Elevated Serum Levels of Pro-Inflammatory Markers Are Associated with Glucose Intolerance in Metabolic Syndrome Patients from Jordan = ارتفاع مستويات العلامات ما قبل الالتهابية في المرضى الأردنيين الذين يعانون من خلل في الجلوكوز ومتلازمة التمثيل الأيضي

2016 ◽  
Vol 50 (4) ◽  
pp. 169-176
Author(s):  
Amal A. Akour ◽  
Violet N. Kasabri ◽  
Nailya Y. Bulatova
Keyword(s):  
Metabolic Syndrome ◽  
Glucose Intolerance ◽  
Inflammatory Markers ◽  
Elevated Serum ◽  
Serum Levels

Anti-Inflammatory Effects of Exercise on Metabolic Syndrome Patients: A Systematic Review and Meta-Analysis

2020 ◽  
pp. 109980042095806 ◽  
Author(s):  
Heidar Alizaei Yousefabadi ◽  
Arghavan Niyazi ◽  
Sahar Alaee ◽  
Mehrdad Fathi ◽  
Gholam Rasul Mohammad Rahimi
Keyword(s):  
Metabolic Syndrome ◽  
Exercise Training ◽  
Inflammatory Markers ◽  
Meta Analysis ◽  
Serum Levels ◽  
Future Research ◽  
The Metabolic Syndrome ◽  
Inflammatory Status ◽  
Tnf Α ◽  
Training Impact

Background: Increments in inflammatory indicators and low levels of physical activity are correlated to the expansion of the metabolic syndrome (MetS). Objective: The purpose of this study was to establish if exercise training ameliorates inflammatory status in MetS patients. Data sources: PubMed, CINAHL, and Medline, Google Scholar, and Scopus databases and reference lists of included studies were searched. Study selection: Twenty randomized controlled trials (RCTs) of exercise-training impact on inflammatory markers (tumor necrosis factor (TNF) α, C-reactive protein (CRP), interleukin (IL) 6, IL-8, IL-10, and IL-18) with concurrent control groups were included in this analysis. Results: Results demonstrated an overall significant decrease in serum levels of TNF-α (mean difference (MD): −1.21 pg/ml; 95% confidence interval (CI): −1.77, −0.66), CRP (MD: −0.52 mg/l; 95% CI: −0.79, −0.25), IL-8 (MD: −1.31 pg/ml; 95% CI: −2.57, −0.06), and a significant increase in IL-10 (MD: 0.48 pg/ml; 95% CI: 0.10, 0.86). But exercise training did not change the level of IL-6 (MD: −0.69 pg/ml; 95% CI: −1.53, 0.14) and IL-18 (MD: −53.01 pg/ml; 95% CI: −166.64, 60.62). Conclusion: Exercise training improves TNF-α, CRP, IL-8, and IL-10 levels in patients with MetS. For some variables, isolated aerobic exercise, and combined aerobic and resistance exercise appears to be optimal. Future research is needed to clarify the mechanisms underlying exercise training’s effect on this population’s inflammatory markers. More studies are required to confirm these findings.

scholarly journals Elevated Serum Levels of Pigment Epithelium-Derived Factor in the Metabolic Syndrome

2006 ◽  
Vol 91 (6) ◽  
pp. 2447-2450 ◽  
Author(s):  
Sho-ichi Yamagishi ◽  
Hisashi Adachi ◽  
Akio Abe ◽  
Takako Yashiro ◽  
Mika Enomoto ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Pigment Epithelium ◽  
Elevated Serum ◽  
Serum Levels ◽  
The Metabolic Syndrome ◽  
Pigment Epithelium Derived Factor

P836 ELEVATED SERUM LEVELS OF ALT ARE ASSOCIATED WITH METABOLIC SYNDROME INDEPENDENT OF FATTY LIVER DIAGNOSED BY ULTRASOUND

2014 ◽  
Vol 60 (1) ◽  
pp. S350
Author(s):  
Y. Imamura ◽  
H. Uto ◽  
Y. Hiramine ◽  
K. Hosoyamada ◽  
S. Yoshifuku ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Liver ◽  
Elevated Serum ◽  
Serum Levels

scholarly journals Selective Elevation of Adiponectin Production by the Natural Compounds Derived from a Medicinal Herb Alleviates Insulin Resistance and Glucose Intolerance in Obese Mice

Endocrinology ◽  
2009 ◽  
Vol 150 (2) ◽  
pp. 625-633 ◽  
Author(s):  
Aimin Xu ◽  
Hongbing Wang ◽  
Ruby L. C. Hoo ◽  
Gary Sweeney ◽  
Paul. M. Vanhoutte ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glucose Intolerance ◽  
Elevated Serum ◽  
Chronic Administration ◽  
Serum Levels ◽  
Natural Compounds ◽  
Cardiovascular Complications ◽  
Medicinal Herb ◽  
Pharmacological Intervention ◽  
Obese Mice

Adiponectin is an adipocyte-derived insulin-sensitizing hormone with antidiabetic, antiinflammatory, and antiatherosclerotic properties. A decreased serum level of adiponectin in obesity has been identified as an independent risk factor for diabetes and cardiovascular complications, suggesting that pharmacological intervention aimed at elevating adiponectin production might hold promise for the treatment and/or prevention of these diseases. Here we report the identification of two structurally related natural compounds (astragaloside II and isoastragaloside I) from the medicinal herb Radix Astragali that possess such an activity. Astragaloside II and isoastragaloside I selectively increased adiponectin secretion in primary adipocytes without any obvious effects on a panel of other adipokines. Furthermore, an additive effect on induction of adiponectin production was observed between these two compounds and rosiglitazone, a thiazolidinedione class of insulin-sensitizing drugs. Chronic administration of astragaloside II and isoastragaloside I in both dietary and genetic obese mice significantly elevated serum levels of total adiponectin and selectively increased the composition of its high molecular weight oligomeric complex. These changes were associated with an alleviation of hyperglycemia, glucose intolerance, and insulin resistance. By contrast, the beneficial effects of these two compounds on insulin sensitivity and glucose metabolism were diminished in adiponectin knockout mice. In conclusion, our results suggest that pharmacological elevation of circulating adiponectin alone is sufficient to ameliorate insulin resistance and diabetes and support the use of adiponectin as a biomarker for future drug discovery. The two natural compounds might provide the lead as a novel class of therapeutics for obesity-related diseases. Natural compounds alleviate insulin resistance by inducing adiponectin production.

Fitness is associated with lower inflammatory markers in obesity: the FATCOR study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
H Midtboe ◽  
A Ulvik ◽  
K Meyer ◽  
P.M Ueland ◽  
H Halland ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Inflammatory Markers ◽  
Cardiopulmonary Exercise Testing ◽  
Serum Levels ◽  
Peak Oxygen Uptake ◽  
Low Grade ◽  
Funding Source ◽  
Amyloid A ◽  
Anti Inflammatory ◽  
Overweight Subjects

Abstract Background Obesity is associated with chronic low-grade inflammation, but exercise has anti-inflammatory properties. It is unknown whether the anti-inflammatory effects of fitness may influence the obesity-associated inflammation. Purpose To assess levels of inflammatory markers in fit vs. unfit overweight and obese subjects without known cardiovascular disease. Methods Peak oxygen uptake (VO2max) was measured by treadmill cardiopulmonary exercise testing in 566 subjects (mean age 48±9 years, 60% women) with body mass index >27.0 kg/m2 in the FAT associated CardiOvasculaR dysfunction (FATCOR) study. Fitness was defined from age- and sex adjusted reference levels of VO2max. Serum levels of C-reactive protein (CRP), serum amyloid A (SAA) and calprotectin were assessed by Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight (MALDI-TOF) mass spectrometry and log transformed before inclusion in analyses. Results Fit subjects (n=147) were older and had less metabolic syndrome, obesity and hypertension compared to unfit subjects (n=419) (all p<0.05). Serum levels of CRP and SAA were lower in fit subjects vs. unfit (p<0.01), while serum calprotectin showed no difference (p=0.06). In multivariable logistic regression analyses, lower CRP (odds ratio [OR] 0.73, 95% confidence interval [CI] 0.61–0.87, p<0.001) and SAA (OR 0.61, 95% CI 0.40–0.93, p=0.02) remained associated with being fit after adjusting for age, sex, obesity, metabolic syndrome and hypertension. When looking at obese (n=357, fit n=53) and overweight subjects (n=209, fit n=94) separately, lower CRP (OR 0.60, 95% CI 0.46–0.78, p<0.001) and SAA (OR 0.44, 95% CI 0.24–0.83, p=0.01) remained associated with being fit in obese, but not in overweight subjects after adjustment for age, sex and metabolic syndrome. Conclusion Fitness was associated with lower circulatory inflammatory markers in obesity independent of cardiometabolic risk factors. Our results suggest that fitness may promote cardiovascular benefit through the anti-inflammatory properties of exercise also in obesity. Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): The Western Norway Regional Health Authority

scholarly journals Pigment Epithelium-Derived Factor (PEDF) Suppresses IL-1β-Mediated c-Jun N-Terminal Kinase (JNK) Activation to Improve Hepatocyte Insulin Signaling

Endocrinology ◽  
2014 ◽  
Vol 155 (4) ◽  
pp. 1373-1385 ◽  
Author(s):  
Arijeet K. Gattu ◽  
Andreas L. Birkenfeld ◽  
Yasuko Iwakiri ◽  
Steven Jay ◽  
Mark Saltzman ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Insulin Signaling ◽  
Pigment Epithelium ◽  
Elevated Serum ◽  
Serum Levels ◽  
Akt Signaling ◽  
Human Hepatocytes ◽  
The Metabolic Syndrome ◽  
Pigment Epithelium Derived Factor

Pigment epithelium-derived factor (PEDF) is an antiinflammatory protein that circulates at high levels in the metabolic syndrome. Metabolic studies of PEDF knockout (KO) mice were conducted to investigate the relationship between PEDF, inflammatory markers, and metabolic homeostasis. Male PEDF KO mice demonstrated a phenotype consisting of increased adiposity, glucose intolerance, and elevated serum levels of metabolites associated with the metabolic syndrome. Genome expression analysis revealed an increase in IL-1β signaling in the livers of PEDF KO mice that was accompanied by impaired IRS and Akt signaling. In human hepatocytes, PEDF blocked the effects of an IL-1β challenge by suppressing activation of the inflammatory mediator c-Jun N-terminal kinase while restoring Akt signaling. RNA interference of PEDF in human hepatocytes was permissive for c-Jun N-terminal kinase activation and decreased Akt signaling. A metabolomics profile identified elevated circulating levels of tricarboxyclic acid cycle intermediates including succinate, an inducer of IL-1β, in PEDF KO mice. Succinate-dependent IL-1β expression was blocked by PEDF in PEDF KO, but not wild-type hepatocytes. In vivo, PEDF restoration reduced hyperglycemia and improved hepatic insulin signaling in PEDF KO mice. These findings identify elevated PEDF as a homeostatic mechanism in the human metabolic syndrome.

scholarly journals Elevated Serum Levels of Cysteine and Tyrosine: Early Biomarkers in Asymptomatic Adults at Increased Risk of Developing Metabolic Syndrome

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Nina Mohorko ◽  
Ana Petelin ◽  
Mihaela Jurdana ◽  
Gianni Biolo ◽  
Zala Jenko-Pražnikar
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Amino Acids ◽  
Metabolic Diseases ◽  
Elevated Serum ◽  
Serum Levels ◽  
Metabolic Complications ◽  
Markers Of Inflammation ◽  
Increased Risk

As there is effective intervention for delaying or preventing metabolic diseases, which are often present for years before becoming clinically apparent, novel biomarkers that would mark metabolic complications before the onset of metabolic disease should be identified. We investigated the role of fasting serum amino acids and their associations with inflammatory markers, adipokines, and metabolic syndrome (MetS) components in subjects prior to the onset of insulin resistance (IR). Anthropometric measurements, food records, adipokines, biochemical markers, and serum levels of amino acids were determined in 96 asymptomatic subjects aged 25–49 years divided into three groups according to the number of MetS components present. Cysteine and tyrosine were significantly higher already in group with one component of MetS present compared to subjects without MetS components. Serum amino acid levels correlated with markers of inflammation and adipokines. Alanine and glycine explained 10% of insulin resistance variability. The role of tyrosine and cysteine, that were higher already with 1 component of MetS present, should be further investigated as they might point to future insulin disturbances.

scholarly journals Correlation between CH2DS2-VASc Score and Serum Leptin Levels in Cardioembolic Stroke Patients: The Impact of Metabolic Syndrome

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Anna Szczepańska-Szerej ◽  
Jacek Kurzepa ◽  
Aneta Grabarska ◽  
Joanna Bielewicz ◽  
Ewa Wlizło-Dyś ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Elevated Serum ◽  
Female Gender ◽  
Serum Levels ◽  
Cardioembolic Stroke ◽  
Control Group ◽  
Stroke Patients ◽  
Serum Leptin ◽  
Potential Biomarker ◽  
The Impact

Objective. To determine adipokines levels in patients with different etiologic subtypes of acute ischemic stroke (AIS) and metabolic syndrome (MetS) status.Methods. Serum adiponectin, leptin, and resistin levels were determined by ELISA in 99 AIS patients and 59 stroke-free control group subjects. Stroke patients were grouped based on MetS, modified TOAST classification, and CHA2DS2-VASc scale in case of cardioembolic stroke following atrial fibrillation.Results. No differences were found in all adipokine serum levels between AIS patients and appropriately matched control group. MetS-AIS patients had significantly higher leptin levels (22.71 ± 19.01 ng/ml versus 8.95 ± 9.22 ng/ml,p<0.001) and lower adiponectin levels (10.71 ± 8.59 ng/ml versus 14.93 ± 10.95 ng/ml,p<0.05) than non-MetS-AIS patients. In patients with cardioembolic stroke, leptin levels were significantly higher than in remaining stroke cases (19.57 ± 20.53 ng/ml versus 13.17 ± 12.36 ng/ml,p<0.05) and CHA2DS2-VASc score positively correlated with leptin levels only (p<0.001). Analysis of individual components of CHA2DS2-VASc score showed that hypertension, female gender, and diabetes had greatest impact on elevated serum leptin level.Conclusion. This pilot study revealed that leptin could be a potential biomarker for risk stratification of cardioembolic stroke in MetS patients and that heterogeneity of stroke subtypes should be considered for more refined and precise clinical stroke studies.

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