scholarly journals Blood serum Vitamin D status evaluated in healthy people

2013 ◽  
Vol 26 (3) ◽  
pp. 317-320
Keyword(s):  
Vitamin D ◽  
Blood Serum ◽  
Healthy Subjects ◽  
Serum Alkaline Phosphatase ◽  
Randomized Study ◽  
Serum Vitamin ◽  
Blood Collection ◽  
Serum Vitamin D ◽  
Alp Activity ◽  
Inorganic Phosphates

The purpose of the study was to evaluate the status of vitamin D in healthy subjects. Vitamin D level was determined on the basis of blood serum 25(OH)D concentrations, taking into account the time of blood collection and age. Moreover, it was to find correlations between serum concentrations of: 25(OH)D, calcium, inorganic phosphates and serum alkaline phosphatase (ALP) activity. The randomized study was carried out on a group of 40 healthy subjects. Each person had venous blood samples drawn twice: from 6 March, 2012 to 15 March, 2012 and from 25 June, 2012 to 6 July, 2012. The results found the majority of subjects had lowered serum 25(OH)D concentrations compared to the reference range determined in the winter months of little insolation and in the summer months of much insolation. In the summer the blood serum concentration of 25(OH)D and ALP activity were statistically significantly higher in comparison with the winter and spring. The concentration of 25(OH)D was not statistically significantly related to age, concentrations of Ca, inorganic phosphates and ALP activity.

STUDY OF SERUM VITAMIN-D IN TYPE-2 DIABETES MELLITUS PATIENTS.

2021 ◽  
pp. 187-188
Author(s):  
Ajay Jain ◽  
Debina sarkar ◽  
G.G. Kaushik ◽  
Ankita Sharma
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Healthy Subjects ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Type 2 Diabetic

Background: Type-2 diabetes mellitus (T2DM) is a progressive and chronic disease characterized by both β-cell dysfunction and increased insulin resistance. Diabetes mellitus is now considered a giant killer disease of the 21st century with its vicious prongs in the South-East Asian countries, specially India, which is rightly said to be the ''Diabetes Capital'' of the world. Vitamin D has important effects on insulin action, and may impact on a number of pathways which may be of importance in the development of type 2 diabetes mellitus. Materials & Methods: In this study 62 Type-2 diabetic patients, 62 healthy controls were enrolled. Biochemical analytes measured were Serum glucose (Fasting Blood Sugar & Post Prandial Blood Sugar), Glycosylated Haemoglobin, Serum Vitamin-D. Results: The mean Serum Vitamin-D in Type-2 diabetic subjects were (16.3 ±3.0) while in healthy subjects(controls) the values were (39.3±5.2) respectively. These values were found to be statistically highly signicant(p<0.001). Conclusion: Serum Vitamin-D levels were decreased in Type 2 diabetic subjects as compared to the values in healthy subjects(controls).

Serum vitamin D levels in patients with vernal keratoconjunctivitis and its relationship with disease severity

2020 ◽  
pp. 112067212097888
Author(s):  
Rana Sorkhabi ◽  
Mohammad Hosein Ahoor ◽  
Amir Ghorbanihaghjo ◽  
Sasan Jafari
Keyword(s):  
Vitamin D ◽  
Healthy Subjects ◽  
Serum Vitamin ◽  
Vernal Keratoconjunctivitis ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D ◽  
The Difference ◽  
Grade 3

Purpose To evaluate the serum vitamin D levels of patients with vernal keratoconjunctivitis (VKC) Method A total of 39 VKC patients (21 males and 18 females) and 32 healthy individuals (19 males and 13 females) were enrolled in this study with the mean age of 18.38 ± 8.83 and 21.6 ± 9.43, respectively. The type and the grade of VKC were identified for each patient and serum 25-hydroxyvitamin D (25(OH)D) levels of all subjects were evaluated. Results The patients affected by VKC had statistically significant lower 25(OH)D levels (27.64 ± 8.50 ng/mL) than healthy subjects group (35.96 ± 11.34 ng/mL) ( p = 0.001). A reverse correlation was found between the serum vitamin D levels and the severity of the VKC but it was not statistically significant ( r = −0.159, p = 0.33). Besides, there were a few cases with severe and very severe VKC (2 in grade 3 and 4 in grade 4). Patients with the mixed type of the disease had lower serum vitamin D levels in comparison to tarsal and limbal forms but the difference was not statistically significant ( p = 0.38). Conclusion This study shows that the patients affected by VKC have lower vitamin D levels in comparison to healthy subjects and the screening of all patients with VKC for vitamin D levels seems rational.

scholarly journals Infantile Blount’s Disease: A case report of 3 years old female of Zhob, Pakistan

2021 ◽  
Vol 15 (8) ◽  
pp. 1993-1995
Author(s):  
Sumera Akram ◽  
Muhammad Ahmed Khan
Keyword(s):  
Vitamin D ◽  
Serum Alkaline Phosphatase ◽  
Early Stage ◽  
Clinical Signs ◽  
Serum Vitamin ◽  
Disease Process ◽  
Lower Limbs ◽  
Genu Varum ◽  
Blount’S Disease ◽  
Serum Vitamin D

Background; Blount’s disease is a rare developmental disorder of children which causes progressive bowing of lower limbs. The term “Blount” was named after American orthopedic surgeon “Walter Putnam Blount” who first described this condition. The etiology of Blount’s disease is unknown but believed to be multifactorial. Various predisposing factors have been attributed including obesity, early walking, race, pre-existing varus, increased pressure on growth plate and nutrition. Blount’s disease has been suggested to be more frequent in African, Afro-american populations. Blount’s disease has to be differentiated from physiological bowing (physiologic genu varum) and rickets. Early diagnosis and treatment of Blount’s disease is essential as the disease process is reversible in early stage. Case; A three years old female child was brought by her mother with complaint of progressive bowing of both lower limbs for last one year. She achieved her milestones at appropriate age and started walking at 11 months of age without support. On examination, her height was 90 cms (at 10th centile) and weight was 17 kgs (at 90th centile). BMI (body mass index) was 20.9 (obese). There were no clinical signs or symptoms of rickets i.e frontal bossing, wide wrist, rachitic rosary, carpopedal spasm, fits or muscle weakness etc. Roentgenogram showed tibia in varus with a peculiar beak at metaphysic and raised metaphyseal-diaphyseal angle (>16 degrees). Serum calcium and serum vitamin D (25-hydroxy vitamin D) were normal. Serum alkaline phosphatase level was raised. Keeping in view typical history, examination findings and radiological epiphyseal beaking along with raised metaphyseal-diaphyseal angle, diagnosis of Infantile Blount’s disease was made. Conclusion; The clinicians should have a high suspicion of infantile blount’s disease when a child, more than 3 year’s age presents with severe varus deformity at proximal tibia with typical radiological findings. Characteristic radiologic findings along with history and examination help to distinguish it from physiologic bowing (physiologic genu varum) and rickets. Keywords; Blount’s disease, Physiologic genu varum, Rickets, Tibia vara, Osteochondrosis deformans tibiae

Vitamin D inadequacy among asthmatic Iraqi Children

2018 ◽  
Vol 9 (SPL1) ◽  
Author(s):  
Zainab A Razak Al-Sharifi ◽  
Haider Abd Al Jabbar
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Alkaline Phosphatase ◽  
Serum Vitamin ◽  
Sun Exposure ◽  
Clinical History ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
History Of ◽  
Laboratory Investigations

Vitamin D assumes a part in the pathogenesis of asthma as it has an intense immunomodulatory impact following up on the cells of the innate immunity. It additionally decreases the danger of respiratory viral diseases which are critical initiators of asthma intensifications. Additionally,it potentiates the mitigating activity of corticosteroids which are viewed as the best controllers of asthma. To identify the recurrence of vitamin D inadequacy and lack among Iraqi asthmatic kids and to relate vitamin D levels to the seriousness of asthma. This case control study was directed on 50 asthmatic kids and 50 healthy controls. All were subjected to clinical history taking including history of sun introduction and asthma medication and full clinical examination. Laboratory investigations included estimation of serum calcium,serum alkaline phosphatase and serum 25-OH-D levels. There was a significant association between vitamin D deficiency and seriousness of asthma,yet there was no significant correlation between sun exposure and 25-OH-D level. Vitamin D deficiency is common in Iraqi children with asthma.Low levels of serum vitamin D are connected with high asthma seriousness,decreased asthma control.

Vitamin D Status and Acute Coronary Syndrome – A Single-Centre Study

2021 ◽  
Vol 13 (2) ◽  
pp. 183-188
Author(s):  
Mohammad Saidur Rahman ◽  
Muhammad Badrul Alam ◽  
AKM Monwarul Islam ◽  
Tanveer Ahmad ◽  
Md Wareshuzzaman ◽  
...  
Keyword(s):  
Vitamin D ◽  
Acute Coronary Syndrome ◽  
Vitamin D Deficiency ◽  
Healthy Subjects ◽  
Serum Vitamin ◽  
Vitamin D Insufficiency ◽  
Care Hospital ◽  
Serum Vitamin D ◽  
Coronary Syndrome ◽  
Severe Vitamin

Background: Vitamin D are needed for normal functioning of cardiovascular system, and its deficiency has been linked to different cardiovascular disorders, including hypertension. However, the relationship between vitamin D deficiency and ischaemic heart disease is not yet clear. The present study was intended to find out the association between serum vitamin D level and acute coronary syndrome (ACS). Methods: The cross-sectional analytical study was carried out in a tertiary care hospital of Dhaka, Bangladesh. Fifty-one consecutive ACS patients admitted into the Department of Cardiology of the hospital were considered as the cases and 51 apparently healthy subjects were considered as the controls. The exposure and outcome variables were serum vitamin D and ACS respectively. Vitamin D insufficiency and deficiency were defined as serum 25(OH) D <30-20 ng/ml and <20 ng/ml, respectively. Severe vitamin D deficiency was defined as serum 25(OH) D <10 ng/ml. Results: Hypovitaminosis D was prevalent in both cases and controls; however, the mean serum 25(OH) D was significantly lower in the former than the latter (14.2 ± 5.9 ng/ml vs. 18.2 ± 6.3 ng/ ml, respectively; p <0.001). Vitamin D insufficiency and moderate deficiency (serum 25(OH) D <20- 10 ng/ml) did not differ significantly between the groups, but severe deficiency (<10 ng/ml) was significantly more common in patients with ACS compared to the healthy controls. The risk of having moderate and severe vitamin D deficiency was 1.9-fold (95% CI = 0.8 – 4.7) and 22.8-fold (2.9 – 180.4) higher for ACS patients than for healthy subjects (p = 0.173 and p <0.001, respectively). Conclusion: Vitamin D deficiency is more common in patients with ACS compared to those without ACS. However, the independent association between vitamin D deficiency and ACS needs further evaluation. Cardiovasc. j. 2021; 13(2): 183-188

scholarly journals Serum vitamin D levels in treatment-naïve chronic hepatitis B patients

2017 ◽  
Vol 5 (4) ◽  
pp. 230-234 ◽  
Author(s):  
Ebada Said ◽  
Waleed El Agawy ◽  
Rehab Ahmed ◽  
Mohamed Hassany ◽  
Amal Ahmed ◽  
...  
Keyword(s):  
Vitamin D ◽  
Healthy Subjects ◽  
Serum Vitamin ◽  
Hbv Dna ◽  
Group Iii ◽  
Serum Vitamin D ◽  
Group I ◽  
Vitamin D Levels ◽  
Chronic Hbv

AbstractBackground and ObjectivesAccording to the demographic health survey conducted in 2015, Egypt had 10% documented prevalence of anti-HBc positive patients aged 1-59 and 1% viremic patients amongst the population in the same age group, with a domination of genotype D. Several studies claimed the possible role of vitamin D deficiency in hepatitis B virus (HBV) replication and disease progression.Patients and MethodsSerum vitamin D levels [25(OH D3] were assessed in 96 HBeAg negative non-cirrhotic chronic HBV patients and 25 healthy subjects classified as following: Group I: 48 chronic HBV patients with persistently normal ALT levels and HBV DNA level < 2000 IU/mL for ≥ 6 months; Group II: 48 chronic HBV patients with CHB with persistently elevated ALT and HBV DNA level ≥ 2000 IU/mL for ≥ 6 months; and Group III: 25 apparently healthy subjects with normal liver enzymes and negative hepatitis viral markers were taken as the control group.ResultsVitamin D was much more deficient in group II than in group I and group III being 11.55 ± 3.97 ng/mL, 15.03 ± 3.45, 27.00 ± 6.76 ng/mL (P< 0.001), respectively, and a strong negative correlation was observed between vitamin D levels and HBV DNA levels (P= 0.043) in groups I and II.ConclusionThe current study showed high HBV DNA replication in patients with vitamin D deficiency suggesting the antimicrobial immunomodulatory role of vitamin D.

Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

2020 ◽  
Vol 90 (3-4) ◽  
pp. 346-352
Author(s):  
Vincenzo Pilone ◽  
Salvatore Tramontano ◽  
Carmen Cutolo ◽  
Federica Marchese ◽  
Antonio Maria Pagano ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Female Sex ◽  
Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

Relationship Between Nutrient Intake and Vitamin D Status in Osteoporotic Women

2007 ◽  
Vol 77 (6) ◽  
pp. 376-381 ◽  
Author(s):  
de Souza Genaro ◽  
de Paiva Pereira ◽  
de Medeiros Pinheiro ◽  
Szejnfeld ◽  
Araújo Martini
Keyword(s):  
Vitamin D ◽  
Mineral Metabolism ◽  
Sodium Intake ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Dietary Intakes ◽  
Mineral Density ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Dietary Records

Vitamin D is essential for maintaining calcium homeostasis and optimizing bone health. Its inadequacy is related to many factors including dietary intake. The aim of the present study was to evaluate serum 25(OH)D and its relationship with nutrient intakes in postmenopausal Brazilian women with osteoporosis. This cross-sectional study comprised 45 free-living and assisted elderly at São Paulo Hospital. Three-day dietary records were used to assess dietary intakes. Bone mineral density was measured with a dual-energy X-ray absorptiometer (DXA). Blood and urine sample were collected for analysis of biochemical markers of bone and mineral metabolism. Insufficiency of vitamin D was observed in 24.4% of the women and optimal levels (≥ 50 nmol/L) were observed in 75.6%. Parathyroid hormone was above the reference range in 51% of the participants. The mean calcium (724 mg/day) and vitamin D (4.2 μ g/day) intakes were lower than the value proposed by The Food and Nutrition Board and sodium intake was more than two-fold above the recommendation. Higher levels of serum 25(OH)D were inversely associated with sodium intake. Dietary strategies to improve serum vitamin D must focus on increasing vitamin D intake and should take a reduction of sodium intake into consideration.

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