The effect of 6-aminonicotinaniide on limb development

Development ◽  
1980 ◽  
Vol 55 (1) ◽  
pp. 307-318
Author(s):  
John C. McLachlan
Keyword(s):  
Special Reference ◽  
Growth And Development ◽  
Limb Development ◽  
Normal Growth ◽  
Embryonic Chick ◽  
Morphological Effect

The morphological effect of the nicotinamide analogue 6-aminonicotinamide on the development of the embryonic chick limb was studied, with special reference to muscle, cartilage, feather germ formation, and ossification. No evidence was found to support theories of control of differentiation by nicotinamide-like substances, although the effect of nicotinamide analogues has often been quoted as evidence for such theories. However, the effect of 6-AN in shortening the limb provides an opportunity to study the interaction of various tissues in normal growth and development, and the results are used to shed further light on the processes involved in muscle splitting, and feather germ formation.

CONGENITAL SUCRASE-ISOMALTASE DEFICIENCY

PEDIATRICS ◽  
1972 ◽  
Vol 49 (6) ◽  
pp. 847-853
Author(s):  
I. Antonowicz ◽  
J. D. Lloyd-Still ◽  
K. T. Khaw ◽  
H. Shwachman
Keyword(s):  
Growth And Development ◽  
Clinical Presentation ◽  
Quantitative Estimation ◽  
Failure To Thrive ◽  
Normal Growth ◽  
Significant Rise ◽  
Small Intestinal Mucosa ◽  
Severe Diarrhea ◽  
Young Infants ◽  
Small Intestinal

Observations over a period of 6 years are reported on 10 children in whom the diagnosis of congenital sucrase isomaltase deficiency (SID) was confirmed by quantitative estimation of disaccharidase activity of the small intestinal mucosa. Repeat biopsies were performed on eight of the ten patients and showed no evidence that sucrase isomaltase activity is acquired. Sucrose tolerance tests (2 gm/kg) showed no significant rise in blood glucose in the seven patients in whom they were performed. This condition may appear in young infants with severe diarrhea resulting in a malabsorption syndrome and failure to thrive. It may also be manifest in a milder clinical presentation with bothersome diarrhea in spite of normal growth and development in the older infant or young child. The diagnosis in this latter group can be difficult, and is frequently missed.

Effect of dietary menhaden oil on normal growth and development and on ameliorating mucosal injury in rats

1991 ◽  
Vol 54 (2) ◽  
pp. 346-350 ◽  
Author(s):  
J A Vanderhoof ◽  
D J Blackwood ◽  
H Mohammadpour ◽  
J H Park
Keyword(s):  
Growth And Development ◽  
Normal Growth ◽  
Mucosal Injury ◽  
Menhaden Oil

scholarly journals Surgical cause of respiratory distress in a newborn

2021 ◽  
Vol 8 (9) ◽  
pp. 1629
Author(s):  
Vishnu Vardhan Reddy M. ◽  
Suguna Reddy C. ◽  
Yoga Nagendhar ◽  
Vardhini Sree D.
Keyword(s):  
Respiratory Distress ◽  
Growth And Development ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Normal Growth ◽  
Surgical Excision ◽  
Term Infant ◽  
Congenital Heart Diseases ◽  
Common Causes ◽  
Lobar Emphysema

Common causes of respiratory distress in a term infant include transient tachypnoea of newborn, sepsis/congenital pneumonia and congenital heart diseases. Surgical causes of distress in a newborn are rare and should be considered when other causes have been ruled out. We report a case of an early term female neonate who developed respiratory distress immediately after birth which was gradually progressive and required respiratory support. On evaluation with chest radiography and CT, a diagnosis of congenital lobar emphysema (CLE) was made. Immediate surgical resection was planned and done on day 8 of life. Post operatively she had no respiratory distress and discharged within a week. Baby is now healthy with normal growth and development. Half of the cases of CLE are diagnosed within the first 6 months of life but very few cases present with respiratory distress since birth. Timely diagnosis and early surgical excision in neonates <2 months improve the outcome, as seen in our case.

Immunoperoxidase localization of type X collagen in chick tibiae

1986 ◽  
Vol 6 (2) ◽  
pp. 155-162 ◽  
Author(s):  
Alvin P. L. Kwan ◽  
Anthony J. Freemont ◽  
Michael E. Grant
Keyword(s):  
Growth And Development ◽  
Superficial Layer ◽  
Embryonic Chick ◽  
Skeletal System ◽  
Type X Collagen ◽  
Cartilage Growth ◽  
Proliferative Zone ◽  
Calcified Cartilage ◽  
Cartilage Growth Plate

Type X collagen was prepared from medium of long-term cultures of embryonic chick tibiotarsal chondrocytes. Antibodies to type X collagen were raised and used in immunoperoxidase localization studies with embryonic and growing chick tibiotarsus. Strong anti-type X collagen reactivity was detected mainly in the region of hypertrophic chondrocytes, and to a lesser extent in the zone of calcified cartilage. No reactivity was detected in the proliferative zone nor the superficial layer of the cartilage growth plate. These results suggest that type X collagen may play a key role in matrix calcification during growth and development of the skeletal system.

scholarly journals The nutritional adequacy of plant-based diets

1999 ◽  
Vol 58 (2) ◽  
pp. 265-269 ◽  
Author(s):  
T. A. B. Sanders
Keyword(s):  
Growth And Development ◽  
Normal Growth ◽  
Vitamin B ◽  
Plant Origin ◽  
Nutritional Adequacy ◽  
Bioactive Substances ◽  
Vegetarian Diets

The nutritional adequacy of plant-based diets is discussed. Energy and protein intakes are similar for plant-based diets compared with those containing meat. Fe and vitamin B12 are the nutrients most likely to be found lacking in such diets. Bioactive substances present in foods of plant origin significantly influence the bioavailability of minerals and requirements for vitamins. Well-balanced vegetarian diets are able to support normal growth and development. It is concluded that meat is an optional rather than an essential constituent of human diets.

Improved Student Learning of Infant Growth and Development

PEDIATRICS ◽  
1978 ◽  
Vol 62 (5) ◽  
pp. 775-777
Author(s):  
Paula L. Stillman ◽  
Jane S. Ruggill ◽  
Darrell Sabers
Keyword(s):  
Medical Students ◽  
Growth And Development ◽  
Traditional Instruction ◽  
Normal Growth ◽  
Normal Infant ◽  
Healthy Children ◽  
Longitudinal Development ◽  
Comparison Groups ◽  
Experimental Group

All physicians who care for children require a knowledge of normal growth and development in order to detect and interpret abnormalities. Yet traditional instruction tends to focus on the ill child and rarely provides students the opportunity to follow up the cases of healthy children over a prolonged period of time. A new course was developed that enabled students to observe the longitudinal development of a normal infant from birth to age 16 months. At the completion of the course, a multiple-choice examination covering developmental concepts from birth to age 6 years was administered to the students who participated in this course (experimental group) and to two comparison Groups. The experimental group scored substantially higher than both comparison groups on items covering birth to age 18 months. The program offers an opportunity for medical students to observe the longitudinal development of a normal infant and appears complementary to other instructional methods.

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