Application of transcutaneus electroneurostimulation in complex therapy and rehabilitation of diabetic neuropathic pain

10.12737/7217 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 0-0
Author(s):  
Аль-Замиль ◽  
M. Al-Zamil ◽  
Божко ◽  
S. Bozhko ◽  
Кудаева ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Lower Extremity ◽  
High Frequency ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Control Group ◽  
Control Groups ◽  
Clinical Signs And Symptoms ◽  
And Control ◽  
Low Amplitude

. In this article expediency of application of monophasic, high frequency and low amplitude transcutaneous neuroelectrostimulation in treatment of neuropathic pain in patients with diabetic distal polyneuropathy of lower extremity was proved. This study included 159 patients with acute distal neuropathic pain in lower extremity. In all patients di-abetic mellitus 2 type was diagnosed and clinical signs and symptoms of distal polyneuropathy were found. Comparative dynamics of clinical and electromyographic manifestations of diabetic distal polyneuropathy between basis and control groups were analyzed. 62 patients in control group undergone treatment by the Duloxetine 60 mg every day within 3 months. In basis group 97 patients in addition to the Duloxetine were treated by transcutaneous neuroelectrostimulation during 30 minutes per day after day for 15 days. This study showed that complex treatment by combination use of transcutaneous neuroelectrostimula-tion with central analgesic more effective than traditional analgesic therapy in treatment of neuropathic pain in patients with diabetic distal polyneuropathy.

Clinical value of (1,3)-β-D-glucan, mannan, antimannan IgG and IgM antibodies in diagnosis of invasive candidiasis

2019 ◽  
Vol 57 (8) ◽  
pp. 976-986
Author(s):  
Fengtian Li ◽  
Xiaotian Yu ◽  
Liyan Ye ◽  
Guang Zhou ◽  
Leili Wang ◽  
...  
Keyword(s):  
Sensitivity And Specificity ◽  
Invasive Candidiasis ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Immunoglobulin M ◽  
Control Group ◽  
Clinical Value ◽  
Serum Samples ◽  
Clinical Signs And Symptoms ◽  
And Control

Abstract Diagnosis of invasive candidiasis (IC) is still challenging due to absence of specific clinical signs and symptoms. In this study we investigate the clinical value of (1,3)-β-D-glucan (BDG), mannan (MN), antimannan immunoglobulin G (AM-IgG), and antimannan immunoglobulin M (AM-IgM) assay in diagnosis of IC. During 2016 to 2018 serum samples from 71 patients with IC and 185 patients without IC were collected. Serum samples from 41 patients with bacteremia were also enrolled as additional control. Significant differences in mean serum biomarkers levels between IC and control group were observed. At low cutoff threshold the sensitivity and specificity of BDG (70 pg/ml), MN (50 pg/ml), AM-IgG (80 AU/ml), and AM-IgM (80 AU/ml) assay were 64.8% and 90.8%, 64.8 and 89.2%,74.6% and 87.0%, 57.7% and 60.0%, respectively. Combined use of BDG/MN, BDG/AM-IgG and MN/AM-IgG improved the sensitivity and specificity to 85.9% and 81.1%, 85.9% and 80.0%, 81.7% and 81.6%, respectively. The combination of BDG/MN, BDG/AM-IgG, or MN/AM-IgG may provide an encouraging approach for diagnosis of IC.

Determination of thallium in urine, blood, and hair in illicit opioid users in Iran

2020 ◽  
Vol 39 (6) ◽  
pp. 808-815
Author(s):  
N Molavi ◽  
A Ghaderi ◽  
HR Banafshe
Keyword(s):  
Graphite Furnace ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Absorption Spectrometry ◽  
Control Group ◽  
Opioid Use ◽  
Clinical Signs And Symptoms ◽  
Opioid Users ◽  
Thallium Exposure ◽  
Illicit Opioid Use

Context: Heavy metals, including thallium and lead, are introduced to illicit drug users’ body as a result of using drugs such as cocaine and heroin. Objective: This study aimed to determine urine, blood, and hair thallium (Tl) concentrations in illicit opioid users along with the relevant clinical signs and symptoms consistent with thallotoxicosis and to compare them with the corresponding variables in the control non-opioid user group. Materials and Methods: This case–control study was conducted on 50 illicit opioid users who had abused opioids continuously for more than a year, referred to Amirie Drug Abuse Treatment Clinic in Kashan, Iran. The control group included 50 non-opioid users. Thallium concentrations in urine, blood, and hair were assessed in both groups ( n = 100) using electrothermal (graphite furnace) atomic absorption spectrometry (ET AAS, GF AAS). Results: In the studied group, the median (interquartile range) concentrations of thallium in urine, blood, and hair were 54.8 ± 79.9 μg/L, 14.5 ± 11.1 μg/L, and 5.4 ± 3.7 µg/g, respectively; these values were 4.8 ± 5.2 μg/L, 2.5 ± 2.4 μg/L, and 1.4 ± 1.1 µg/g, respectively, in the control group. There were significant differences in urine, blood, and hair thallium concentrations between the study group and the control group ( p < 0.001). There were significant correlations between duration of illicit opioid use and urine thallium concentrations ( r = 0.394, p = 0.005) and hair thallium concentrations ( r = 0.293, p = 0.039), but not with blood thallium concentrations ( r = 0.246, p = 0.085). Urine and blood thallium concentrations of illicit opioid users with clinical signs and symptoms consistent with thallotoxicosis of weakness ( p = 0.01), depression ( p = 0.03), and headache ( p = 0.03) were higher than users without these problems. Discussion and conclusion: The results of the study showed that thallium concentrations in urine, blood, and hair in illicit opioid users were significantly higher than the comparable concentrations in the control group. This can be due to the use of illicit opioids adulterated with thallium. Also, this study showed long-term illicit opioid use may lead to thallium exposure. In addition, cigarette smoking was associated with increased thallium exposure.

ELECTRODIAGNOSTIC CRITERIA FOR DIAGNOSING CARPAL TUNNEL SYNDROME NEED TO BE REVISED IN HYPOTHYROID PATIENTS

2017 ◽  
Vol 20 (03) ◽  
pp. 1750014
Author(s):  
Mahdieh Asadi ◽  
Sharareh Roshanzamir
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Carpal Tunnel ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Control Group ◽  
Tunnel Syndrome ◽  
Clinical Signs And Symptoms ◽  
Relationship Of ◽  
Hypothyroid Patients

Background: Previous studies do not agree with each other on the association between electrodiagnostic findings and clinical symptoms of Carpal tunnel syndrome (CTS). In most of these studies, many variables such as age, sex, obesity and hypothyroidism have not been taken into account. Material & methods: About 62 patients with hypothyroidism and 62 patients without hypothyroidism with sign and symptoms of CTS were included in this study. Electrodiagnostic tests were done for all patients. And relationship of the severity of CTS signs and symptoms with electrodiagnostic parameters was examined statistically in each group. Results: This study showed that distal motor latency in control group (without hypothyroidism) is significantly more prolonged than hypothyroid patients. Also there was significant correlation between clinical symptoms and electrodiagnostic findings in control group, but there was not such correlation in hypothyroid patients. In 62% of hypothyroid patients with clinical signs and symptoms of CTS, electrodiagnostic findings were normal and only in 38% of cases, electrodiagnostic findings were suggestive of CTS. Conclusion: Relationship of the severity of CTS signs and symptoms with electrodiagnostic parameters is very weak in hypothyroid patients. Many hypothyroid patients with clinical signs and symptoms of CTS have normal electrodiagnostic findings; so we need more studies for revising the para-clinic criteria of labeling patients having CTS in hypothyroid patients.

scholarly journals Oral Administration of Lactobacillus Strains Isolated from Breast Milk as an Alternative for the Treatment of Infectious Mastitis during Lactation

2008 ◽  
Vol 74 (15) ◽  
pp. 4650-4655 ◽  
Author(s):  
E. Jiménez ◽  
L. Fernández ◽  
A. Maldonado ◽  
R. Martín ◽  
M. Olivares ◽  
...  
Keyword(s):  
Breast Milk ◽  
Clinical Signs ◽  
Control Group ◽  
Control Groups ◽  
Lactobacillus Salivarius ◽  
Probiotic Group ◽  
Efficient Alternative ◽  
The Mean ◽  
And Control ◽  
Infectious Mastitis

ABSTRACT In this study, 20 women with staphylococcal mastitis were randomly divided in two groups. Those in the probiotic group daily ingested 10 log10 CFU of Lactobacillus salivarius CECT5713 and the same quantity of Lactobacillus gasseri CECT5714 for 4 weeks, while those in the control one only ingested the excipient. Both lactobacillus strains were originally isolated from breast milk. On day 0, the mean staphylococcal counts in the probiotic and control groups were similar (4.74 and 4.81 log10 CFU/ml, respectively), but lactobacilli could not be detected. On day 30, the mean staphylococcal count in the probiotic group (2.96 log10 CFU/ml) was lower than that of the control group (4.79 log10 CFU/ml). L. salivarius CECT5713 and L. gasseri CECT5714 were isolated from the milk samples of 6 of the 10 women of the probiotic group. At day 14, no clinical signs of mastitis were observed in the women assigned to the probiotic group, but mastitis persisted throughout the study period in the control group women. In conclusion, L. salivarius CECT5713 and L. gasseri CECT5714 appear to be an efficient alternative for the treatment of lactational infectious mastitis during lactation.

scholarly journals Possible Association between Diabetes and Bisphosphonate-Related Jaw Osteonecrosis

2007 ◽  
Vol 92 (3) ◽  
pp. 1172-1175 ◽  
Author(s):  
Mogher Khamaisi ◽  
Eran Regev ◽  
Noam Yarom ◽  
Batia Avni ◽  
Eran Leitersdorf ◽  
...  
Keyword(s):  
Fasting Blood Glucose ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Pathological Process ◽  
Control Group ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
Hospital Referral ◽  
Hebrew University ◽  
Clinical Signs And Symptoms

Abstract Context: Bisphosphonate-related osteonecrosis (BON) of the jaws is a newly identified condition for which the exact mechanism involved in its pathogenesis remains obscure. Objective: The objective of the study was to evaluate whether diabetes mellitus (DM) may be a contributing factor in the development of BON. Design: From 2004 to 2006, 31 patients were diagnosed with BON. The diagnosis of BON was based on the medical and dental history of each patient as well as the observation of clinical signs and symptoms of this pathological process. DM was based on two consecutive fasting blood glucose levels above 7 mmol/liter. Setting: The study was completed in the Hebrew University-Hadassah Hospital referral center. Results: Of the 31 patients with BON, 18 (58%) were found to have DM or impaired fasting glucose. The proportion of diabetic patients was much higher than expected relative to the incidence of DM in the general population (14%) and compared with the proportion of diabetic patients in a control group of oncological patients treated with bisphosphonates and without BON (12%) (P = 0.00003). Conclusions: This finding indicates that DM may be a risk factor for BON and that DM patients treated with bisphosphonates should be carefully monitored. We discuss here the bone metabolic pathways characteristic of DM patients and the way in which these pathways can augment the effects of bisphosphonates.

scholarly journals The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis

2021 ◽  
Vol 11 (1) ◽  
pp. 6-11
Author(s):  
Ömür Dereci ◽  
Görkem Tekin ◽  
Yasin Çağlar Koşar
Keyword(s):  
Hyaluronic Acid ◽  
Clinical Signs ◽  
Physiological Saline ◽  
Signs And Symptoms ◽  
Control Group ◽  
Chlorhexidine Digluconate ◽  
Saline Irrigation ◽  
Significant Difference ◽  
Alveolar Osteitis ◽  
Clinical Signs And Symptoms

Aim:  The aim of this study was to compare the efficacy of Alveogyl, 0.8% hyaluronic acid (HA), and 0.2% chlorhexidine digluconate (CHX) gel in reducing pain and improving clinical signs and symptoms of alveolar osteitis. Methodology: The clinical data of patients treated for alveolar osteitis between 01/01/2015 and 01/01/2019 were retrieved for this study. All patients were initially treated by curettage and physiological saline irrigation. Patients were then divided into 4 groups. Group 1 was considered the control group; no other biomaterials were administered after curettage and physiological saline irrigation. All other groups were administered an additional treatment in the socket after curettage and physiological saline irrigation (Group 1 – Alveogyl; Group 2 - 0.8% HA; Group 3 - 0.2% CHX). Patents were evaluated before surgery as well as days 3 and 7 after surgery. The postoperative evaluations included: Visual analog scale(VAS) pain scores, the presence of clinical signs and symptoms of exposed alveolar bone, disorganized blood clot, inflammation around the socket, and bad odor and taste. Results: Sixty-seven patients were included in the study. There was no statistically significant difference between groups in all control evaluations (p>0.05). There was significantly reduced inflammation around the extraction socket on postoperative day 7 in the CHX group compared to that in the control group (p<0.05). No other significant changes in clinical signs and symptoms were observed among groups. Conclusion: There was no significant difference between curettage with physiological saline irrigation alone and the addition of Alveogyl, 0.8% HA, or 0.2% CHX in the reduction of pain in alveolar osteitis. Nonetheless, CHX may reduce inflammation around the extraction sockets.   How to cite this article: Dereci Ö, Görkem T, Koşar YÇ. The comparison of the efficacy of Alveogyl, 0.8% Hyaluronic acid, and 0.2% Chlorhexidine Digluconate in alveolar osteitis. Int Dent Res 2021;11(1):6-11. https://doi.org/10.5577/intdentres.2021.vol11.no1.2   Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

Embolization treatment of recurrent varices of pelvic origin

2006 ◽  
Vol 21 (1) ◽  
pp. 3-11 ◽  
Author(s):  
J Leal Monedero ◽  
S Zubicoa Ezpeleta ◽  
J Castro Castro ◽  
M Calderón Ortiz ◽  
G Sellers Fernández
Keyword(s):  
Lower Extremity ◽  
Varicose Veins ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Venous Stasis ◽  
High Incidence ◽  
Embolization Treatment ◽  
Clinical Signs And Symptoms ◽  
Collateral Vessels ◽  
Pelvic Venous Insufficiency

Objective: To present our experience with embolization of pelvic reflux routes in patients with recurrent varices after surgery (REVAS). Method: Single patient group study of patients with previous surgical treatment for varicose veins, with REVAS in Unidad de Angiología y Cirugía Vascular, Hospital Ruber Internacional, Madrid, España. Patients presenting with REVAS with pelvic venous insufficiency (PVI) documented per transvaginal colour duplex, undergoing selective pelvic venography, were treated with embolization of insufficient gonadal and hypogastric mainstem and collateral veins. Results: In all, 215 patients (89.9%) reported relief of pelvic pain and symptoms of lower extremity venous stasis six months postembolization; total relief in 120 (50.2%) and partial relief in 95 (39.7%). Conclusions: There is high incidence of PVI in patients with REVAS. Embolization of insufficient gonadal and hypogastric mainstem and collateral vessels is associated with significant relief of clinical signs and symptoms of pelvic and lower extremity venous stasis in patients with REVAS and PVI.

Benefit effect of naloxone in benzodiazepines intoxication: Findings of a preliminary study

2010 ◽  
Vol 30 (7) ◽  
pp. 535-540 ◽  
Author(s):  
Hassan Solhi ◽  
Babak Mostafazadeh ◽  
Hamid Reza Khoddami Vishteh ◽  
Ali Reza Ghezavati ◽  
Ali Shooshtarizadeh
Keyword(s):  
Signs And Symptoms ◽  
Drug Group ◽  
Control Group ◽  
Case Group ◽  
Control Groups ◽  
Level Of Consciousness ◽  
The Mean ◽  
Preliminary Study ◽  
And Control ◽  
Addition Level

Background: Naloxone, as a low-priced and available drug, may be useful in improvement of signs and symptoms of benzodiazepines intoxication. The aim of this study was assessment of its effect on benzodiazepines poisoning. Methods: In this clinical-trial study, patients with typical signs and symptoms of benzodiazepines poisoning, who were referred to a poisoning center in Tehran in 2008, were selected. After recording of patients’ characteristics, supportive treatment was initiated and patients were randomly assigned to the case group with intravenous (IV) injection of two 0.4 mg naloxone ampules or to the control group. Their signs and symptoms were evaluated again 0.5 hour later. Each of diazepam, clonazepam and alperazolam drug group had 30 patients and lorazepam drug group had 26 patients, half of which patients in each drug group received naloxone. Results: Most of the participants were female and the mean age was 28 years. There were no significant differences between case and control groups in age, sex, time of drug consumption, tablet counts, signs and symptoms and level of consciousness at the admission time in each drug types. After naloxone injection in case groups, all signs and symptoms significantly improved in all drug types in comparison to control groups except nystagmus. In addition, level of consciousness significantly improved in case groups in all drug types except lorazepam. Conclusion: Findings of the study showed that naloxone is effective in management of benzodiazepines poisoning. However, future clinical trials with greater sample size are recommened.

scholarly journals Associations of SNP rs_7927894 of FLG gene and TARC/CCL17 with atopic dermatitis in children

2021 ◽  
pp. 12-18
Author(s):  
V.O. Dityatkovsky ◽  
◽  
O.E. Abaturov ◽  
N.V. Naumenko ◽  
O.O. Alifirenko ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Statistical Significance ◽  
Venous Blood ◽  
Clinical Signs ◽  
Main Group ◽  
Control Group ◽  
Serum Concentrations ◽  
Control Groups ◽  
And Control ◽  
Severity Degree

One of the main genetic factors of the development of atopic dermatitis (AD) in children are single nucleotide polymorphisms (SNP) of the filagrin gene (FLG), particularly rs_7927894 FLG. One of the mostly studied and promising AD marker chemokines (CK) is the thymusE and activation regulated chemokine (TARC/CCL17). Purpose – to detect the associations and role of different variants of SNP rs_7927894 FLG gene and TARC/CCL17 in children suffering different AD clinical proE files (CP) – isolated or combined with comorbid atopic disorders (AtD). Materials and methods. The main group comprised 39 patients aged 3 to 18 years, suffering the isolated AD or combined with comorbid AtD. The control group comprised 47 patients aged 3 to 18 years, suffering the pathology of gastrointestinal tract without clinical signs of atopy. All the patients of the main and control groups had undergone detection of the genotype variants of SNP rs_7927894 FLG gene by real-time polymerase chain reaction and detection of TARC/CCL17 serum concentrations in venous blood. The cutEoff value of statistical significance was set as p<0.05. Results. The incidence and association of genotype variants C/C, C/T and T/T SNP rs_7927894 FLG gene in patients of cohorts of the studied groups were detected as follows: C/T rs_7927894 FLG was significantly the most common in the general main group (56.4%, p<0.05), within the cohort of CP AD isolated (61.1%, p<0.05) and CP of AD combined with comorbid AtD (52.4%, p<0.05). There were detected the associations of studied SNP with AD: C/T rs_7927894 FLG is significantly directly associated with AD (r=0.291, p<0.05), C/C rs_7927894 FLG has a reverse association with a trend to significance (r=-0.194, p=0.07). Mean serum concentrations of TARC/CCL17 did not differ significantly among patients cohorts of the main and control groups, respectively: general main group — 615.8 pg/ml, main with a CP AD isolated — 651.3 pg/ml, main with a CP of AD combined with comorbid AtD — 585.4 pg/ml, control — 608.4 pg/ml (p>0.05). Associations of serum TARC/CCL17 concentrations were determined as follows: elevation trending to significance within increasing AD severity degree (r=0.290, p=0.07) and significant elevation within the AD exhacerbation period (r=0.426, p<0.05). No significant association of TARC/CCL17 as to AD patients compared to the control group was detected in our study (r=-0.027, p>0.05). Conclusions. The genotype heterozygote variant C/T rs_7927894 FLG is significantly the most common and associated with all AD CP in children — isolated and combined with comorbid AtD. Variant C/C rs_7927894 of FLG gene is significantly reversely associated with AD in children. Serum concentrations of TARC/CCL17 did not reveal any significant differences between the AD patients and nonEatopic ones. However, they significantly elevate within AD exacerbation phase and trending to significance within AD severity degree increase in children. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local Ethics Committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: atopic dermatitis, children, associations, polymorphism, filaggrin, thymus- and activation regulated chemokine.

scholarly journals Power Doppler Ultrasound Evaluation of Peripheral Joint, Entheses, Tendon, and Bursa Abnormalities in Psoriatic Patients: A Clinical Study

2018 ◽  
Vol 45 (6) ◽  
pp. 811-817 ◽  
Author(s):  
Yuanjiao Tang ◽  
Yujia Yang ◽  
Xi Xiang ◽  
Liyun Wang ◽  
Lingyan Zhang ◽  
...  
Keyword(s):  
Middle Age ◽  
Power Doppler ◽  
Age Groups ◽  
Clinical Signs ◽  
Joint Effusion ◽  
Control Group ◽  
Power Doppler Ultrasound ◽  
Control Groups ◽  
Ultrasound Evaluation ◽  
And Control

Objective.To evaluate the prevalence rates of peripheral joint, enthesis, tendon, and bursa abnormalities by power Doppler (PD) ultrasonic examination in patients with psoriatic arthritis (PsA), psoriatic patients without clinical signs of arthritis (non-PsA psoriasis group), and healthy individuals, to detect subclinical PsA.Methods.A total of 253 healthy volunteers, 242 non-PsA psoriatic patients, and 86 patients with PsA were assessed by 2-dimensional and power Doppler (PD) ultrasound. Peripheral joint, enthesis, tendon, and bursa abnormalities were observed, characterizing abnormal PD. The affected patients and sites with abnormalities in various ages were compared among groups; PD signal grades for the abnormalities were also compared.Results.In the PsA group, significantly higher percentages of sites showing joint effusion/synovitis, enthesitis, and tenosynovitis in all age groups, and markedly higher rates of sites with bursitis were found in young and middle age groups, compared with the non-PsA and control groups (all p < 0.01). Meanwhile, the non-PsA group showed significantly higher rates of joint effusion/synovitis and enthesitis sites, and elevated PD signal grades of synovitis, enthesitis, and tenosynovitis in comparison with the control group, both in young and middle age groups (all p < 0.01).Conclusion.Patients with PsA have high percentages and PD signal grades of peripheral joint, tendon, enthesis, and bursa involvement. Young and middle-aged non-PsA patients have high synovitis and enthesitis percentages, and elevated PD signal grades of synovitis, enthesitis, and tenosynovitis.

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