involved in four 13.88% of patients. In patients undergone iodine ablation, 5.56% of them had a recurrence. Mortality at two years was 2.7%. In this study, Thyroid cancer is commonly seen between twenty-one to thirty years.Conclusions: The incidence of thyroid malignancies is more common among women (80.66%) than men. Papillary carcinoma (86.11%) is the common differentiated thyroid cancer. The prevalence of distant metastasis is 2.78% to the vertebral body. In our study, 41.66% of patients belongs to less than 30 years of age; this may be due to the trend of overdiagnosis due to the introduction of ultrasonography guided Fine needle aspiration study.

scholarly journals Management of papillary and follicular (differentiated) thyroid carcinoma - an update

1970 ◽  
Vol 16 (2) ◽  
pp. 126-130
Author(s):  
Md Abdul Mobin Choudhury ◽  
Md Abdul Alim Shaikh
Keyword(s):  
Thyroid Cancer ◽  
Total Thyroidectomy ◽  
Differentiated Thyroid Cancer ◽  
Radioiodine Therapy ◽  
Endemic Goiter ◽  
Follicular Carcinoma ◽  
Differentiated Thyroid Carcinoma ◽  
Thyroid Cancers ◽  
Surgical Options ◽  
Definitive Management

Thyroid cancers are quite rare, accounting for only 1.5% of all cancers in adults and 3% of all cancers in children. Differentiated thyroid cancer comprises 95% of all thyroid cancers. Of all thyroid cancers 74-80% of cases are papillary cancers. Incidences of follicular carcinoma are higher in regions where incidence of endemic goiter is high. Surgery is the definitive management of thyroid cancer. There is agreement that patients with large, locally aggressive or metastatic differentiated thyroid cancer require total thyroidectomy but there is continuing disagreement on the most appropriate operation for 'low risk' differentiated thyroid cancer. Adjuvant treatments are thyroid hormone suppression and radioiodine therapy rather than chemotherapy and radiotherapy. Prognosis is generally excellent and is influenced by factors related to the patient, the disease and the therapy. This article reviews the basis of surgical treatment of differentiated thyroid cancer and assesses the evidences supporting the surgical options. Key words: Papillary Carcinoma; Follicular Carcinoma; Hemithyroidectomy; Total Thyroidectomy DOI: 10.3329/bjo.v16i2.6848Bangladesh J Otorhinolaryngol 2010; 16(2): 126-130

Clinico-statistical Considerations on Thyroid Cancer in the Youth

1966 ◽  
Vol 52 (3) ◽  
pp. 201-229 ◽  
Author(s):  
Umberto Ballarati ◽  
Ugo Marinoni ◽  
Gianpeglio Puricelli ◽  
Gianluigi Spreafico
Keyword(s):  
Thyroid Cancer ◽  
Lymph Nodes ◽  
Thyroid Nodule ◽  
Total Thyroidectomy ◽  
Neck Dissection ◽  
Radical Neck Dissection ◽  
Papillary Adenocarcinoma ◽  
Cervical Lymph Nodes ◽  
Solid Carcinoma ◽  
Diagnosis Of Thyroid Cancer

On a series of 220 patients with carcinoma of the thyroid, 17 (10 females and 7 males) were under the 24th year of age. In four cases the tumor was diagnosed between the 5th and the 14th year of age and in 13 cases between the 15th and the 24th year; there were 13 cases of papillary adenocarcinoma, 2 cases of follicular adenocarcinoma, and 2 cases of solid carcinoma. In 7 cases the tumor was preceded by the appearance of goiter; only one patient had been previously irradiated. The first clinical sign of disease was a thyroid nodule in 10 cases, metastases to cervical lymph nodes in 7 cases; in 3 of these last cases primary neoplasia of the thyroid remained clinically occult. Scanning with I181 was used in 13 cases for the diagnosis of thyroid cancer. Surgical and radiological therapies were associated in all cases; the enucleation of the tumor was performed in one case, emithyroidectomy in 7 cases, total thyroidectomy in 6 cases. Surgery was limited to dissection of the neck in 3 cases. In addition, thyroidectomy was associated to radical neck dissection in 9 cases with metastases. In all cases I181 was administered; in 7 cases it was associated to X-therapy and in 8 cases to telecobaltotherapy. One patient is alive 3 months after the beginning of the treatment, 6 patients from 1 to 3 years, 3 patients from 5 to 6 years, 2 patients after 8 years and 5 patients from 10 to 15 years.

scholarly journals Risk of Second Primary Malignancy in Patients Treated with Radioactive Iodine for Thyroid Cancer

2021 ◽  
Author(s):  
K McNamara ◽  
Veronica Barry ◽  
Alexander Yao ◽  
Joanne Weekes ◽  
Thomas Saunders ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Total Thyroidectomy ◽  
Neck Dissection ◽  
Differentiated Thyroid Cancer ◽  
Radioactive Iodine ◽  
Second Primary ◽  
Second Primary Malignancy ◽  
Recurrence Rates ◽  
Primary Malignancy ◽  
Increased Risk

ABSTRACT Introduction Radioactive iodine (RAI) is widely used as a treatment for differentiated thyroid cancer following total thyroidectomy. There is a risk of second primary malignancy (SPM) in these patients which is estimated between 0-5% although research to support this is limited. The primary aim of this study was to ascertain the rate of SPM in patients who have undergone RAIT for thyroid cancer. The secondary objectives were to assess whether the risk is dose dependant and examine the overall survival and recurrence rates. Methods A retrospective review of all patients treated with radioactive iodine for thyroid cancer between 2002 and 2014. Patient information was collected from a structured database. Data regarding second cancers and recurrence rates was obtained from an online clinical portal. Follow up was 5 years minimum. Results 199 patients underwent RAI treatment. Median age was 53. 71.4% patients were female and 28.6% were male. All patients underwent total thyroidectomy. 13.6% underwent total thyroid and central neck dissection. 11% underwent total thyroidectomy and lateral neck dissection. 5.5% required post-operative radiotherapy. 12% patients developed recurrent thyroid cancer. 8% developed a SPM of which prostate, skin, head and neck SCC were the most common. A dose ≥3.7 (Gigabecquerel) GBq was statistically significantly more likely to lead to a SPM with a P value of 0.041 (95% CI -0.52 – 0.01318). Conclusions Increased risk of developing a second primary malignancy should be taken into account, especially in younger patients with low risk disease, when deciding on RAIT. Key words Radioactive iodine, Differentiated thyroid cancer, Second primary malignancy, Radioiodine, Thyroid cancer

scholarly journals Clinical characteristics associated with the finding of thyroid cancer originating from hot nodules in patients with hyperthyroidism: a case report and systematic review of the literature

2021 ◽  
Vol 36 (4) ◽  
pp. 682-695
Author(s):  
Carlos Osorio ◽  
Jorge Ballestas ◽  
Diego Barrios ◽  
Andrés Arévalo ◽  
Shekyna Montaño ◽  
...  
Keyword(s):  
Systematic Review ◽  
Thyroid Cancer ◽  
Malignant Tumors ◽  
Nodular Goiter ◽  
Follicular Carcinoma ◽  
Toxic Nodular Goiter ◽  
Factors Associated ◽  
Diagnosis Of Cancer ◽  
Nodular Lesions ◽  
Diagnosis Of Thyroid Cancer

Coexistence between thyroid cancer and hyperthyroidism is rare, and most of the nodular lesions from which a malignant tumor is documented in this group of patients correspond to cold nodules. Justified by the increasing number of reports in the literature about malignant tumors diagnosed from hot nodules, a systematic review was carried out to determine possible factors associated with the diagnosis of thyroid cancer from hot nodules in patients with hyperthyroidism. The results suggest that the clinical diagnosis of toxic nodular goiter, nodular lesions of diameter > 10 mm and a histological type compatible with a follicular carcinoma, are factors that on their own increase the risk of making the diagnosis of cancer from a hot nodule.

Abstract #1070 An Unusual Case of Metastatic Follicular Thyroid Cancer 40 Years After Initial Diagnosis

2018 ◽  
Vol 24 ◽  
pp. 255
Author(s):  
Lakshmi Menon ◽  
Yuanjie Mao ◽  
Sanaz Abedzadeh-Anaraki ◽  
Spyridoula Maraka
Keyword(s):  
Thyroid Cancer ◽  
Unusual Case ◽  
Initial Diagnosis ◽  
Follicular Thyroid Cancer

Abstract #1086: Patient Experience with Severe Low Energy Following Total Thyroidectomy for Papillary Thyroid Cancer

2017 ◽  
Vol 23 ◽  
pp. 258
Author(s):  
Elizabeth Wendt ◽  
Maria Bates ◽  
Reese Randle ◽  
Jason Orne ◽  
Cameron Macdonald ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Total Thyroidectomy ◽  
Papillary Thyroid Cancer ◽  
Patient Experience ◽  
Low Energy ◽  
Papillary Thyroid

Socio-demographic and Clinical Characteristics of Patient with Thyroid Cancer

2020 ◽  
Vol 11 (1) ◽  
pp. 54-58
Author(s):  
AKM Farhad Hossain ◽  
Md Mahmudur Rahman Siddiqui ◽  
Sayada Fatema Khatun
Keyword(s):  
Public Health ◽  
Thyroid Cancer ◽  
Clinical Characteristics ◽  
Family Income ◽  
Ethical Issues ◽  
Endocrine System ◽  
Public Health Problem ◽  
Follicular Carcinoma ◽  
Public Health Issue ◽  
Cross Sectional

Background: Thyroid cancer is the most common malignant disease in endocrine system. It is an emerging public health issue associated with burden on the family, community and the nation. The aim of this study is to determine the socio-demographic and clinical characteristics of patient with thyroid cancer attending in tertiary hospital. Methods: This cross sectional study was conducted among 246 thyroid cancer patients in two tertiary hospitals of Dhaka city from 01 July 2018 to 30 June 2019. The subjects were selected purposively following specific selection criteria and maintaining ethical issues. Data were collected by face to face interview using a semi-structured questionnaire and checklist. Data were analyzed by the statistical package for the social science (SPSS) version 23. Results: This study revealed that majority (74.4%) of respondents was female, married (72%), housewife (61.4%), rural respondent (41.1%) and had primary education (69%). Mean (± SD) age of the respondent was 37.85(±12.20) years (Range 14-70 years) and mean (± SD) monthly family income was Tk. 17681(±10602). Out of 246 cases, 204 (82.9%) was papillary and 42 (17.1%) was follicular carcinoma. Various clinical presentations included visible neck swelling in 225 (91.5%), swollen lymph node in 103 (41.9%), pain 90 (36.6%), Difficulties in swallowing 87 (35.4%), Hoarseness of voice in 141 (57.3%), cough along with swelling 47(19.1%), Difficulties in breathing due to swelling in 13(5.3%) of the patients. Conclusion: Incidence of thyroid cancer has increased worldwide specially in female patients in 3rd and 4th decades of life. As thyroid cancer is a growing public health problem in Bangladesh, proper screening and early diagnostic facilities at all level should be available to measure its actual burden in the country. Anwer Khan Modern Medical College Journal Vol. 11, No. 1: Jan 2020, P 54-58

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