Granuloma annulare presenting as multiple nodules on the pinna

2004 ◽  
Vol 118 (8) ◽  
pp. 640-642 ◽  
Author(s):  
N. Raghava ◽  
J.R. Mitchard ◽  
R.P. Youngs
Keyword(s):  
Young Adults ◽  
Histological Examination ◽  
Clinical Assessment ◽  
Granuloma Annulare ◽  
Inflammatory Dermatosis ◽  
History Of ◽  
Nodular Lesions ◽  
Children And Young Adults ◽  
Multiple Nodules

Granuloma annulare is a benign, idiopathic, inflammatory dermatosis characterized clinically by dermal papules and annular plaques. We describe the case of a 40-year-old man who presented with a long history of multiple nodules on the left pinna. Histological examination revealed the typical necrobiotic granulomas of granuloma annulare. The condition predominantly affects the extremities of children and young adults; cases involving the pinna are extremely rare.Nodular lesions are common in otolaryngological practice, and this case illustrates the need for careful clinical assessment and appropriate biopsy in diagnosing lesions of the outer ear

scholarly journals Increased Intracranial Pressure in a Boy with Gorham-Stout Disease

2016 ◽  
Vol 8 (1) ◽  
pp. 66-71 ◽  
Author(s):  
Manisha K. Patel ◽  
Brent R. Mittelstaedt ◽  
Frank E. Valentin ◽  
Linda P. Thomas ◽  
Christian L. Carlson ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Young Adults ◽  
Intracranial Pressure ◽  
Clinical Symptoms ◽  
Increased Intracranial Pressure ◽  
Migraine Headaches ◽  
History Of ◽  
Children And Young Adults ◽  
Excessive Proliferation ◽  
Csf Leaks

Gorham-Stout disease (GSD), also known as vanishing bone disease, is a rare disorder, which most commonly presents in children and young adults and is characterized by an excessive proliferation of lymphangiomatous tissue within the bones. This lymphangiomatous proliferation often affects the cranium and, due to the proximate location to the dura surrounding cerebrospinal fluid (CSF) spaces, can result in CSF leaks manifesting as intracranial hypotension with clinical symptoms to include orthostatic headache, nausea, and vertigo. We present the case of a boy with GSD and a known history of migraine headaches who presented with persistent headaches due to increased intracranial pressure. Although migraine had initially been suspected, he was eventually diagnosed with intracranial hypertension after developing ophthalmoplegia and papilledema. We describe the first known instance of successful medical treatment of increased intracranial pressure in a patient with GSD.

scholarly journals Risk factors of coronary heart disease in children and young adults with parental history of premature coronary heart disease

2016 ◽  
Vol 43 (2) ◽  
pp. 51
Author(s):  
Murti Andriastuti ◽  
Sudigdo Sastroasmoro ◽  
Agus Firmansyah
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Young Adults ◽  
Heart Disease ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Parental History ◽  
Passive Smoker ◽  
History Of ◽  
Children And Young Adults

Background Morbidity and mortality of coronary heart disease(CHD) are recently increasing. This is related to changes in lifestyle,such as lack of activity and high consumption of fatty diet. Themain cause of CHD is atherosclerosis. The development of ath-erosclerosis takes a long time, is asymptomatic, and might beginin childhood. The important risk factors that have roles in increas-ing the likelihood of atherosclerosis are family history of prematureCHD, hypertension, hyperlipidemia, obesity, smoking and irregu-lar activity.Objective The aim of this study was to find out the prevalence ofCHD risk factors in children and young adults who had parentalhistory of premature CHD.Methods This was a descriptive cross sectional study conductedon offspring of premature CHD patients who were admitted in theintensive cardiology care unit (ICCU) of Cipto MangunkusumoHospital between January 1999 to December 2001 and of prema-ture CHD patients who visited the Cardiology Clinic of the Depart-ment of Internal Medicine, Cipto Mangunkusumo Hospital duringMarch and April 2002. Subjects were aged 12 to 25 year-old.Results Among the subjects, 40% had hyperlipidemia, 8% hadhypertension, 11% were obese, 21% were active smokers, 41%were passive smokers, and 73% had irregular activity. Ninety-sevenpercents subjects had more than 1 risk factors.Conclusions The prevalence of hyperlipidemia, hypertension,obesity, passive smoker, active smoker and irregular activity inchildren and young adults with parental history of premature CHDin this study were higher than those in the normal population.Most had more than 1 risk factor, increasing the likelihood of CHD.A screening test should be performed on children with parentalhistory of premature CHD so that early preventive measures mightbe done to minimize the risk factors

scholarly journals Detection of anti-pertussis toxin IgG in oral fluids for use in diagnosis and surveillance of Bordetella pertussis infection in children and young adults

2006 ◽  
Vol 55 (9) ◽  
pp. 1223-1228 ◽  
Author(s):  
David J. Litt ◽  
Dhanraj Samuel ◽  
John Duncan ◽  
Anthony Harnden ◽  
Robert C. George ◽  
...  
Keyword(s):  
Young Adults ◽  
Pertussis Toxin ◽  
Bordetella Pertussis ◽  
Oral Fluid ◽  
Disease Diagnosis ◽  
Pertussis Infection ◽  
Oral Fluids ◽  
History Of ◽  
Children And Young Adults ◽  
Serum Elisa

Bordetella pertussis infection is being increasingly recognized as a cause of prolonged, distressing cough (without whooping symptoms) in children and young adults. Diagnosis of infection in this population is important for treatment and surveillance purposes, and may also prove useful in reducing transmission to unvaccinated babies, for whom disease can be fatal. Serum IgG titres against pertussis toxin (PT) are routinely used as a marker of recent or persisting B. pertussis infection. However, collection of serum from young children is difficult, and compliance amongst these subjects to give samples is low. To circumvent these problems, an IgG-capture ELISA capable of detecting anti-PT IgG in oral fluid was devised. The assay was evaluated by comparison to a serum ELISA, using 187 matched serum and oral fluid samples from children (aged 5–16 years) with a history of prolonged coughing, whose serum anti-PT titre had already been determined (69 seropositive, 118 seronegative). The results showed that, using a cutoff of 70 arbitrary units (AU), the oral fluid assay detected seropositive subjects with a sensitivity of 79.7 % [95 % confidence interval (CI) 68.3–88.4] and a specificity of 96.6 % (95 % CI 91.5–99.1). Thus, oral fluid titres of ⩾70 AU would possess a positive predictive value of 76.2–93.2 % for pertussis amongst children with chronic coughs when used as a surrogate for the serum ELISA (assuming disease prevalence of 12–37 %). This oral fluid ELISA will greatly assist in the convenience of B. pertussis disease diagnosis and surveillance.

Vocal Quality, Articulation and Audiological Characteristics of Children and Young Adults with Diagnosed Allergies

1982 ◽  
Vol 91 (3) ◽  
pp. 277-280 ◽  
Author(s):  
Barbara M. Baker ◽  
Claude D. Baker ◽  
Ha Thanh Le
Keyword(s):  
Allergic Rhinitis ◽  
Young Adults ◽  
Bronchial Asthma ◽  
Speech Sound ◽  
Previous History ◽  
Hearing Disorders ◽  
History Of ◽  
Children And Young Adults ◽  
Vocal Quality ◽  
Fluctuating Hearing Loss

This study details vocal quality, articulation errors, and hearing disorders in 80 children and young adults with diagnosed allergies. Results indicated that almost 50 % had abnormalities in vocal quality and/or articulation and 13% had reduced auditory acuity. Vocal quality disorders showed a significant relationship to bronchial asthma in association with other allergic reactions. All subjects with diminished hearing had allergic rhinitis either singly or in combination with another disorder. Findings suggest that bronchial asthma and allergic rhinitis are related to the development of vocal quality disorders and that allergic rhinitis is associated with misarticulations and diminished hearing. The presence of speech sound omissions in allergic rhinitis patients above age 8 may predict the presence or previous history of fluctuating hearing loss.

scholarly journals Infection in infancy and subsequent risk of developing lymphoma in children and young adults

Blood ◽  
2011 ◽  
Vol 117 (5) ◽  
pp. 1670-1672 ◽  
Author(s):  
Lynn R. Goldin ◽  
Ola Landgren ◽  
Sigurdur Y. Kristinsson ◽  
Magnus Björkholm ◽  
Ora Paltiel
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Odds Ratio ◽  
Surrogate Marker ◽  
Population Based ◽  
Increased Risk ◽  
History Of ◽  
Children And Young Adults ◽  
Immune Defects ◽  
Subsequent Risk

Abstract There is evidence that certain infections and autoimmunity predispose to the development of non-Hodgkin lymphomas (NHLs). A previous study reported that hospitalization for infections in infancy led to an increased risk of NHL. By using population-based registries in Sweden, we compared the rate of hospitalization for infections in infancy between lymphoma cases and matched controls for patients born since 1964. A history of infection was associated with a significantly increased risk of aggressive B-cell lymphomas (odds ratio 2.1, 95% confidence interval 1.11-4.04, P = .02). The specific infections involved were respiratory and intestinal. No effects were observed among cases of Hodgkin lymphoma. This association could result from the infection, its treatment, or could be a surrogate marker for underlying immune defects. Further studies are needed to determine whether this association is present among NHL occurring in older adults and if improved survival of patients with immune defects has contributed to the secular increases in incidence of NHLs.

scholarly journals Current epidemiological aspects of human parvovirus B19 infection during pregnancy and childhood in the western part of Germany

2006 ◽  
Vol 135 (4) ◽  
pp. 563-569 ◽  
Author(s):  
M. ENDERS ◽  
A. WEIDNER ◽  
G. ENDERS
Keyword(s):  
Young Adults ◽  
Risk Factor ◽  
Pregnant Women ◽  
Parvovirus B19 ◽  
Major Risk Factor ◽  
Human Parvovirus B19 ◽  
History Of ◽  
Parvovirus B19 Infection ◽  
Specific Igg ◽  
Children And Young Adults

SUMMARYThis investigation was undertaken to provide detailed information on the epidemiology of human parvovirus B19 (B19) infection during pregnancy and childhood in the western part of Germany. Between 1997 and 2004, 40 517 sera from pregnant women aged 17–45 years and 6060 sera from children and young adults were tested for B19 IgG and IgM in our laboratory. In pregnant women, both the history of a ‘specific’ (OR 7·7, 95% CI 5·2–11·4) and a ‘non-specific’ rash (OR 3·3, 95% CI 1·5–7·1) was predictive for B19 IgM positivity. The B19 IgG prevalence was 69·2% (4097/5924) in a subgroup of asymptomatic pregnant women screened for B19 antibodies. In children, the age-specific IgG-positivity rate increased from 12·2% (66/541) at 2 years of age to 71·9% (396/551) in those older than 10 years. In conclusion, the prevalence of B19 IgG in pregnant women from the western part of Germany is higher then previously reported. Contact with children aged 3–10 years is a major risk factor for exposure to B19. Pregnant women with the history of a ‘non-specific’ rash should also be evaluated for acute B19 infection.

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