Clinical and serological responses to an inactivated influenza vaccine in adults with HIV infection, diabetes, obstructive airways disease, elderly adults and healthy volunteers

1997 ◽  
Vol 8 (12) ◽  
pp. 776-779 ◽  
Author(s):  
L Dorrell ◽  
I Hassan ◽  
P Chakraverty ◽  
E Ong
Keyword(s):  
Influenza Vaccine ◽  
Hiv Infection ◽  
Healthy Volunteers ◽  
Lung Diseases ◽  
The Elderly ◽  
Cd4 Count ◽  
The Other ◽  
Elderly Persons ◽  
Serological Response ◽  
Elderly Adults

Summary: To investigate the clinical and serological responses to an inactivated influenza vaccine (split-virion A/Singapore/6/86-like strains H1N1 (15 ug HA), A/Beijing/353/89-like H3N2 (15 ug HA) and B/Yamagata/16/88-like strain (15 ug HA): MFV-JECT, Merieux, UK) in persons with HIV infection, diabetes, obstructive lung diseases, elderly adults and healthy volunteers. Forty-nine HIV-infected persons received 2 doses of the vaccine at one-month intervals; 34 healthy volunteers, 30 elderly persons, 29 with insulin and non-insulin diabetes and 14 with obstructive airways diseases were vaccinated with one single dose between October 1992 to January 1993. Serological testing of antibody responses was done using haemagglutination assay. beta2-microglobulin in HIVinfected persons was measured using radioimmunodiffusion between 1st and 2nd dose. Fructosamine levels in diabetic persons were assessed for diabetic control and peak expiratory flow rate (PEFR) was self monitored in persons with lung diseases. All groups apart from the elderly filled in a symptom score chart for the first 5 days following vaccination. A 4-fold rise in titre equal to or more than 1:64 to all the 3 antigens occurred in 20 (58.8%) of healthy volunteers compared with 13 (44.8%) diabetics, 5 (35.7%) with lung diseases, 10 (33.3%) elderly and 13 (26.5%) with HIV infection. A significant correlation of serological response to number of CD4 count in persons with HIV infection was noted (H1N1 P =0.0013, H3N2 P =0.025, BYAM P =0.0018). Mean beta2- microglobulin levels did not change significantly post 1st and 2nd vaccination. Mean fructosamine level did not change significantly. There was no significant change in PEFR. The vaccine was well tolerated. Persons with HIV infection and low CD4 count do not serologically respond well to influenza vaccine even with 2 doses compared to the other 4 groups. The other 4 groups had adequate protective serologic responses. The vaccine was well tolerated in all groups.

scholarly journals Adjuvanted Influenza Vaccines Elicits Higher Antibody Responses against the A(H3N2) Subtype than Non-Adjuvanted Vaccines

Vaccines ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 704
Author(s):  
Laura Sánchez de Prada ◽  
Iván Sanz Muñoz ◽  
Javier Castrodeza Sanz ◽  
Raúl Ortiz de Lejarazu Leonardo ◽  
José María Eiros Bouza
Keyword(s):  
Influenza Vaccine ◽  
Influenza A ◽  
Seasonal Influenza ◽  
The Elderly ◽  
Antibody Responses ◽  
Serological Response ◽  
Serum Samples ◽  
H3n2 Subtype ◽  
Serological Studies ◽  
Vaccination Campaigns

Background: vaccination is the best approach to prevent influenza infections so far. Serological studies on the effect of different vaccine types are important to address vaccination campaigns and protect our population. In our study, we compared the serological response against influenza A subtypes using the non-adjuvanted influenza vaccine (NAIV) in adults and the elderly and the adjuvanted influenza vaccine (AIV) in the elderly. Methods: We performed a retrospective analysis by hemagglutination inhibition assay (HI) of serum samples right before and 28 days after seasonal influenza vaccination during the 1996–2017 seasons. Conclusions: The AIV presents better performance against the A(H3N2) subtype in the elderly whereas the NAIV induces a better response against A(H1N1)pdm09 in the same group.

scholarly journals Development of enteral homemade diets for elderly persons receiving home care and analysis of macro and micronutrient composition

2017 ◽  
Vol 20 (3) ◽  
pp. 387-397
Author(s):  
Ann Kristine Jansen ◽  
Simone de Vasconcelos Generoso ◽  
Eduarda Guimarães Guedes ◽  
Ana Maria Rodrigues ◽  
Lígia Amanda Ventura de Oliveira Miranda ◽  
...  
Keyword(s):  
Vitamin E ◽  
Chemical Composition ◽  
Home Care ◽  
The Elderly ◽  
The Other ◽  
Elderly Persons ◽  
Vitamin Deficiencies ◽  
Enteral Diet ◽  
Macronutrient Distribution ◽  
Viscosity Stability

Abstract Objective: the development and analysis of the macro and micronutrient composition of homemade enteral diets. Method: A standard homemade enteral diet was developed at three caloric concentrations - 1500, 1800 and 2100 Kcal. After preparation and testing of viscosity, stability, odor and color, plus evaluation of cost, the chemical composition of the nutrients of the diets were analytically determined. Folic acid, vitamin D and vitamin B12 values were calculated using chemical composition tables. The results were compared with recommended nutritional standards for the elderly. Result: The diets exhibited normal macronutrient distribution. The 1500 caloric level presented some mineral and vitamin deficiencies. Suitable values were obtained at the other caloric levels for all minerals except magnesium. There were appropriate levels of all the vitamins in the 2100 Kcal diet, while vitamin E, D and B6 levels were below the recommended dietary allowances in the 1800 Kcal diet. Conclusion: The standard homemade enteral diets studied can contribute to the food and nutritional safety of elderly persons undergoing home care, if all are supplemented with magnesium and the 1800 Kcal diet is supplemented with vitamin E, D and B6. The 1500 Kcal diet was not nutritionally safe in terms of micronutrients.

scholarly journals VH3 Antibody Response to Immunization with Pneumococcal Polysaccharide Vaccine in Middle-Aged and Elderly Persons

2011 ◽  
Vol 18 (3) ◽  
pp. 362-366 ◽  
Author(s):  
Jose A. Serpa ◽  
Josemon Valayam ◽  
Daniel M. Musher ◽  
Roger D. Rossen ◽  
Liise-anne Pirofski ◽  
...  
Keyword(s):  
The Elderly ◽  
Polysaccharide Vaccine ◽  
Antibody Responses ◽  
Elderly Subjects ◽  
Enzyme Linked Immunosorbent Assay ◽  
Elderly Persons ◽  
Pneumococcal Polysaccharide Vaccine ◽  
Elderly Adults ◽  
Middle Aged ◽  
Idiotypic Antibody

ABSTRACTPneumococcal disease continues to cause substantial morbidity and mortality among the elderly. Older adults may have high levels of anticapsular antibody after vaccination, but their antibodies show decreased functional activity. In addition, the protective effect of the pneumococcal polysaccharide vaccine (PPV) seems to cease as early as 3 to 5 years postvaccination. Recently, it was suggested that PPV elicits human antibodies that use predominantly VH3 gene segments and induce a repertoire shift with increased VH3 expression in peripheral B cells. Here we compared VH3-idiotypic antibody responses in middle-aged and elderly subjects receiving PPV as initial immunization or revaccination. We studied pre- and postvaccination sera from 36 (18 vaccine-naïve and 18 previously immunized subjects) middle-aged and 40 (22 vaccine-naïve and 18 previously immunized subjects) elderly adults who received 23-valent PPV. Concentrations of IgGs to four individual serotypes (6B, 14, 19F, and 23F) and of VH3-idiotypic antibodies (detected by the monoclonal antibody D12) to the whole pneumococcal vaccine were determined by enzyme-linked immunosorbent assay (ELISA). PPV elicited significant IgG and VH3-idiotypic antibody responses in middle-aged and elderly subjects, regardless of whether they were vaccine naïve or undergoing revaccination. Age did not influence the magnitude of the antibody responses, as evidenced by similar postvaccination IgG and VH3 antibody levels in both groups, even after stratifying by prior vaccine status. Furthermore, we found similar proportions (around 50%) of elderly and middle-aged subjects experiencing 2-fold increases in VH3 antibody titers after vaccination. Age or repeated immunization does not appear to affect the VH3-idiotypic immunogenicity of PPV among middle-aged and elderly adults.

scholarly journals Relative effectiveness of influenza vaccines in elderly persons in the United States, 2012/2013-2017/2018 seasons

npj Vaccines ◽  
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Marina Amaral de Avila Machado ◽  
Cristiano S. Moura ◽  
Michal Abrahamowicz ◽  
Brian J. Ward ◽  
Louise Pilote ◽  
...  
Keyword(s):  
Standard Dose ◽  
Relative Effectiveness ◽  
The Elderly ◽  
The United States ◽  
The Other ◽  
Influenza Vaccines ◽  
Quadrivalent Vaccine ◽  
High Dose ◽  
Elderly Persons ◽  
Real World Setting

AbstractInfluenza immunization protects seniors against influenza and its potentially serious complications. It is uncertain whether standard-dose (SD) quadrivalent vaccine offers better protection over other formulations in the elderly. In this study, we compared the effectiveness of SD-trivalent, high-dose (HD) trivalent, SD-quadrivalent, and adjuvanted trivalent vaccines in seniors (≥65 years) in a real-world setting. We selected over 200,000 individuals in each of 6 influenza seasons from 2012 to 2018 using MarketScan® databases. The two outcomes were hospitalization or emergency room (ER) visit due to (1) influenza or (2) pneumonia. Here, SD-quadrivalent was associated with higher risk of influenza-related hospitalization/ER visit (adjusted hazard ratio (aHR) 1.14 and 95% confidence interval (95% CI) 1.05–1.24) and of pneumonia-related hospitalization/ER visit (aHR 1.04 and 95% CI 1.01–1.07) vs. HD-trivalent. SD-trivalent followed similar trends compared to HD-trivalent (aHR 1.16 and 95% CI 1.06–1.27 for hospitalized/ER visit influenza; aHR 1.07 and 95% CI 1.05–1.10 for hospitalized/ER visit pneumonia). We could not demonstrate risk differences between SD vaccine formulations and between adjuvanted trivalent and one of the other three vaccines. Risk estimates slightly varied across seasons. These findings suggest that SD vaccine formulations vs. HD-trivalent were associated with higher risk of hospitalization/ER visit for influenza and pneumonia in seniors.

Release from Multiple Maskers in Elderly Persons

1973 ◽  
Vol 16 (1) ◽  
pp. 152-160 ◽  
Author(s):  
Tom W. Tillman ◽  
Raymond Carhart ◽  
Sheina Nicholls
Keyword(s):  
Young Adults ◽  
Time Delay ◽  
White Noise ◽  
Duty Cycle ◽  
The Elderly ◽  
The Other ◽  
Elderly Subjects ◽  
Elderly Persons ◽  
Parallel Time ◽  
Dichotic Presentation

Masked thresholds for spondees were measured in 27 binaural conditions covering homophasic, antiphasic, parallel time-delayed, and opposed time-delayed listening in the presence of one to three competing maskers. One of the maskers was white noise modulated four times per second by 10 dB with 50% duty cycle; the other two were sentences spoken by different male talkers. These stimuli were variously combined to produce seven masker conditions. Subjects were 10 young adults, 23 women aged 70 to 85 years, and 22 men aged 63 to 88 years. Masking level differences (re homophasic performance) were observed in every instance of dichotic presentation. MLDs for the young adults were usually somewhat larger than those for the elderly subjects. Both groups showed (1) somewhat larger MLDs when the competing background included two talkers, (2) somewhat smaller MLDs during time-delay modes, and (3) smaller MLDs in opposed time-delay than in parallel time-delay. This last feature was particularly noteworthy for the elderly listeners, whose MLDs during opposed time delay averaged only 2.3 dB.

scholarly journals IMMUNE RESPONSE TO INFLUENZA VACCINATION IN HIV PATIENTS

2020 ◽  
Vol 12 (1) ◽  
pp. 75-82
Author(s):  
R. G. Yapparov ◽  
E. Yu. Karnaukhova ◽  
T. V. Antonova ◽  
D. A. Lioznov
Keyword(s):  
Immune Response ◽  
Influenza Virus ◽  
Influenza Vaccine ◽  
Hiv Infection ◽  
Influenza A ◽  
Control Group ◽  
Serological Response ◽  
Virus Antigens ◽  
Antigen A

The Aim: to characterize the immune response to the influenza vaccine in patients with HIV infection with different degrees of immunosuppression.Materials and methods. 171 HIV-infected adult patients with the different degrees of immunodeficiency and 50 HIV-uninfected persons (control group) were vaccinated against influenza. A single dose of trivalent polymer-subunit vaccine containing adjuvant was administered intramuscularly. The blood titer of antibodies to influenza virus antigens A/H1N1/California/, A/H3N2/Hong Kong/, B/Brisbane/ in the hemagglutination inhibition reaction was determined before vaccination and 21 and 180 days after. The average geometric titers of antibodies were compared between groups of HIV-infected patients with the different degrees of immunosuppression and the control group.Results. Тhe mean geometric antibody titers increase among HIV-infected with different degrees of immunodeficiency was below 2,0 and the seroconversion rate was below 8,0% for all influenza virus antigens on 21 and 180 days after vaccination. At the same time, during follow-up period in patients with level less than 200 cells /μl of CD4+lymphocytes in blood, the seroconversion index was equal to 0%. The rate of seroprotection to all antigens before vaccination in HIVinfected patients with the different degrees of immunosuppression was above 90%. Naturally, during follow-up period, more than 95,0% of vaccinated patients determined the protective level of antibodies to antigen A /H1N1 and 100,0% of patients to antigen A/H3N2 and B, without reducing this index to the day-180 of observation. Persons from control group showed a sufficient level of seroconversion and seroprotection, corresponding to the criteria of immunogenicity for all antigens of the influenza virus. Conclusion: a single immunization of influenza vaccine does not cause a sufficient degree of serological response in patients with HIV infection, regardless of the severity of immunodeficiency. Seroprotection in case of its developing persists up to 180 day after vaccination. 

Validity of the Elderly Behavior Assessment for Relatives (EBAR)

2000 ◽  
Vol 16 (1) ◽  
pp. 77-83 ◽  
Author(s):  
Lina Pezzuti ◽  
Caterina Laicardi ◽  
Marco Lauriola
Keyword(s):  
Cognitive Functioning ◽  
Mini Mental State Examination ◽  
Rating Scale ◽  
Good Health ◽  
The Elderly ◽  
Behavior Assessment ◽  
Elderly Persons ◽  
Behavior Rating Scale ◽  
Components Analysis ◽  
State Examination

Summary: An Elderly Behavior Assessment for Relatives (EBAR), updating the GERRI ( Schwartz, 1983 ), was administered to relatives (or significant others) of 349 elderly persons, from 60 to over 80 years of age, living at home, in good health and without cognitive impairment. A trained psychologist administered subjects the Life Satisfaction for Elderly Scale (LSES), the Instrumental Activity of Daily Living (IADL), the Mini Mental State Examination (MMSE), and personally answered to an overall elderly behavior rating scale (RA). EBAR items were first examined. The more attractive and less discriminative statements were excluded. A principal components analysis was carried out on the remaining EBAR items. Three factors were extracted. After varimax rotation they were tentatively labeled: Everyday Cognitive Functioning, Depression, and Hostility. Factor-driven EBAR subscales were designed, taking into account simpler items in the factor matrix. Results provide evidence for EBAR construct validity. Everyday Cognitive Functioning is connected to the IADL and the RA scores; Depression is very highly related to the LSES; Hostility is weakly related to RA, IADL, and MMSE, indicating that the scale needs further investigation.

Senior Living - Lighting, Circadian Rhythm and Dementia I

2019 ◽  
pp. 4-8
Author(s):  
Tadej Glažar ◽  
Marjeta Zupancic ◽  
Samo Kralj ◽  
Robert Peternelj
Keyword(s):  
The Elderly ◽  
Living Environment ◽  
Elderly Persons ◽  
Light Spectrum ◽  
Average Life Expectancy ◽  
The Real Estate ◽  
Lighting Conditions ◽  
Light Levels ◽  
Joint Fracture ◽  
Lease Contracts

The Real Estate Fund of Pension and Disability Insurance (Nepremicninski Sklad) in Slovenia, founded in1997 is the owner of 3255 properties in 116 locations throughout the country and is intended for solving housing issues of pensioners of 65 years or older and other elderly persons who are allowed independently to live. The lease contracts are concluded for an indefinite period of time. The aim and vision of the Fund is to improve the quality of life for the elderly tenants by adapting the living environment, the flats and surroundings according to the physical needs of aging tenants. Homes for seniors often have low light levels and poor light spectrum caused by fluorescent or incandescent lighting. Demographic changes in most European countries show rising average life expectancy which means that the number of people with weak visual capacity or visual impairment is increasing. Equally the risks of injuries due to poor lighting conditions are increasing, e.g. missing a step resulting in a hip joint fracture. Better lighting conditions are of critical importance for aging population, as stated also in the recently published CIE227:2017. To facilitate safe environment for the elderly, the Fund in 2013 initiated a lighting research study that should provide facts and evidence for a lighting standard for their own premises.

Development of a Mobile Time Banking system on Blockchain (MTBB) for Community Elderly Care (Preprint)

2019 ◽  
Author(s):  
Hungyi Chen ◽  
Yuan-Chia Chu ◽  
Feipei Lai
Keyword(s):  
Care Service ◽  
Elderly Care ◽  
Banking System ◽  
The Elderly ◽  
Community Services ◽  
The Other ◽  
Smartphone App ◽  
Smartphone Apps ◽  
Member Service ◽  
Blockchain Technology

BACKGROUND Time banking is a good mechanism to provide elderly care in community services with members having mutual benefits, besides social welfare and out-of-pocket fee payment mechanisms. With further integration with off-line works, mobile time banking may provide a better way, compared to traditional web access. On the other hand, blockchain technology has been long encountering difficulty in integrating with real-world economies or activities. Development of a mobile time banking system on blockchain (MTBB) may provide a realistic solution for community elderly care. Besides, the tracking mechanism from blockchain technology itself may also help track the elderly care service transaction records in order to measure better Sustainable Development Goals (SDGs) set by United Nations (UN). OBJECTIVE The aim of this study was to develop the MTBB, which enables tracking service transaction records in community elderly care through mutual helps. METHODS The MTBB was developed to empower organizations, either Corporate Social Responsibility (CSR) organizations, or Non-Profit Organizations (NPOs), to issue time tokens of their proprietary token types to the members who participate in the volunteer activities organized by the organizations respectively. In the service activities, members sign in and sign out before and after the services by using a smartphone app, and then get the time tokens afterwards. Members with time tokens can then exchange time tokens for elderly care services using the same smartphone app. MultiChain is used as the blockchain technology stack, as one of its features to support multiple token types is critical. RESULTS Database applications with smartphone apps integrated with MultiChain were developed. The whole set of the database schema was integrated with two smartphone apps, one for members, and the other for organizations, in addition to the two backend operations modules, one for organizations, and the other for managing all organizations and members. The MultiChain wallet was also integrated into the member app, as well as the organization backend modules for keeping track of the service transactions and time tokens. Metadata with the service transaction information is stored in the MultiChain blocks so that the transaction records are immutable and can thus be analyzed in the future. CONCLUSIONS The twelve characteristics of Cahn’s time banking are the guidelines of developing this MTBB with integration of MultiChain blockchain technology for tracking service transaction records. The study also combines the 1-to-1 member service exchange with organizations holding volunteer activities and issuing proprietary time tokens. With the blockchain transaction tracking mechanism, all of the elderly care service records through or within organizations can be tracked and analyzed to align with UN’s five SDGs.

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