scholarly journals Recent advances in phototherapy for psoriasis

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 1684 ◽  
Author(s):  
Mio Nakamura ◽  
Benjamin Farahnik ◽  
Tina Bhutani
Keyword(s):  
Combination Therapy ◽  
Effective Treatment ◽  
Ultraviolet Light ◽  
Excimer Laser ◽  
Biologic Agents ◽  
Repeated Exposure ◽  
Therapeutic Modalities ◽  
Scalp Psoriasis ◽  
Skin Conditions ◽  
Made In

Phototherapy involves repeated exposure of the skin to ultraviolet light to treat various inflammatory skin conditions such as psoriasis. Recent studies have identified specific immunologic effects of phototherapy that may underlie phototherapy efficacy. Furthermore, recent advancements have been made in developing safe and effective targeted phototherapy modalities for difficult-to-treat areas such as scalp psoriasis. Targeted phototherapy in the form of the excimer laser holds potential for more aggressive, effective treatment and long-lasting remission of psoriasis. Phototherapy is now also used successfully with biologic agents as combination therapy to treat recalcitrant psoriasis. Therefore, though one of the oldest therapeutic modalities for psoriasis, phototherapy remains a mainstay treatment with promise for further advancement.

Hyaluronan based Multifunctional Nano-carriers for Combination Cancer Therapy

2020 ◽  
Vol 20 ◽  
Author(s):  
Menghan Gao ◽  
Hong Deng ◽  
Weiqi Zhang
Keyword(s):  
Cancer Therapy ◽  
Combination Therapy ◽  
Cancer Cells ◽  
Drug Loading ◽  
Tumor Therapy ◽  
Drug Carriers ◽  
Functional Sites ◽  
Therapeutic Modalities ◽  
Combination Cancer Therapy ◽  
Targeting Strategy

: Hyaluronan (HA) is a natural linear polysaccharide that has excellent hydrophilicity, biocompatibility, biodegradability, and low immunogenicity, making it one of the most attractive biopolymers used for biomedical researches and applications. Due to the multiple functional sites on HA and its intrinsic affinity for CD44, a receptor highly expressed on various cancer cells, HA has been widely engineered to construct different drug-loading nanoparticles (NPs) for CD44- targeted anti-tumor therapy. When a cocktail of drugs is co-loaded in HA NP, a multifunctional nano-carriers could be obtained, which features as a highly effective and self-targeting strategy to combat the cancers with CD44 overexpression. The HA-based multidrug nano-carriers can be a combination of different drugs, various therapeutic modalities, or the integration of therapy and diagnostics (theranostics). Up to now, there are many types of HA-based multidrug nano-carriers constructed by different formulation strategies including drug co-conjugates, micelles, nano-gels and hybrid NP of HA and so on. This multidrug nano-carrier takes the full advantages of HA as NP matrix, drug carriers and targeting ligand, representing a simplified and biocompatible platform to realize the targeted and synergistic combination therapy against the cancers. In this review, recent progresses about HA-based multidrug nano-carriers for combination cancer therapy are summarized and its potential challenges for translational applications have been discussed.

scholarly journals Deploying triple artemisinin-based combination therapy (TACT) for malaria treatment in Africa: ethical and practical considerations

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Paulina Tindana ◽  
Freek de Haan ◽  
Chanaki Amaratunga ◽  
Mehul Dhorda ◽  
Rob W. van der Pluijm ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Combination Therapy ◽  
Southeast Asia ◽  
Malaria Control ◽  
Lessons Learned ◽  
Line Treatment ◽  
African Continent ◽  
First Line ◽  
First Line Treatment ◽  
Made In

AbstractMalaria remains a major cause of morbidity and mortality in Africa, particularly in children under five years of age. Availability of effective anti-malarial drug treatment is a cornerstone for malaria control and eventual malaria elimination. Artemisinin-based combination therapy (ACT) is worldwide the first-line treatment for uncomplicated falciparum malaria, but the ACT drugs are starting to fail in Southeast Asia because of drug resistance. Resistance to artemisinins and their partner drugs could spread from Southeast Asia to Africa or emerge locally, jeopardizing the progress made in malaria control with the increasing deployment of ACT in Africa. The development of triple artemisinin-based combination therapy (TACT) could contribute to mitigating the risks of artemisinin and partner drug resistance on the African continent. However, there are pertinent ethical and practical issues that ought to be taken into consideration. In this paper, the most important ethical tensions, some implementation practicalities and preliminary thoughts on addressing them are discussed. The discussion draws upon data from randomized clinical studies using TACT combined with ethical principles, published literature and lessons learned from the introduction of artemisinin-based combinations in African markets.

scholarly journals Antithrombotic Therapy in Patients with Atrial Fibrillation and Acute Coronary Syndrome

2020 ◽  
Vol 9 (7) ◽  
pp. 2020
Author(s):  
Wilbert Bor ◽  
Diana A. Gorog
Keyword(s):  
Atrial Fibrillation ◽  
Acute Coronary Syndrome ◽  
Combination Therapy ◽  
Bleeding Risk ◽  
Careful Consideration ◽  
P2y12 Inhibitor ◽  
Coronary Syndrome ◽  
Antithrombotic Efficacy ◽  
Selection Of ◽  
Made In

Acute coronary syndrome and atrial fibrillation are both common and can occur in the same patient. Combination therapy with dual antiplatelet therapy and oral anticoagulation increases risk of bleeding. Where the two conditions coexist, careful consideration is needed to determine the optimal antithrombotic treatment to reduce the risks of future ischaemic events associated with both conditions. Choices can be made in intraprocedural anticoagulation, type and dosing of oral anticoagulant, duration of combination therapy, and selection of P2Y12 inhibitor including genetic testing. This review article provides an overview of the available evidence to support clinicians in finding the delicate balance between antithrombotic efficacy and bleeding risk in patients with acute coronary syndrome and atrial fibrillation.

scholarly journals Development of Immunopathogenesis Strategies to Treat Behçet’s Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Osman Köse
Keyword(s):  
Molecular Structure ◽  
Biologic Agents ◽  
Treatment Modalities ◽  
The Novel ◽  
Therapeutic Modalities ◽  
Novel Treatment ◽  
Unclear Etiology ◽  
Antigen Presenting ◽  
Disease Understanding ◽  
Novel Therapeutic

Behçet disease is a chronic relapsing vasculitis with unclear etiology and immunopathogenesis. Antigenic stimuli, antigen presenting cells, T cells, monocyte, and neutrophil and endothelial cells are major parts of the pathology of the disease. Understanding of the new pathogenic mechanisms based on molecular structure of the disease helps us in improving the novel therapeutic modalities. These drugs target specific and nonspecific inhibition of the immun system. These therapies include biologic agents, new topical and systemic immunosuppressants, tolerizing agents, and immunoablation. Novel treatment will be promising to treat the especially recalcitrant cases to conventional therapy. In this paper, new aspect of the immunopathogenesis of Behçet’s diseases and novel treatment modalities will be discussed.

A 308-nm excimer laser for the treatment of scalp psoriasis

2004 ◽  
Vol 34 (2) ◽  
pp. 136-140 ◽  
Author(s):  
Charles R. Taylor ◽  
Ashley L. Racette
Keyword(s):  
Excimer Laser ◽  
Scalp Psoriasis

The Potato-Root Eelworm in Lincolnshire

1929 ◽  
Vol 7 (2) ◽  
pp. 63-80 ◽  
Author(s):  
D. O. Morgan ◽  
B. G. Peters
Keyword(s):  
Effective Treatment ◽  
Pathological Condition ◽  
Potato Crop ◽  
Hydrogen Ion ◽  
Ion Concentration ◽  
Heterodera Schachtii ◽  
Considerable Importance ◽  
Potato Root ◽  
Hydrogen Ion Concentration ◽  
Made In

In 1924, Morgan visited South Lincolnshire to investigate the part played by the potato-root eelworm (Heterodera schachtii) in the serious failure of the local potato crop: a note on the investigation appears in this Journal (1925, p. 185). A second visit was made in 1925, as a result of which certain conclusions regarding manuring and the rotation of crops were put forward (this Journal, 1926, p. 49). Towards the end of 1925 the second writer (Peters) made a hurried survey with the object of seeking a possible correlation between the distribution of eelworm cysts and the hydrogen ion concentration of the soil. Such a correlation was actually demonstrated (this Journal, 1926, p. 87) in the case of a selected field for which Morgan had complete data of cyst-counts. The question thus arose as to whether any clear correlations should be shown to exist between the three factors: concentration of cysts, pathological condition of the crop, and reaction of the soil. In other words, was the eelworm associated with the damage? and was it controlled (and therefore controllable) by the effective acidity of the soil? To decide these questions might be a matter of considerable importance, particularly if the eelworm was found to be responsible for the damage, for affirmative answers would open the way to effective treatment, by the adequate liming of soils for instance.

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