Autoimplantation technique in the treatment of anogenital warts: a clinico-immunological study

1996 ◽  
Vol 7 (1) ◽  
pp. 55-56 ◽  
Author(s):  
N Usman ◽  
K Udayashankar ◽  
S Subramanian ◽  
S P Thyagarajan
Keyword(s):  
Immune Responses ◽  
Clinical Cure ◽  
Immune Status ◽  
Control Group ◽  
Immunological Study ◽  
Anogenital Warts ◽  
Matched Group ◽  
Before And After ◽  
Significant Change

An autoimplantation technique was adopted in the treatment of 50 cases of anogenital warts and was compared with the conventionally used podophyllin regimen in a matched group of 50 patients. They were assessed with 15 untreated subjects in a control group for the rate of clinical cure after 6 weeks, recurrence after 1 year follow up and for humoral and cell mediated immune responses before and after treatment. In the podophyllin group, 70% of patients were cured after 6 weeks while in autoimplantation, only 44% of patients were cured, and none in the control group had natural remission of warts without any treatment. After 1 year all the cured cases (100%) that completed follow up had recurrence of warts with podophyllin treatment, while none had recurrence of lesions in the autoimplantation group. Results of the humoral and cell mediated immune (CMI) response studies revealed that autoimplantation technique significantly augmented both humoral and CMI responses while there was no significant change in the immune status after podophyllin treatment (P>0.001).

scholarly journals PREPARATION AND EVALUATION OF CHEMICALLY INACTIVATED SALMONELLA ENTERITIDIS VACCINE IN CHICKENS

2017 ◽  
Vol 10 (11) ◽  
pp. 341
Author(s):  
Mounir M El-safty ◽  
Hala Mahmoud ◽  
Eman Sa Zaki ◽  
Howaida I Abd-alla
Keyword(s):  
Immune Responses ◽  
Salmonella Enteritidis ◽  
Serum Antibody ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Chemically Induced ◽  
Before And After ◽  
Group A ◽  
Group B ◽  
Cell Envelopes

  Objective: Salmonella enteritidis ghosts (SEGs) is a non-living empty bacterial cell envelopes which were generated using a different concentration of sodium hydroxide (NaOH) 6.4 mg/mL and evaluated as a vaccine candidate in specific pathogen-free (SPF) chicken. SEGs have been produced by chemical-mediated lysis and evaluated the potential efficacy of chemically induced SEG vaccine and its ability to induce protective immune responses against virulent S. enteritidis challenge in SPF chickens.Methods: SPF chickens were divided into three groups: Group A (non-vaccinated control), Group B (vaccinated with prepared vaccine), and Group C (vaccinated with commercial vaccine).Results: Vaccination of SPF chicken with SEGs induced higher immune responses before and after virulent challenge. SPF chicken vaccinated with SEGs showed increasing in serum enzyme-linked immunosorbent assay (ELISA) antibodies. During the vaccination period, Groups B and C showed higher serum antibody titer compared to Group A. The minimal inhibitory concentration (MIC) of NaOH was capable of inducing non-living SEGs, and it has successfully generated non-living SEGs by MIC of NaOH.Conclusion: It is a one-step process which means easy manufacturing and low production cost compared to protein E-mediated lysis method. Chemically induced SEG vaccine is a highly effective method for inducing protective immunity. This study strongly suggests that SEGs will be a permissive vaccine, as the method of inhibition of S. enteritidis was safe and cheaper than other methods, and it gave a good protection.

scholarly journals Efficacy of Online Group Counseling with Mindfulness-Based Cognitive Approach to Enhance Students’ Humility

2021 ◽  
Vol 4 (1) ◽  
pp. 78-90
Author(s):  
Rohmatus Naini ◽  
Mungin Eddy Wibowo ◽  
Mulawarman Mulawarman
Keyword(s):  
Group Counseling ◽  
Character Strengths ◽  
Control Group ◽  
Cognitive Approach ◽  
Control Group Design ◽  
Mindfulness Skills ◽  
Significant Change ◽  
Character Building ◽  
Online Group

Character building is an important part of the counseling services in the schools. Humility is a character strengths as a basic development others virtue. This study aims to examine the effectiveness of online group counseling with mindfulness-based cognitive approach to enhance students' humility. This study is pretest posttest control group design with 16 students who divided in to experimental and control groups. To measure the students' humility, authors used 32 items of humility scale (α = .901). Furthermore, to measure mindfulness skills using children and adolescence mindfulness measurement (α = .790). Based on the results of the paired t-test data analysis, obtained the pretest – posttest (t = 18,391; p = .56), posttest – follow up (t = -5,769; p = .001), and pretest – follow up (t = -30.549; p = .001). There was a significant change in the humility score which marked by (p < .05). Comparison analysis between the control group (MD = 12.62; SE = .87; p = .001) was interpreted as a significant increase change in the students' humility. In addition, there is a significant interaction between students' humility in the group as evidenced by (F (2,4) = 56,764, P = .001, Ƞp2 = .73). As the result, there is a significant change in mindfulness group counseling effect on increasing humility and has a large interaction effect.

scholarly journals CLINICAL EVALUATION OF THE EFFICACY OF LEKHANBASTI AND MEDOHARAVIDANGADILAUHA IN THE MANAGEMENT OF DYSLIPIDEMIA

2021 ◽  
Vol 9 (7) ◽  
pp. 1362-1365
Author(s):  
Noor Sayeda Shabnam Ahmed ◽  
Om Prakash Gupta ◽  
Bishnu Prasad Sarma
Keyword(s):  
Lipid Profile ◽  
Clinical Evaluation ◽  
Oral Intake ◽  
Before And After ◽  
Significant Change ◽  
Ethical Clearance

This study was conducted to evaluate the efficacy of lekhanbasti and medoharavidangadilauha in the management of dyslipidemia. Consent from all the selected patients was taken before the study after explaining to them about the disease and the procedure. Ethical clearance was accredited by the ethical committee of Government Ayurvedic College and Hospital Guwahati, Assam. Patients from IPD and OPD of the department of Kayachikitsa of the aforesaid institute were chosen. Lekhanbasti niruha and tiltaila anuvasana on alternate days was administered for 8 days Follow up was done at an interval of 30,60 and 90 days. Oral intake of medoharavidangadilauha was advised during these 90 days. The basti was repeated in the follow-up period. After comparing the fasting lipid profile before and after treatment it was found that there was a significant change in it. Keywords: Dyslipidemia, Lekhanbasti, Medoharavidangadilauha, Medoroga, Fasting lipid profile.

Evaluation of a Group Programme for Parents of Problem Children

1987 ◽  
Vol 15 (3) ◽  
pp. 224-239 ◽  
Author(s):  
M. J. Scott ◽  
S. G. Stradling
Keyword(s):  
Low Income ◽  
Parental Depression ◽  
Child Behaviour ◽  
Control Group ◽  
Management Skills ◽  
Before And After ◽  
Child Behaviour Problems ◽  
Treatment Gains ◽  
Group Programme

A behaviourally based Programme was developed to assist parents with problem children. The Programme was intended for the typical social service clientele of single parent, low income or state benefit families and may be administered by social workers or assistants conversant with the Programme Manual. The Programme consists of six 90 min sessions run at weekly intervals during which a variety of behavioural techniques are taught, largely through role play, with a seventh follow up session a month later.The Programme was evaluated by a range of before and after measures on both a treatment group and a waiting list control group and maintenance of treatment gains was tested at three and, for some measures, six months interval. The Programme significantly reduced: the perceived number and intensity of child behaviour problems; parental depression, inward irritability and outward irrirability; and the level of perceived chlid conduct problems, impulsivity and anxiety. It significantly improved parents' chlid management skills. Improvement in parental depression and irritability was maintained at three months and reduction in chlid beviour problems was tested for and found at both three and six months.

Refractive, Tomographic and Biomechanical Outcomes after Implantation of Ferrara ICRS in Keratoconus Patients

2012 ◽  
Vol 1 (1) ◽  
pp. 16-21 ◽  
Author(s):  
José M Salgado-Borges ◽  
Cláudia Costa-Ferreira ◽  
Manuel Monteiro ◽  
José Guilherme-Monteiro
Keyword(s):  
Wilcoxon Test ◽  
Before And After ◽  
Biomechanical Parameters ◽  
The Mean ◽  
Significant Change ◽  
Corneal Flattening

ABSTRACT Background Nowadays, ICRS are a step in the treatment of keratoconus. The purpose of this study was to evaluate the refractive effect and the tomographic and biomechanical parameters in keratoconus patients implanted with Ferrara ICRS, and their stability after 18 months. Materials and methods Twenty eyes of 20 keratoconus patients implanted with ICRS were evaluated. The average follow-up was 18 months. UDVA, CDVA, biomicroscopy, tomography (Pentacam) and biomechanics (ORA) of the cornea were evaluated before and after surgery. For the comparison of groups, the Wilcoxon test was used. Results The mean UDVA improved from 1.00 to 0.30 and the mean CDVA improved from 0.51 to 0.12; both were statistically significant (p = 0.0001). The average keratometry decreased from 50.7D to 47.5D (p = 0.0003), and the average astigmatism decreased from 5.5D to 3.5D (p = 0.0058). The mean CCT did not change significantly after surgery, but the mean TPP increased from 441.2 to 455.2 µm (p = 0.004). There was a significant reduction in the anterior cornea elevation, both the central (from 16.2-8.8; p = 0.0066) and the minimum (from–43.2 to −57.1; p = 0.0228). No significant change was found for posterior corneal elevation and for biomechanical parameters (hysteresis or CRF). Discussion There was a significant improvement of UDVA and CDVA after ICRS implantation, in keratoconic eyes. There was a significant and stable corneal flattening, and a decrease of the astigmatism. Corneal biomechanic parameters did not change. How to cite this article Salgado-Borges JM, Costa-Ferreira C, Monteiro M, Guilherme-Monteiro J, Torquetti L, Ferrara P, Ambrósio R Jr. Refractive, Tomographic and Biomechanical Outcomes after Implantation of Ferrara ICRS in Keratoconus Patients. Int J Keratoco Ectatic Corneal Dis 2012;1(1):16-21.

Circulating tumor cells (CTC) in newly diagnosed breast or colorectal cancers

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 14512-14512 ◽  
Author(s):  
M. D. Groot ◽  
M. Croonen ◽  
W. Mastboom ◽  
I. Vermes ◽  
A. Tibbe ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Malignant Disease ◽  
Recurrence Risk ◽  
Control Group ◽  
Newly Diagnosed ◽  
Pathological Stage ◽  
Before And After ◽  
Disease Specificity ◽  
Definitive Surgery

14512 Background: The presence of CTCs is associated with poor prognosis in patients with metastatic carcinomas. The significance of CTCs at the time of diagnosis and after therapy is not known. A prospective clinical trial is conducted to determine if monitoring CTC levels in pts diagnosed with breast and colorectal cancer identify pts at risk for recurrence. CTCs are correlated with pathological stage as follow-up is too short to assess recurrence risk. Methods: Currently 213 pts with newly diagnosed breast and 119 pts with colorectal cancer before surgery with curative intend have been enrolled as well as a control group of 120 patients in whom diagnosis of breast or colorectal cancer was excluded. Thirty ml of blood was screened for the presence of CTCs at baseline before surgery and every following year using the CellSearch™ System. Results: Presence of CTCs in 30mL of blood in breast, colorectal cancer and the control group is provided in the table . In colorectal cancer the average number of CTCs /30 mL at baseline for Dukes A, B and C was 0.2, 0.7 and 1.1 respectively, for stage 0, I, II, III breast cancer 0.3, 0.5, 0.6 and 1.8 respectively and for the control group 0.24 CTCs /30 mL. Conclusions: CTC can be detected in a substantial proportion of pts before and after definitive surgery for breast and colorectal cancer. The number of CTCs before surgery correlated with the stage of the disease. Specificity of the CellSearch™ System is being increased to improve the discrimination of patients with benign and malignant disease. Follow-up must clarify whether the presence CTCs is an identifier for the risk of recurrence. [Table: see text] No significant financial relationships to disclose.

scholarly journals Clinical and immunological study of percutaneous revaccination in children who originally received smallpox vaccine subcutaneously

1978 ◽  
Vol 7 (2) ◽  
pp. 158-164
Author(s):  
J D Cherry ◽  
U T Rolfe ◽  
J P Dudley ◽  
A J Garakian ◽  
M Murphy
Keyword(s):  
Lymphocyte Transformation ◽  
Neutralizing Antibody ◽  
Study Groups ◽  
Smallpox Vaccination ◽  
Immunological Study ◽  
Primary Immunization ◽  
Before And After ◽  
The Mean ◽  
Study Center

In a large multicenter smallpox vaccination study carried out from 1970 to 1973, it was found that 39% of children who were initially immunized by the subcutaneous route and then challenged percutaneously with a standard vaccination did not have measurable neutralizing antibody upon follow-up. Because of this finding, a percutaneous revaccination study was conducted at the St. Louis study center in 1975 and 1976. There were four study groups, which were composed on the basis of route of primary immunization (subcutaneous or percutaneous) and whether neutralizing antibody was detectable following the original percutaneous challenge immunization. Of 52 children revaccinated, all but four had accelerated reactions. There was no difference in size of lesions or day of maximum erythema among the four study groups. Only 66% of children originally vaccinated subcutaneously who did not have postchallenge neutralizing antibody had measurable neutralizing antibody following revaccination. Transformation studies with vaccinia viral antigen before and after revaccination were performed on lymphocytes from 50 children. There was no appreciable differences in responses either before or after revaccination when the four groups were compared. However, the mean stimulation ratio for the total group increased from 2.4 before revaccination to 4.6 3 weeks later. In primary subcutaneous vaccine recipients without pre-revaccination neutralizing antibody, lymphocyte transformation correlated directly with the neutralizing antibody response.

scholarly journals Protocol on Comparative Clinical Efficacy of Tryushanadi Guggul and Navaka Guggul in Sthoulya (Overweight)

2021 ◽  
pp. 169-175
Author(s):  
Ashvini Dineshrao Pardhekar ◽  
Sadhana Misar(Wajpeyi) ◽  
Vinod Ade
Keyword(s):  
Clinical Efficacy ◽  
The Body ◽  
Control Group ◽  
Arm Circumference ◽  
Before And After ◽  
Group A ◽  
Excessive Intake ◽  
Group B ◽  
Excessive Accumulation

Background: Sthoulya is Medovaha Strotodushtijanya vyadhi, which includes abnormal and excessive accumulation of Medodhatu in the body. This is caused by lack of physical and mental activity, daytime sleep, excessive intake of madhur (sweet), snigdha ahar (oily diet) results in  increase Kaphadosha and meda which results in Sthoulya (overweight) having symptoms of mild dysponea, thirst, drowsiness, excess sleep, appetite, offensive smell from the body, incapability to work and incapability to participate in sexual intercourse. Aim: Comparative clinical efficacy of Tryushanadi Guggul and Navaka Guggul in Sthoulya (overweight). Materials and methods: Total 60 patients of Sthoulya will enrolled and will divided into two groups (each group contains 30). Patients in group A (experimental group) will be given 1 gram Tryushanadi Guggul two times a day after meal with honey and in group B (control group)1 gram Navaka Guggul will administered two times a day after meal with honey for 30 days. Dietary changes and walking (30 minutes) will be advised to patients of both groups. Follow up will be taken on 15th day and 30th day. Assessment of subjective parameters like kshudrashwasa (exertional dyspnoea), swedadhikya (perspiration), atikshudha (increased appetite), nidradhikya (increased sleep) and objective parameters like body weight, B.M.I., mid arm circumference, waist-hip ratio and lipid profile will be done before and after treatment. Results: Subjective and objectives outcomes will be assessed by statistical analysis. Conclusion: It will be drawn from the result obtained.

scholarly journals Effect of Ketoprofenphonophoresis and Femoral Nerve Block in Knee Osteoarthritis

2021 ◽  
Vol 5 (6) ◽  
pp. 72-78
Author(s):  
Fan Fan ◽  
Wei Wei ◽  
Binyan He ◽  
Chaonan Li ◽  
Qing Yang ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Nerve Block ◽  
Femoral Nerve Block ◽  
Combined Treatment ◽  
Femoral Nerve ◽  
Control Group ◽  
Before And After ◽  
Effective Efficiency ◽  
Experimental Group

Objective: To evaluate the effect of ketoprofenphonophoresis and femoral nerve block in knee osteoarthritis. Methods: One hundred and fourteen patients with knee osteoarthritis were randomly divided into two groups. The control group consisted of 57 patients who were treated with only ketoprofenphonophoresis. The experimental group consisted of patients were treated with ketoprofenphonophoresis and femoral nerve block. The patients were followed for more than one month. The treatment effect assessed by observing their WOMAC index before and after therapy. Results: All the patients finished the follow-up. Their WOMAC indexes were reduced after therapy and one month after treatment, especially in the experimental group (P < 0.05). The effective efficiency of ketoprofenphonophoresis and femoral nerve block were higher than that in the control group after treatment and after one month of follow-up (P < 0.05). Conclusion: Compared with only ketoprofenphonophoresis, the combined treatment of ketoprofenphonophoresis and femoral nerve block was more appropriate in knee osteoarthritis.

scholarly journals The Effect of Manual Therapy and Stabilizing Exercises on Forward Head and Rounded Shoulder Postures: a six-week intervention with a one-month follow-up study (Preprint)

2017 ◽  
Author(s):  
Kiana Fatholahnezhad ◽  
Amir Letafatkar ◽  
Malihe Hadadnezhad
Keyword(s):  
Neck Pain ◽  
Manual Therapy ◽  
Combined Treatment ◽  
Control Group ◽  
Post Intervention ◽  
Before And After ◽  
Group 2 ◽  
And Function ◽  
Group 1

BACKGROUND forward head and round shoulder posture is believed to alter scapular kinematics and muscle activity placing increased stress on the shoulder, leading to shoulder pain and dysfunction. OBJECTIVE The purpose of this study was to evaluate the effect of a six-week combined treatment consisting of manual therapy and stabilizing exercises, with a one-month follow-up, on neck pain with forward head and rounded shoulder postures. METHODS A total of 60 women aged 32-42 years of age with neck pain, and forward head and rounded shoulder postures were randomized into three groups: group 1 performed stabilizing exercises and received manual therapy (n=20), group 2 performed stabilizing exercises (n=20), and group 3 (control group) performed home exercises (n=20) over six weeks.The follow-up time was one month after the post test. The craniocervical and rounded shoulder angles, pain, and function were measured before and after six-week interventions, and a one-month follow- up. RESULTS The results showed significant positive changes within the experimental groupsin all variables, but there were minor changes in the control group in all variables before and after the intervention. Also, there were significant function and pain improvement in the experimental group 1 comparing to group 2. There were no differences between post intervention and one-month follow-up on posture and function in the experimental groups. CONCLUSIONS These findings suggest that both interventions were significantly effective for reducing neck pain, and improving function and posture in patients with chronic neck pain, and forward head and rounded shoulder postures. However, the improvement in function and pain was more effective in group 1 than those of group 2 suggesting that manual therapy can be used as a supplement method to the stabilizing intervention in the treatment of neck pain. More research is needed to confirm the result of this study.

Sign in / Sign up

Export Citation Format

Share Document