Age-bodyweight relationships to lung growth in the F344 rat as indexed by lung weight measurements

1986 ◽  
Vol 20 (3) ◽  
pp. 189-194 ◽  
Author(s):  
S. I. Tillery ◽  
B. E. Lehnert
Keyword(s):  
Dry Weight ◽  
Lung Growth ◽  
Lung Weight ◽  
Lung Lobe ◽  
F344 Rat ◽  
Wet Weight ◽  
The Individual ◽  
The Right ◽  
F344 Rats ◽  
Lung Lobes

Measurements of the total lung weights and the individual weights of the lung lobes of male F344 rats ranging in age from about 30 days to 140 days or more were made in order to determine how lung growth and the growths of the individual lung lobes relate to bodyweight over the course of maturation of this species. Additionally, in this study we also (1) compared how each lung lobe grows relative to total lung growth, (2) evaluated the ratios of lung dry weight to wet weight and (3) obtained information on the weights of the trachea and extra-hilar main-stem bronchi as the F344 rat matures. The wet weights WLT of the trachea-lung preparations and the pooled lobe weights WPL as functions of rat bodyweight WB could be readily described by the following logarithmic expressions: WLT = 0·596 ln WB - 1·923, r = 0·95; WPL = 0·464 ln WB - 1·566, r = 0·96. Expressed as percentages of the pooled lobe weights, the individual lobes remained at constant values as the animals grew with the exception of the right caudal lobe which decreased between bodyweights of 72 and 96 g; absolute wet weight measurements of the individual lobes indicated that the right cranial, right middle and right intermediate lobes actually decreased in weight between bodyweights of 300 and 385 g. The dry weights of the lobes consistently represented approximately 22% of the wet weights regardless of animal age or bodyweight, and on average the airways represented about 20% of the weights of the intact airway-lung preparations over the course of animal maturation.

Rapidity of compensatory lung growth following pneumonectomy in adult rats

1979 ◽  
Vol 46 (2) ◽  
pp. 326-333 ◽  
Author(s):  
D. E. Rannels ◽  
D. M. White ◽  
C. A. Watkins
Keyword(s):  
Body Weight ◽  
Cell Size ◽  
Left Lung ◽  
Weight Ratio ◽  
Lung Growth ◽  
Body Weight Ratio ◽  
Adult Rats ◽  
Lung Weight ◽  
Wet Weight ◽  
The Right

The rapidity with which lung growth was initiated following pneumonectomy was investigated using rats (330 g) in which lung weight-to-body weight ratio and lung cell size had stabilized. Following removal of the left lung, right lung weight increased from 823 to 1.161 mg within 7 days. Right lung weight in sham-operated animals did not change significantly. At day 7, right lung weight-to-body weight ratio in pneumonectomized rats was equal to that of both lungs in sham-operated animals; these values remained equal through day 14. Growth of individual lobes of the right lung was generally in proportion to their initial weights. Dry-to-wet weight ratio in either lung of sham-operated or pneumonectomized animals was unchanged, as compared to unoperated controls. Total right lung RNA and protein increased significantly by day 2 and reached levels equal to those in both lungs of sham-operated animals by day 7. Synthesis of lung proteins, estimated during 120 min of perfusion in situ, was elevated 25% on day 3. Incorporation of [3H]thymidine into DNA increased somewhat on day 2 and was elevated fourfold on day 3, corresponding with the initial accumulation of total DNA within the lung. These observations suggested that increased cell size may accompany early compensatory growth following pneumonectomy, but that the major portion of the response involved cellular hyperplasia.

scholarly journals Respons Pertumbuhan dan Rendemen Minyak Klon Nilam (Pogostemon cablin Benth) terhadap Aplikasi Berbagai Dosis Urea (Growth Response And Yield Of Patchouli Clones (Pogostemon Cablin Benth) On Dose Urea Various Applications)

2020 ◽  
pp. 109-119
Author(s):  
Retno Ayu Diah Pangestu ◽  
M. Tahir ◽  
Fatahillah Fatahillah
Keyword(s):  
Block Design ◽  
Dry Weight ◽  
Optimal Dose ◽  
Fertilizer Application ◽  
Control Treatment ◽  
Randomized Block Design ◽  
Best Response ◽  
Pogostemon Cablin ◽  
Wet Weight ◽  
The Right

Patchouli (Pogostemon cablin Benth) is a plant that produces essential oils and important foreign exchange earner for Indonesia. Using superior clones  with the right fertilizer application will increase the yield of patchouli oil. The research aims to obtain patchouli plants that have the best response of urea fertilization application and optimum dosage of urea for patchouli plant growth. The study was conducted at the Politeknik Negeri lampung’s teaching farm in December 2018 until May 2019. The experiment was conducted using a factorial randomized block design (RBD), consisting of two treatment factors, namely the type of urea clone. The first factor is the type of clone consisting of 2 levels, namely NPL 9 clone and Lhokseumawe clone. The second factor is the treatment of urea doses consisting of 4 levels, namely control, 250 kg.ha-1, 300 kg.ha-1, and 350 kg.ha-1. Variables observed included plant’s height, bough, diameter, number of leaves, stalk angle, chlorophyll content, wet weight of plant, wind dry weight of plant, and yield. The results of research showed  NPL 9 clone had a superior appearance and 350 kg.ha-1 of urea dose  was the optimal dose compared to other doses and could increase patchouli yield 2,3% compared to the control treatment.

Constrictive Bronchiolitis Obliterans in a Dog

2019 ◽  
Vol 55 (2) ◽  
Author(s):  
Stacey Lynn Wylie ◽  
Daniel Langlois ◽  
Stephan Carey ◽  
Nathan C. Nelson ◽  
Kurt J. Williams
Keyword(s):  
Bronchiolitis Obliterans ◽  
Clinical Signs ◽  
Histopathologic Examination ◽  
Lung Lobe ◽  
Computed Tomographic ◽  
Airway Lumen ◽  
Alveolar Collapse ◽  
Airway Pathology ◽  
The Right ◽  
Lung Lobes

ABSTRACTA 2 yr old, neutered male rottweiler was evaluated for a chronic cough that had acutely worsened. Computed tomographic examination revealed a diffuse alveolar pattern in the right, middle, and left cranial lung lobes. Aerated parenchymal tissue was not observed in the left cranial lung lobe, and both lobes were markedly decreased in volume. Lobectomy of the right middle and left cranial lung lobes was performed. Histopathologic examination of both lungs identified alveolar collapse associated with marked chronic bronchial and bronchiolar luminal concentric fibrosis leading to reduced airway lumen diameter and bronchiolar destruction. The clinical signs and airway pathology were consistent with constrictive bronchiolitis obliterans. The dog remained stable for over 2 yr with glucocorticoid therapy and intermittent antimicrobics. Although the polypoid form of bronchiolitis obliterans has been described in cattle and occasionally in dogs, constrictive bronchiolitis obliterans has not been reported previously in veterinary species.

Spontaneous Feline Pneumothorax Caused by Ruptured Pulmonary Bullae Associated With Possible Bronchopulmonary Dysplasia

2010 ◽  
Vol 46 (2) ◽  
pp. 138-142 ◽  
Author(s):  
Marjorie E. Milne ◽  
Christina McCowan ◽  
Ben P. Landon
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Bronchopulmonary Dysplasia ◽  
Spontaneous Pneumothorax ◽  
Histopathological Examination ◽  
Lung Lobe ◽  
First Case ◽  
Adult Cat ◽  
The Right ◽  
Lung Lobes

Spontaneous pneumothorax is rarely reported in the cat. This case report describes the use of computed tomography (CT) to diagnose pulmonary bullae in an adult cat with recurrent spontaneous pneumothorax. A large bulla in the right middle lung lobe and several blebs in other lobes were identified by CT. Partial lobectomy of the right middle and right and left cranial lung lobes was successfully performed to remove the affected portions of lung. Histopathological examination suggested bronchopulmonary dysplasia (BPD) as the underlying cause for development of the pulmonary bulla. This is the first case report in the veterinary literature describing the use of CT to identify pulmonary bullae in the cat with BPD as a possible underlying cause.

Adverse effects of prostacyclin used to perfuse isolated lung lobes

1982 ◽  
Vol 242 (5) ◽  
pp. H745-H750 ◽  
Author(s):  
M. M. Krausz ◽  
T. Utsunomiya ◽  
L. L. Levine ◽  
B. Dunham ◽  
D. Shepro ◽  
...  
Keyword(s):  
Hydrolysis Product ◽  
Weight Ratio ◽  
Dry Weight ◽  
Antiplatelet Antibody ◽  
Lung Lobe ◽  
Isolated Lung ◽  
Stable Product ◽  
Wet Weight ◽  
Pulmonary Arterial ◽  
Foreign Surface

To test the hypothesis that preservation of circulating platelets would prolong the function of an isolated perfused canine lung lobe, prostacyclin (PGI2) was added to the perfusate. Platelet count in heparinized controls (n = 7) fell to 44,500 platelets/mm3, lower than 136,000 platelets/mm3 seen with 1 microgram/min PGI2 (n = 7, P less than 0.005). Surprisingly, with PGI2, thromboxane B2 (TXB2) the stable product of thromboxane A2 (TXA2), rose from 0.07 to 0.25 ng/ml, a level higher than controls (P less than 0.005). PGI2, in comparison to controls, also led to higher pulmonary arterial pressure, an increase in lobe weight, an increase in wet weight-dry weight ratio, an increase in physiological shunt, and a decrease in compliance (P less than 0.005). Further, with PGI2 there was hemorrhagic edema. Infusion of the PGI2 hydrolysis product 6-keto-prostaglandin F1 alpha (n = 2) led to results similar to controls. Adverse PGI2 effects were eliminated by pretreatment with ibuprofen (12.5 mg/kg, n = 5) or an antiplatelet antibody (n = 6). Infusion of PGI2 into a lobar pulmonary artery of an intact animal was without effect on the lung (n = 2). These results show that platelets exposed to a foreign surface will aggregate and be lost from the circulation. PGI2 prevents platelet loss but not the synthesis of TXA2. This vasoconstrictor is likely to be the cause of pulmonary hypertension and hemorrhagic pulmonary edema.

DEXAMETHASONE IN THE MANAGEMENT OF KEROSENE PNEUMONIA

PEDIATRICS ◽  
1974 ◽  
Vol 53 (1) ◽  
pp. 86-90
Author(s):  
J. Wolfsdorf ◽  
Dip. Paed. ◽  
H. Kündig
Keyword(s):  
Body Weight ◽  
Aspiration Pneumonia ◽  
Inflammatory Process ◽  
Statistical Difference ◽  
Dry Weight ◽  
Control Group ◽  
Lung Weight ◽  
Group Iii ◽  
Group I ◽  
Wet Weight

The efficacy of steroids in the treatment of acute aspiration pneumonia, following intratracheal kerosene instillation in primates, was examined. Forty Chacma baboons were utilized in three groups: group I (normal animals), group II (animals receiving 0.3 ml/kg intratracheal kerosene alone, control group), and group III (animals receiving 0.3 ml/kg intratracheal kerosene plus pre- and posttreatment with 5 mg/kg IMI dexamethasone). The lungs from all animals were examined macroscopically and microscopically and their lung wet weight-dry weight and lung weight-body weight ratios determined. On all parameters utilized, the lungs from groups II and III were different from group I. No statistical difference, however, could be detected between values obtained from groups II and III. These data tend to support the contention that steroids, even when given early, and in large doses, in the course of kerosene pneumonitis, do not alter the acute inflammatory process that occurs.

The effect of locomotor activity on the growth of brook charr, Salvelinus fontinalis Mitchill

1987 ◽  
Vol 65 (4) ◽  
pp. 843-846 ◽  
Author(s):  
Pierre East ◽  
Pierre Magnan
Keyword(s):  
Salvelinus Fontinalis ◽  
Dry Weight ◽  
Individual Growth ◽  
Water Current ◽  
Brook Charr ◽  
Internal Organs ◽  
Relative Water ◽  
Wet Weight ◽  
The Individual ◽  
Water Speed

Yearling hatchery-reared brook charr, Salvelinus fontinalis Mitchill, were trained during a 20-day period at different water velocities: 0.00, 0.85, 1.72, and 2.50 body lengths/s (bl/s). Our results indicate that growth (wet weight), food conversion efficiency, and the deposition of lipids on the digestive tract were maximized at 0.85 bl/s. The individual growth (wet weight) was also more homogeneous at this water speed. The storage of lipids in the white muscles was significantly lower in still water (0.00 bl/s) while the increase in length, the increase in the dry weight of the carcass (whole fish less internal organs), and the relative water content of the muscle showed no significant differences between the tested water velocities. Behavioural observations indicated that the frequency of agonistic behaviours between individuals was important in still water, but decreased significantly in the presence of a water current.

Perivascular interstitial fluid pressure measured by micropipettes in isolated dog lung

1982 ◽  
Vol 52 (1) ◽  
pp. 9-15 ◽  
Author(s):  
S. J. Lai-Fook
Keyword(s):  
Interstitial Fluid ◽  
Fluid Pressure ◽  
Transpulmonary Pressure ◽  
Alveolar Pressure ◽  
Lung Weight ◽  
Lung Inflation ◽  
Water Accumulation ◽  
The Right ◽  
Alveolar Surface ◽  
Lung Lobes

Micropipettes in conjunction with a servo-nulling system were used to measure fluid pressure (Pf) in the interstitium around the partially exposed vein near the hilus of the right upper lung lobes of the dog. Lobes were studied at constant transpulmonary pressure (Ptp). In the absence of extravascular water accumulation, Pf was -1.5 cmH2O relative to pleural pressure at Ptp of 6 cmH2O and vascular pressure (Pv) of 0 cmH2O and was more negative in lobes tested at higher Ptp values. In five lobes made edematous with plasma at Ptp of 6 cmH2O and Pv of 15 cmH2O, mean Pf increased from -1 to 4.4 cmH2O as lung weight increased up to 400% of the initial excised weight. In four other lobes, at Ptp of 15 cmH2O and Pv of 20 cmH2O, Pf increased from -2.4 to 8.8 for a similar increase in weight. In lobes degassed and filled with saline or plasma, Pf always equilibrated to alveolar pressure (PA). Results suggest that alveolar surface tension (tau) in air-filled lobes with gross edema prevented Pf from reaching PA. Reduction in Pf below PA was larger at higher Ptp, consistent with increased tau with lung inflation.

scholarly journals Efektifitas Pemberian Stimulant Better dan Waktu Sadap Terhadap Produksi Lateks Tanaman Karet (Hevea brasiliensis Muell Arg

2019 ◽  
Vol 7 (2) ◽  
pp. 58
Author(s):  
Engelbertus Huvat ◽  
Akhmad Sopian ◽  
Tutik Nugrahini ◽  
Zainudin Zainudin
Keyword(s):  
Block Design ◽  
Dry Weight ◽  
Production Potential ◽  
Randomized Block Design ◽  
Main Plot ◽  
Wet Weight ◽  
High Doses ◽  
The Right ◽  
Latex Production ◽  
Plot Design

The factors that influence rubber production are planted clones, plant care and tapping techniques. With the right tapping technique, both tapping time, tapping method and mature tapping age, the production potential of a superior clone of rubber plants that has been well maintained can be maintained. The technique of rubber tapping is closely related to the expected level of production, even very determining the age of the tree economy. The research objective was to determine the effect of stimulant better and tapping time on latex production. The method used was a randomized block design with two-factor split plot design. The first factor (main plot) is the time of tapping consists of 3 levels, namely; w1: 05 in the morning, w2: 06 in the morning, w3: 07 in the morning. The second factor (sub-plot), namely the stimulant dosage better consists of 4 levels, namely; b0: control, b1; 0.5 g, b2; : 1 g, b3; 1.5 g. The results showed that stimulate better treatment had a significant effect on latex volume, wet weight and latex dry weight, but was not significant for latex dryness levels. Tapping time was not significant for latex yield, latex volume, wet weight, latex dry weight and highest dry rubber content at 7am. Stimulant Better treatment has a significant effect on latex volume, wet weight, and latex dry weight, but if given at high doses it will reduce the dry content of rubber. The interaction of treatment when tapping and stimulant is better not significant for latex production. The stimulant application better does not exceed the dose of 0.5 g / principal. Doses> 0.5 g / staple will have an impact on the dry tapping field.

Changes in lung glycosaminoglycans during postresectional lung growth

1987 ◽  
Vol 63 (3) ◽  
pp. 1033-1039 ◽  
Author(s):  
M. P. Mueller ◽  
L. A. Thet
Keyword(s):  
Heparan Sulfate ◽  
Temporal Pattern ◽  
Dermatan Sulfate ◽  
Left Lung ◽  
Dry Weight ◽  
Male Rats ◽  
Lung Growth ◽  
Sulfate Content ◽  
Lung Weight ◽  
Control Value

We studied changes in glycosaminoglycan content and concentration during postresectional compensatory lung growth in adult male rats. After right trilobectomy, left lung dry weight was normal at 4 days, increased 74% between 4 and 7 days, and more slowly over the next week. Total glycosaminoglycan content per milligram dry lung weight increased early and rapidly, reaching 189% of the control value at 4 days postresection. The magnitude and temporal pattern of increase was different for different glycosaminoglycan subtypes. Hyaluronate and chondroitin sulfate content were increased by 198 and 113%, respectively, at 4 days, with no further increases subsequently. Heparan sulfate content increased more slowly and steadily, and dermatan sulfate concentrations did not change. At 4 days, the percent of total glycosaminoglycans that was hyaluronate was almost doubled, whereas the percent that was heparan sulfate was decreased; by day 7 the percent compositions had returned to normal. We conclude that changes in glycosaminoglycans occur early in postresectional lung growth and speculate that they may play a facilitatory role.

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