scholarly journals Infantile Blount’s Disease: A case report of 3 years old female of Zhob, Pakistan

2021 ◽  
Vol 15 (8) ◽  
pp. 1993-1995
Author(s):  
Sumera Akram ◽  
Muhammad Ahmed Khan
Keyword(s):  
Vitamin D ◽  
Serum Alkaline Phosphatase ◽  
Early Stage ◽  
Clinical Signs ◽  
Serum Vitamin ◽  
Disease Process ◽  
Lower Limbs ◽  
Genu Varum ◽  
Blount’S Disease ◽  
Serum Vitamin D

Background; Blount’s disease is a rare developmental disorder of children which causes progressive bowing of lower limbs. The term “Blount” was named after American orthopedic surgeon “Walter Putnam Blount” who first described this condition. The etiology of Blount’s disease is unknown but believed to be multifactorial. Various predisposing factors have been attributed including obesity, early walking, race, pre-existing varus, increased pressure on growth plate and nutrition. Blount’s disease has been suggested to be more frequent in African, Afro-american populations. Blount’s disease has to be differentiated from physiological bowing (physiologic genu varum) and rickets. Early diagnosis and treatment of Blount’s disease is essential as the disease process is reversible in early stage. Case; A three years old female child was brought by her mother with complaint of progressive bowing of both lower limbs for last one year. She achieved her milestones at appropriate age and started walking at 11 months of age without support. On examination, her height was 90 cms (at 10th centile) and weight was 17 kgs (at 90th centile). BMI (body mass index) was 20.9 (obese). There were no clinical signs or symptoms of rickets i.e frontal bossing, wide wrist, rachitic rosary, carpopedal spasm, fits or muscle weakness etc. Roentgenogram showed tibia in varus with a peculiar beak at metaphysic and raised metaphyseal-diaphyseal angle (>16 degrees). Serum calcium and serum vitamin D (25-hydroxy vitamin D) were normal. Serum alkaline phosphatase level was raised. Keeping in view typical history, examination findings and radiological epiphyseal beaking along with raised metaphyseal-diaphyseal angle, diagnosis of Infantile Blount’s disease was made. Conclusion; The clinicians should have a high suspicion of infantile blount’s disease when a child, more than 3 year’s age presents with severe varus deformity at proximal tibia with typical radiological findings. Characteristic radiologic findings along with history and examination help to distinguish it from physiologic bowing (physiologic genu varum) and rickets. Keywords; Blount’s disease, Physiologic genu varum, Rickets, Tibia vara, Osteochondrosis deformans tibiae

scholarly journals Blood serum Vitamin D status evaluated in healthy people

2013 ◽  
Vol 26 (3) ◽  
pp. 317-320
Keyword(s):  
Vitamin D ◽  
Blood Serum ◽  
Healthy Subjects ◽  
Serum Alkaline Phosphatase ◽  
Randomized Study ◽  
Serum Vitamin ◽  
Blood Collection ◽  
Serum Vitamin D ◽  
Alp Activity ◽  
Inorganic Phosphates

The purpose of the study was to evaluate the status of vitamin D in healthy subjects. Vitamin D level was determined on the basis of blood serum 25(OH)D concentrations, taking into account the time of blood collection and age. Moreover, it was to find correlations between serum concentrations of: 25(OH)D, calcium, inorganic phosphates and serum alkaline phosphatase (ALP) activity. The randomized study was carried out on a group of 40 healthy subjects. Each person had venous blood samples drawn twice: from 6 March, 2012 to 15 March, 2012 and from 25 June, 2012 to 6 July, 2012. The results found the majority of subjects had lowered serum 25(OH)D concentrations compared to the reference range determined in the winter months of little insolation and in the summer months of much insolation. In the summer the blood serum concentration of 25(OH)D and ALP activity were statistically significantly higher in comparison with the winter and spring. The concentration of 25(OH)D was not statistically significantly related to age, concentrations of Ca, inorganic phosphates and ALP activity.

scholarly journals Calcification of coronary arteries in patients with calcium pyrophosphate crystal deposition disease and knee osteoarthritis

2021 ◽  
Vol 59 (4) ◽  
pp. 411-417
Author(s):  
M. S. Eliseev ◽  
D. S. Novikova ◽  
A. M. Novikova ◽  
L. M. Blank ◽  
O. V. Zhelyabina ◽  
...  
Keyword(s):  
Vitamin D ◽  
Clinical Signs ◽  
Serum Vitamin ◽  
Calcium Score ◽  
Calcium Pyrophosphate ◽  
Crystal Deposition ◽  
Crystal Deposition Disease ◽  
Serum Vitamin D ◽  
Deposition Disease ◽  
Vitamin D Levels

The frequency of vascular calcification in patients with osteoarthritis (OA) and calcium pyrophosphate crystal deposition disease (CPPD) has not yet been studied, and the role of calcium crystals (basic and pyrophosphates) in the development of calcification is also unknown.Objective. Determine the presence and degree of calcification of the coronary vessels in patients with calcium pyrophosphate crystal deposition disease and osteoarthritis of the knee joints with no clinical signs of cardiovascular diseases.Materials and methods. One-stage, single-center study, performed by the “case – control” method. The main group – 20 patients with CPPD, the comparison group – 20 patients with OA of the knee joints. Inclusion criteria: age from 18 to 65 years; absence of clinical signs of cardiovascular disease at the time of examination and indications of a history of cardiovascular accidents. Exclusion criteria: unsigned informed consent; pregnancy; breastfeeding; other rheumatic disease; cancer; high and very high cardiovascular risk on the SCORE scale. The survey included an assessment of anthropometric data, blood pressure (BP), lipid profile, serum levels of glucose, creatinine, uric acid, C-reactive protein, vitamin D, osteoprotegerin, parathyroid hormone, and the levels of magnesium, phosphorus, and total calcium were studied. All patients underwent multispiral computed tomography with determination of calcium count and the number of affected arteries. To calculate the coronary score, the A.S. Agatston et al.Results and discussion. Most of the parameters in the compared groups did not differ. When assessing the calcification of the coronary arteries according to the A.S. Agatston et al. 9 (45%) patients with CPPD and 8 (40%) patients with OA had a coronary calcium score >1. Quantitative indicators of calcium score can correspond to coronary artery stenosis ≥20% in 8 (40%) patients with CPPD and in 5 (25%) patients with OA according to J.A. Rumberger et al. The serum level of osteoprotegerin was significantly higher in patients with a calcium score ≥27 according to J.A. Rumberger et al. (p=0.04). Calcification was detected in 9 (56%) of 16 patients with serum vitamin D levels <30 ng/ml and in 8 (33%) of 24 patients with serum vitamin D levels >30 ng/ml.Conclusions. In patients with an initially low cardiovascular risk, the probability of a combination of chondrocalcinosis and cardiovascular calcification is 45%, in OA it is 40%. The risk factors for coronary calcification in patients with CPPD and OA should be studied further.

Vitamin D inadequacy among asthmatic Iraqi Children

2018 ◽  
Vol 9 (SPL1) ◽  
Author(s):  
Zainab A Razak Al-Sharifi ◽  
Haider Abd Al Jabbar
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Alkaline Phosphatase ◽  
Serum Vitamin ◽  
Sun Exposure ◽  
Clinical History ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
History Of ◽  
Laboratory Investigations

Vitamin D assumes a part in the pathogenesis of asthma as it has an intense immunomodulatory impact following up on the cells of the innate immunity. It additionally decreases the danger of respiratory viral diseases which are critical initiators of asthma intensifications. Additionally,it potentiates the mitigating activity of corticosteroids which are viewed as the best controllers of asthma. To identify the recurrence of vitamin D inadequacy and lack among Iraqi asthmatic kids and to relate vitamin D levels to the seriousness of asthma. This case control study was directed on 50 asthmatic kids and 50 healthy controls. All were subjected to clinical history taking including history of sun introduction and asthma medication and full clinical examination. Laboratory investigations included estimation of serum calcium,serum alkaline phosphatase and serum 25-OH-D levels. There was a significant association between vitamin D deficiency and seriousness of asthma,yet there was no significant correlation between sun exposure and 25-OH-D level. Vitamin D deficiency is common in Iraqi children with asthma.Low levels of serum vitamin D are connected with high asthma seriousness,decreased asthma control.

scholarly journals The Interplay of Vitamin D Deficiency and Cellular Senescence in the Pathogenesis of Obesity-Related Co-Morbidities

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4127
Author(s):  
Abdulhadi Bima ◽  
Basmah Eldakhakhny ◽  
Dina Nuwaylati ◽  
Abrar Alnami ◽  
Mohammed Ajabnoor ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Cellular Senescence ◽  
Early Stage ◽  
Subclinical Atherosclerosis ◽  
Serum Vitamin ◽  
Low Grade ◽  
Cardiac Events ◽  
Alcoholic Fatty Liver ◽  
Serum Vitamin D

This scoping review aims to clarify the interplay between obesity, vitamin D deficiency, cellular senescence, and obesity-related metabolic consequences, mainly subclinical atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). Obesity is a significant global health problem that involves cellular, environmental, behavioral, and genetic elements. The fundamental cause of obesity throughout all life stages is an energy imbalance, and its consequences are countless and, foremost, very common. Obesity has been comprehensively studied in the literature given its association with low serum vitamin D, with many proposed mechanisms linking the two conditions. Moreover, markers of exaggerated cellular senescence have been proven to accumulate in obese individuals. Subclinical atherosclerosis initiates an early stage that ends in serious cardiac events, and obesity, low vitamin D, and senescent cells largely contribute to its associated chronic low-grade inflammation. Furthermore, NAFLD signifies the hepatic manifestation of metabolic syndrome, and studies have highlighted the important role of obesity, vitamin D deficiency, and cellular senescence in its development. Therefore, we outlined the most important mechanisms tying these conditions to one another.

Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

2020 ◽  
Vol 90 (3-4) ◽  
pp. 346-352
Author(s):  
Vincenzo Pilone ◽  
Salvatore Tramontano ◽  
Carmen Cutolo ◽  
Federica Marchese ◽  
Antonio Maria Pagano ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Female Sex ◽  
Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

Relationship Between Nutrient Intake and Vitamin D Status in Osteoporotic Women

2007 ◽  
Vol 77 (6) ◽  
pp. 376-381 ◽  
Author(s):  
de Souza Genaro ◽  
de Paiva Pereira ◽  
de Medeiros Pinheiro ◽  
Szejnfeld ◽  
Araújo Martini
Keyword(s):  
Vitamin D ◽  
Mineral Metabolism ◽  
Sodium Intake ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Dietary Intakes ◽  
Mineral Density ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Dietary Records

Vitamin D is essential for maintaining calcium homeostasis and optimizing bone health. Its inadequacy is related to many factors including dietary intake. The aim of the present study was to evaluate serum 25(OH)D and its relationship with nutrient intakes in postmenopausal Brazilian women with osteoporosis. This cross-sectional study comprised 45 free-living and assisted elderly at São Paulo Hospital. Three-day dietary records were used to assess dietary intakes. Bone mineral density was measured with a dual-energy X-ray absorptiometer (DXA). Blood and urine sample were collected for analysis of biochemical markers of bone and mineral metabolism. Insufficiency of vitamin D was observed in 24.4% of the women and optimal levels (≥ 50 nmol/L) were observed in 75.6%. Parathyroid hormone was above the reference range in 51% of the participants. The mean calcium (724 mg/day) and vitamin D (4.2 μ g/day) intakes were lower than the value proposed by The Food and Nutrition Board and sodium intake was more than two-fold above the recommendation. Higher levels of serum 25(OH)D were inversely associated with sodium intake. Dietary strategies to improve serum vitamin D must focus on increasing vitamin D intake and should take a reduction of sodium intake into consideration.

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