scholarly journals Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma

2020 ◽  
Vol 36 (7) ◽  
Author(s):  
Xiaoxia Dai ◽  
Tao Feng ◽  
Xuejuan Zhang ◽  
Kaishu Li
Keyword(s):  
Symptom Score ◽  
Bronchial Asthma ◽  
Persistent Asthma ◽  
Inflammatory Factors ◽  
Control Group ◽  
Efficacy Rate ◽  
Observation Group ◽  
Creative Commons ◽  
The Difference ◽  
Open Access Article

Objective: To analyze the clinical effect of budesonide/fomoterol combined with montelukast in the treatment of chronic persistent asthma. Methods: Ninety-four patients with asthma who came to our hospital for treatment from April 2017 to April 2019 were randomly divided into control group and observation group, with 47 patients in each group. The control group was treated with budesonide/formoterol, and the observation group was treated with montelukast on the basis of the control group. The treatment effect of the two groups was observed and compared. Results: The total efficacy rate of the observation group was significantly higher than that of the control group (P<0.05); the daytime symptom score and nighttime symptom score of the observation group were significantly higher than those of the control group (P<0.05). The pulmonary function indexes of the two groups after treatment were significantly higher than that before treatment, and the improvement of the observation group was more significant (P<0.05); the FeNO and EO levels of the observation group after treatment were superior to those of the control group, and the difference was statistically significant (P<0.05). Conclusion: Budesonide/formoterol powder inhalation combined with montelukast can effectively improve the lung function, reduce the level of inflammatory factors, and accelerate the regression of symptoms in the treatment of chronic persistent asthma. It is worth clinical application. doi: https://doi.org/10.12669/pjms.36.7.2018 How to cite this:Dai X, Feng T, Zhang X, Li K. Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma. Pak J Med Sci. 2020;36(7):---------. doi: https://doi.org/10.12669/pjms.36.7.2018 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Clinical Observation of Zhuang Medicine Crystal Sugar Ye’An Decoction in Treating Senile Skin Pruritus and Its Effects on Serum IgE

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Yun Zhang ◽  
Yuying Lan
Keyword(s):  
Adverse Reactions ◽  
Clinical Observation ◽  
Skin Lesions ◽  
Effective Rate ◽  
Inflammatory Factors ◽  
Control Group ◽  
Observation Group ◽  
Serum Ige ◽  
The Difference ◽  
Lesion Severity

Objective: To discuss the specific application of Zhuang Medicine Crystal Sugar Ye’An Decoction in senile skin pruritus and its effects on serum IgE detection level. Methods: 90 patients with senile skin pruritus admitted to our hospital from February 2019 to April 2020 were randomly grouped. The general treatment effect, itching, secondary skin lesion severity, serum IL-6, IgE level and adverse reactions between 45 patients treated with Chlorcyclizine Hydrochloride Tablets (The control group) and 45 patients treated with Crystal Sugar Ye’An Decoction were compared. Results: The total effective rate of the treatment in the observation group was 93.33%, much higher than that in the control group, 75.56%. The difference was verified and statistically significant (P<0.05). Before the treatment, the itching area, frequency, duration and severity of secondary skin lesions were at the same level (P>0.05). After the treatment, the above data were all reduced, and the reduction of the observation group was more significant than that of the control group, indicating the difference was statistically significant (P<0.05). Before the treatment, there was no difference in serum IL-6 and IgE test data between the two groups (P>0.05). After the treatment, the tendency all declined, and that of the observation group was more obvious, indicating the difference was statistically significant (P<0.05). During the experiment, no obvious adverse reactions were observed in both groups. Conclusion: In the treatment of patients with senile pruritus, the application of Zhuang Medicine Crystal Sugar Ye’An Decoction is not only safe and reliable, but can promote the improvement of patients’ symptoms, adjust the level of inflammatory factors, and enhance clinical efficacy.

scholarly journals The Guiding Role of Pharmaceutical Care in the Rational Drug Use of Bronchial Asthma

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Hongmei Chen
Keyword(s):  
Drug Use ◽  
Medication Error ◽  
Pharmaceutical Care ◽  
Bronchial Asthma ◽  
Control Group ◽  
Observation Group ◽  
Rational Drug Use ◽  
Rational Drug ◽  
The Difference

Objective: To investigate the guiding role of pharmaceutical care in the treatment of bronchial asthma. Methods: Eighty patients with bronchial disease admitted to our hospital from November 2008 to December 1818 were enrolled in this research. The computer program was used to generate random numbers. The method was divided into two groups: control group and observation group, 40 cases respectively. 40 patients in the control group were treated with normal medication according to the doctor's advice; 40 patients in the observation group were enrolled in the pharmacological care on the basis of the control group, and the rational drug use was compared between the two groups. Results: The incidence of adverse reactions in the observation group and the control group were 5.00% and 17.50%, respectively, and the difference was statistically significant (P<0.05); the incidence of medication error events in the observation group was 7.50%, which was significantly lower than that of the control group, which was 25.00%, and the difference was statistically significant (P<0.05). The medication errors mainly include improper administration, incorrect dosage, and unscientific administration. Conclusion: The guiding role of pharmaceutical care in bronchial asthma rational drug use can reduce medication error events and ensure rational drug use, which is worthy of popularization in clinical practice.

scholarly journals Clinical effect of minimally invasive aspiration and drainage of intracranial hematoma in the treatment of cerebral hemorrhage

2021 ◽  
Vol 38 (1) ◽  
Author(s):  
Chao Deng ◽  
Yuanling Ji ◽  
Wei Song ◽  
Jingfang Bi
Keyword(s):  
Minimally Invasive ◽  
Cerebral Hemorrhage ◽  
Clinical Effect ◽  
Statistical Significance ◽  
Control Group ◽  
Efficacy Rate ◽  
Observation Group ◽  
Intracranial Hematoma ◽  
Significant Difference ◽  
The Difference

Objectives: To explore the clinical value of minimally invasive aspiration and drainage of intracranial hematoma in the treatment of cerebral hemorrhage. Methods: Seventy-eight patients with cerebral hemorrhage who were treated in the Taian City Central Hospital and the Second Affiliated Hospital of Shandong First Medical University between June 2018 and December 2019 were selected. The patients were randomly numbered and divided into two groups by drawing lots, 39 in each group. The control group was treated with the traditional internal medicine conservative therapy, and the observation group was treated with minimally invasive intracranial hematoma aspiration and drainage. The indexes of the two groups were compared. Results: The efficacy rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). The National Institutes of Health Stroke Scale (NIHSS) score of the observation group was lower than that of the control group after treatment, and the difference was statistically significant (P<0.05). After treatment, the good recovery rate of the observation group was higher compared to the control group, and the difference had statistical significance (P<0.05). The incidence of complications in the observation group was lower than that of the control group, with a statistically significant difference (P<0.05). Conclusion: In the treatment of cerebral hemorrhage, minimally invasive intracranial hematoma aspiration and drainage facilitates the recovery of patients, promotes the improvement of neurological function, and has a high safety profile and an ideal prognostic quality. doi: https://doi.org/10.12669/pjms.38.1.4618 How to cite this:Deng C, Ji Y, Song W, Bi J. Clinical effect of minimally invasive aspiration and drainage of intracranial hematoma in the treatment of cerebral hemorrhage. Pak J Med Sci. 2022;38(1):---------. doi: https://doi.org/10.12669/pjms.38.1.4618 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Evaluation on the Effects of Pulmicort Respules, Ventolin combined with Methylprednisolone in the Adjuvant Treatment of Bronchiolitis in Children

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Shimin Miao
Keyword(s):  
Adjuvant Treatment ◽  
Group Treatment ◽  
Random Number ◽  
Inflammatory Factors ◽  
Control Group ◽  
Observation Group ◽  
Before And After ◽  
Random Number Table ◽  
The Difference ◽  
Necrosis Factor

Objective: To investigate the effects of Pulmicort Respules, Ventolin combined with methylprednisolone in the adjuvant treatment of bronchiolitis in children. Methods: A total of 100 children with bronchiolitis in our hospital from March 2018 to March 2020 were selected and divided into 2 groups with 50 cases in each group by using random number table. Both groups received conventional treatment. Based on this, the control group was given Pulmicort Respules and Ventolin, and the observation group was given methylprednisolone in combination with the conventional regimens on the basis of the control group treatment, the course of treatment was 5 days. The levels of inflammatory factors [tumor necrosis factor-a (TNF-a), interleukin 6 (IL-6)] and the time to symptom disappearance before and after treatment were compared and analyzed between the two groups. Results: After treatment, the levels of serum TNF-a and IL-6 in the two groups decreased, and the observation group was lower than the control group, the difference was statistically significant (P<0.05); the disappearance of pulmonary moist rales, lung wheezing, cough and wheezing in the observation group were all earlier than the control group, the difference was statistically significant (P<0.05). Conclusion: Pulmicort Respules, Ventolin combined with methylprednisolone is effective in adjuvant treatment of bronchiolitis in children, which can reduce inflammation and promote the recovery of children.

scholarly journals Comparison of azithromycin and erythromycin in the treatment of mycoplasma pneumonia in children

2019 ◽  
Vol 36 (2) ◽  
Author(s):  
Rui Han ◽  
Qianqian Yu ◽  
Guohui Zhang ◽  
Baoqiang Li ◽  
Shuzhen Han ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Clinical Symptoms ◽  
Control Group ◽  
Clinical Effects ◽  
Observation Group ◽  
Research Subjects ◽  
Creative Commons ◽  
Significant Difference ◽  
Mycoplasma Pneumonia ◽  
The Difference

Objective: To study and compare the clinical effects of azithromycin and erythromycin on children with mycoplasma pneumonia. Methods: Total 132 children with mycoplasma pneumonia who were admitted to our hospital between November 2017 and September 2018 were selected as the research subjects. All the children were divided into an observation group and a control group according to random number table, 66 each. The observation group was treated with azithromycin, while the control group was treated with erythromycin. The therapeutic effect, incidence of adverse reactions and disappearance time of clinical symptoms were compared between the two groups. Results: The total efficacy of the observation group was 98.04%, and that of the control group was 74.51%; there was a significant difference (X2=7.184, P=0.007). The incidence of adverse reactions in the observation group was 15.69%, significantly lower than that in the control group (41.18%) (X2=6.376, P=0.002). The disappearance of fever, cough, rale and X ray shadow of the observation group was significantly earlier than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: Compared with erythromycin, azithromycin is more effective in the treatment of mycoplasma pneumonia in children. Azithromycin can further shorten the improvement time of clinical symptoms and signs and has few adverse reactions and high safety. It is worth clinical application. doi: https://doi.org/10.12669/pjms.36.2.1441 How to cite this:Han R, Yu Q, Zhang G, Li B, Han S, Li G. Comparison of azithromycin and erythromycin in the treatment of mycoplasma pneumonia in children. Pak J Med Sci. 2020;36(2):---------. doi: https://doi.org/10.12669/pjms.36.2.1441 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Effects of combined use of atorvastatin and losartan in treating patients with diabetic nephropathy

2018 ◽  
Vol 16 ◽  
pp. 205873921879670
Author(s):  
Chao Ding ◽  
Xiaohua Hu
Keyword(s):  
Diabetic Nephropathy ◽  
Endothelial Function ◽  
Cardiovascular Events ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Inflammatory Factors ◽  
Control Group ◽  
Vascular Endothelial ◽  
Observation Group ◽  
Vascular Endothelial Function

This study is to investigate the effect of atorvastatin combined with losartan on inflammatory factors, vascular endothelial function, and cardiovascular events in patients with diabetic nephropathy. A total of 128 patients with diabetic nephropathy treated in our hospital from January 2014 to December 2015 were selected as the study subjects, and 64 cases were randomly divided into observation group and 64 cases in the control group. The control group was treated with losartan on the basis of routine treatment, and the observation group was treated with atorvastatin on the basis of the control group. The blood lipid, inflammatory factors, changes in vascular endothelial function and cardiovascular events were compared between the two groups. The levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were not significantly different between the two groups before treatment ( P > 0.05); after treatment, the levels of TC, TG, and LDL-C in the observation group were significantly lower than those of the control group, and the level of HDL-C was significantly higher than that of the control group ( P < 0.05). The levels of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-α), and interleukin 6 (IL-6) were not statistically different between the two groups before treatment ( P > 0.05); after treatment, the levels of hs-CRP, TNF-α, and IL-6 in the observation group were significantly lower than those of the control group ( P < 0.05), the level of HDL-C was significantly higher than that of the control group ( P < 0.05). There were no significant differences in the levels of endothelin-1 (ET-1) and nitric oxide (NO) between the two groups before treatment ( P > 0.05). After treatment, the level of ET-1 in the observation group was significantly lower than that of the control group ( P < 0.05), and the level of NO was significantly higher than that of the control group ( P < 0.05). After treatment, all patients were followed up for 2 years, and the incidence of secondary cardiovascular events in the observation group was 12.50% (8/64), which was significantly lower than 29.69% (19/64) of the control group ( P < 0.05). Combination of atorvastatin and losartan can significantly improve the levels of blood lipid, inflammatory factors, and vascular endothelial function in patients with diabetic nephropathy and can effectively reduce the incidence of cardiovascular events.

scholarly journals Research on the Correlation of Serum PCT and Plasma GSN Levels with the Prognosis of Urosepsis Patients

2020 ◽  
Vol 36 (5) ◽  
Author(s):  
Na Cui ◽  
Zhanbiao Yu ◽  
Zhi Chen ◽  
Ning Chen
Keyword(s):  
Poor Prognosis ◽  
Original Work ◽  
Protective Factor ◽  
Good Prognosis ◽  
Control Group ◽  
Creative Commons ◽  
The Poor ◽  
Prognosis Group ◽  
Good Prognosis Group ◽  
Open Access Article

Objective: To explore the correlation of procalcitonin (PCT) and gelsolin (GSN) with the prognosis of urosepsis patients. Method: The data of 71 urosepsis patients from March 2015 to April 2019 who were admitted to and treated in Affiliated Hospital of Hebei University were analyzed and compared with those of 92 healthy persons. Serum PCT and plasma GSN levels at different times after treatment were detected. According to prognosis, patients were classified into the good prognosis group or the poor prognosis group. The serum PCT and plasma GSN levels of both groups were compared. Result: The serum PCT level of the urosepsis group on the 1st, 3rd, 5th and 7th days was obviously higher than that of the control group (P<0.05). The plasma GSN levels of the urosepsis group on the 1st, 3rd, 5th and 7th days were obviously lower than those of the control group (P<0.05).The serum PCT level of the poor prognosis group on the 1st, 3rd, 5th and 7th days was obviously higher than that of the good prognosis group (P<0.05). The plasma GSN level of the poor prognosis group on the 1st, 3rd, 5th and 7th days was obviously lower than that of the good prognosis group (P<0.05). PCT was an independent risk factor influencing the prognosis of urosepsis patients and that GSN was a protective factor (P<0.05). Conclusion: The serum PCT and plasma GSN levels can accurately predict the severity and prognosis of urosepsis patients and reflect the disease state of early urosepsis patients. High PCT levels and low GSN levels indicate poor prognosis, and clinicians should consider these values. doi: https://doi.org/10.12669/pjms.36.5.2143 How to cite this:Cui N, Yu Z, Chen Z, Chen N. Research on the Correlation of Serum PCT and Plasma GSN Levels with the Prognosis of Urosepsis Patients. Pak J Med Sci. 2020;36(5):---------. doi: https://doi.org/10.12669/pjms.36.5.2143 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Analysis of the Effect of Three - Row Nail in Gastric Cancer Operation

1970 ◽  
Vol 1 (1) ◽  
Author(s):  
Wang Guang yong
Keyword(s):  
Gastric Cancer ◽  
Methylene Blue ◽  
Clinical Application ◽  
Skin Flap ◽  
Control Group ◽  
Observation Group ◽  
External Reinforcement ◽  
Methylene Blue Test ◽  
The Difference ◽  
Observational Group

To study on the clinical efficacy of the repairing of the toe defect of the tip of the toe artery with skin flap. 48 patients with tip of toe defects who were admitted to our department from May 2014 to December 2015 were randomly divided into two groups: control group and observation group, 24 cases in each group. The patients in the control group were treated with abdominal pedicle flap while the patients in the observation group were treated with the toe artery skin flap for repair. The clinical curative effect of the two groups was analyzed. The total effective rate of clinical treatment was 23 (95.83%) in the observation group was significantly higher than that in the control group, 19 (79.16%), and the elasticity and texture of the flap were good and no obvious adverse reaction occurred. The difference between the two groups was significant, p<0.05. The use of the toe artery skin flap for the treatment of the tip of toe defect has a significant clinical effect, and no serious adverse reactions occurred, highly safety.15To explore the clinical application of three-row stapler in the operation of gastric cancer, and to provide a reference for clinical application. 31 patients with gastric cancer from January 2015 to April 2017 were randomly divided into observational group and control group. The observational group (n = 16) received three rows of the stapler; the control group (n = 15) received two rows of the stapler. The general condition, complication and anastomotic condition of the two groups were recorded, and the occurrence of anastomotic leakage was tested by methylene blue test. There was no significant difference in the operation time between the two groups ( P> 0.05). The length of stay in the hospital for the observational group was (16.17 ± 5.25) d, which was significantly lower than that of the control group (22.35 ± 7.18) d, the difference was statistically significant (P < 0.05). The incidence of complications was 7.14%, which was significantly lower than that of the control group (26.67%, P < 0.05). The number of bleeding in the anastomosis of the observational group was (0.87 ± 0.61), and the number of the outermost anastomosis was 0.95 ± 0.49, which was significantly lower than that of the control group (P<0.01). In the observational group, only one case (6.28%) was positive in the methylene blue test, which was significantly lower than that in the control group (20%) (P < 0.05). Three-row stapler can be used to treat the traditional two-row nail stapler, and no external reinforcement is needed after anastomosis. At the same time, it can effectively control the anastomotic bleeding, outer ring nail exposure and anastomotic leakage complications occur and clinical hospital stays shorter, more efficient treatment, worthy of clinical application.

scholarly journals Study on the clinical efficacy and mechanism of octreotide combined with thrombin in patients with liver

1970 ◽  
Vol 1 (1) ◽  
Author(s):  
Zhang Xiuqin
Keyword(s):  
Liver Cirrhosis ◽  
Liver Function ◽  
Clinical Efficacy ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group ◽  
Before And After ◽  
Octreotide Treatment ◽  
The Difference ◽  
Treatment Observation

Objective: To observe the clinical efficacy of octreotide and thrombin in the treatment of patients with liver cirrhosis, and to explore the mechanism of octreotide and thrombin. Methods: 53 patients with cirrhosis were randomly divided into control group and observation group from January 2014 to January 2016. The control group of 26 patients, given octreotide treatment. Observation group of 27 cases, given octreotide and thrombin combination therapy. Comparison of two groups of patients with clinical efficacy and changes in liver function before and after treatment. Results: The effective rate (88.89%) in the observation group was significantly higher than that in the control group (65.38%), the difference was statistically significant (p < 0.05). Before treatment, the difference of liver function between the two groups was not statistically significant (p > 0.05). After treatment, the liver function indexes of the two groups were improved, and the observation group was superior to the control group, the difference was statistically significant (p < 0.05).

scholarly journals A Comparative Study on the Efficacy between Minimally Invasive Caries Removal Technique involving Carisolv and Traditional Mechanical Caries Removal in Treating Dental Caries in Children

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Jiaying Song
Keyword(s):  
Dental Caries ◽  
Minimally Invasive ◽  
Recovery Time ◽  
Control Group ◽  
Observation Group ◽  
Research Subjects ◽  
Removal Method ◽  
Caries Removal ◽  
The Difference ◽  
Removal Technique

Objective: To explore the curative effect of Carisolv, a minimally invasive caries removal technique and traditional mechanical caries removal treatment on children's dental caries. Methods: A total of 97 children with dental caries who were treated in the Department of Stomatology in Affiliated Hospital of Chifeng University, Chifeng from September 2017 to May 2019 were selected and recruited as the research subjects. They were divided into two groups by random number table method. Forty-nine individuals were assigned in the control group while the remaining 48 individuals in the observation group. The control group was treated with traditional mechanical caries removal method, and the observation group was treated with minimally invasive caries removal technique, i.e. Carisolv. Both groups were followed up for six months. The degree of pain, recovery time of dental function and complications after six months of treatment were observed in the two groups of children. Results: During the treatment, compared with the control group, the children in the observation group experienced lower degree of pain and had shorter recovery time of dental function. After six months of treatment, the incidence of complications in the observation group was lower than that in the control group. The difference was statistically significant (P<0.05). Conclusion: Compared with traditional mechanical caries removal method, Carisolv, a minimally invasive caries removal technique could reduce the pain of children during the treatment process, shorten the time to restore dental function, reduce the occurrence of complications, and had a better therapeutic effect in treating children’s dental caries.

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